352 research outputs found
Excitotoxicity Triggered by Neurobasal Culture Medium
- Author
- AA Shute
- B Gustafsson
- C Peterson
- CF Zorumski
- CF Zorumski
- Charles F. Zorumski
- DC Crawford
- DD Schoepp
- Devon C. Crawford
- DK Patneau
- DW Choi
- DW Choi
- G Shanker
- G Tong
- GA Mathisen
- GJ Brewer
- GM Durand
- H Monyer
- J Ferkany
- J Hogins
- JH Weiss
- JM Gidday
- Joshua Hogins
- JW Olney
- JW Olney
- KL Moulder
- KL Moulder
- LD Brewer
- MA Moskowitz
- MJ Croucher
- ML Mayer
- MP Goldberg
- MP Mattson
- MS Grubb
- PB Nunn
- Q Shi
- R Janaky
- S Mennerick
- S Mennerick
- S Mennerick
- S Rothman
- SM Rothman
- Steven Mennerick
- Stuart E. Dryer
- XC Tang
- Y Izumi
- ZZ Pan
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Neurobasal defined culture medium has been optimized for survival of rat embryonic hippocampal neurons and is now widely used for many types of primary neuronal cell culture. Therefore, we were surprised that routine medium exchange with serum- and supplement-free Neurobasal killed as many as 50% of postnatal hippocampal neurons after a 4 h exposure at day in vitro 12–15. Minimal Essential Medium (MEM), in contrast, produced no significant toxicity. Detectable Neurobasal-induced neuronal death occurred with as little as 5 min exposure, measured 24 h later. D-2-Amino-5-phosphonovalerate (D-APV) completely prevented Neurobasal toxicity, implicating direct or indirect N-methyl-D-aspartate (NMDA) receptor-mediated neuronal excitotoxicity. Whole-cell recordings revealed that Neurobasal but not MEM directly activated D-APV-sensitive currents similar in amplitude to those gated by 1 µM glutamate. We hypothesized that L-cysteine likely mediates the excitotoxic effects of Neurobasal incubation. Although the original published formulation of Neurobasal contained only 10 µM L-cysteine, commercial recipes contain 260 µM, a concentration in the range reported to activate NMDA receptors. Consistent with our hypothesis, 260 µM L-cysteine in bicarbonate-buffered saline gated NMDA receptor currents and produced toxicity equivalent to Neurobasal. Although NMDA receptor-mediated depolarization and Ca2+ influx may support survival of young neurons, NMDA receptor agonist effects on development and survival should be considered when employing Neurobasal culture medium
The meaning and measurement of implementation climate
- Author
- A Cohen
- A Cohen
- AE Akgun
- AE Reichers
- AP Jones
- B Schneider
- B Schneider
- B Schneider
- B Schneider
- B Schneider
- B Schneider
- B Schneider
- BB Baltes
- BD Smith
- BD Smith
- BF Chorpita
- BJ Weiner
- Bryan J Weiner
- C Glisson
- C Glisson
- C Oser
- C Pullig
- CB Oser
- CD Helfrich
- Charles M Belden
- CP Ruppel
- D Chan
- D Hellrieg
- D Mayer
- D Rousseau
- D Zohar
- D Zohar
- D Zohar
- D Zohar
- D Zohar
- D Zohar
- D Zohar
- DA Newman
- Dawn M Bergmire
- DYP Leung
- EL Lev
- F Dansereau
- F Dansereau
- G Ekvall
- G Luria
- G Robinson-Smith
- GA Aarons
- GA Aarons
- GA Aarons
- GE Mathisen
- GH Litwin
- H van Mierlo
- J Finkelstein
- JA Colquitt
- JF Etter
- JM LeBreton
- KJ Klein
- KJ Klein
- KJ Klein
- KJ Klein
- KJ Klein
- KM Osei-Bryson
- LC Hughes
- LJ Damschroder
- LJ Damschroder
- LM Minasian
- LR James
- LR James
- LR James
- LY Dong
- Matthew Johnston
- MG Patterson
- NCW van der Ven
- NE Allen
- P Brennan
- PD Bliese
- PJ Holahan
- RD Brown
- RK Dishman
- RK Dishman
- RM Guion
- SE Naumann
- SG Isaksen
- SP Lin
- ST Hunter
- SWJ Kozlowski
- T Greenhalgh
- TM Amabile
- V Gonzalez-Roma
- V Gonzalez-Roma
- W Mischel
- WH Glick
- WH Glick
- WH Glick
- WR Carpenter
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Climate has a long history in organizational studies, but few theoretical models integrate the complex effects of climate during innovation implementation. In 1996, a theoretical model was proposed that organizations could develop a positive climate for implementation by making use of various policies and practices that promote organizational members' means, motives, and opportunities for innovation use. The model proposes that implementation climate--or the extent to which organizational members perceive that innovation use is expected, supported, and rewarded--is positively associated with implementation effectiveness. The implementation climate construct holds significant promise for advancing scientific knowledge about the organizational determinants of innovation implementation. However, the construct has not received sufficient scholarly attention, despite numerous citations in the scientific literature. In this article, we clarify the meaning of implementation climate, discuss several measurement issues, and propose guidelines for empirical study.</p> <p>Discussion</p> <p>Implementation climate differs from constructs such as organizational climate, culture, or context in two important respects: first, it has a strategic focus (implementation), and second, it is innovation-specific. Measuring implementation climate is challenging because the construct operates at the organizational level, but requires the collection of multi-dimensional perceptual data from many expected innovation users within an organization. In order to avoid problems with construct validity, assessments of within-group agreement of implementation climate measures must be carefully considered. Implementation climate implies a high degree of within-group agreement in climate perceptions. However, researchers might find it useful to distinguish implementation climate level (the average of implementation climate perceptions) from implementation climate strength (the variability of implementation climate perceptions). It is important to recognize that the implementation climate construct applies most readily to innovations that require collective, coordinated behavior change by many organizational members both for successful implementation and for realization of anticipated benefits. For innovations that do not possess these attributes, individual-level theories of behavior change could be more useful in explaining implementation effectiveness.</p> <p>Summary</p> <p>This construct has considerable value in implementation science, however, further debate and development is necessary to refine and distinguish the construct for empirical use.</p
RNA viruses in community-acquired childhood pneumonia in semi-urban Nepal; a cross-sectional study
- Author
- A Christensen
- AL Drews
- BG van den Hoogen
- Biswa N Sharma
- BL Rao
- CB Hall
- CDC
- D Giri
- Dag Hvidsten
- DD Erdman
- DJ Nokes
- EH Choi
- F Chew
- F Freymuth
- F Maggi
- F Shann
- G Reed
- GA Weinberg
- Halvor Sommerfelt
- J Jian
- JA McCullers
- JS Peiris
- K Hasan
- K McIntosh
- KA Poehling
- KE Arden
- KJ Henrickson
- KJ Henrickson
- KR Risnes
- L Liolios
- LC Nacul
- LG Stensballe
- LP Shek
- LT Daum
- Maria Mathisen
- MK Iwane
- MW Syrmis
- MW Weber
- N Principi
- P Bharaj
- Palle Valentiner-Branth
- PK Chan
- PR Murray
- Prakash S Shrestha
- PW Chan
- Ram K Chandyo
- Ramesh K Adhikari
- RS Maitreyi
- S Altizer
- S Banerjee
- S Broor
- SA Madhi
- SC Agarwal
- SC Kehl
- SE Robertson
- SS Chiu
- Sudha Basnet
- T Allander
- T Cherian
- TA Strand
- Tor A Strand
- W Thanasugarn
- WA Brooks
- WHO Multicentre Growth Reference Study Group
- WHO UNICEF
- WHO UNICEF
- WJ Alonso
- YL Shakya
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Pneumonia is among the main causes of illness and death in children <5 years of age. There is a need to better describe the epidemiology of viral community-acquired pneumonia (CAP) in developing countries.</p> <p>Methods</p> <p>From July 2004 to June 2007, we examined nasopharyngeal aspirates (NPA) from 2,230 cases of pneumonia (World Health Organization criteria) in children 2 to 35 months old recruited in a randomized trial of zinc supplementation at a field clinic in Bhaktapur, Nepal. The specimens were examined for respiratory syncytial virus (RSV), influenza virus type A (InfA) and B (InfB), parainfluenza virus types 1, 2 and 3 (PIV1, PIV2, and PIV3), and human metapneumovirus (hMPV) using a multiplex reverse transcriptase polymerase chain reaction (PCR) assay.</p> <p>Results</p> <p>We identified 919 virus isolates in 887 (40.0%) of the 2,219 NPA specimens with a valid PCR result, of which 334 (15.1%) yielded RSV, 164 (7.4%) InfA, 129 (5.8%) PIV3, 98 (4.4%) PIV1, 93 (4.2%) hMPV, 84 (3.8%) InfB, and 17 (0.8%) PIV2. CAP occurred in an epidemic pattern with substantial temporal variation during the three years of study. The largest peaks of pneumonia occurrence coincided with peaks of RSV infection, which occurred in epidemics during the rainy season and in winter. The monthly number of RSV infections was positively correlated with relative humidity (<it>r</it><sub><it>s </it></sub>= 0.40, <it>P </it>= 0.01), but not with temperature or rainfall. An hMPV epidemic occurred during one of the three winter seasons and the monthly number of hMPV cases was also associated with relative humidity (<it>r</it><sub><it>s </it></sub>= 0.55, <it>P </it>= 0.0005).</p> <p>Conclusion</p> <p>Respiratory RNA viruses were detected from NPA in 40% of CAP cases in our study. The most commonly isolated viruses were RSV, InfA, and PIV3. RSV infections contributed substantially to the observed CAP epidemics. The occurrence of viral CAP in this community seemed to reflect more or less overlapping micro-epidemics with several respiratory viruses, highlighting the challenges of developing and implementing effective public health control measures.</p
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abed Abud A
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Achkar B
- Adam Bourdarios C
- Adam L
- Adamczyk L
- Adamek L
- Adelman J
- Adiguzel A
- Adorni S
- Adye T
- Affolder AA
- Afik Y
- Agapopoulou C
- Agaras MN
- Agarwala J
- Aggarwal A
- Agheorghiesei C
- Aguilar-Saavedra JA
- Ahmad A
- Ahmadov F
- Ahmed WS
- Ai X
- Aielli G
- Akatsuka S
- Akbiyik M
- Akimov AV
- Al Khoury K
- Alberghi GL
- Albert J
- Alconada Verzini MJ
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexopoulos T
- Alfonsi A
- Alfonsi F
- Alhroob M
- Ali B
- Ali S
- Aliev M
- Alimonti G
- Allaire C
- Allbrooke BMM
- Allport PP
- Aloisio A
- Alonso F
- Alpigiani C
- Alunno Camelia E
- Alvarez Estevez M
- Alviggi MG
- Amaral Coutinho Y
- Ambler A
- Ambroz L
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amoroso S
- Amrouche CS
- Anastopoulos C
- Andari N
- Andeen T
- Anders JK
- Andrean SY
- Andreazza A
- Andrei V
- Angelidakis S
- Angerami A
- Anisenkov AV
- Annovi A
- Antel C
- Anthony MT
- Antipov E
- Antonelli M
- Antrim DJA
- Anulli F
- Aoki M
- Aparisi Pozo JA
- Aparo MA
- Aperio Bella L
- Aranzabal N
- Araujo Ferraz V
- Arcangeletti C
- Arce ATH
- Arena E
- Arguin J-F
- Argyropoulos S
- Arling J-H
- Armbruster AJ
- Armstrong A
- Arnaez O
- Arnold H
- Arrubarrena Tame ZP
- Artoni G
- Asada H
- Asai K
- Asai S
- Asbah NA
- Asimakopoulou EM
- Asquith L
- Assahsah J
- Assamagan K
- Astalos R
- Atkin RJ
- Atkinson M
- Atlay NB
- Atmani H
- Atmasiddha PA
- Augsten K
- Auricchio S
- Austrup VA
- Avolio G
- Ayoub MK
- Azuelos G
- Babal D
- Bachacou H
- Bachas K
- Backman F
- Badea A
- Bagnaia P
- Bahrasemani H
- Bailey AJ
- Bailey VR
- Baines JT
- Bakalis C
- Baker OK
- Bakker PJ
- Bakos E
- Bakshi Gupta D
- Balaji S
- Balasubramanian R
- Baldin EM
- Balek P
- Ballabene E
- Balli F
- Balunas WK
- Balz J
- Banas E
- Bandieramonte M
- Bandyopadhyay A
- Barak L
- Barberio EL
- Barberis D
- Barbero M
- Barbour G
- Barends KN
- Barillari T
- Barisits M-S
- Barkeloo J
- Barklow T
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barranco Navarro L
- Barreiro Guimarães da Costa J
- Barreiro F
- Barron U
- Barsov S
- Bartels F
- Bartoldus R
- Bartolini G
- Barton AE
- Bartos P
- Basalaev A
- Basan A
- Bashta I
- Bassalat A
- Basso MJ
- Basson CR
- Bates RL
- Batlamous S
- Batley JR
- Batool B
- Battaglia M
- Bauce M
- Bauer F
- Bauer P
- Bawa HS
- Bayirli A
- Beacham JB
- Beau T
- Beauchemin PH
- Becherer F
- Bechtle P
- Beck HP
- Becker K
- Becot C
- Beddall AJ
- Bednyakov VA
- Bee CP
- Beermann TA
- Begalli M
- Begel M
- Behera A
- Behr JK
- Beirao Da Cruz E Silva C
- Beirer JF
- Beisiegel F
- Belfkir M
- Bella G
- Bellagamba L
- Bellerive A
- Bellos P
- Beloborodov K
- Belotskiy K
- Belyaev NL
- Benchekroun D
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Bentvelsen S
- Beresford L
- Beretta M
- Berge D
- Bergeaas Kuutmann E
- Berger N
- Bergmann B
- Bergsten LJ
- Beringer J
- Berlendis S
- Bernardi G
- Bernius C
- Bernlochner FU
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- Berta P
- Berthold A
- Bertram IA
- Bessidskaia Bylund O
- Bethke S
- Betti A
- Bevan AJ
- Bhatta S
- Bhattacharya DS
- Bhattarai P
- Bhopatkar VS
- Bi R
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- Biesuz NV
- Biglietti M
- Billoud TRV
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- Biondi S
- Birch-sykes CJ
- Bird GA
- Birman M
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- Biswal JP
- Biswas D
- Bitadze A
- Bittrich C
- Bjørke K
- Bloch I
- Blocker C
- Blue A
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VS
- Bogavac D
- Bogdanchikov AG
- Bohm C
- Boisvert V
- Bokan P
- Bold T
- Bomben M
- Bona M
- Boonekamp M
- Booth CD
- Borbély AG
- Borecka-Bielska HM
- Borgna LS
- Borissov G
- Bortoletto D
- Boscherini D
- Bosman M
- Bossio Sola JD
- Bouaouda K
- Boudreau J
- Bouhova-Thacker EV
- Boumediene D
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- Boveia A
- Boyd J
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- Boyko IR
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- Bracinik J
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- Breaden Madden WD
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- Brener R
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- Brickwedde B
- Briglin DL
- Britton D
- Britzger D
- Brock I
- Brock R
- Brooijmans G
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- Bruckman de Renstrom PA
- Bruncko D
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- Brüers B
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- Buat Q
- Buchholz P
- Buckley AG
- Budagov IA
- Bugge MK
- Bulekov O
- Bullard BA
- Burch TJ
- Burdin S
- Burgard CD
- Burger AM
- Burghgrave B
- Burr JTP
- Burton CD
- Burzynski JC
- Bussey PJ
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Buxo Vazquez CJ
- Buzykaev AR
- Büscher V
- Cabras G
- Cabrera Urbán S
- Caforio D
- Cai H
- Cairo VMM
- Cakir O
- Calace N
- Calafiura P
- Calderini G
- Calfayan P
- Callea G
- Caloba LP
- Caltabiano A
- Calvente Lopez S
- Calvet D
- Calvet S
- Calvet TP
- Calvetti M
- Camacho Toro R
- Camarda S
- Camarero Munoz D
- Camarri P
- Camerlingo MT
- Cameron D
- Camincher C
- Campanelli M
- Camplani A
- Canale V
- Canesse A
- Cano Bret M
- Cantero J
- Cao Y
- Capua M
- Carbone A
- Cardarelli R
- Cardillo F
- Carducci G
- Carli T
- Carlino G
- Carlson BT
- Carlson EM
- Carminati L
- Carnesale M
- Carney RMD
- Caron S
- Carquin E
- Carratta G
- Carrá S
- Carter JWS
- Carter TM
- Casadei D
- Casado MP
- Casha AF
- Castiglia EG
- Castillo Garcia L
- Castillo Gimenez V
- Castillo FL
- Castro NF
- Catinaccio A
- Catmore JR
- Cattai A
- Cavaliere V
- Cavalli N
- Cavasinni V
- Celebi E
- Celli F
- Cerny K
- Cerqueira AS
- Cerri A
- Cerrito L
- Cerutti F
- Cervelli A
- Cetin SA
- Chadi Z
- Chakraborty D
- Chala M
- Chan J
- Chan WS
- Chan WY
- Chapman JD
- Chargeishvili B
- Charlton DG
- Charman TP
- Chatterjee M
- Chau CC
- Chekanov S
- Chekulaev SV
- Chelkov GA
- Chen A
- Chen B
- Chen C
- Chen CH
- Chen H
- Chen H
- Chen J
- Chen J
- Chen J
- Chen S
- Chen SJ
- Chen X
- Chen Y
- Chen Y-H
- Cheng CL
- Cheng HC
- Cheng HJ
- Cheplakov A
- Cheremushkina E
- Cherkaoui El Moursli R
- Cheu E
- Cheung K
- Chevalier L
- Chiarella V
- Chiarelli G
- Chiodini G
- Chisholm AS
- Chitan A
- Chiu I
- Chiu YH
- Chizhov MV
- Choi K
- Chomont AR
- Chou Y
- Chow YS
- Christopher LD
- Chu MC
- Chu X
- Chudoba J
- Chwastowski JJ
- Cieri D
- Ciesla KM
- Cindro V
- Cioară IA
- Ciocio A
- Cirotto F
- Citron ZH
- Citterio M
- Ciubotaru DA
- Ciungu BM
- Clark A
- Clark PJ
- Clavijo Columbie JM
- Clawson SE
- Clement C
- Clissa L
- Coadou Y
- Cobal M
- Coccaro A
- Cochran J
- Coelho Barrue RF
- Coelho Lopes De Sa R
- Coelli S
- Cohen H
- Coimbra AEC
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- Collot J
- Conde Muiño P
- Connell SH
- Connelly IA
- Conroy EI
- Conventi F
- Cooke HG
- Cooper-Sarkar AM
- Cormier F
- Corpe LD
- Corradi M
- Corrigan EE
- Corriveau F
- Costa MJ
- Costanza F
- Costanzo D
- Cote BM
- Cowan G
- Cowley JW
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- Cranmer K
- Creager RA
- Crescioli F
- Cristinziani M
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- Crosetti G
- Crépé-Renaudin S
- Cueto A
- Cuhadar Donszelmann T
- Cui H
- Cukierman AR
- Cunningham WR
- Czekierda S
- Czodrowski P
- Czurylo MM
- Da Cunha Sargedas De Sousa MJ
- Da Fonseca Pinto JV
- Da Via C
- Dabrowski W
- Dado T
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- Dai T
- Dallapiccola C
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- Dandoy JR
- Daneri MF
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- Dao V
- Darbo G
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- Dattagupta A
- David C
- Davidek T
- Davis DR
- Davis-Purcell B
- Dawson I
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- De Castro S
- De Groot N
- de Jong P
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- De Maria A
- De Pedis D
- De Salvo A
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- De Santo A
- De Vivie De Regie JB
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- Dedovich DV
- Degens J
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- Delabat Diaz Y
- Deliot F
- Delitzsch CM
- Della Pietra M
- Della Volpe D
- Dell’Acqua A
- Dell’Asta L
- Delmastro M
- Delsart PA
- Demers S
- Demichev M
- Denisov SP
- Derendarz D
- Derkaoui JE
- Derue F
- Dervan P
- Desch K
- Dette K
- Deutsch C
- Deviveiros PO
- Di Bello FA
- Di Ciaccio A
- Di Ciaccio L
- Di Donato C
- Di Girolamo A
- Di Gregorio G
- Di Luca A
- Di Micco B
- Di Nardo R
- Diaconu C
- Dias Do Vale T
- Dias FA
- Diaz Capriles FG
- Diaz MA
- Dickinson J
- Didenko M
- Diehl EB
- Dietrich J
- Diez Pardos C
- Dimitrievska A
- Ding W
- Dingfelder J
- Dinu I-M
- Dittmeier SJ
- Dittus F
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- Djobava T
- Djuvsland JI
- Do Vale MAB
- Dodsworth D
- Doglioni C
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- Dolezal Z
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- Dreyer E
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- Dubreuil A
- Duchovni E
- Duckeck G
- Ducu OA
- Duda D
- Dudarev A
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- Dumitriu AE
- Dunford M
- Dungs S
- Duperrin A
- Duran Yildiz H
- Durglishvili A
- Dutta B
- Duvnjak D
- Dyckes GI
- Dyndal M
- Dysch S
- Dziedzic BS
- Díez Cornell S
- Dührssen M
- Dülsen C
- Düren M
- D’amen G
- D’Amico V
- D’Auria S
- D’Eramo L
- D’onofrio A
- D’Onofrio M
- D’uffizi M
- Eckerova B
- Eggleston MG
- Egidio Purcino De Souza E
- Ehrke LF
- Eifert T
- Eigen G
- Einsweiler K
- Ekelof T
- El Ghazali Y
- El Jarrari H
- El Moussaouy A
- Ellajosyula V
- Ellert M
- Ellinghaus F
- Elliot AA
- Ellis N
- Elmsheuser J
- Elsing M
- Emeliyanov D
- Emerman A
- Enari Y
- Erdmann J
- Ereditato A
- Erland PA
- Errenst M
- Escalier M
- Escobar C
- Estrada Pastor O
- Etzion E
- Evans G
- Evans H
- Evans MO
- Ezhilov A
- Fabbri F
- Fabbri L
- Fabiani V
- Facini G
- Fadeyev V
- Fakhrutdinov RM
- Falciano S
- Falke PJ
- Falke S
- Faltova J
- Fan Y
- Fang Y
- Fang Y
- Fanourakis G
- Fanti M
- Faraj M
- Farbin A
- Farilla A
- Farina EM
- Farooque T
- Farrington SM
- Farthouat P
- Fassi F
- Fassouliotis D
- Faucci Giannelli M
- Fawcett WJ
- Fayard L
- Fedin OL
- Fehr A
- Feickert M
- Feligioni L
- Fell A
- Feng C
- Feng M
- Fenton MJ
- Fenyuk AB
- Ferguson SW
- Ferrando J
- Ferrari A
- Ferrari P
- Ferrari R
- Ferrere D
- Ferretti C
- Fiedler F
- Filipčič A
- Filthaut F
- Fiolhais MCN
- Fiorini L
- Fischer F
- Fischer J
- Fisher WC
- Fitschen T
- Fleck I
- Fleischmann P
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- Zemaityte G
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhu Y
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- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Ziolkowski M
- Zoccoli A
- Zoch K
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- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abulaiti Y
- Abusleme Hoffman AC
- Acharya BS
- Adam Bourdarios C
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- Addepalli SV
- Addison MJ
- Adelman J
- Adiguzel A
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- Zhemchugov A
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- Zhulanov V
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Measurements of W+W−+ ≥ 1 jet production cross-sections in pp collisions at s = 13 TeV with the ATLAS detector
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- Zemaityte G
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- Zhao Y
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2021
- Field of study
Fiducial and differential cross-section measurements of W+W− production in
association with at least one hadronic jet are presented. These measurements are sensitive
to the properties of electroweak-boson self-interactions and provide a test of perturbative
quantum chromodynamics and the electroweak theory. The analysis is performed using
proton-proton collision data collected at p
s = 13TeV with the ATLAS experiment, corresponding
to an integrated luminosity of 139 fb−1. Events are selected with exactly one oppositely
charged electron-muon pair and at least one hadronic jet with a transverse momentum
of pT > 30 GeV and a pseudorapidity of |�| < 4.5. After subtracting the background
contributions and correcting for detector effects, the jet-inclusive W+W−+ � 1 jet fiducial
cross-section and W+W−+ jets differential cross-sections with respect to several kinematic
variables are measured. These measurements include leptonic quantities, such as the lepton
transverse momenta and the transverse mass of the W+W− system, as well as jet-related
observables such as the leading jet transverse momentum and the jet multiplicity. Limits on
anomalous triple-gauge-boson couplings are obtained in a phase space where interference
between the Standard Model amplitude and the anomalous amplitude is enhanced
Measurements of differential cross-sections in top-quark pair events with a high transverse momentum top quark and limits on beyond the Standard Model contributions to top-quark pair production with the ATLAS detector at √s = 13 TeV
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
- Abud AA
- Abulaiti Y
- Acharya BS
- Achkar B
- Adam L
- Adamczyk L
- Adamek L
- Addepalli SV
- Adelman J
- Adiguzel A
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- Adye T
- Affolder AA
- Afik Y
- Agaras MN
- Agarwala J
- Aggarwal A
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- Aguilar-Saavedra JA
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- Ahmad A
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- Ahmed WS
- Ai X
- Aielli G
- Aizenberg I
- Akbiyik M
- Akesson TPA
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- Alberghi GL
- Albert J
- Albicocco P
- Alderweireldt S
- Aleksa M
- Aleksandrov IN
- Alexa C
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- Ali B
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- Carlson BT
- Carlson EM
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- Megy T
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- Melini D
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- Milov A
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- Minegishi Y
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- Mitani T
- Mitra A
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- Mizukami A
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- Mobius S
- Mochizuki K
- Moder P
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- Moskvitina P
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- Poblete PAU
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- Pokharel I
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- Rivadeneira P
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- Roberts BR
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- Schroeder TV
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- Sciolla G
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- Sebastiani CD
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- Sekula SJ
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- Senthilkumar V
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- Serkin L
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- Severini H
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- Sindhu S
- Sinervo P
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- Sinha S
- Sinha S
- Sioli M
- Siral I
- Sivoklokov SY
- Sjolin J
- Skaf A
- Skorda E
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- Slawinska M
- Smakhtin V
- Smart BH
- Smiesko J
- Smirnov SY
- Smirnov Y
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- Snesarev AA
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- Tikhonov YA
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- Tskhadadze EG
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- Tsukerman II
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- Tzanis P
- Tzovara E
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- Vacek V
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- Vadla KOH
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- Veliscek I
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- Villhauer EM
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- Virdee GS
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- Vorobel V
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- Vujinovic OV
- Vukotic I
- Wada S
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- Wahdan S
- Wahlberg H
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- Wessels M
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- Whiteson D
- Wickremasinghe L
- Wiedenmann W
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- Wiik-Fuchs LAM
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- Winklmeier F
- Winter BT
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- Wobisch M
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- Wollrath J
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- Wongel AF
- Worm SD
- Wosiek BK
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- Wu SL
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- Wu Y
- Wu Z
- Wuerzinger J
- Wyatt TR
- Wynne BM
- Xella S
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- Xiang J
- Xiao X
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- Xiotidis I
- Xu D
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- Xu W
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- Xu Z
- Yabsley B
- Yacoob S
- Yamaguchi N
- Yamaguchi Y
- Yamauchi H
- Yamazaki T
- Yamazaki Y
- Yan J
- Yan S
- Yan Z
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- Yang HT
- Yang S
- Yang T
- Yang X
- Yang X
- Yang Y
- Yang Z
- Yao WM
- Yap YC
- Ye H
- Ye J
- Ye S
- Ye X
- Yeletskikh I
- Yexley MR
- Yildiz HD
- Yin P
- Yorita K
- Young C
- Young CJS
- Yuan M
- Yuan R
- Yue X
- Zaazoua M
- Zabinski B
- Zacharis G
- Zagazeta LFG
- Zaid E
- Zaitsev AM
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zanzi D
- Zaplatilek O
- Zeissner SV
- Zeitnitz C
- Zeng JC
- Zenger DT
- Zenin O
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- Zerradi S
- Zerwas D
- Zhang B
- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang M
- Zhang R
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- Zhang X
- Zhang X
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
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- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Cross-section measurements of top-quark pair production where the hadronically decaying top quark has transverse momentum greater than 355 GeV and the other top quark decays into ℓνb are presented using 139 fb−1 of data collected by the ATLAS experiment during proton-proton collisions at the LHC. The fiducial cross-section at s = 13 TeV is measured to be σ = 1.267 ± 0.005 ± 0.053 pb, where the uncertainties reflect the limited number of data events and the systematic uncertainties, giving a total uncertainty of 4.2%. The cross-section is measured differentially as a function of variables characterising the tt¯ system and additional radiation in the events. The results are compared with various Monte Carlo generators, including comparisons where the generators are reweighted to match a parton-level calculation at next-to-next-to-leading order. The reweighting improves the agreement between data and theory. The measured distribution of the top-quark transverse momentum is used to search for new physics in the context of the effective field theory framework. No significant deviation from the Standard Model is observed and limits are set on the Wilson coefficients of the dimension-six operators OtG and Otq(8), where the limits on the latter are the most stringent to date. [Figure not available: see fulltext.]
Combination of searches for heavy spin-1 resonances using 139 fb−1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
- Author
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- Aakvaag E
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- Abicht NJ
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- Zhao H
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- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
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- Zhu CG
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- Zhuang X
- Zhukov K
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fb−1 of proton-proton collisions at
= 13 TeV collected during 2015–2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (τν and ττ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
Measurements of sensor radiation damage in the ATLAS inner detector using leakage currents
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- Zemaityte G
- Zeng JC
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- Zhemchugov A
- Zheng Z
- Zhong D
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- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zou W
- Zwalinski L
- Publication venue
- IOP
- Publication date
- 01/01/2021
- Field of study
Non-ionizing energy loss causes bulk damage to the silicon sensors of the ATLAS pixel and strip detectors. This damage has important implications for data-taking operations, charged-particle track reconstruction, detector simulations, and physics analysis. This paper presents simulations and measurements of the leakage current in the ATLAS pixel detector and semiconductor tracker as a function of location in the detector and time, using data collected in Run 1 (2010–2012) and Run 2 (2015–2018) of the Large Hadron Collider. The extracted fluence shows a much stronger |z|-dependence in the innermost layers than is seen in simulation. Furthermore, the overall fluence on the second innermost layer is significantly higher than in simulation, with better agreement in layers at higher radii. These measurements are important for validating the simulation models and can be used in part to justify safety factors for future detector designs and interventions.publishedVersio
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
- Author
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- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
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- Ahnen JV
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- Butterworth JM
- Buttinger W
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- Chevalérias TJA
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- Chiu I
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- Cindro V
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- Ciocio A
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- Öncel ÖO
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
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