Ocean Bottom Seismometer Experiment on the Beaufort shelf and slope region conducted during Expedition ARA04C on the IBRV Araon

Expedition ARA04C (conducted from September 10 - September 26, 2013 in Canadian waters) on the Korean icebreaker IBRV Araon was laid out to investigate the Beaufort Sea shelf and slope region and collect geo-scientific data for various aspects relevant to the GSC's mandated regional geo-hazard assessment of the offshore Beaufort region. A critical element of the geohazards is the distribution of permafrost across the submerged shelf. To address this question a set of six Ocean Bottom Seismometers (OBS) were deployed in a grid pattern across the near shelf-edge zone, and a set of three OBS was used in a second deployment along a central shelfcrossing north-east to south-west oriented line. Initial data processing was carried out, which is required for any follow-up detailed velocity analysis. The processing included definition of exact shot times, geometry calculation, OBS position re-location, and OBS orientation analysis. A preliminary analysis of the hydrophone and vertical-component data from the OBS stations reveals a P-wave-velocity structure with values ranging from 1800 m/s to over 4000 m/s indicative of wide-spread ice-bearing sediments. This open-file report also contains the digital OBS data for all stations in standard SEGY format, together with the required raw and processed geometry information

International lower limb collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures

Trauma remains a major cause of mortality and disability across the world1, with a higher burden in developing nations2. Open lower extremity injuries are devastating events from a physical3, mental health4, and socioeconomic5 standpoint. The potential sequelae, including risk of chronic infection and amputation, can lead to delayed recovery and major disability6. This international study aimed to describe global disparities, timely intervention, guideline-directed care, and economic aspects of open lower limb injuries

The impact of diabetes on the pathogenesis of sepsis

Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones

Ancient mitochondrial DNA provides high-resolution time scale of the peopling of the Americas

The exact timing, route, and process of the initial peopling of the Americas remains uncertain despite much research. Archaeological evidence indicates the presence of humans as far as southern Chile by 14.6 thousand years ago (ka), shortly after the Pleistocene ice sheets blocking access from eastern Beringia began to retreat. Genetic estimates of the timing and route of entry have been constrained by the lack of suitable calibration points and low genetic diversity of Native Americans. We sequenced 92 whole mitochondrial genomes from pre-Columbian South American skeletons dating from 8.6 to 0.5 ka, allowing a detailed, temporally calibrated reconstruction of the peopling of the Americas in a Bayesian coalescent analysis. The data suggest that a small population entered the Americas via a coastal route around 16.0 ka, following previous isolation in eastern Beringia for ~2.4 to 9 thousand years after separation from eastern Siberian populations. Following a rapid movement throughout the Americas, limited gene flow in South America resulted in a marked phylogeographic structure of populations, which persisted through time. All of the ancient mitochondrial lineages detected in this study were absent from modern data sets, suggesting a high extinction rate. To investigate this further, we applied a novel principal components multiple logistic regression test to Bayesian serial coalescent simulations. The analysis supported a scenario in which European colonization caused a substantial loss of pre-Columbian lineages