308 research outputs found
Attorney Grievance Commission v. Childress: Excessive Focus on Mitigating Factors in Attorney Misconduct Case Fails to Preserve Public Confidence in the Legal Profession
Geology and ground-water resources of Cerro Gordo County, Iowa
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The solar influence on the probability of relatively cold UK winters in the future
Recent research has suggested that relatively cold UK winters are more common when solar activity is low (Lockwood et al 2010 Environ. Res. Lett. 5 024001). Solar activity during the current sunspot minimum has fallen to levels unknown since the start of the 20th century (Lockwood 2010 Proc. R. Soc. A 466 303–29) and records of past solar variations inferred from cosmogenic isotopes (Abreu et al 2008 Geophys. Res. Lett. 35 L20109) and geomagnetic activity data (Lockwood et al 2009 Astrophys. J. 700 937–44) suggest that the current grand solar maximum is coming to an end and hence that solar activity can be expected to continue to decline. Combining cosmogenic isotope data with the long record of temperatures measured in central England, we estimate how solar change could influence the probability in the future of further UK winters that are cold, relative to the hemispheric mean temperature, if all other factors remain constant. Global warming is taken into account only through the detrending using mean hemispheric temperatures. We show that some predictive skill may be obtained by including the solar effect
First Measurement of Collectivity of Coexisting Shapes based on Type II Shell Evolution: The Case of Zr
Background: Type II shell evolution has recently been identified as a
microscopic cause for nuclear shape coexistence. Purpose: Establish a low-lying
rotational band in 96-Zr. Methods: High-resolution inelastic electron
scattering and a relative analysis of transition strengths are used. Results:
The B(E2; 0_1^+ -> 2_2^+) value is measured and electromagnetic decay strengths
of the secdond 2^+ state are deduced. Conclusions: Shape coexistence is
established for 96-Zr. Type II shell evolution provides a systematic and
quantitative mechanism to understand deformation at low excitation energies.Comment: 5 pages, 4 figure
Evolution of the dipole polarizability in the stable tin isotope chain
The dipole polarizability of stable even-mass tin isotopes
112,114,116,118,120,124 was extracted from inelastic proton scattering
experiments at 295 MeV under very forward angles performed at RCNP. Predictions
from energy density functionals cannot account for the present data and the
polarizability of 208Pb simultaneously. The evolution of the polarizabilities
in neighboring isotopes indicates a kink at 120Sn while all model results show
a nearly linear increase with mass number after inclusion of pairing
corrections.Comment: 10 pages, 6 figures, submitted to Phys. Lett.
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology
Multitarget design offers access to bioactive small molecules with potentially superior efficacy and safety. Particularly multifactorial chronic inflammatory diseases demand multiple pharmacological interventions for stable treatment. By minor structural changes, we have developed a close analogue of the cysteinyl-leukotriene receptor antagonist zafirlukast that simultaneously inhibits soluble epoxide hydrolase and activates peroxisome proliferator-activated receptor \u3b3. The triple modulator exhibits robust anti-inflammatory activity in vivo and highlights the therapeutic potential of designed multitarget agents
A new model of cosmogenic production of radiocarbon 14C in the atmosphere
We present the results of full new calculation of radiocarbon 14C production
in the Earth atmosphere, using a numerical Monte-Carlo model. We provide, for
the first time, a tabulated 14C yield function for the energy of primary cosmic
ray particles ranging from 0.1 to 1000 GeV/nucleon. We have calculated the
global production rate of 14C, which is 1.64 and 1.88 atoms/cm2/s for the
modern time and for the pre-industrial epoch, respectively. This is close to
the values obtained from the carbon cycle reservoir inventory. We argue that
earlier models overestimated the global 14C production rate because of outdated
spectra of cosmic ray heavier nuclei. The mean contribution of solar energetic
particles to the global 14C is calculated as about 0.25% for the modern epoch.
Our model provides a new tool to calculate the 14C production in the Earth's
atmosphere, which can be applied, e.g., to reconstructions of solar activity in
the past.Comment: Published in EPSL, 337, 114, 201
Estimating the frequency of extremely energetic solar events, based on solar, stellar, lunar, and terrestrial records
The most powerful explosions on the Sun [...] drive the most severe
space-weather storms. Proxy records of flare energies based on SEPs in
principle may offer the longest time base to study infrequent large events. We
conclude that one suggested proxy, nitrate concentrations in polar ice cores,
does not map reliably to SEP events. Concentrations of select radionuclides
measured in natural archives may prove useful in extending the time interval of
direct observations up to ten millennia, but as their calibration to solar
flare fluences depends on multiple poorly known properties and processes, these
proxies cannot presently be used to help determine the flare energy frequency
distribution. Being thus limited to the use of direct flare observations, we
evaluate the probabilities of large-energy solar explosions by combining solar
flare observations with an ensemble of stellar flare observations. We conclude
that solar flare energies form a relatively smooth distribution from small
events to large flares, while flares on magnetically-active, young Sun-like
stars have energies and frequencies markedly in excess of strong solar flares,
even after an empirical scaling with the mean activity level of these stars. In
order to empirically quantify the frequency of uncommonly large solar flares
extensive surveys of stars of near-solar age need to be obtained, such as is
feasible with the Kepler satellite. Because the likelihood of flares larger
than approximately X30 remains empirically unconstrained, we present indirect
arguments, based on records of sunspots and on statistical arguments, that
solar flares in the past four centuries have likely not substantially exceeded
the level of the largest flares observed in the space era, and that there is at
most about a 10% chance of a flare larger than about X30 in the next 30 years.Comment: 14 pages, 3 figures (in press as of 2012/06/18); Journal of
Geophysical Research (Space Physics), 201
Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly.
The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a common belief attributes to asthma the definition of "rare" disease. Indeed, asthma in the elderly is often underdiagnosed or diagnosed as COPD, thus leading to undertreatment of improper treatment. This is also due to the heterogeneity of clinical and functional presentations of geriatric asthma, including the partial loss of reversibility and the lower occurrence of the allergic component in this age range. The older asthmatic patients are also characterized the coexistence of comorbid conditions that, in conjunction with age-associated structural and functional changes of the lung, may contribute to complicate the management of asthma. The current review addresses the main issues related to the management of allergic asthma in the geriatric age. In particular, the paper aims at revising current pharmacological and non pharmacological treatments for allergic asthmatics of advanced ages, primarily focusing on their safety and efficacy, although most behaviors are an arbitrary extrapolation of what has been tested in young ages. In fact, age has always represented an exclusion criterion for eligibility to clinical trials. Experimental studies and real life observations specifically testing the efficacy and safety of therapeutic approaches in allergic asthma in the elderly are urgently needed
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