154 research outputs found
Symbolic Shareholder Democracy:Toward a Behavioral Understanding of the Role of Shareholder Voting in CEO Dismissals
We investigate the effect of expressive shareholder dissent voting, in which shareholders use their votes symbolically to express their discontent with management, on subsequent chief executive officer (CEO) dismissals. Using the routine but highly symbolic executive board discharge proposal voted on at the annual shareholder meetings of German firms, we argue that the board of directors understands these votes as a "vote of confidence in management" that challenges the CEO's mandate to lead the firm. Arguing that board chairs are uniquely positioned to take up the stance of a steward of the firm and its leadership, we examine how independent and family board chairs moderate the board's response to expressive voting dissent. Using a sample of German public firms over the period 2008-2015, we find that expressive voting dissent increases the chance of CEO dismissal increasingly with the level of dissent expressed. Contrary to prevailing agency theoretical expectations, we do not find that independent chairs are more responsive to expressive voting dissent, nor that this relationship is strengthened by the degree of minority institutional investor ownership of the firm. Consistent with the symbolic perspective on shareholder voting that we seek to develop, however, we find that family chairs are more likely to lead the board to dismiss the CEO due to the intrinsic disvalue they incur from symbolic leadership legitimacy challenges in their firms, and that the positive effect of having a family chair on the dissent induced chance of CEO dismissal is strengthened by the level of family ownership in the firm
Randomized rumor spreading in dynamic graphs
International audienceWe consider the well-studied rumor spreading model in which nodes contact a random neighbor in each round in order to push or pull the rumor. Unlike most previous works which focus on static topologies, we look at a dynamic graph model where an adversary is allowed to rewire the connections between vertices before each round, giving rise to a sequence of graphs, G1, G2, . . . Our first result is a bound on the rumor spreading time in terms of the conductance of those graphs. We show that if the degree of each node does not change much during the protocol (that is, by at most a constant factor), then the spread completes within t rounds for some t such that the sum of conductances of the graphs G1 up to Gt is O(log n). This result holds even against an adaptive adversary whose decisions in a round may depend on the set of informed vertices before the round, and implies the known tight bound with conductance for static graphs. Next we show that for the alternative expansion measure of vertex expansion, the situation is different. An adaptive adversary can delay the spread of rumor significantly even if graphs are regular and have high expansion, unlike in the static graph case where high expansion is known to guarantee fast rumor spreading. However, if the adversary is oblivious, i.e., the graph sequence is decided before the protocol begins, then we show that a bound close to the one for the static case holds for any sequence of regular graphs
How asynchrony affects rumor spreading time
International audienceIn standard randomized (push-pull) rumor spreading, nodes communicate in synchronized rounds. In each round every node contacts a random neighbor in order to exchange the rumor (i.e., either push the rumor to its neighbor or pull it from the neighbor). A natural asynchronous variant of this algorithm is one where each node has an independent Poisson clock with rate 1, and every node contacts a random neighbor whenever its clock ticks. This asynchronous variant is arguably a more realistic model in various settings, including message broadcasting in communication networks, and information dissemination in social networks. In this paper we study how asynchrony affects the rumor spreading time, that is, the time before a rumor originated at a single node spreads to all nodes in the graph. Our first result states that the asynchronous push-pull rumor spreading time is asymptotically bounded by the standard synchronous time. Precisely, we show that for any graph G on n nodes, where the synchronous push-pull protocol informs all nodes within T (G) rounds with high probability, the asynchronous protocol needs at most time O(T (G) + log n) to inform all nodes with high probability. On the other hand, we show that the expected synchronous push-pull rumor spreading time is bounded by O(√ n) times the expected asynchronous time. These results improve upon the bounds for both directions shown recently by Acan et al. (PODC 2015). An interesting implication of our first result is that in regular graphs, the weaker push-only variant of synchronous rumor spreading has the same asymptotic performance as the synchronous push-pull algorithm
Imaging of the Inner Zone of Blast Furnaces Using MuonRadiography: The BLEMAB Project
The aim of the BLEMAB project (BLast furnace stack density Estimation through online Muons ABsorption measurements) is the application of muon radiography techniques, to image a blast furnace’s inner zone. In particular, the goal of the study is to characterize the geometry and size of the so-called “cohesive zone”, i.e., the spatial region where the slowly downward-moving material begins to soften and melt, which plays such an important role in the performance of the blast furnace itself. Thanks to the high penetration power of natural cosmic-ray muon radiation, muon transmission radiography could be an appropriate non invasive methodology for the imaging of large high-density structures such as a blast furnace, whose linear dimensions can be up to a few tens of meters. A state-of-the-art muon tracking system is currently in development and will be installed at a blast furnace on the ArcelorMittal site in Bremen (Germany), where it will collect data for a period of various months. In this paper, the status of the project and the
expectations based on preliminary simulations are presented and briefly discussed
The BLEMAB European project: Muon radiography as an imaging tool in the industrial field
The European project called BLEMAB (BLast furnace stack density Estimation through on-line Muons ABsorption measurements), provides for the application of the muon radiography technique in the industrial environment. The project represents a non-invasive way of monitoring a blast furnace and in particular aims to study the geometric and density development of the so-called “cohesive zone”, which is important for the performance of the blast furnace itself. The installation of the detectors is expected in 2022 at the ArcelorMittal site in Bremen (Germany). This paper describes the status of the project, the experimental setup and the first results obtained with preliminary simulations. © 2022 Societa Italiana di Fisica. All rights reserved
An ancient family of SelB elongation factor-like proteins with a broad but disjunct distribution across archaea
<p>Abstract</p> <p>Background</p> <p>SelB is the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome. In archaea, only a subset of methanogens utilizes selenocysteine and encodes archaeal SelB (aSelB). A SelB-like (aSelBL) homolog has previously been identified in an archaeon that does not encode selenosysteine, and has been proposed to be a pyrrolysyl-tRNA-specific elongation factor (EF-Pyl). However, elongation factor EF-Tu is capable of binding archaeal Pyl-tRNA in bacteria, suggesting the archaeal ortholog EF1A may also be capable of delivering Pyl-tRNA to the ribosome without the need of a specialized factor.</p> <p>Results</p> <p>We have phylogenetically characterized the aSelB and aSelBL families in archaea. We find the distribution of aSelBL to be wider than both selenocysteine and pyrrolysine usage. The aSelBLs also lack the carboxy terminal domain usually involved in recognition of the selenocysteine insertion sequence in the target mRNA. While most aSelBL-encoding archaea are methanogenic Euryarchaea, we also find aSelBL representatives in Sulfolobales and Thermoproteales of Crenarchaea, and in the recently identified phylum Thaumarchaea, suggesting that aSelBL evolution has involved horizontal gene transfer and/or parallel loss. Severe disruption of the GTPase domain suggests that some family members may employ a hitherto unknown mechanism of nucleotide hydrolysis, or have lost their GTPase ability altogether. However, patterns of sequence conservation indicate that aSelBL is still capable of binding the ribosome and aminoacyl-tRNA.</p> <p>Conclusions</p> <p>Although it is closely related to SelB, aSelBL appears unlikely to either bind selenocysteinyl-tRNA or function as a classical GTP hydrolyzing elongation factor. We propose that following duplication of aSelB, the resultant aSelBL was recruited for binding another aminoacyl-tRNA. In bacteria, aminoacylation with selenocysteine is essential for efficient thermodynamic coupling of SelB binding to tRNA and GTP. Therefore, change in tRNA specificity of aSelBL could have disrupted its GTPase cycle, leading to relaxation of selective pressure on the GTPase domain and explaining its apparent degradation. While the specific role of aSelBL is yet to be experimentally tested, its broad phylogenetic distribution, surpassing that of aSelB, indicates its importance.</p
Ancient horizontal gene transfer and the last common ancestors
Background
The genomic history of prokaryotic organismal lineages is marked by extensive horizontal gene transfer (HGT) between groups of organisms at all taxonomic levels. These HGT events have played an essential role in the origin and distribution of biological innovations. Analyses of ancient gene families show that HGT existed in the distant past, even at the time of the organismal last universal common ancestor (LUCA). Most gene transfers originated in lineages that have since gone extinct. Therefore, one cannot assume that the last common ancestors of each gene were all present in the same cell representing the cellular ancestor of all extant life.
Results
Organisms existing as part of a diverse ecosystem at the time of LUCA likely shared genetic material between lineages. If these other lineages persisted for some time, HGT with the descendants of LUCA could have continued into the bacterial and archaeal lineages. Phylogenetic analyses of aminoacyl-tRNA synthetase protein families support the hypothesis that the molecular common ancestors of the most ancient gene families did not all coincide in space and time. This is most apparent in the evolutionary histories of seryl-tRNA synthetase and threonyl-tRNA synthetase protein families, each containing highly divergent “rare” forms, as well as the sparse phylogenetic distributions of pyrrolysyl-tRNA synthetase, and the bacterial heterodimeric form of glycyl-tRNA synthetase. These topologies and phyletic distributions are consistent with horizontal transfers from ancient, likely extinct branches of the tree of life.
Conclusions
Of all the organisms that may have existed at the time of LUCA, by definition only one lineage is survived by known progeny; however, this lineage retains a genomic record of heterogeneous genetic origins. The evolutionary histories of aminoacyl-tRNA synthetases (aaRS) are especially informative in detecting this signal, as they perform primordial biological functions, have undergone several ancient HGT events, and contain many sites with low substitution rates allowing deep phylogenetic reconstruction. We conclude that some aaRS families contain groups that diverge before LUCA. We propose that these ancient gene variants be described by the term “hypnologs”, reflecting their ancient, reticulate origin from a time in life history that has been all but erased”.National Science Foundation (U.S.) (Grant DEB 0830024)Exobiology Program (U.S.) (Grant NNX10AR85G)United States. National Aeronautics and Space Administration (Postdoctoral Program
Genetic Variants of the FADS Gene Cluster and ELOVL Gene Family, Colostrums LC-PUFA Levels, Breastfeeding, and Child Cognition
Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children"s Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes
Genetic Variants of the FADS Gene Cluster and ELOVL Gene Family, Colostrums LC-PUFA Levels, Breastfeeding, and Child Cognition
Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children"s Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes
- …