The Actionable Gaps of the Journey of Patients with Lung Cancer

Peer reviewe

Retention and diffusion of radioactive and toxic species on cementitious systems: Main outcome of the CEBAMA project

Cement-based materials are key components in radioactive waste repository barrier systems. To improve the available knowledge base, the European CEBAMA (Cement-based materials) project aimed to provide insight on general processes and phenomena that can be easily transferred to different applications. A bottom up approach was used to study radionuclide retention by cementitious materials, encompassing both individual cement mineral phases and hardened cement pastes. Solubility experiments were conducted with Be, Mo and Se under high pH conditions to provide realistic solubility limits and radionuclide speciation schemes as a prerequisite for meaningful adsorption studies. A number of retention mechanisms were addressed including adsorption, solid solution formation and precipitation of radionuclides within new solid phases formed during cement hydration and evolution. Sorption/desorption experiments were carried out on several anionic radionuclides and/or toxic elements which have received less attention to date, namely: Be, Mo, Tc, I, Se, Cl, Ra and 14C. Solid solution formation between radionuclides in a range of oxidation states (Se, I and Mo) with the main aqueous components (OH−, SO4 −2, Cl−) of cementitious systems on AFm phases were also investigated

NO reduction by CO over gold catalysts based on ceria supports prepared by mechanochemical activation modified by Me3+ (Me=Al or lanthanides): Effect of water in the feed gas

Cataloged from PDF version of article.The reduction of NO by CO was studied over gold catalysts supported on ceria modified by Me3+ ions (Me = Al, La, Sm, Gd and Yb). The ceria supports were prepared by mechanochemical activation. The samples were characterized using XRD, TPR, XPS and Raman spectroscopy. According to the XPS data the concentration of the oxidized gold species was higher than that of metallic gold in the fresh samples modified by lanthanides. On the fresh samples modified by Al only a small part of metallic gold existed in oxidized state. After the catalytic test, only metallic gold was found on the lanthanide-containing catalysts while on the M-modified catalyst a small amount of oxidized Au species in addition to metallic Au was detected. No substantial differences in the average particle sizes of gold, the lattice parameters and the average size of ceria particles were observed. The nature of the modifier and the applied method of ceria supports preparation and gold deposition determined most likely the differences observed in the Raman and TPR data, as well as the catalytic activity results. The catalytic tests were performed under two different conditions: (i) in the presence of H-2 in the gas feed and (ii) adding also water to the gas feed. The lowest activity was observed over the Al-containing catalyst under dry feed, which correlates with the TPR results. The addition of water to the feed led to a significant improvement of the NO and CO conversions over all of the samples studied. At 200 degrees C, Yb-containing gold catalyst exhibited the highest NO and CO conversions. Very promising results for the selectivity toward N-2 were achieved using the lanthanides as dopants. In contrast to the gold supported on Al-doped ceria, no NH3 formation was observed within the whole temperature interval up to 400 degrees C over gold catalysts supported on ceria modified by La, Sm, Gd or Yb. (C) 2009 Elsevier B.V. All rights reserved

NO reduction by CO over gold catalysts based on ceria supports, prepared by mechanochemical activation, modified by Me3+ (Me = Al or lanthanides): Effect of water in the feed gas

The reduction of NO by CO was studied over gold catalysts supported on ceria modified by Me3+ ions (Me = Al, La, Sm, Gd and Yb). The ceria supports were prepared by mechanochemical activation. The samples were characterized using XRD, TPR, XPS and Raman spectroscopy. According to the XPS data the concentration of the oxidized gold species was higher than that of metallic gold in the fresh samples modified by lanthanides. On the fresh samples modified by Al only a small part of metallic gold existed in oxidized state. After the catalytic test, only metallic gold was found on the lanthanide-containing catalysts while on the Al-modified catalyst a small amount of oxidized Au species in addition to metallic Au was detected. No substantial differences in the average particle sizes of gold, the lattice parameters and the average size of ceria particles were observed. The nature of the modifier and the applied method of ceria supports preparation and gold deposition determined most likely the differences observed in the Raman and TPR data, as well as the catalytic activity results. The catalytic tests were performed under two different conditions: (i) in the presence of H2 in the gas feed and (ii) adding also water to the gas feed. The lowest activity was observed over the Al-containing catalyst under dry feed, which correlates with the TPR results. The addition of water to the feed led to a significant improvement of the NO and CO conversions over all of the samples studied. At 200 °C, Yb-containing gold catalyst exhibited the highest NO and CO conversions. Very promising results for the selectivity toward N2 were achieved using the lanthanides as dopants. In contrast to the gold supported on Al-doped ceria, no NH3 formation was observed within the whole temperature interval up to 400 °C over gold catalysts supported on ceria modified by La, Sm, Gd or Yb. © 2009 Elsevier B.V. All rights reserved

Advancing microbiome research with machine learning: key findings from the ML4Microbiome COST action

The rapid development of machine learning (ML) techniques has opened up the data-dense field of microbiome research for novel therapeutic, diagnostic, and prognostic applications targeting a wide range of disorders, which could substantially improve healthcare practices in the era of precision medicine. However, several challenges must be addressed to exploit the benefits of ML in this field fully. In particular, there is a need to establish “gold standard” protocols for conducting ML analysis experiments and improve interactions between microbiome researchers and ML experts. The Machine Learning Techniques in Human Microbiome Studies (ML4Microbiome) COST Action CA18131 is a European network established in 2019 to promote collaboration between discovery-oriented microbiome researchers and data-driven ML experts to optimize and standardize ML approaches for microbiome analysis. This perspective paper presents the key achievements of ML4Microbiome, which include identifying predictive and discriminatory ‘omics’ features, improving repeatability and comparability, developing automation procedures, and defining priority areas for the novel development of ML methods targeting the microbiome. The insights gained from ML4Microbiome will help to maximize the potential of ML in microbiome research and pave the way for new and improved healthcare practices

Юбилейна научна конференция 50 години катедра по педиатрия и медицинска генетика

Варненски медицински форум (Varna Medical Forum) V. 2, Suppl 5(2013

In vitro characterization of naturally occurring influenza H3NA- viruses lacking the NA gene segment: toward a new mechanism of viral resistance?

International audienceAmong a panel of 788 clinical influenza H3N2 isolates, two isolates were characterized by an oseltamivir-resistant phenotype linked to the absence of any detectable NA activity. Here, we established that the two H3NA- isolates lack any detectable full-length NA segment, and one of these could be rescued by reverse genetics in the absence of any NA segment sequence. We found that the absence of NA segment induced a moderate growth defect of the H3NA- viruses as on cultured cells. The glycoproteins density at the surface of H3NA- virions was unchanged as compared to H3N2 virions. The HA protein as well as residues 188 and 617 of the PB1 protein were shown to be strong determinants of the ability of H3NA- viruses to grow in the absence of the NA segment. The significance of these findings about naturally occurring seven-segment influenza A viruses is discussed