Experimental evaluation of an advanced Space Shuttle main engine hot-gas manifold design concept

This study, using an extensively modified, full-scale space shuttle main engine (SSME) hot-gas manifold (HGM), established a detailed aerodynamic data base to support development of an advanced, three-dimensional, fluid-dynamic analysis computer model. In addition, the advanced SSME hot-gas manifold design used in this study demonstrated improved flow environment (uniformity) in the fuel side turbine exit and transfer duct exit regions. Major modifications were incorporated in the full-scale HGM flow test article model using two large transfer ducts on the fuel turbine side of the HGM in place of the three small transfer ducts in the present design. Other model features included an increases in the flow areas downstream of the 180-degree turn and in the fishbowl regions

Coupled FEM-DBEM Simulation of 3D Crack Growth under Fatigue Load Spectrum

Abstract Numerical predictions of fatigue crack growth under load spectrum are obtained by coupled FEM-DBEM approach. An initial part-through corner crack, in a pre-notched specimen undergoing a traction fatigue load, propagates becoming through the thickness. A two parameter crack growth law ("Unified Approach") is calibrated by in house made constant amplitude experimental tests and the crack growth retardation after an overload application is reproduced. The residual stresses responsible for such retardation are calculated by a sequence of elastic-plastic static FEM analysis; such stresses are then applied to the crack faces for the propagation simulation in a DBEM environment. A satisfactory agreement between numerical and experimental crack growth rates are displayed, for both part-through crack and through the thickness crack. This approach provide general modeling capabilities, with allowance for general crack front shape and fully automatic propagation

Aromatase immunoreactivity in fetal ovine neuronal cell cultures exposed to oxidative injury

A lot of evidence testifies that aromatase is expressed in the central nervous system where it has been detected not only in hypothalamic and limbic regions but also in the cerebral cortex and spinal cord. In physiological conditions, aromatase is expressed exclusively by neurons, where it has been mainly found in cell bodies, processes and synaptic terminals. Moreover, primary cultured cortical astrocytes from female rats are more resistant to oxidant cell death than those from males, suggesting a protective role of estradiol. The aim of this study was to evaluate changes in aromatase expression in response to 3-nitro-L-tyrosine, a marker of oxidative stress, in primary neuronal cell cultures from brains of 60-day old sheep fetuses. Cells were identified as neurons by using class III β-tubulin, a marker of neuronal cells. Two morphological types were consistently recognizable: i) bipolar cells with an oval cell body; ii) multipolar cells whose processes formed a wide net with those of adjacent cells. In situ hybridization technique performed on 60-day old fetal neurons revealed that in baseline conditions aromatase gene expression occurs. Importantly, cells exposed to 360 µM 3-nitro-L-tyrosine were fewer and showed more globular shape and shorter cytoplasmic processes in comparison to control cells. The immunocytochemical study with anti-aromatase antibody revealed that cells exposed to 360 µM 3-nitro-L-tyrosine were significantly more immunoreactive than control cells. Thus, it can be postulated that the oxidant effects of the amino acid analogue 3-nitro-L-tyrosine could be counterbalanced by an increase in aromatase expression that in turn can lead to the formation of neuroprotective estradiol via aromatization of testosterone

Radon concentration in self-bottled mineral spring waters as a possible public health issue

Since 2013, the Council Directive 2013/51/Euratom has been regulating the content of radioactive substances in water intended for human consumption. However, mineral waters are exempted from this regulation, including self-bottled springs waters, where higher radon concentration are expected. Therefore, a systematic survey has been conducted on all the 33 mineral spring waters of Lazio (a region of Central Italy) in order to assess if such waters, when self-bottled, may be of concern for public health. Waters have been sampled in two different ways to evaluate the impact of bottling on radon concentration. Water sampling was possible for 20 different spring waters, with 6 samples for each one. The results show that 2 (10%) of measured mineral spring waters returned radon concentrations higher than 100 Bq L−1, i.e., the parametric value established by the Council Directive. These results, if confirmed by other surveys involving a higher number of mineral spring waters, would suggest regulating also these waters, especially in countries like Italy for which: (i) mineral water consumption is significant; (ii) mineral concession owners generally allow the consumers to fill bottles and containers, intended for transport and subsequent consumption, directly from public fountains or from fountains within the plant; (iii) the consumers’ habit of drinking self-bottled mineral water is widespread

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One- and two-photon time-resolved fluorescence of visible and near-infrared dyes in scattering media

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Esistenza della soluzione del problema (1), (2), con il metodo delle approssimazioni successive

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New methodologies to analyze and study the Hellenistic-Roman quarter in Agrigento

The Agrigento: insula III Project began in 2016 thanks to an agreement between the Parco Archeologico e Paesaggistico Valle dei Templi di Agrigento and DiSCi - Bologna University; it aims to document an entire sector of the Hellenistic-Roman quarter, in a three-year period. The main goal is to start a systematic study of private housing from the Archaic period to Late Antiquity and, at the same time, provide a critical understanding of the town planning scheme in this part of the town, which still lacks a modern archaeological and topographical documentation. The interpretation of the previous documentation is the starting point, along with new mapping with laser scanning and a systematic campaign of geophysical investigations to obtain a BIM. As the Bologna University tradition teaches, modern technologies can answer precise historical and archaeological questions: what are the primary phases of the town map? Which one is the starting module of each lot and what are the changes in different ages? Is it possible to reconstruct the original architecture of Hellenistic houses? What is the relationship between this quarter and the rest of the town? The integration of traditional investigational techniques with more recent ones is the methodological assumption of the project, in order to solve the analysis of the complex stratigraphy of the setting, which was inhabited for at least a millennium, from the Archaic to the Middle Ages