Paclitaxel for malignant pleural mesothelioma: a phase II study of the EORTC Lung Cancer Cooperative Group.

The EORTC Lung Cancer Cooperative Group undertook a phase II study of paclitaxel in 25 chemotherapy-naive patients with malignant pleural mesothelioma. Paclitaxel was given intravenously at a dose of 200 mg m-2 as a 3 h infusion every 3 weeks, after standard premedication with corticosteroids and antihistamines. This regimen was well tolerated, with < 4% of cycles resulting in severe toxicity. No major objective responses were observed and ten patients had stable disease. Median survival time was 39 weeks and the 1 year survival rate was 30%. In conclusion, paclitaxel at the dose and schedule investigated in this trial had no major activity in the treatment of malignant pleural mesothelioma

Clustering of red galaxies around the z=1.53 quasar 3C270.1

In the paradigm of hierarchical galaxy formation, luminous radio galaxies mark mass assembly peaks that should contain clusters of galaxies. Observations of the z=1.53 quasar 3C270.1 with the Spitzer Space Telescope at 3.6-24 micron and with the 6.5-m MMT in the z'- and Y-bands allow detection of potential cluster members via photometric redshifts. Compared with nearby control fields, there is an excess of 11 extremely red objects (EROs) at 1.33 < z_phot < 1.73, consistent with a proto-cluster around the quasar. The spectral energy distributions (SEDs) of 3/4 of the EROs are better fitted with passive elliptical galaxies than withdust-reddened starbursts, and of four sources well-detected on an archival HST snapshot image, all have undisturbed morphologies. However, one ERO, not covered by the HST image, is a double source with 0.8" separation on the z' image and a marginal (2sigma) 24 micron detection indicating a dust-enshrouded starburst. The EROs are more luminous than L* (H = -23.6 AB mag at z=1.5).Comment: 12 pages, 7 figures, accepted by Ap

Correction to: Design of an international multicentre RCT on group schema therapy for borderline personality disorder

Correction to: BMC Psychiatry 14, 319 (2014)..

Critique and Review of Leader-Member Exchange Theory: Issues of Agreement, Consensus, and Excellence

The relationship quality that develops between leaders and those designated as followers is of longstanding interest to researchers and practitioners. The purpose of the present article is to review the more recent developments in the field of leader-member exchange (LMX) theory to identify specific issues related to leader-member agreement and follower consensus that have potentially important theoretical and practical implications. We introduce the concept of LMX excellence, which involves high-quality LMX, high leader-member agreement as well as high group consensus in LMX quality. We outline how leaders and followers' behaviour as well as context can enhance or hinder the development of LMX excellence and conclude with an overview of the practical and theoretical implications as well as future research needs

A pan-chromatic view of the galaxy cluster XMMU J1230.3+1339 at z=0.975 - Observing the assembly of a massive system

We present a comprehensive galaxy cluster study of XMMU J1230.3+1339 based on a joint analysis of X-ray data, optical imaging and spectroscopy observations, weak lensing results, and radio properties for achieving a detailed multi-component view of this newly discovered system at z=0.975. We find an optically very rich and massive system with M200$\simeq$(4.2$\pm$0.8)$\times$10^14 M\sun, Tx$\simeq$5.3(+0.7--0.6)keV, and Lx$\simeq$(6.5$\pm$0.7)$\times$10^44 erg/s, for which various widely used mass proxies are measured and compared. We have identified multiple cluster-related components including a central fly-through group close to core passage with associated marginally extended 1.4GHz radio emission possibly originating from the turbulent wake region of the merging event. On the cluster outskirts we see evidence for an on-axis infalling group with a second Brightest Cluster Galaxy (BCG) and indications for an additional off-axis group accretion event. We trace two galaxy filaments beyond the nominal cluster radius and provide a tentative reconstruction of the 3D-accretion geometry of the system. In terms of total mass, ICM structure, optical richness, and the presence of two dominant BCG-type galaxies, the newly confirmed cluster XMMU J1230.3+1339 is likely the progenitor of a system very similar to the local Coma cluster, differing by 7.6 Gyr of structure evolution.Comment: 26 pages, 14 color figures, accepted for publication in A&

Current challenges in software solutions for mass spectrometry-based quantitative proteomics

This work was in part supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme; The Netherlands Proteomics Centre, embedded in The Netherlands Genomics Initiative; The Netherlands Bioinformatics Centre; and the Centre for Biomedical Genetics (to S.C., B.B. and A.J.R.H); by NIH grants NCRR RR001614 and RR019934 (to the UCSF Mass Spectrometry Facility, director: A.L. Burlingame, P.B.); and by grants from the MRC, CR-UK, BBSRC and Barts and the London Charity (to P.C.

Herschel-ATLAS: Planck sources in the Phase 1 fields

We present the results of a cross-correlation of the Planck Early Release Compact Source Catalog (ERCSC) with the catalog of Herschel-ATLAS sources detected in the Phase 1 fields, covering 134.55 deg2. There are 28 ERCSC sources detected by Planck at 857 GHz in this area. As many as 16 of them are probably high Galactic latitude cirrus; 10 additional sources can be clearly identified as bright, low-z galaxies; one further source is resolved by Herschel as two relatively bright sources; and the last is resolved into an unusual condensation of low-flux, probably high-redshift point sources, around a strongly lensed Herschel-ATLAS source at z = 3.26. Our results demonstrate that the higher sensitivity and higher angular resolution H-ATLAS maps provide essential information for the interpretation of candidate sources extracted from Planck sub-mm maps.Comment: 14 pages, 12 figures, 2 tables. Submitted to A&

Tailored Print Communication and Telephone Motivational Interviewing Are Equally Successful in Improving Multiple Lifestyle Behaviors in a Randomized Controlled Trial

Background: Computer tailoring and motivational interviewing show promise in promoting lifestyle change, despite few head-to-head comparative studies. Purpose: Vitalum is a randomized controlled trial in which the efficacy of these methods was compared in changing physical activity and fruit and vegetable consumption in middle-aged Dutch adults. Methods: Participants (n?=?1,629) were recruited via 23 general practices and randomly received either four tailored print letters, four motivational telephone calls, two of each type of intervention, or no information. The primary outcomes were absolute change in self-reported physical activity and fruit and vegetable consumption. Results: All three intervention groups (i.e., the tailored letters, the motivational calls, and the combined version) were equally and significantly more effective than the control group in increasing physical activity (hours/day), intake of fruit (servings/day), and consumption of vegetables (grams/day) from baseline to the intermediate measurement (week 25), follow-up 1 (week 47) and 2 (week 73). Effect sizes (Cohen's d) ranged from 0.15 to 0.18. Participants rated the interventions positively; interviews were more positively evaluated than letters. Conclusions: Tailored print communication and telephone motivational interviewing or their combination are equally successful in changing multiple behaviors. © 2010 The Author(s)