Persistence Steenrod modules

It has long been envisioned that the strength of the barcode invariant offiltered cellular complexes could be increased using cohomology operations.Leveraging recent advances in the computation of Steenrod squares, we introducea new family of computable invariants on mod 2 persistent cohomology termed$Sq^k$-barcodes. We present a complete algorithmic pipeline for theircomputation and illustrate their real-world applicability using the space ofconformations of the cyclo-octane molecule.<br

Multiple transition zone seismic discontinuities and low velocity layers below western United States

With P-to-S converted waves recorded at seismic stations of the U.S. Transportable Array, we image the fine structure of upper mantle and transition zone (TZ) beneath the western U.S. We map the topographies of seismic discontinuities by stacking data by common conversion points along profiles. Systematic depth and amplitude measurements are performed not only for the well-known “410” and “660” interfaces but also for minor seismic discontinuities identified around 350, 590, and 630 km depths. The amplitude of conversion suggests shear wave velocity (Vs) increase by 4% at the 410 and the 660. The observed 660 velocity contrast is smaller than expected from the 6% in IASP91 but consistent with a pyrolitic model of mantle composition. The Gorda plate, subducted under northern California, is tracked to the TZ where it seems to flatten and induce uplift of the 410 under northern Nevada. Maps of 410/660 amplitude/topography reveal that the TZ is anomalous beneath the geographical borders of Washington, Oregon, and Idaho, with (1) a thickened TZ, (2) a sharp change in depth of the 660, (3) a reduced 410 conversion amplitude in the North, and (4) a positive “630” discontinuity. Such anomalous structure might be inherited from the past history of plate subduction/accretion. A thinned TZ under the Yellowstone suggests higher-than-average temperatures, perhaps due to a deep thermal plume. Both the “350” and the “590” negative discontinuities extend over very large areas. They might be related either to an increased water content in the TZ, a significant amount of oceanic material accumulated through the past 100 Myr, or both.National Science Foundation (U.S.) (VICI grant NWO:VICI865.03.007

New determinations of gamma-ray line intensities of the Ep = 550 keV and Ep = 1747 keV resonances of the 13-C(p,gamma)14-N reaction

Gamma-ray angular distributions for the resonances at Ep = 550 keV and 1747 keV of the radiative capture reaction 13-C(p,g)14-N have been measured, using intense proton beams on isotopically pure 13-C targets. Relative intensities for the strongest transitions were extracted with an accuracy of typically five per cent, making these resonances new useful gamma-ray standards for efficiency calibration in the energy range Egamma = 1.6 to 9 MeV.Comment: 17 pages, 6 figures, Nuclear Instruments and Methods, Sec. A, accepte

Humoral Responses against BQ.1.1 Elicited after Breakthrough Infection and SARS-CoV-2 mRNA Vaccination.

The Omicron BQ.1.1 variant is now the major SARS-CoV-2 circulating strain in many countries. Because of the many mutations present in its Spike glycoprotein, this variant is resistant to humoral responses elicited by monovalent mRNA vaccines. With the goal to improve immune responses against Omicron subvariants, bivalent mRNA vaccines have recently been approved in several countries. In this study, we measure the capacity of plasma from vaccinated individuals, before and after a fourth dose of mono- or bivalent mRNA vaccine, to recognize and neutralize the ancestral (D614G) and the BQ.1.1 Spikes. Before and after the fourth dose, we observe a significantly better recognition and neutralization of the ancestral Spike. We also observe that fourth-dose vaccinated individuals who have been recently infected better recognize and neutralize the BQ.1.1 Spike, independently of the mRNA vaccine used, than donors who have never been infected or have an older infection. Our study supports that hybrid immunity, generated by vaccination and a recent infection, induces higher humoral responses than vaccination alone, independently of the mRNA vaccine used

Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.

Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein's receptor-binding domain (RBD). This region coincides with known epitopes and can therefore have an impact on immune escape. Protracted infections in immunosuppressed patients have been hypothesized to lead to an enrichment of such mutations and therefore drive evolution towards VOCs. Here, we present the case of an immunosuppressed patient that developed distinct populations with immune escape mutations throughout the course of their infection. Notably, by investigating the co-occurrence of substitutions on individual sequencing reads in the RBD, we found quasispecies harboring mutations that confer resistance to known monoclonal antibodies (mAbs) such as S:E484K and S:E484A. These mutations were acquired without the patient being treated with mAbs nor convalescent sera and without them developing a detectable immune response to the virus. We also provide additional evidence for a viral reservoir based on intra-host phylogenetics, which led to a viral substrain that evolved elsewhere in the patient's body, colonizing their upper respiratory tract (URT). The presence of SARS-CoV-2 viral reservoirs can shed light on protracted infections interspersed with periods where the virus is undetectable, and potential explanations for long-COVID cases

Hydrous upwelling across the mantle transition zone beneath the Afar Triple Junction

The mechanisms that drive the upwelling of chemical heterogeneity from the lower to upper mantle (e.g., thermal versus compositional buoyancy) are key to our understanding of whole mantle con- vective processes. We address these issues through a receiver function study on new seismic data from recent deployments located on the Afar Triple Junction, a location associated with deep mantle upwelling. The detailed images of upper mantle and mantle transition zone structure illuminate features that give insights into the nature of upwelling from the deep Earth. A seismic low-velocity layer directly above the mantle transition zone, interpreted as a stable melt layer, along with a prominent 520 km discontinuity sug- gest the presence of a hydrous upwelling. A relatively uniform transition zone thickness across the region suggests a weak thermal anomaly (<100 K) may be present and that upwelling must be at least partly driven by compositional buoyancy. The results suggest that the lower mantle is a source of volatile rich, chemically distinct upwellings that influence the structure of the upper mantle, and potentially the chemis- try of surface lavas

INTEGRAL/SPI ground calibration

Three calibration campaigns of the spectrometer SPI have been performed before launch in order to determine the instrument characteristics, such as the effective detection area, the spectral resolution and the angular resolution. Absolute determination of the effective area has been obtained from simulations and measurements. At 1 MeV, the effective area is 65 cm^2 for a point source on the optical axis, the spectral resolution ~2.3 keV. The angular resolution is better than 2.5 deg and the source separation capability about 1 deg. Some temperature dependant parameters will require permanent in-flight calibration.Comment: 9 pages, 12 figures, 2 tables. Accepted for publication in A&AL (INTEGRAL Special issue

Autocorrelation of the Ground Vibrations Recorded by the SEIS-InSight Seismometer on Mars

Since early February 2019, the SEIS (Seismic Experiment for Interior Structure) seismometer deployed at the surface of Mars in the framework of the InSight mission has been continuously recording the ground motion at Elysium Planitia. In this study, we take advantage of this exceptional data set to put constraints on the crustal properties of Mars using seismic interferometry (SI). To carry out this task, we first examine the continuous records from the very broadband seismometer. Several deterministic sources of environmental noise are identified and specific preprocessing strategies are presented to mitigate their influence. Applying the principles of SI to the single-station configuration of InSight, we compute, for each Sol and each hour of the martian day, the diagonal elements of the time-domain correlation tensor of random ambient vibrations recorded by SEIS. A similar computation is performed on the diffuse waveforms generated by more than a hundred Marsquakes. A careful signal-to-noise ratio analysis and an inter-comparison between the two datasets suggest that the results from SI are most reliable in a narrow frequency band around 2.4 Hz, where an amplification of both ambient vibrations and seismic events is observed. The average autocorrelation functions (ACFs) contain well identifiable seismic arrivals, that are very consistent between the two datasets. Interpreting the vertical and horizontal ACFs as, respectively, the P- and S- seismic reflectivity below InSight, we propose a simple stratified velocity model of the crust, which is mostly compatible with previous results from receiver function analysis. Our results are discussed and compared to recent works from the literature.This study is InSight contribution number 164. The authors acknowledge both “Université Fédérale de Toulouse Midi Pyrénées” and the “Région Occitanie” for funding the PhD grant of Nicolas Compaire. The French authors acknowledge the French Space Agency CNES and ANR (ANR-14-CE36-0012-02 and ANR-19-CE31-0008-08) for funding the InSight Science analysis

Stochastic Inversion of P-to-S Converted Waves for Mantle Composition and Thermal Structure: Methodology and Application

We present a new methodology for inverting P‐to‐S receiver function (RF) waveforms directly for mantle temperature and composition. This is achieved by interfacing the geophysical inversion with self‐consistent mineral phase equilibria calculations from which rock mineralogy and its elastic properties are predicted as a function of pressure, temperature, and bulk composition. This approach anchors temperatures, composition, seismic properties, and discontinuities that are in mineral physics data, while permitting the simultaneous use of geophysical inverse methods to optimize models of seismic properties to match RF waveforms. Resultant estimates of transition zone (TZ) topography and volumetric seismic velocities are independent of tomographic models usually required for correcting for upper mantle structure. We considered two end‐member compositional models: the equilibrated equilibrium assemblage (EA) and the disequilibrated mechanical mixture (MM) models. Thermal variations were found to influence arrival times of computed RF waveforms, whereas compositional variations affected amplitudes of waves converted at the TZ discontinuities. The robustness of the inversion strategy was tested by performing a set of synthetic inversions in which crustal structure was assumed both fixed and variable. These tests indicate that unaccounted‐for crustal structure strongly affects the retrieval of mantle properties, calling for a two‐step strategy presented herein to simultaneously recover both crustal and mantle parameters. As a proof of concept, the methodology is applied to data from two stations located in the Siberian and East European continental platforms.This work was supported by a grant from the Swiss National Science Foundation (SNF project 200021_159907). B. T. was funded by a Délégation CNRS and Congé pour Recherches et Conversion Thématique from the Université de Lyon to visit the Research School of Earth Sciences (RSES), The Australian National University (ANU). B. T. has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement 79382