Current rectification in a single molecule diode: the role of electrode coupling

We demonstrate large rectification ratios (> 100) in single-molecule junctions based on a metal-oxide cluster (polyoxometalate), using a scanning tunneling microscope (STM) both at ambient conditions and at low temperature. These rectification ratios are the largest ever observed in a single-molecule junction, and in addition these junctions sustain current densities larger than 10^5 A/cm^2. By following the variation of the I-V characteristics with tip-molecule separation we demonstrate unambiguously that rectification is due to asymmetric coupling to the electrodes of a molecule with an asymmetric level structure. This mechanism can be implemented in other type of molecular junctions using both organic and inorganic molecules and provides a simple strategy for the rational design of molecular diodes

Testing particle trapping in transition disks with ALMA

We present new Atacama Large Millimeter/submillimeter Array (ALMA) continuum observations at 336GHz of two transition disks, SR21 and HD135344B. In combination with previous ALMA observations from Cycle 0 at 689GHz, we compare the visibility profiles at the two frequencies and calculate the spectral index ($\alpha_{\rm{mm}}$). The observations of SR21 show a clear shift in the visibility nulls, indicating radial variations of the inner edge of the cavity at the two wavelengths. Notable radial variations of the spectral index are also detected for SR21 with values of $\alpha_{\rm{mm}}{\sim}3.8-4.2$ in the inner region ($r<35$ AU) and $\alpha_{\rm{mm}}{\sim}2.6-3.0$ outside. An axisymmetric ring (which we call the ring model) or a ring with the addition of an azimuthal Gaussian profile, for mimicking a vortex structure (which we call the vortex model), is assumed for fitting the disk morphology. For SR21, the ring model better fits the emission at 336GHz, conversely the vortex model better fits the 689GHz emission. For HD135344B, neither a significant shift in the null of the visibilities nor radial variations of $\alpha_{\rm{mm}}$ are detected. Furthermore, for HD135344B, the vortex model fits both frequencies better than the ring model. However, the azimuthal extent of the vortex increases with wavelength, contrary to model predictions for particle trapping by anticyclonic vortices. For both disks, the azimuthal variations of $\alpha_{\rm{mm}}$ remain uncertain to confirm azimuthal trapping. The comparison of the current data with a generic model of dust evolution that includes planet-disk interaction suggests that particles in the outer disk of SR21 have grown to millimetre sizes and have accumulated in a radial pressure bump, whereas with the current resolution there is not clear evidence of radial trapping in HD135344B, although it cannot be excluded either.Comment: Minor changes after language edition. Accepted for publication in A&A (abstract slightly shortened for arXiv

Opciones de productos a partir de la madera de acacia y su promoción : antecedentes de una experiencia con acacias en Chile

La investigación desarrollada por el Instituto Forestal (INFOR) ha generado la base para aprovechar la adaptabilidad que presentan en el país Acacia dealbata, Acacia mearnsii y A. melanoxylon, y su explotación como especies forestales alternativas para la producción de madera. Se ha investigado en las propiedades y aptitudes físico-mecánicas y pulpables de las especies para su uso en la industria del aserrío, tableros, pulpa y papel, y la identificación de las variables que inciden en el porcentaje de taninos obtenibles a partir de la corteza de A. mearnsii que crece en Chile. Este trabajo resume los resultados de la investigación emprendida por INFOR durante el desarrollo de los estudios referidos a los procesos industriales y aplicaciones de la madera.____________________________________Research studies carried out at Instituto Forestal (INFOR) have provided the basis for exploiting the adaptability of Acacia dealbata, A. mearnsii y A. melanoxylon to Chilean environments and its exploitation as an alternative forest species for wood production. The information has been generated about the properties and physical-mechanical aptitudes and pulpables of the species for its use in the industry of the Sawed wood, boards, pulp and paper, and the identification of the variables that impact in the percentage of attainable tannins starting from the bark of A. mearnsii in Chile. This work summarizes the results of the investigation undertaken by INFOR during the development of the studies referred to the industrial processes and applications of the wood

JWST observations of stellar occultations by solar system bodies and rings

In this paper we investigate the opportunities provided by the James Webb Space Telescope (JWST) for significant scientific advances in the study of solar system bodies and rings using stellar occultations. The strengths and weaknesses of the stellar occultation technique are evaluated in light of JWST's unique capabilities. We identify several possible JWST occultation events by minor bodies and rings, and evaluate their potential scientific value. These predictions depend critically on accurate a priori knowledge of the orbit of JWST near the Sun-Earth Lagrange-point 2 (L2). We also explore the possibility of serendipitous stellar occultations by very small minor bodies as a by-product of other JWST observing programs. Finally, to optimize the potential scientific return of stellar occultation observations, we identify several characteristics of JWST's orbit and instrumentation that should be taken into account during JWST's development.Comment: This paper is one of a series for a special issue on Solar System observations with JWST in PASP. Accepted 2-Oct-2015. Preprint 30 pages, 5 tables, 8 figure

Double quantum dot with tunable coupling in an enhancement-mode silicon metal-oxide semiconductor device with lateral geometry

We present transport measurements of a tunable silicon metal-oxide-semiconductor double quantum dot device with lateral geometry. Experimentally extracted gate-to-dot capacitances show that the device is largely symmetric under the gate voltages applied. Intriguingly, these gate voltages themselves are not symmetric. Comparison with numerical simulations indicates that the applied gate voltages serve to offset an intrinsic asymmetry in the physical device. We also show a transition from a large single dot to two well isolated coupled dots, where the central gate of the device is used to controllably tune the interdot coupling.Comment: 4 pages, 3 figures, to be published in Applied Physics Letter

Recovery of betulinic acid from plane tree (Platanus acerifolia L.)

Betulinic acid (3β, hydroxy-lup-20(29)-en-28-oic acid) is a bioactive triterpenic acid which was identified in various botanical sources and in considerable amounts in the bark of plane tree (Platanus acerifolia L.). In this work, the recovery of betulinic acid from plane tree bark was studied using different liquid solvent based extraction methods, namely solid-liquid extraction (SLE), ultrasound assisted extraction (UAE) and pressurized liquid extraction (PLE). Furthermore, preliminary studies of the supercritical fluid extraction (SFE) of plane tree bark are also reported. The liquid solvent based extraction techniques (SLE, UAE and PLE) were carried out using ethanol and ethyl acetate, and produced a recovery of betulinic acid in the range 10-15 mg/g of bark, with concentrations around 25-35% mass. A betulinic acid enrichment in the ethanolic extracts was possible by means of a simple precipitation step adding water. The precipitate contained 42-46% mass of betulinic acid and high recovery (>95%). Increasing the extraction temperature, by means of the PLE assays, has not resulted in an improvement of betulinic acid recovery. The preliminary SFE assays produced lower recoveries of betulinic acid (0.5-8 mg/g) with respect to liquid extraction. The addition of ethanol as cosolvent produced a significant improvement of both betulinic acid recovery and concentration in the SFE extract.This work has been supported by project ALIBIRD-S2009/AGR-1469 from Comunidad Autónoma de Madrid. López-Padilla A. thanks to COLCIENCIAS (568–2012) and Medellin Mayor's Office (Sapiencia/Enlaza Mundos Program, 2013) for the Ph.D. fellowship.Peer Reviewe

High-contrast imaging constraints on gas giant planet formation - The Herbig Ae/Be star opportunity

Planet formation studies are often focused on solar-type stars, implicitly considering our Sun as reference point. This approach overlooks, however, that Herbig Ae/Be stars are in some sense much better targets to study planet formation processes empirically, with their disks generally being larger, brighter and simply easier to observe across a large wavelength range. In addition, massive gas giant planets have been found on wide orbits around early type stars, triggering the question if these objects did indeed form there and, if so, by what process. In the following I briefly review what we currently know about the occurrence rate of planets around intermediate mass stars, before discussing recent results from Herbig Ae/Be stars in the context of planet formation. The main emphasis is put on spatially resolved polarized light images of potentially planet forming disks and how these images - in combination with other data - can be used to empirically constrain (parts of) the planet formation process. Of particular interest are two objects, HD100546 and HD169142, where, in addition to intriguing morphological structures in the disks, direct observational evidence for (very) young planets has been reported. I conclude with an outlook, what further progress we can expect in the very near future with the next generation of high-contrast imagers at 8-m class telescopes and their synergies with ALMA.Comment: Accepted by Astrophysics and Space Science as invited short review in special issue about Herbig Ae/Be stars; 12 pages incl. 5 figures, 2 tables and reference

Identification and characterization of a novel non-structural protein of bluetongue virus

Bluetongue virus (BTV) is the causative agent of a major disease of livestock (bluetongue). For over two decades, it has been widely accepted that the 10 segments of the dsRNA genome of BTV encode for 7 structural and 3 non-structural proteins. The non-structural proteins (NS1, NS2, NS3/NS3a) play different key roles during the viral replication cycle. In this study we show that BTV expresses a fourth non-structural protein (that we designated NS4) encoded by an open reading frame in segment 9 overlapping the open reading frame encoding VP6. NS4 is 77–79 amino acid residues in length and highly conserved among several BTV serotypes/strains. NS4 was expressed early post-infection and localized in the nucleoli of BTV infected cells. By reverse genetics, we showed that NS4 is dispensable for BTV replication in vitro, both in mammalian and insect cells, and does not affect viral virulence in murine models of bluetongue infection. Interestingly, NS4 conferred a replication advantage to BTV-8, but not to BTV-1, in cells in an interferon (IFN)-induced antiviral state. However, the BTV-1 NS4 conferred a replication advantage both to a BTV-8 reassortant containing the entire segment 9 of BTV-1 and to a BTV-8 mutant with the NS4 identical to the homologous BTV-1 protein. Collectively, this study suggests that NS4 plays an important role in virus-host interaction and is one of the mechanisms played, at least by BTV-8, to counteract the antiviral response of the host. In addition, the distinct nucleolar localization of NS4, being expressed by a virus that replicates exclusively in the cytoplasm, offers new avenues to investigate the multiple roles played by the nucleolus in the biology of the cell

La repelencia al agua inducida por el fuego está controlada por pequeñas variaciones en las propiedades del suelo

Fire induced soil water repellency (WR) is controlled by many different factors (temperature reached, amount and type of fuel, etc.). Soil properties may determine the occurrence and intensity of this property in burned soils. The objectives of this paper are to make advances in the study of soil properties as key factors controlling the behaviour of fire-induced WR, and to study the impact of pre-fire SOM content and SOM quality in fire-induced soil WR. In this research, experimental laboratory burnings were carried out using soil samples from different sites with different lithologies, soil types and plant species. Soil samples from the same site differ only in quantity and quality of soil organic matter, as they were collected from under different plant species. All soil samples were heated in a muffle furnace at 200, 250, 300 and 350 ºC without the addition of any fuel load. WR was measured using the water drop penetration time test (WDPT). The results showed significant differences between soil types and plant species, indicating that small differences in soil properties may act as key factors controlling the development and persistence of WR reached, with burned soil samples ranging from wettable to extremely water repellent. The main soil property controlling the response was texture, specifically sand content. The quality of organic matter was also observed to have an effect, since soil samples from the same site with similar organic matter contents, but collected from beneath different plant species, showed different WR values after burningLa repelencia al agua (WR) inducida por el fuego es una propiedad controlada por muchos factores diferentes (temperaturas alcanzadas, cantidad y tipo de combustible, etc.). Algunas propiedades del suelo pueden determinar la presencia y la intensidad de esta propiedad en los suelos quemados. Los objetivos principales son: avanzar en el estudio de la influencia de algunas propiedades clave en el control del comportamiento de la WR en suelos quemados, así como estudiar la influencia de la cantidad y la calidad de la materia orgánica del suelo en su desarrollo cuando es afectada por el calentamiento. En éste estudio, hemos realizado quemas controladas en laboratorio utilizando muestras de suelo de diferentes sitios con litologías y tipos de suelos diferentes y recogidas bajo distintas especies vegetales. Las muestras recogidas en diferentes sitios difieren en algunas propiedades del suelo, mientras que las muestras de suelo tomadas del mismo sitio sólo se diferencian en la cantidad y la calidad de la materia orgánica del suelo, ya que se recogieron bajo distintas especies de plantas. Todas las muestras de suelo se calentaron en horno de mufla a 200, 250, 300 y 350 ºC. La repelencia al agua se midió mediante el test del tiempo de penetración de la gota de agua (WDPT). Los resultados mostraron diferencias significativas entre los tipos de suelos y especies vegetales, y se comprobó que pequeñas diferencias en algunas propiedades del suelo pueden actuar como factores clave controlando el desarrollo y persistencia de la repelencia al agua, con muestras de suelo quemadas que variaban entre hidrofílicas a extremadamente repelentes al agua. La propiedad que principalmente controló el comportamiento de la repelencia al calentamiento fue la textura y más concretamente el contenido de arena. Por otro lado se observó que la calidad de la materia orgánica también afecta, ya que muestras de suelo de mismo sitio y con contenido de materia orgánica similar, pero tomadas bajo diferentes especies vegetales mostraron valores muy diferentes de repelencia al agua tras la quema

Analogue peptides for the immunotherapy of human acute myeloid leukemia

Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies