Space networks: towards hodological space design for urban man, starting with a cognitive / perceptual notation

The main purpose of this thesis on Space Networks is to make a contribution to urban design0A iming at the level of the urban designer's or architect's prestructure (after the site has been seen,and before any plan/section/elevation drawings are done),it is meant for those designers involved in res earth themselves,and who accept the idea that they are,in a way, the first users of what they design.The additional purpose is to provide a sociological, psychological,and spatial scale context for dynamic design. Space is looked upon as a network.Where the space-of-possible- movement (taking the shortest/most agreable/most energy demanding/etc way, depending whether you are in a hurry/strolling/exercising yourself/etc respectively) is called Hodological Space.Movement --through-space-with-intention is used as a generator for design.We start with a proposed cognitive/perceptual notation of four spatial conceptual components: First with Section-Perspective (by which we do away with the facades,and considering the building not in isolation ---in the form of an endless isometric). Then the Tube (employing the anticipation,cognitively,of the projecting brain of man for his path of action),and also the Sequential (progressive sequences) and Binary (visual contrasts of 'wholes')- -these perceived as man moves through his Hodological space.There are six Chapters and an Appendix.Chapter I is introductory,and its three parts are extended in the Chapters that follow: Movement Through Space in Chapters 3 and 4,Space- Movement Notation in Chapters 5 and 6,and the Intended Fieldwork And Pilot Questionnaires in the Appendix.In Chapter 2 the clarifying distinction is made between space for activity and space for profit.Which issue,far from a refinement,shifts the problem back to where it belongs: the society values --of which the designer himself partakes. ln Chapter 3 man is not seen from the stimulus -response,but the cognitive psychology side: not passive,but projecting his intentions into his environment --and if it goes a bit too far in that direction it is in compensation for the opposite view.ln Chapter 4 a comprehensive classification of space,into Hodological,Ambient,and Personal,is made for the designer's understanding and use.All three spaces are more fundamental to him than Euclidean space which is significant only in relation to them.ln Chapter 5 the four-component Notation is a rticulated into the cognitive /perceptual anthropological model of cognitive anticipation (see Tube),and perceptual experience (see Sequential and Binary),together with a comparative discussion of the other notatorst work,ranging between the scales of landscape design (Halprin) and microspace behaviour (Hall),In Chapter 6 the proposition of using the present anthropological model of a cognitive /perceptual notation of design-for-movement has been taken up as a process employed in experimental design.The program of designing for Hodological space --as well as for Ambient space which accompanies progress through Hodological space --links psychological research to design for the pedestrian

Impossible protest: noborders in Calais

Since the closure of the Red Cross refugee reception centre in Sangatte, undocumented migrants in Calais hoping to cross the border to Britain have been forced to take refuge in a number of squatted migrant camps, locally known by all as ‘the jungles.’ Unauthorised shanty-like residences built by the migrants themselves, living conditions in the camps are very poor. In June 2009, European ‘noborder’ activists set up a week-long protest camp in the area with the intention of confronting the authorities over their treatment of undocumented migrants. In this article, we analyse the June 2009 noborder camp as an instance of ‘immigrant protest.’ Drawing on ethnographic materials and Jacques Rancière's work on politics and aesthetics, we construct a typology of forms of border control through which to analyse the different ways in which the politics of the noborder camp were staged, performed and policed. Developing a critique of policing practices which threatened to make immigrant protest ‘impossible’, we highlight moments of protest which, through the affirmation of an ‘axiomatic’ equality, disrupted and disarticulated the borders between citizens and non-citizens, the political and non-political

Relevance of pharmacogenomics for developing countries in Europe : implementation in the Maltese population

Pharmacogenomics is a promising new discipline that can realize personalized treatment for patients suffering from many common diseases, particularly those with multiple treatment modalities. Recent advances in the deciphering of the human genome sequence and high throughput genotyping technology have led to the reduction of the overall genotyping costs and enabled the inclusion of genotype-related dosing recommendations into drug package inserts, hence allowing the integration of pharmacogenomics into clinical practice. Although, pharmacogenomics gradually assumes an integral part in mainstream medical practice in developed countries, many countries, particularly from the developing world, still do not have access either to the knowledge or the resources to individualize drug treatment. The PharmacoGenetics for Every Nation Initiative (PGENI) aims to fill in this gap, by making pharmacogenomics globally applicable, not only by defining population-specific pharmacogenomic marker frequency profiles and formulating country-specific recommendations for drug efficacy and safety but also by increasing general public and healthcare professionals’ awareness over pharmacogenomics and genomic medicine. This article highlights the PGENI activities in Europe and its implementation in the Maltese population, in an effort to make pharmacogenomics readily applicable in European healthcare systems.peer-reviewe

Marine geology data accessibility in the European Framework: The I.G.M.E. participation in the GEO-SEAS project.

Το Ινστιτούτο Γεωλογικών και Μεταλλευτικών Ερευνών, κατά τη διάρκεια περισσοτέρων από 30 χρόνων συμμετοχής σε διάφορα έργα και ερευνητικά προγράμματα, έχει σημαντική δράση στον τομέα της Υποθαλάσσιας Γεωλογίας, με αποτέλεσμα τη συλλογή ενός τεράστιου αριθμού δεδομένων. Για να καταστούν τα δεδομένα αυτά διαθέσιμα στην διεθνή επιστημονική κοινότητα ήταν επιτακτική η ανάγκη τυποποίησης και εναρμόνισής τους. Για το σκοπό αυτό το ΙΓΜΕ, μαζί με 25 ακόμη κέντρα, από 17 χώρες, που διαθέτουν γεωλογικά και γεωφυσικά δεδομένα από τον θαλάσσιο χώρο, συμμετείχε στο έργο GEO  -SEAS    που αφορούσε στη δημιουργία μιας ηλεκτρονικής υποδομής. Οι δράσεις του έργου στόχευαν στο να έχουν οι τελικοί χρήστες τη δυνατότητα αναζήτησης και πρόσβασης σε πανευρωπαϊκά, εναρμονισμένα και σύμφωνα με τα διεθνή πρότυπα δεδομένα υποθαλάσσιας γεωλογίας, μέσω μίας ενιαίας διαδικτυακής πύλης. Όλα τα διαθέσιμα δεδομένα του ΙΓΜΕ εναρμονίστηκαν με βάση τους κανόνες και τα πρότυπα που ορίστηκαν στα πλαίσια του έργου GEO  -SEAS. Παράχθηκαν λεπτομερή  αρχεία μεταδεδομένων που συνοδεύονται από τα αντίστοιχα αρχεία δεδομένων. Η τυποποίηση, εναρμόνιση και διάθεση των δεδομένων, όπως καθορίστηκε μέσα από το έργο    GEO  -SEAS   , είναι σε πλήρη συμφωνία με τις Οδηγίες της Ευρωπαϊκής Ένωσης καθώς και τα πρότυπα που χρησιμοποιούνται σε άλλα προγράμματα διάθεσης δεδομένων σε Ευρωπαϊκές και διεθνής κλίμακες.During more than 30 years of activity and participation in numerous research projects, the Institute of Geology and Mineral Exploration of Greece has carried out extensive work in marine geology and a vast amount of data has been collected. In order for those data to be available and used by the international scientific community, a need for standardization and harmonization was imminent. Towards this scope IGME, along with 25 other marine geological and geophysical data centres, located in 17 European maritime countries, participated in the GEO-SEAS project: the implementation of an e-infrastructure. The aim of the project was to enable users to identify, locate and access pan-European, harmonised and federated marine geological and geophysical datasets and derived data products held by the data centres through a single common data portal. All available data have been harmonized according to the GEO-SEAS guidelines and standards. Detailed metadata files were created, accompanied by the corresponding data and additional information files. The standardization, harmonization and provision of data and metadata, carried out through the GEO-SEAS project, are aligned with European directives and recent large-scale framework programs on global and European scales.

Exploring the effects of real-time online cardiac telerehabilitation using wearable devices compared to gym-based cardiac exercise in people with a recent myocardial infarction: a randomised controlled trial

BackgroundExercise-based cardiac rehabilitation (CR) is a non-pharmacological multidisciplinary programme for individuals after myocardial infarction (MI) that offers multiple health benefits. One of the greatest barriers to CR participation is the travel distance to the rehabilitation centre. Remotely monitored CR appears to be at least as effective in improving cardiovascular risk factors and exercise capacity as traditional centre-based CR. Nevertheless, the efficacy of remotely monitored CR in individuals with a recent MI has yet to be examined.MethodsA total of 30 individuals (8 women, 22 men) after a recent (i.e., <4 weeks) MI were randomly allocated into two groups (online home-based and gym-based groups). Both groups underwent a 26-week CR programme three times per week. All patients performed baseline and 24-week follow-up measurements where peak oxygen uptake (VO2peak), mean daily steps, distance, and calories were assessed.ResultsThe online group showed an improvement in mean daily steps (p < 0.05) and mean daily distance (p < 0.05) at 24 weeks compared to the gym-based group. The paired-sample t-test showed that all the assessed variables were statistically (p < 0.001) improved for both groups at 24 weeks. Pearson's r demonstrated positive correlations between VO2peak and mean daily distance (r = 0.375), and negative correlations between VO2peak and muscle (r = −0.523) and fat masses (r = −0.460). There were no exercise-induced adverse events during the study.ConclusionOur findings might indicate that a real-time online supervised CR exercise programme using wearable technology to monitor the haemodynamic responses in post-MI patients is equally effective as a gym-based exercise programme

A(1)ATVar: A Relational Database of Human SERPINA1 Gene Variants Leading to alpha(1)-Antitrypsin Deficiency and Application of the VariVis Software

We have developed a relational database of human SERPINA1 gene mutations, leading to a,antitrypsin (AAT) deficiency, called A(1)ATVar, which can be accessed over the World Wide Web at www.goldenhelix.org/A1ATVar. Extensive information has been extracted from the literature and converted into a searchable database, including genotype information, clinical phenotype, allelic frequencies for the commonest AAT variant alleles, methods of detection, and references. Mutation summaries are automatically displayed and user-generated queries can be formulated based on fields in the database. A separate module, linked to the FINDbase database for frequencies of inherited disorders allows the user to access allele frequency information for the three most frequent AAT alleles, namely PiM, PiS, and PiZ. The available experimental protocols to detect AAT variant alleles at the protein and DNA levels have been archived in a searchable format. A visualization tool, called VariVis, has been implemented to combine A(1)ATVar variant information with SERPINA1 sequence and annotation data. A direct data submission tool allows registered users to submit data on novel AAT variant alleles as well as experimental protocols to explore SERPINA1 genetic heterogeneity, via a password-protected interface. Database access is free of charge and there are no registration requirements for querying the data. The A(1)ATVar database is the only integrated database on the Internet offering summarized information on AAT allelic variants and could be useful not only for clinical diagnosis and research on AAT deficiency and the SERPINA1 gene, but could also serve as an example for an all-in-one solution for locus-specific database (LSDB) development and curation. Hum Mutat 30, 308-313, 2009

Adaptation of a Conference Key Distribution System for the Wireless Ad Hoc Network

In this paper we review previous works done with respect to Conference Key Distribution Systems (CKDS). We focus on the system proposed by Kim et al. and we propose improvements on that scheme a) from the perspective of security and anonymity, b) from the perspective of efficient calculation of the Lagrange polynomial coefficients, and c) from the perspective of adaptation into the dynamic wireless ad hoc network. The security of the proposed scheme is based on the difficulty of computing discrete logarithms over elliptic curves, the intractability of inverting a one-way hash function and the pseudo-randomness of user coordinates. We demonstrate the effectiveness of the proposed scheme through the analysis of characteristic attack scenarios

Учебная история болезни по внутренним болезням и военно-полевой терапии

ВНУТРЕННИЕ БОЛЕЗНИВОЕННО-ПОЛЕВАЯ ТЕРАПИЯИСТОРИЯ БОЛЕЗНИМЕТОДИЧЕСКИЕ УКАЗАНИЯМетодические указания учат студентов правильно оформлять историю болезни пациента

Photodynamic Therapy for Juxtapapillary Retinal Capillary Hemangioma

Various treatment modalities have been described for retinal capillary hemangioma. Our purpose is to present a case of juxtapapillary retinal capillary hemangioma treated with photodynamic therapy. A 69-year-old woman with no previous ocular history presented with blurred vision and photopsias in the right eye three months ago. At presentation, her best corrected visual acuity was 6/9 in the right eye and 6/6 in the left eye. The anterior segment was totally normal and IOP was normal in both eyes as well. Dilated fundoscopy revealed a yellowish, well-circumscribed, elevated area with blood vessels, on the inferior margin of the right optic disc, as optic disc edema. Fluorescein angiography and angiogram with indocyanine green confirmed the diagnosis of juxtapapillary retinal capillary hemangioma. The patient was treated with photodynamic therapy with verteporfin and three months later her visual acuity was 6/7.5 in the right eye, while the lesion was slightly smaller. These findings remained stable at the one-year follow-up. In conclusion, photodynamic therapy offers promising anatomical and functional results for juxtapapillary retinal capillary hemangioma, providing visual acuity improvement or even stabilization and restriction of enlargement of the lesion