Hybrid Generators-based AC Microgrid Performance Assessment in Island Mode

Achieving an accurate steady-state averaged active power sharing between parallel inverters in islanded AC microgrids could be realized by a traditional droop control. For identical inverters having the same droop gains, it is assumed that the transient average power responses will be similar, and no circulating current will flow between the units. However, different line impedances could influence the instantaneous power significantly and thus circulating power flows among the inverters particularly during sudden disturbances such as load changes. This power, if absorbed by an inverter, will lead the DC link voltage to rise abruptly and trip the inverter, thus, degrading the performance of the whole microgrid. The problem becomes worse when hybrid generators are serving as unidirectional power source. This paper assesses the performance of hybrid generators within an islanded microgrid against the mismatch in line impedances. Two schemes to stabilize the microgrid are proposed. In addition, a participation factor analysis is developed to select the most effective controller scheme to bound the DC link voltage and minimize the circulating power. Simulation and experimental results are presented to verify the analysis and the capability of the proposed controller

Adrenal lesions found incidentally: how to improve clinical and cost-effectiveness

Introduction Adrenal incidentalomas are lesions that are incidentally identified while scanning for other conditions. While most are benign and hormonally non-functional, around 20% are malignant and/or hormonally active, requiring prompt intervention. Malignant lesions can be aggressive and life-threatening, while hormonally active tumours cause various endocrine disorders, with significant morbidity and mortality. Despite this, management of patients with adrenal incidentalomas is variable, with no robust evidence base. This project aimed to establish more effective and timely management of these patients. Methods We developed a web-based, electronic Adrenal Incidentaloma Management System (eAIMS), which incorporated the evidence-based and National Health Service–aligned 2016 European guidelines. The system captures key clinical, biochemical and radiological information necessary for adrenal incidentaloma patient management and generates a pre-populated outcome letter, saving clinical and administrative time while ensuring timely management plans with enhanced safety. Furthermore, we developed a prioritisation strategy, with members of the multidisciplinary team, which prioritised high-risk individuals for detailed discussion and management. Patient focus groups informed process-mapping and multidisciplinary team process re-design and patient information leaflet development. The project was partnered by University Hospital of South Manchester to maximise generalisability. Results Implementation of eAIMS, along with improvements in the prioritisation strategy, resulted in a 49% reduction in staff hands-on time, as well as a 78% reduction in the time from adrenal incidentaloma identification to multidisciplinary team decision. A health economic analysis identified a 28% reduction in costs. Conclusions The system’s in-built data validation and the automatic generation of the multidisciplinary team outcome letter improved patient safety through a reduction in transcription errors. We are currently developing the next stage of the programme to proactively identify all new adrenal incidentaloma cases

Metallicities of 0.3<z<1.0 Galaxies in the GOODS-North Field

We measure nebular oxygen abundances for 204 emission-line galaxies with redshifts 0.3<z<1.0 in the Great Observatories Origins Deep Survey North (GOODS-N) field using spectra from the Team Keck Redshift Survey (TKRS). We also provide an updated analytic prescription for estimating oxygen abundances using the traditional strong emission line ratio, R_{23}, based on the photoionization models of Kewley & Dopita (2003). We include an analytic formula for very crude metallicity estimates using the [NII]6584/Halpha ratio. Oxygen abundances for GOODS-N galaxies range from 8.2< 12+log(O/H)< 9.1 corresponding to metallicities between 0.3 and 2.5 times the solar value. This sample of galaxies exhibits a correlation between rest-frame blue luminosity and gas-phase metallicity (i.e., an L-Z relation), consistent with L-Z correlations of previously-studied intermediate-redshift samples. The zero point of the L-Z relation evolves with redshift in the sense that galaxies of a given luminosity become more metal poor at higher redshift. Galaxies in luminosity bins -18.5<M_B<-21.5 exhibit a decrease in average oxygen abundance by 0.14\pm0.05 dex from z=0 to z=1. This rate of metal enrichment means that 28\pm0.07% of metals in local galaxies have been synthesized since z=1, in reasonable agreement with the predictions based on published star formation rate densities which show that ~38% of stars in the universe have formed during the same interval. (Abridged)Comment: AASTeX, 49 pages, 16 figures, accepted for publication in The Astrophysical Journa

The Reddest DR3 SDSS/XMM Quasars

We have cross-correlated the SDSS DR3 Schneider et al. (2005) quasar catalog with the XMM-Newton archive. Color and redshift selections (g - r > 0.5 and 0.9 z < 2.1) result in a sample of 17 red, moderate redshift quasars. The redshift selection minimizes possible contamination due to host galaxy emission and Lyalpha forest absorption. Both optical and X-ray information are required to distinguish between the two likely remaining causes of the red colors: 1) dust-reddening and 2) an intrinsically red continuum. We find that 7 of 17 quasars can be classified as probable `intrinsically red' objects. These 7 quasars have unusually broad MgII emission lines (=10,500 km s^{-1}), moderately flat, but unabsorbed X-ray spectra =1.66+/-0.08), and low accretion rates (mdot/mdot_{Edd}} ~ 0.01). We suggest low accretion rates as a possible physical explanation for quasars with intrinsically red optical continua. We find that 8 of 17 quasars can be classified as dust-reddened. Three of these have upper-limits on the absorption column from X-ray spectral fits of N_H = 3-13 x 10^{22} cm^2, while the other five quasars must be absorbed by at least N_H = 10^{23} cm^2 in order to be consistent with a comparably selected alpha_{ox}-l_{uv} distribution. Two objects in the sample are unclassified.Comment: 20 pages, 12 figures, Accepted for publication in Ap

Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.

Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40-60% of cases. We prospectively analyzed matched pairs of bone marrow and buccal cell (normal) DNA samples from 51 MDS patients by single nucleotide polymorphism (SNP) arrays, and identified somatically acquired clonal genomic abnormalities in 21 patients (41%). Among the 33 patients with normal bone marrow cell karyotypes, 5 (15%) had clonal, somatically acquired aberrations by SNP array analysis, including 4 with segmental uniparental disomies (UPD) and 1 with three separate microdeletions. Each abnormality was detected more readily in CD34+ cells than in unselected bone marrow cells. Paired analysis of bone marrow and buccal cell DNA from each patient was necessary to distinguish true clonal genomic abnormalities from inherited copy number variations and regions with apparent loss of heterozygosity. UPDs affecting chromosome 7q were identified in two patients who had a rapidly deteriorating clinical course despite a low-risk International Prognostic Scoring System score. Further studies of larger numbers of patients will be needed to determine whether 7q UPD detected by SNP array analysis will identify higher risk MDS patients at diagnosis, analogous to those with 7q cytogenetic abnormalities

Multi-wavelength analysis of the dust emission in the Small Magellanic Cloud

We present an analysis of dust grain emission in the diffuse interstellar medium of the Small Magellanic Cloud (SMC). This study is motivated by the availability of 170 microns ISOPHOT data covering a large part of the SMC, with a resolution enabling to disentangle the diffuse medium from the star forming regions. After data reduction and subtraction of Galactic foreground emission, we used the ISOPHOT data together with HiRes IRAS data and ATCA/Parkes combined HI column density maps to determine dust properties for the diffuse medium. We found a far infrared emissivity per hydrogen atom 30 times lower than the Solar Neighborhood value. The modeling of the spectral energy distribution of the dust, taking into account the enhanced interstellar radiation field, gives a similar conclusion for the smallest grains (PAHs and very small grains) emitting at shorter wavelength. Assuming Galactic dust composition in the SMC, this result implies a difference in the gas-to-dust ratio (GDR) 3 times larger than the difference in metallicity. This low depletion of heavy elements in dust could be specific of the diffuse ISM and not apply for the whole SMC dust if it results from efficient destruction of dust by supernovae explosions.Comment: 11 pages, 10 figures. Accepted for publication in Astronomy & Astrophysic

Epigenetics as a mechanism driving polygenic clinical drug resistance

Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development. It is increasingly recognised that such epimutations may occur at a much higher frequency than gene mutation and therefore have a greater impact on selection of subpopulations of cells during tumour progression or acquisition of resistance to anticancer drugs. Although laboratory-based models of acquired resistance to anticancer agents tend to focus on specific genes or biochemical pathways, such 'one gene : one outcome' models may be an oversimplification of acquired resistance to treatment of cancer patients. Instead, clinical drug resistance may be due to changes in expression of a large number of genes that have a cumulative impact on chemosensitivity. Aberrant CpG island methylation of multiple genes occurring in a nonrandom manner during tumour development and during the acquisition of drug resistance provides a mechanism whereby expression of multiple genes could be affected simultaneously resulting in polygenic clinical drug resistance. If simultaneous epigenetic regulation of multiple genes is indeed a major driving force behind acquired resistance of patients' tumour to anticancer agents, this has important implications for biomarker studies of clinical outcome following chemotherapy and for clinical approaches designed to circumvent or modulate drug resistance

Identification of the Red Supergiant Progenitor of Supernova 2005cs: Do the Progenitors of Type II-P Supernovae Have Low Mass?

The stars that end their lives as supernovae (SNe) have been directly observed in only a handful of cases, due mainly to the extreme difficulty in identifying them in images obtained prior to the SN explosions. Here we report the identification of the progenitor for the recent Type II-plateau (core-collapse) SN 2005cs in pre-explosion archival images of the Whirlpool Galaxy (M51) obtained with the Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS). From high-quality ground-based images of the SN from the Canada-France-Hawaii Telescope, we precisely determine the position of the SN and are able to isolate the SN progenitor to within 0".04 in the HST/ACS optical images. We further pinpoint the SN location to within 0".005 from HST/ACS ultraviolet images of the SN, confirming our progenitor identification. From photometry of the SN progenitor obtained with the pre-SN ACS images, and also limits to its brightness in pre-SN HST/NICMOS images, we infer that the progenitor is a red supergiant star of spectral type K0--M3, with initial mass 7--9 Msun. We also discuss the implications of the SN 2005cs progenitor identification and its mass estimate. There is an emerging trend that the most common Type II-plateau SNe originate from low-mass supergiants 8--15 Msun.Comment: Submitted to ApJ. A high resolution version can be found at http://astron.berkeley.edu/~weidong/sn05cs.p