Performance characteristics of the 12 GHz, 200 watt transmitter experiment package for CTS

The experiment package consists of a 200 W output stage tube (OST) powered by a power processing system (PPS). Descriptions of both the PPS and OST are given. The PPS provides the necessary voltages with a measured dc/dc conversion efficiency of 89 percent. The OST, a traveling wave tube with multiple collectors, has a saturated rf output power of 224 W and operates at an overall efficiency exceeding 40 percent over an 85 MHz bandwidth at 12 GHz. OST performance given includes frequency response, saturation characteristics, group delay, AM to PM conversion, inter-modulation distortion, and two channel gain suppression. Single and dual channel FM video performance is presented. It was determined that for 12 MHz peak to peak frequency deviation on each channel, dual channel FM television signals can be transmitted through the TEP at 60 W, each channel, with 40 MHz channel spacing (center to center)

On the Development of Agricultural Mechanization to Ensure a Long- Term World Food Supply

Rosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is an Invited Paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 4 (2002): J. Pawlak, G. Pellizzi and M. Fiala. On the Development of Agricultural Mechanization to Ensure a Long- Term World Food Supply. Club of Bologna. Vol. IV. June 200

CEDNIK: Phenotypic and molecular characterization of an additional patient and review of the literature

Synaptosomal-associated protein 29 (SNAP29) is a t-SNARE protein that is implicated in intracellular vesicle fusion. Mutations in the SNAP29 gene have been associated with cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma syndrome (CEDNIK). In patients with 22q11.2 deletion syndrome, mutations in SNAP29 on the nondeleted chromosome are linked to similar ichthyotic and neurological phenotypes. Here, the authors report a patient with cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma syndrome who presented with global developmental delay, polymicrogyria, dysgenesis of the corpus callosum, optic nerve dysplasia, gaze apraxia, and dysmorphic features. He has developed ichthyosis and palmoplantar keratoderma as he has grown. Exome sequencing identified a homozygous nonsense mutation in SNAP29 gene designated as c.85C>T (p.Arg29X). The authors compare the findings in the proband with previously reported cases. The previously unreported mutation in this patient and his phenotype add to the characterization of cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma syndrome and the accumulating scientific evidence that implicates synaptic protein dysfunction in various neuroectodermal conditions

Yeast activity monitoring by fluorescent methods

Yeast activity was monitored during pilot plant yeast propagation under aerobic and anaerobic conditions. The work was carried out with three widely used Czech lager yeast strains. Fluorescent intensity of DNA was analysed by flow cytometry and signal was used as a marker for cell cycle determination. During experiments were monitored changes in significant properties of yeast (glycogen, proteins, and DNA) by fluorescent methods. It seemed that the impact of aerobic conditions on preservation of flocculation abilities depends on the genetic properties of each strain. Only one strain did not show significant losses in flocculation abilities neither under aerobic nor strictly anaerobic conditions.Socrates Erasmus program; Super Bock

MC4.3 - Optically Coupled Mode-Locked Laser Array for Spectroscopy in InP Generic Integration

We propose a two-element mode-locked laser array operating at 1.56 µm. Optical pulses with 14.5-ps width, spectral bandwidth exceeding 7 nm, and RF line width of 260 kHz at 12.448 GHz are experimentally reported

External optical self-injection stabilization of an InP generic foundry platform based passively mode-locked ring laser

Timing stabilization of a photonic integrated circuit extended cavity passively mode-locked semiconductor ring laser with four gain sections and two saturable absorbers in a symmetric ring geometry by optical self-injection is presented. The laser has been fabricated using an InP generic integration technology platform. Repetition rate tuning up to 5.5MHz and a timing jitter reduction by optical self-injection from 99 fs (solitary laser operation) to 20 fs is demonstrated. The experimental results are in excellent agreement with results obtained by a stochastic time domain model which yet had been solely applied to edge-emitting straight waveguide semiconductor lasers

Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma

Despite advancements in understanding the pathophysiology of Multiple Myeloma (MM), the cause of rapid progressing disease in a subset of patients is still unclear. MM\u27s progression is facilitated by complex interactions with the surrounding bone marrow (BM) cells, forming a microenvironment that supports tumor growth and drug resistance. Understanding the immune microenvironment is key to identifying factors that promote rapid progression of MM. To accomplish this, we performed a multi-center single-cell RNA sequencing (scRNA-seq) study on 102,207 cells from 48 CD13

A generic transcoding tool for making web applications adaptive

Abstract. As personalization and device independence become prominent issues in Web development, tools to adapt existing Web Information Systems (WISs) are required. Still, current development approaches lack support for adding adaptation to existing WISs. This paper presents the Generic Adaptation Component (GAC), a transcoding tool for making Web applications adaptable and adaptive. It can be seamlessly integrated into existing Web architectures as an autonomous adaptation and personalization module. For configuring the GAC an RDF-based rule language is presented, allowing to define both content adaptation and context data update rules. Moreover, based on the document generation architecture of the AMACONT project a collection of transformation operations is provided to realize these rules. The main functionality of the GAC is elucidated by an example implementation

The N-methyl-d-aspartate receptor antagonist CPP alters synapse and spine structure and impairs long-term potentiation and long-term depression induced morphological plasticity in dentate gyrus of the awake rat

Long-term morphological synaptic changes associated with homosynaptic long-term potentiation (LTP) and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats were analyzed using three-dimensional (3-D) reconstructions of electron microscope images of ultrathin serial sections from the molecular layer of the dentate gyrus. For the first time in morphological studies, the specificity of the effects of LTP and LTD on both spine and synapse ultrastructure was determined using an N-methyl-d-aspartate (NMDA) receptor antagonist CPP (3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid). There were no differences in synaptic density 24 h after LTP or LTD induction, and CPP alone had no effect on synaptic density. LTP increased significantly the proportion of mushroom spines, whereas LTD increased the proportion of thin spines, and both LTP and LTD decreased stubby spine number. Both LTP and LTD increased significantly spine head evaginations (spinules) into synaptic boutons and CPP blocked these changes. Synaptic boutons were smaller after LTD, indicating a pre-synaptic effect. Interestingly, CPP alone decreased bouton and mushroom spine volumes, as well as post-synaptic density (PSD) volume of mushroom spines.These data show similarities, but also some clear differences, between the effects of LTP and LTD on spine and synaptic morphology. Although CPP blocks both LTP and LTD, and impairs most morphological changes in spines and synapses, CPP alone was shown to exert effects on aspects of spine and synaptic structure