517 research outputs found

    Numerical modeling of landquakes

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    International audienceThe Thurwieser landslide that occurred in Italy in 2004 and the seismic waves it generated have been simulated and compared to the seismic signal recorded a few tens of kilometers from the landslide source (i.e., landquake). The main features of the low frequency seismic signal are reproduced by the simulation. Topography effects on the flowing mass have a major impact on the generated seismic signal whereas they weakly affect low-frequency wave propagation. Simulation of the seismic signal makes it possible to discriminate between possible alternative scenarios for flow dynamics and to provide first estimates of the rheological parameters during the flow. As landquakes are continuously recorded by seismic networks, our results provide a new way to collect data on the dynamics and rheology of natural flows

    Subchondral chitosan/blood implant-guided bone plate resorption and woven bone repair is coupled to hyaline cartilage regeneration from microdrill holes in aged rabbit knees

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    SummaryObjectiveLittle is known of how to routinely elicit hyaline cartilage repair tissue in middle-aged patients. We tested the hypothesis that in skeletally aged rabbit knees, microdrill holes can be stimulated to remodel the bone plate and induce a more integrated, voluminous and hyaline cartilage repair tissue when treated by subchondral chitosan/blood implants.DesignNew Zealand White rabbits (13 or 32 months old, N = 7) received two 1.5 mm diameter, 2 mm depth drill holes in each knee, either left to bleed as surgical controls or press-fit with a 10 kDa (distal hole: 10K) or 40 kDa (proximal hole: 40K) chitosan/blood implant with fluorescent chitosan tracer. Post-operative knee effusion was documented. Repair tissues at day 0 (N = 1) and day 70 post-surgery (N = 6) were analyzed by micro-computed tomography, and by histological scoring and histomorphometry (SafO, Col-2, and Col-1) at day 70.ResultsAll chitosan implants were completely cleared after 70 days, without increasing transient post-operative knee effusion compared to controls. Proximal control holes had worse osteochondral repair than distal holes. Both implant formulations induced bone remodeling and improved lateral integration of the bone plate at the hole edge. The 40K implant inhibited further bone repair inside 50% of the proximal holes, while the 10K implant specifically induced a “wound bloom” reaction, characterized by decreased bone plate density in a limited zone beyond the initial hole edge, and increased woven bone (WB) plate repair inside the initial hole (P = 0.016), which was accompanied by a more voluminous and hyaline cartilage repair (P < 0.05 vs control defects).ConclusionIn a challenging aged rabbit model, bone marrow-derived hyaline cartilage repair can be promoted by treating acute drill holes with a biodegradable subchondral implant that elicits bone plate resorption followed by anabolic WB repair within a 70-day repair period

    Актуальные задачи совершенствования государственного менеджмента в развитии Украины

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    У статті визначено недоліки використання в Україні доктрини дерегулювання. Обґрунтовано важливість державного регулювання крупного виробництва. Визначено головні завдання влади у розвитку економіки держави.In the article lacks of the use in Ukraine of doctrine of deregulation are considered. Importance of government control of large production is grounded. Main tasks of power in development of economy of the state are determined

    Groundwater recharge from heavy rainfall in the southwestern Lake Chad Basin: evidence from isotopic observations

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    We examine groundwater recharge processes and their relationship to rainfall intensity in the semi-arid, southwestern Lake Chad Basin of Nigeria using a newly compiled database of stable isotope data (δ2H, δ18O) from groundwater and rainfall. δ18O signatures in groundwater proximate to surface waters are enriched in 18O relative to regional rainfall and trace focused groundwater recharge from evaporated waters via ephemeral river discharge and Lake Chad; groundwater remote from river channels is comparatively depleted and associated with diffuse recharge, often via sand dunes. Stable isotope ratios of O and H (δ2H, δ18O) in groundwater samples regress to a value along the local meteoric waterline that is depleted relative to weighted mean composition of rainfall, consistent with rainfall exceeding the 60th percentile of monthly precipitation intensity. The observed bias in groundwater recharge to heavy monthly rainfall suggests that the intensification of tropical rainfall under global warming favours groundwater recharge in this basin
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