Gender identification through handwriting: An online approach

The present study was designed to identify writer's gender trough online handwriting and drawing analysis. Two groups - one of 126 males (mean age 24.65, SD=2.45) and the other of 114 females (mean age 24.51, SD=2.50) participants were recruited in the experiment. They were asked to perform seven writing and drawing tasks utilizing a digitizing tablet and a special writing device. Seventeen writing features grouped into five categories have been considered. The experiment's results show that the set of considered features enable to discriminate between male and female writers investigating their performance while copying a house drawing (task 2), writing words in capital letters (task 3) and writing a complete sentence in cursive letters (task 7), in particular focusing on Ductus (number of strokes) and Time categories of writing features

Emotional State Recognition Performance Improvement on a Handwriting and Drawing Task

In this work we combine time, spectral and cepstral features of the signal captured in a tablet to characterize depression, anxiety, and stress emotional state recognition on the EMOTHAW database. EMOTHAW contains the emotional states of users represented by capturing signals from sensors on the tablet and pen when the user is performing 3 specific handwriting and 4 drawing tasks, which had been categorized into depressed, anxious, stressed, and typical, according to the Depression, Anxiety and Stress Scale (DASS). Each user was characterized with six time-domain features, and the number of spectral-domain and cepstral-domain features for the horizontal and vertical displacement of the pen, the pressure on the paper, and the time spent on-air and off-air, depended on the configuration of the filterbank. As next step, we select the best features using the Fast Correlation-Based Filtering method. Since our dataset has 129 users, then as next step, we augmented the training data by randomly selecting a percentage of the training data and adding a small random Gaussian noise to the extracted features. We then train a radial basis SVM model using the Leave-One-Out (LOO) methodology. The experimental results show an average accuracy classification improvement ranging of 15%, and an accuracy classification improvement ranging from 4% to 34% compared with baseline (state of the art) for specific emotions such as depression, anxiety, stress, and typical emotional states

Data Mining and Machine Learning in Astronomy

We review the current state of data mining and machine learning in astronomy. 'Data Mining' can have a somewhat mixed connotation from the point of view of a researcher in this field. If used correctly, it can be a powerful approach, holding the potential to fully exploit the exponentially increasing amount of available data, promising great scientific advance. However, if misused, it can be little more than the black-box application of complex computing algorithms that may give little physical insight, and provide questionable results. Here, we give an overview of the entire data mining process, from data collection through to the interpretation of results. We cover common machine learning algorithms, such as artificial neural networks and support vector machines, applications from a broad range of astronomy, emphasizing those where data mining techniques directly resulted in improved science, and important current and future directions, including probability density functions, parallel algorithms, petascale computing, and the time domain. We conclude that, so long as one carefully selects an appropriate algorithm, and is guided by the astronomical problem at hand, data mining can be very much the powerful tool, and not the questionable black box.Comment: Published in IJMPD. 61 pages, uses ws-ijmpd.cls. Several extra figures, some minor additions to the tex

The HST Survey of BL Lacertae Objects: Morphological Properties of Low redshift Host Galaxies

We report on the optical properties of a sample of 30 BL Lac host galaxies in the redshift range $0.03<z<0.2$, as derived from HST observations. All galaxies are fully resolved in the WFPC2 (F702W filter) images, allowing a quantitative analysis in two dimensions. Most and possibly all these galaxies have characteristics very similar to those of ``normal'' giant ellipticals. The luminosity, ellipticity, isophote twisting and amount of disky or boxy isophotes are consistent with those found in non-active ellipticals and in radio galaxies. In all cases the BL Lac nucleus is well centered in the main body of its host galaxy, a result that argues strongly against the microlensing hypothesis for any significant fraction of the population. A search for faint sub-structures in the host galaxies has not revealed notable signatures of tidal distortions or sub-components (faint disks, bars, X features, etc.), and with only one exception, there are no prominent dusty features in the central regions. Instead, the BL Lac host galaxies are smooth and unperturbed, suggesting that strong external gravitational interactions are not important to ongoing activity. A careful examination of the environment around the nucleus, however, shows a high incidence of close companion objects, whose nature remains unclear pending spectroscopic observations.Comment: 16 pages, 8 figures. Ap.J accepte

The Mid-Infrared Colours of Galactic Bulge, Disk and Magellanic Planetary Nebulae

We present mid-infrared (MIR) photometry for 367 Galactic disk, bulge and Large Magellanic Cloud (LMC) planetary nebulae, determined using GLIMPSE II and SAGE data acquired using the Spitzer Space Telescope. This has permitted us to make a comparison between the luminosity functions of bulge and LMC planetary nebulae, and between the MIR colours of all three categories of source. It is determined that whilst the 3.6 microns luminosity function of the LMC and bulge sources are likely to be closely similar, the [3.6]-[5.8] and [5.8]-[8-0] indices of LMC nebulae are different from those of their disk and bulge counterparts. This may arise because of enhanced 6.2 microns PAH emission within the LMC sources, and/or as a result of differences between the spectra of LMC PNe and those of their Galactic counterparts. We also determine that the more evolved disk sources listed in the MASH catalogues of Parker et al. and Miszalski et al. (2008) have similar colours to those of the less evolved (and higher surface brightness) sources in the catalogue of Acker et al. (1992); a result which appears at variance with previous studies of these sources.Comment: 14 pages, 9 figures, Publicated in MNRAS. 58 pages in arXi

Mycobacterium tuberculosis Responds to Chloride and pH as Synergistic Cues to the Immune Status of its Host Cell

PubMed ID: 23592993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

The coronal line regions of planetary nebulae NGC6302 and NGC6537: 3-13um grating and echelle spectroscopy

We report on advances in the study of the cores of NGC6302 and NGC6537 using infrared grating and echelle spectroscopy. In NGC6302, emission lines from species spanning a large range of ionization potential, and in particular [SiIX]3.934um, are interpreted using photoionization models (including CLOUDY), which allow us to reestimate the central star's temperature to be about 250000K. All of the detected lines are consistent with this value, except for [AlV] and [AlVI]. Aluminium is found to be depleted to one hundredth of the solar abundance, which provides further evidence for some dust being mixed with the highly ionized gas (with photons harder than 154eV). A similar depletion pattern is observed in NGC6537. Echelle spectroscopy of IR coronal ions in NGC6302 reveals a stratified structure in ionization potential, which confirms photoionization to be the dominant ionization mechanism. The lines are narrow (< 22km/s FWHM), with no evidence of the broad wings found in optical lines from species with similar ionization potentials, such as [NeV]3426A. We note the absence of a hot bubble, or a wind blown bipolar cavity filled with a hot plasma, at least on 1'' and 10km/s scales. We also provide accurate new wavelengths for several of the infrared coronal lines observed with the echelle.Comment: Accepted for publication in MNRA

Benznidazole biotransformation and multiple targets in <i>Trypanosoma</i> cruzi revealed by metabolomics

&lt;b&gt;Background&lt;/b&gt;&lt;p&gt;&lt;/p&gt; The first line treatment for Chagas disease, a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, involves administration of benznidazole (Bzn). Bzn is a 2-nitroimidazole pro-drug which requires nitroreduction to become active, although its mode of action is not fully understood. In the present work we used a non-targeted MS-based metabolomics approach to study the metabolic response of T. cruzi to Bzn.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methodology/Principal findings&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Parasites treated with Bzn were minimally altered compared to untreated trypanosomes, although the redox active thiols trypanothione, homotrypanothione and cysteine were significantly diminished in abundance post-treatment. In addition, multiple Bzn-derived metabolites were detected after treatment. These metabolites included reduction products, fragments and covalent adducts of reduced Bzn linked to each of the major low molecular weight thiols: trypanothione, glutathione, γ-glutamylcysteine, glutathionylspermidine, cysteine and ovothiol A. Bzn products known to be generated in vitro by the unusual trypanosomal nitroreductase, TcNTRI, were found within the parasites, but low molecular weight adducts of glyoxal, a proposed toxic end-product of NTRI Bzn metabolism, were not detected.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusions/significance&lt;/b&gt;&lt;p&gt;&lt;/p&gt; Our data is indicative of a major role of the thiol binding capacity of Bzn reduction products in the mechanism of Bzn toxicity against T. cruzi

Inactivation and sub-lethal injury of salmonella typhi, salmonella typhimurium and vibrio cholerae in copper water storage vessels

Background: This study provides information on the antibacterial effect of copper against the water-borne pathogens Salmonella Typhi, Salmonella Typhimurium and Vibrio cholerae. Methods: Suspensions of each pathogen were kept in water within a traditional copper vessel at 30°C for 24 h. Samples were withdrawn, diluted and plated onto suitable growth media. Conventional enumeration of healthy (uninjured) bacteria was carried out using standard aerobic incubation conditions. Additionally, reactive oxygen species-neutralised (ROS-n) conditions were achieved by adding the peroxide scavenger sodium pyruvate to the medium with anaerobic incubation, to enumerate uninjured (ROS-insensitive) and injured (ROS-sensitive) bacteria. Differences between log-transformed means of conventional (aerobic) and ROS-n counts were statistically evaluated using t tests. Results: Overall, all three pathogens were inactivated by storage in copper vessels for 24 h. However, for shorter-term incubation (4-12 h), higher counts were observed under ROS-n conditions than under aerobic conditions, which demonstrate the presence of substantial numbers of sub-lethally injured cells prior to their complete inactivation. Conclusions: The present study has for the first time confirmed that these bacterial pathogens are inactivated by storage in a copper vessel within 24 h. However, it has also demonstrated that it is necessary to account for short-term sub-lethal injury, manifest as ROS-sensitivity, in order to more fully understand the process. This has important practical implications in terms of the time required to store water within a copper vessel to completely inactivate these bacteria and thereby remove the risk of water-borne disease transmission by this route