Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Pramipexole

One of the most common causes of hyponatremia is inappropriate antidiuretic hormone release syndrome (SIADH). Serotonin reuptake inhibitors, tricyclic antidepressants, carbamazepine, amantadine and cytotoxic drugs can cause of hyponatremia as a result of SIADH. Pramipexole is a non-ergot dopamine agonist. It is frequently used for treatment of Parkinson disease and restless legs syndrome. Pramipexole-associated SIADH are rare in Parkinson disease. Also, pathogenetic mechanisms are uncertain. In our case, SIADH associated with pramipexole was presented in Parkinson disease. Clinical symptoms and hyponatremia occurred 12 days after the drug dose increase. Serum sodium level and clinical complaints returned to normal with drug dose reduction. SIADH-related hyponatremia occurs especially within the first 2-3 weeks after pramipexole treatment. Therefore, patients treated with pramipexole should be monitored more frequently for hyponatremia in the first weeks and dose increase

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

A faculty of medicine hospital indoor air quality and its effect on those in the environment

Amaç: Bu çalıĢmada Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Hastanesi‘nde iç ortam hava kalitesi parametrelerini ölçmek ve hastane çalıĢanları ile hasta/hasta yakınlarının iç ortamla ilgili sağlık yakınmalarını tespit etmek amaçlanmıĢtır. Yöntem: Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Hastanesi‘nde 28 ġubat – 22 Mart 2021 tarihleri arasında yapılan kesitsel tipteki bu araĢtırmada, 442 katılımcıya, yüz yüze görüĢme yöntemiyle anket uygulanmıĢtır. Hastane iç ortam hava kalitesi için sıcaklık, bağıl nem, hava akım hızı, aydınlık düzeyi, NO, H2S, SO2, CO, CO2 gaz ölçümleri yapılarak ölçüm sonuçları standartlara göre değerlendirilmiĢtir. Verilerin analizleri bilgisayar ortamında IBM SPSS 27.0 programında yapılmıĢtır. Bulgular: ÇalıĢmada ölçülen hava sıcaklığı ortalaması 22,81±2,03 °C olarak tespit edildi. Ölçümlerin %80,3‗ünün standartlara uygun olduğu belirlendi. ÇalıĢmadaki bağıl nem ölçümlerinin ortancası %20,85 (16,62-29,00) ve tüm ölçümlerin % 22,7‘si standartlara uygundu. Ölçümlerin neredeyse tümünde hava akımı hızının standartlara uygun olmadığı belirlendi. Aydınlatma düzeyi ölçümlerinin %81,0‘ının standartlara uygun olmadığı belirlendi. Ġç ortam partiküler madde düzeyi ölçümü ile tüm ortamların ISO 5 sınıfına ait olduğu tespit edildi. Ġç ortam gaz ölçümleri sonucu hastanede NO, H2S, SO2 gazlarına rastlanmadı. CO gazı hastanenin küçük bir kısmında tespit edildi. CO2 ölçümlerinin neredeyse tamamı standartlara uygundu. Katılımcıların %53,2‘si kadın, %46,8‘i erkekti. Katılımcıların hastane iç ortamı ile ilgili en sık görülen yakınmaları yorgunluk, ortam havasından bunalma, uyku hali olarak tespit edildi. Sonuç: Ġç ortam hava kalitesi parametrelerinden bir kısmının standartlara uymadığı ve buna bağlı katılımcıların sağlık yakınmaları belirlenmiĢtir. Ġç ortam hava kalitesi parametreleri düzenli aralıklarla ölçülmeli ve standartlara uygun olması için gerekli düzenlemeler yapılmalıdır.Objective: In this study, it was aimed to measure indoor air quality parameters in Necmettin Erbakan University Meram Medical Faculty Hospital and to determine the health complaints of hospital staff and patients/patient relatives related to the indoor environment. Method: In this cross-sectional study conducted in Necmettin Erbakan University Meram Medical Faculty Hospital between February 28 - March 22, 2021, a questionnaire was applied to 442 participants by face-to-face interview method. For the indoor air quality of the hospital, temperature, relative humidity, air flow rate, illumination level, NO, H2S, SO2, CO, CO2 gas measurements were made and the measurement results were evaluated according to the standards. Analysis of the data was made in computer environment using IBM SPSS 27.0 program. Results: The average air temperature measured in the study was found to be 22.81 ± 2.03 °C. It was determined that 80.3% of the measurements were in accordance with the standards. The median of the humidity measurements in the study was 20.85% (16.62- 29.00) and 22.7% of all measurements were in compliance with the standards. In almost all of the measurements, it was determined that the air flow velocity did not comply with the standards. It was determined that 81.0% of the lighting level measurements did not comply with the standards. With the indoor particulate matter level measurement, it was seen that all environments belong to ISO 5 class. NO, H2S, SO2 gases were not found in the hospital as a result of indoor gas measurements. CO gas was detected in a small part of the hospital. Almost all of the CO2 measurements were in compliance with the standards. Of all the participants, 53.2% were women and 46.8% were men. The most common complaints of the participants about the internal environment of the hospital were determined as fatigue, exhaustion from the ambient air, and sleepiness. Conclusion: Some of the indoor air quality parameters did not comply with the standards and the health complaints of the participants were determined. Indoor air quality parameters should be measured at regular intervals and necessary arrangements should be made to bring them into compliance with the standards

An inverse synthesis method for the determination of effective mechanical properties for additively manufactured aperiodic structures with finite thickness

The production of thin-walled structures via Additive Manufacturing is common for thermo-mechanical applications such as heat exchanger cores. However, accurate and efficient models predicting the effective material response of complex geometries with periodic inclusions where the finite size effect or aperiodicity is considered are limited. To address this challenge, here an inverse synthesis approach to calculate the effective material properties of periodic structures with finite thickness or aperiodicity is studied based on the Hill-Mandel equivalence principle under specific loading conditions using ANSYS optimization solver. The method is demonstrated on periodic microstructures with finite thickness/aperiodicity and square unit cells with circular inclusions. Results show that boundary conditions need to be revised to capture the finite size effect, but the framework has the potential of incorporating metrics and loadings for a variety of geometries with aperiodicity

Clinical significance of miR-140-5p and miR-193b expression in patients with breast cancer and relationship to IGFBP5

The functional role of IGFBP5 in breast cancer is complicated. Experimental and bioinformatics studies have shown that IGFBP5 is targeted by miR-140-5p and miR-193b, although this has not yet been proven in clinical samples. The aim of this study was to evaluate the expression of miR-140-5p and miR-193b in breast cancer and adjacent normal tissue and assess its correlation with IGFBP5 and the clinicopathological characteristics of the tumors. IGFBP5 protein expression was analyzed immunohistochemically and IGFBP5, miR-140 and miR-193b mRNA expression levels were analyzed with real-time RT-PCR. Tumor tissue had higher miR-140-5p expression than adjacent normal tissue (p = 0.015). Samples with no immunohistochemical staining for IGFBP5 showed increased miR-140-5p expression (p = 0.009). miR-140-5p expression was elevated in invasive ductal carcinomas (p = 0.002), whereas basal-like tumors had decreased expression of miR-140-5p compared to other tumors (p = 0.008). Lymph node-positive samples showed an approximately 13-fold increase in miR-140-5p expression compared to lymph node-negative tissue (p = 0.049). These findings suggest that miR-140-5p, but not miR-193b, could be an important determinant of IGFBP5 expression and clinical phenotype in breast cancer patients. Further studies are needed to clarify the expressional regulation of IGFBP5 by miR-140-5p