Defining properties of neural crest-derived progenitor cells from the apex of human developing tooth

The connective tissue of the human tooth arises from cells that are derived from the cranial neural crest and, thus, are termed as "ectomesenchymal cells." Here, cells being located in a pad-like tissue adjacent to the apex of the developing tooth, which we designated the third molar pad, were separated by the microexplant technique. When outgrowing from the explant, dental neural crest-derived progenitor cells (dNC-PCs) adhered to plastic, proliferated steadily, and displayed a fibroblast-like morphology. At the mRNA level, dNC-PCs expressed neural crest marker genes like Sox9, Snail1, Snail2, Twist1, Msx2, and Dlx6. Cytofluorometric analysis indicated that cells were positive for CD49d (alpha4 integrin), CD56 (NCAM), and PDGFRalpha, while negative for CD31, CD34, CD45, and STRO-1. dNC-PCs could be differentiated into neurogenic, chondrogenic, and osteogenic lineages and were shown to produce bone matrix in athymic mice. These results demonstrate that human third molar pad possesses neural crest-derived cells that represent multipotent stem/progenitor cells. As a rather large amount of dNC-PCs could be obtained from each single third molar, cells may be used to regenerate a wide range of tissues within the craniofacial region of humans

Role-based Runtime Model Synchronization

Model-driven Software Development (MDSD) promotes the use of multiple related models to realize a software system systematically. These models usually contain redundant information but are independently edited. This easily leads to inconsistencies among them. To ensure consistency among multiple models, model synchronizations have to be employed, e.g., by means of model transformations, trace links, or triple graph grammars. Model synchronization poses three main problems for MDSD. First, classical model synchronization approaches have to be manually triggered to perform the synchronization. However, to support the consistent evolution of multiple models, it is necessary to immediately and continuously update all of them. Second, synchronization rules are specified at design time and, in classic approaches, cannot be extended at runtime, which is necessary if metamodels evolve at runtime. Finally, most classical synchronization approaches focus on bilateral model synchronization, i.e., the synchronization between two models. Consequently, for more than two models, they require the definition of pairwise model synchronizations leading to a combinatorial explosion of synchronization rules. To remedy these issues, we propose a role-based approach for runtime model synchronization. In particular, we propose role-based synchronization rules that enable the immediate and continuous propagation of changes to multiple interrelated models (and back again). Additionally, our approach permits adding new and customized synchronization rules at runtime. We illustrate the benefits of role-based runtime model synchronization using the Families to Persons case study from the Transformation Tool Contest 2017

Das Grundeinkommen : Würdigung - Wertungen - Wege

Das Buch umfasst 25 Beiträge von Wissenschaftlern verschiedenster Disziplinen zum Thema Grundeinkommen und ein Essay aus der Sicht eines Künstlers. Alle Arbeiten widmen sich dem Ziel der Verbesserung der Wohlfahrt der Gesellschaft und ihrerGlieder. Die Autoren sind überzeugt, dass die Einführung von Grundeinkommen sowohl in quantitativer als auch in qualitativer Hinsicht einen bedeutenden Beitrag zur Lösung der großen gesellschaftlichen Probleme unserer Zeit wie Arbeitslosigkeit, Armut, Menschenwürde, wachsende Ungleichheit der Einkommensverteilung leisten kann

Investigation on spatial auditory perception using non-uniform spatial distribution of binaural room impulse responses

For spatial audio reproduction in the context of virtual and augmented reality, a position-dynamic binaural synthesis can be used to reproduce the ear signals for a moving listener. A set of binaural room impulse responses (BRIRs) is required for each possible position of the listener in the room. The required spatial resolution of the BRIR positions can be estimated by spatial auditory perception thresholds. If the resolution is too low, jumps in perception of direction and distance and coloration effects occur. This contribution presents an evaluation of spatial audio quality using different spatial resolutions of the position of the used BRIRs. The evaluation is performed with a moving listener. The test persons evaluate any abnormalities in the spatial audio quality. The result is a comparison of the quality and the spatial resolution of the various conditions used

Wozu Führung - Dimensionen einer Kunst

Führen als eine Kunst zu begreifen, diesem Anliegen gehen die Beiträge des von Götz W. Werner und Peter Dellbrügger herausgegebenen Sammelbands nach. Ein Schwerpunkt liegt dabei auf dem Thema der Freiheit: Stefan Brotbeck entwirft eine Phänomenologie der Unfreiheit, indem er soziale Mechanismen entlarvt, die uns und anderen das Leben schwer machen. Weiterhin geht es u.a. um die "Befreiung" der Führung (Rehn), Hierarchie (Hardorp), Vertrauen (Lavecchia), Bildung (Dietz) und Sinnstiftung (Werner)

Unconditional basic income as answer to the crisis of the work society : debate on opportunities, risks and consequences

Die Podiumsdiskussion fand als öffentliche Abendveranstaltung im Rahmen des sozialwissenschaftlichen Workshops "Krise der 'Arbeitsgesellschaft' - Transformation zur 'Grundeinkommensgesellschaft'? Diskurse, Deutungsmuster und Habitusformen im Wandel" statt, der vom 14. bis 15. Juli 2006 an der Goethe-Universität in Frankfurt am Main abgehalten wurde. Veranstalter war das soziologische Forschungsprojekt "Praxis als Erzeugungsquelle von Wissen" (Leiter: Prof. Dr. Ulrich Oevermann) im Forschungskolleg und Sonderforschungsbereich 435 "Wissenskultur und gesellschaftlicher Wandel" der Deutschen Forschungsgemeinschaft an der Goethe-Universität Frankfurt am Main. Initiiert und organisiert wurde der Workshop von Manuel Franzmann mit Unterstützung zahlreicher Kollegen und Förderer

Wozu Führung - Dimensionen einer Kunst

To understand leadership as an art is the objective of this book. One key aspect is the topic of freedom: Stefan Brotbeck develops a phenomenology of "Unfreiheit" by unmasking mechanisms which he describes as social denaturation. Further topics are amongst others the "liberation" of leadership (Rehn), Hierarchie (Hardorp), confidence (Lavecchia), education (Dietz) and sense-making (Werner)

Das Grundeinkommen : Würdigung - Wertungen - Wege

Das Buch umfasst 25 Beiträge von Wissenschaftlern verschiedenster Disziplinen zum Thema Grundeinkommen und ein Essay aus der Sicht eines Künstlers. Alle Arbeiten widmen sich dem Ziel der Verbesserung der Wohlfahrt der Gesellschaft und ihrer Glieder. Die Autoren sind überzeugt, dass die Einführung von Grundeinkommen sowohl in quantitativer als auch in qualitativer Hinsicht einen bedeutenden Beitrag zur Lösung der großen gesellschaftlichen Probleme unserer Zeit wie Arbeitslosigkeit, Armut, Menschenwürde, wachsende Ungleichheit der Einkommensverteilung leisten kann

Ordered phases in spin-Peierls systems

The microscopic description of spin-Peierls substances is discussed. Particular attention is paid to the ordered (dimerised and incommensurably modulated) phases. Important points are the adiabatic and the antiadiabatic approach, generic soliton forms, elastic and magnetic interchain couplings. The wealth and the accuracy of experimental information collected for the first inorganic spin-Peierls substance CuGeO_3 motivates this work.Comment: 6 pages, 4 figures included, submitted to Physica B in the Proceedings to LT22, Helsinki, 199