Euphorbia paniculata Desf. subsp. paniculata en el sureste ibérico

Euphorbia paniculata Desf. subsp. paniculata in SE SpainPalabras clave. Euphorbia, Corología, Murcia, Almeria, España.Keywords. Euphorbia, Chorology, Murcia, Almeria, Spain

EVIDENCIA DE INTROGRESIÓN EN CISTUS HETEROPHYLLUS SUBSP. CARTHAGINENSIS (CISTACEAE) A PARTIR DE MARCADORES MOLECULARES RAPD

In this work nine RAPD primers were used to assess genetic differentiation among C. heterophyllus subsp. carthaginensis from both Murcia and Valencia populations. In addition, we included a C. albidus population, a hybrid sample between C. albidus and C. heterophyllus subsp. carthaginensis and an individual of C. heterophyllus s. str. from Norhtern Africa. Our results (UPGMA cluster, PCO) suggest the existence of introgression processes in Murcian populations caused by inter-specifi c crosses with C. albidus, as well the taxonomic invalidity of subsp. carthaginensis. These results could be of interest to future conservation policies of C. heterophyllus in the Iberian Peninsule.En el presente trabajo se han utilizado 9 cebadores RAPD para estudiar la diferenciación genética entre los individuos de las poblaciones naturales existentes de Cistus heterophyllus subsp. carthaginensis en Valencia y Murcia. Además, se ha incluido en el muestreo individuos de C. albidus, un individuo híbrido entre C. albidus y C. heterophyllus subsp. carthaginensis y un individuo de C. heterophyllus s. str. del Norte de Africa. Los resultados obtenidos (cluster UPGMA, PCO) avalan la hipótesis de la introgresión genética de los individuos de la población murciana con C. albidus, así como la escasa consistencia taxonómica de la subespecie carthaginensis. Los datos obtenidos resultan de interés respecto a las pautas de conservación y gestión de la especie en la Península Ibérica

Full wave modelling of hts dual mode patch filters and staggered coupled-line filters

In order to obtain high-power handling, dual-mode patch HTS filters have been analyzed through Green's function and desegmentation techniques. A precise circuit model has been obtained and applied to the filter design process, and useful design curves relating filter parameters and physical dimensions of the square patch have been plotted. Several designs have been made using them and then optimized with the Method of Moments in the Spectral Domain. For higher order circuits, staggered coupled-line HTS filters have been considered. The designs have been made using the method of moments to compute the coupling capacitances, and then optimized with the Method of Moments in the Spectral Domain. One dual-mode patch filter and one staggered coupled-line filter have been fabricated on a YBCO film. Measurements agree well with simulationsPeer Reviewe

Potential reactivity assessment of mechanically activated kaolin as alternative cement precursor

This work aims to assess the potential reactivity of a mechanically activated kaolin for its use as an alternative cement precursor. The mechanical activation was successfully achieved by grinding at different rotation speeds (250, 300, and 350 rpm) and times (60, 90, and 120 min), obtaining a highly amorphous and reactive material. The amorphization was monitored through XRD with amorphous content estimation and FTIR deconvolution. The potential reactivity was evaluated through chemical attacks, obtaining SiO2 and Al2O3 availabilities up to 95 wt% and 93 wt% of total SiO2 and Al2O3 content. XRD and FTIR also allowed the identification of the nonreactive phases on the insoluble residue after chemical attacks. NMR analysis revealed that part of the aluminium was in IV coordination, limiting the reactivity in the alkali activation process. This work demonstrated the effectiveness of mechanical activation as a greener treatment than thermal dehydroxylation to increase the raw kaolin's reactivity

Toward Sustainable Adoption of Integrated Care for Prevention of Unplanned Hospitalizations: A Qualitative Analysis

Introduction: Complex chronic patients are prone to unplanned hospitalizations leading to a high burden on healthcare systems. To date, interventions to prevent unplanned admissions show inconclusive results. We report a qualitative analysis performed into the EU initiative JADECARE (2020-2023) to design a digitally enabled integrated care program aiming at preventing unplanned hospitalizations. Methods: A two-phase process with four design thinking (DT) sessions was conducted to analyse the management of complex chronic patients in the region of Catalonia (ES). In Phase I, Discovery, two DT sessions, October 2021 and February 2022, were done using as background information: i) the results of twenty structured interviews (five patients and fifteen professionals), ii) two governmental documents on regional deployment of integrated care and on the Catalan digital health strategy, respectively, and iii) the results of a cluster analysis of 761 hospitalizations. In Phase II, Confirmation, we examined the 30- and 90 -day post -discharge periods of 49,604 hospitalizations as input for two additional DT sessions conducted in November and December 2022. Discussion: The qualitative analysis identified poor personalization of the interventions, the need for organizational changes, immature digitalization, and suboptimal services evaluation as main explanatory factors of the observed efficacyeffectiveness gap. Additionally, a program for prevention of unplanned hospitalizations, to be evaluated during the period 2024-2025, was generated. Conclusions: A digitally enabled adaptive case management approach to foster collaborative work and personalization of care, as well as organizational re -engineering, are endorsed for value -based prevention of unplanned hospitalizations

Euphorbia paniculata Desf. subsp. paniculata en el sureste ibérico

Euphorbia paniculata Desf. subsp. paniculata in SE SpainPalabras clave. Euphorbia, Corología, Murcia, Almeria, España.Keywords. Euphorbia, Chorology, Murcia, Almeria, Spain

VARIABILIDAD GENÉTICA DE PINUS NIGRA SUBSP. SALZMANNII EN LA REGIÓN DE MURCIA MEDIANTE MICROSATÉLITES CLOROPLÁSTICOS

In this work five chloroplast simple sequence repeat markers (cpSSR) were used to describe the genetic variation of Pinus nigra subsp. salzmannii populations from SE Spain (Murcia province). The infinite allele model (IAM) was used to analyze the genetic structure of both natural and reforested populations, and to assess the geographical distribution of haplotypic variation. Overall, large levels of genetic variation whitin and between populations was detected. Genetic variation follow a clear geographic pattern. These results could be explained by a dramatic decline of its distribution and by the fragmentation of populations since Holocene times in Southeast Spain. It is suggested that the population from Rincon de los Huertos could have been originated from propagules from the Baetic range. In addition, populations from Sierra Espuña (reforested) and El Carche could have their origin from samples located on the Iberian range.En el presente trabajo se han utilizado cinco microsatélites cloroplásticos (cpSSR) para describir la diversidad genética intrapoblacional y la diferenciación genética de Pinus nigra subsp. salzmannii de Murcia. El modelo de alelos infinitos (IAM) ha sido el utilizado para el análisis de la estructura genética y la distribución geográfica de la variación de las poblaciones, tanto naturales como reforestadas. En términos generales, las poblaciones muestreadas presentan una gran variación genética intra e interpoblacional. Estos resultados pueden ser debidos a un descenso dramático de las áreas de distribución, y a la fragmentación de las poblaciones del Sureste ibérico desde el Holoceno. Además, los datos obtenidos indican un claro patrón geográfico de la distribución de la variación genética. Se sugiere que la población del Rincón de los Huertos podría haberse originado a partir de poblaciones de distribución Bética, mientras que las poblaciones de Sierra Espuña (repobladas) y El Carche podrían haberse originado a partir de poblaciones de rango ibérico

Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR

The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with pegIFNα+ribavirin anti-HCV therapy. Plasma samples at baseline and week 24 after SVR were used to perform neutralization assays against fve JFH1-based HCV recombinant viruses coding for E1 and E2 from genotypes 1a (H77), 1b (J4), 2a (JFH1), 3a (S52) and 4a (ED43). At baseline, the majority of plasma samples neutralized 1a, 1b, 2a, and 4a, but not 3a, genotypes. Twenty-four weeks following SVR, most neutralizing titers declined substantially. Furthermore, titers against 3a and 2a were not detected in many patients. Plasma samples with high HCV-nAb titers neutralized all genotypes, and the highest titers at the starting point correlated with the highest titers at week 24 after SVR. In conclusion, high titers of broad-spectrum HCV-nAbs were detected in HIV/HCV-coinfected individuals, however, those titers declined soon after SVRThis study was supported by grants from Instituto de Salud Carlos III (ISCIII; grant numbers PI14/01094 and PI17/00657 to JB, PI17/00903 to JGG, PI14CIII/00011 and PI17CIII/00003 to SR) and Ministerio de Sanidad, Servicios Sociales e Igualdad (grant number EC11-241). Te study was also funded by the RD16CIII/0002/0002, RD16/0025/0018, and RD16/0025/0017 projects as part of the Plan Nacional R+D+I and co-funded by ISCIII- Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER

On evaluating temperature as observable for CMOS technology variability

The temperature at surface of a silicon die depends on the activity of the circuits placed on it. In this paper, it is analyzed how Process, Voltage and Temperature (PVT) variations affect simultaneously some figures of merit (FoM) of some digital and analog circuits and the power dissipated by such circuits. It is shown that in some cases, a strong correlation exists between the variation of the circuit FoM and the variation of the dissipated power. Since local temperature increase at the silicon surface close to the circuit linearly depends on dissipated power, the results show that temperature can be considered as an observable magnitude for CMOS technology variability monitoring.Postprint (published version