Hemorragia en el tronco del encéfalo: una locaclización inusual del sangrado

Las hemorragias intracraneales pueden ser espontáneas o traumáticas. Las hemorragias intracerebrales espontáneas constituyen el 5-19% de todos los ictus, se presentan sobre todo en la edad media de la vida, sin una clara predominancia por sexos. Suele ser la manifestación de una enfermedad vascular cerebral subyacente, siendo la hipertensión arterial el factor de riesgo más importante. Otros factores predisponentes son la diabetes, el alcoholismo o el tabaquismo. Los traumatismos craneoencefálicos también pueden causarlas. Las hemorragias hipertensivas intraparenquimatosas suelen localizarse anatómicamente en el putamen (60% de los casos), tálamo, puente cerebral, hemisferios cerebelosos (rara vez) y en otras regiones del cerebro. La hipertensión arterial y los angiomas cavernosos son las causas más frecuentes. Estas hemorragias son graves y pueden causar la muerte instantánea o de forma rápida en personas sin antecedentes conocidos, en cuyo caso se incluyen en el concepto médico de muerte súbita, y legal de 'sospechosa de criminalidad', de modo que se les practica la autopsia judicial para conocer entre otros, la causas y circunstancias de la muerte. Presentamos tres casos de muerte súbita en adultos causadas por hemorragias intracraneales. En dos casos el sangrado fue espontáneo y se localizó en el tronco de encéfalo o Puente de Varolio; en el tercero, se encontró una hemorragia en el mesencéfalo, que se consideró secundaria y de etiología traumática.Intracranial hemorrhages can be spontaneous or traumatic. Spontaneous intracerebral hemorrhages constitute 5-19% of all strokes, are mostly in the middle age of life, with no clear gender predominance. It is often a manifestation of underlying cerebrovascular disease, hypertension being the most important risk factor. Other predisposing factors include diabetes, alcoholism or smoking. Head injuries can also cause them. Hypertensive intraparenchymal hemorrhages usually located anatomically in the putamen (60% of cases), thalamus, cerebral bridge, cerebellar hemispheres (rarely) and in other brain regions. Hypertension and cavernous angiomas are the most common causes. These hemorrhages are serious and can cause instant death or quickly in people with no known history, in which case they are included in the concept of sudden death medical, legal and "suspected crime" so they were necropsied court to hear among others, the causes and circumstances of death. We present three cases of sudden death in adults caused by intracranial bleeding. In two cases the bleeding was spontaneous and was located in the brain stem or Pons, in the third, was found bleeding in the midbrain, which was considered secondary and traumatic etiology

Unraveling the ecological processes modulating the population structure of Escherichia coli in a highly polluted urban stream network

Escherichia coli dynamics in urban watersheds are affected by a complex balance among external inputs, niche modulation and genetic variability. To explore the ecological processes influencing E. coli spatial patterns, we analyzed its abundance and phylogenetic structure in water samples from a stream network with heterogeneous urban infrastructure and environmental conditions. Our results showed that environmental and infrastructure variables, such as macrophyte coverage, DIN and sewerage density, mostly explained E. coli abundance. Moreover, main generalist phylogroups A and B1 were found in high proportion, which, together with an observed negative relationship between E. coli abundance and phylogroup diversity, suggests that their dominance might be due to competitive exclusion. Lower frequency phylogroups were associated with sites of higher ecological disturbance, mainly involving simplified habitats, higher drainage infrastructure and septic tank density. In addition to the strong negative relationship between phylogroup diversity and dominance, the occurrence of these phylogroups would be associated with increased facilitated dispersal. Nutrients also contributed to explaining phylogroup distribution. Our study proposes the differential contribution of distinct ecological processes to the patterns of E. coli in an urban watershed, which is useful for the monitoring and management of fecal pollution.Fil: Saraceno, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Gómez Lugo, Sebastian. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; ArgentinaFil: Ortiz, Nicolás. Provincia de Mendoza. Ministerio de Infraestructura y Vivienda. Secretaria de Obras Publicas. Instituto Nacional del Agua; ArgentinaFil: Gómez, Bárbara M.. Provincia de Mendoza. Ministerio de Infraestructura y Vivienda. Secretaria de Obras Publicas. Instituto Nacional del Agua; ArgentinaFil: Sabio y García, Carmen Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Frankel, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Graziano, Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentin

Integration of proteomics with transcriptomics and metallomics for the study of environmental issues

Comunicaciones a congreso

Nutritional composition assessment of 3000 individualized parenteral nutrition bags in a tertiary referral hospital: Current prescribing patterns

Individualized parenteral nutrition is the most specialized type of nutritional support in the hospital setting. The composition and prescribing patterns for parenteral nutrition have evolved due to new emerging scientific evidence. In the last few years, there has been a tendency to increase the nitrogen and lipid content and decrease the carbohydrate content. To assess the prescribing pattern in a tertiary referral hospital in Spain, the nutritional composition of individualized parenteral nutrition was evaluated retrospectively from January to December of 2016. A total of 3029 parenteral nutrition units were analysed, corresponding to 257 hospitalized adult patients. Medical specialists in General Surgery and Haematology were the most common petitioners. The three most frequently prescribed parenteral nutrition formulae contained 13.4 (28.8%), 15.7 (19.54%) and 17.9 (17.79%) g of nitrogen. The quantity of carbohydrates and lipids showed a mean non-protein calories-to-nitrogen ratio of approximately 78:1 and a carbohydrate-to-lipid ratio that was near 50:50 in most cases. These results suggest a trend towards the administration of parenteral nutrition with a high content of nitrogen and smaller proportion of the non-protein components

Comparative studies on lectin–carbohydrate interactions in low and high density homo- and heteroglycoclusters

12 páginas, 5 figuras, 3 tablas, 3 esquemas.A versatile synthetic procedure to construct series of high- and low-density homo- and heteroglycoclusters is reported. The binding properties of these synthetic multivalent glycoconjugates to concanavalin A (Con A), a model lectin, have been assessed by using a range of competitive and non-competitive binding assays including enzyme-linked lectin assays (ELLA), isothermal titration microcalorimetry (ITC) and surface plasmon resonance (SPR). In all cases, highly dense glycoclusters showed a substantial amplification of the lectin-binding strength in comparison with low-density counterparts. Interestingly, highly-dense glycoligand presentations, regardless of their homo- or heteroglycoligand pattern, furnished similar Con A binding properties, supporting the existence of a synergic effect (heterocluster effect) due to secondary interactions of “non-active” structural motifs in the presence of a certain density of “active” glycoligands.We thank the Spanish Ministerio de Educación y Ciencia (contracts number CTQ2006-15515-C02-01/BQUand CTQ2007-61180/PPQ) and the Junta de Andalucía for financial support.Peer reviewe

Regular consumption of LIPIGO® promotes the reduction of body weight and improves the rebound effect of obese people undergo a comprehensive weight loss program

Obesity is a global public health problem. Objective: To evaluate the effect of the regular consumption of the product Lipigo® on body weight and rebound effect on overweight/obese subjects undergoing a comprehensive weight loss program. Methods: A randomized, parallel, double-blind, placebo-controlled clinical trial was conducted with male and female subjects presenting a BMI 25–39.9 kg/m . All subjects underwent a comprehensive weight loss program (WLP) for 12 weeks, which included an individualized hypocaloric diet, physical activity recommendations, nutritional education seminars, and three times a day consumption of the product Lipigo® or Placebo. After-WLP, subjects continued the treatment for 9 months to assess rebound effect. Body weight (BW), BMI, and body composition were measured at the beginning and the end of the WLP, and in the follow-up. Results: A total of 120 subjects (85% women) 49.0 ± 9.5 years old and with a BW of 81.57 ± 13.26 kg (BMI 31.19 ± 3.44 kg/m ) were randomized and 73 subjects finished the study. At the end of the WLP, there was a tendency toward reduced BW (p = 0.093), BMI (p = 0.063), and WC (p = 0.059) in the treated group. However, subjects with obesity type 1 (OB1) from the treated group significantly reduced body weight (−5.27 ± 2.75 vs. −3.08 ± 1.73 kg; p = 0.017) and BMI (−1.99 ± 1.08 vs. −1.09 ± 0.55 kg/m ; p = 0.01) compared with placebo. They also presented a minor rebound effect after 9 months with product consumption (−4.19 ± 3.61 vs. −1.44 ± 2.51 kg; p = 0.026), minor BMI (−1.61 ± 1.43 vs. −0.52 ± 0.96 kg/m ; p = 0.025) and tended to have less fat-mass (−3.44 ± 2.46 vs. −1.44 ± 3.29 kg; p = 0.080) compared with placebo. Conclusions: The regular consumption of the product Lipigo® promotes the reduction of body weight and reduces the rebound effect of obese people after 52 weeks (12 months), mainly in obesity type 1, who undergo a comprehensive weight loss program. 2 2 2 2This study was supported by the DAMM S.A. group through the project RTC-2016-5317-1 from the RETOS COLABORACIÓN 2016 program of Economy and Competitiveness Ministry of Spain (MINECO

Una propuesta de innovación para la mejora del desarrollo de las prácticas clínicas 1 de la titulación de Graduado en Enfermería. Facultad de Enfermería. Universidad de Murcia. Póster

El curso académico 2009/2010, supuso un gran avance al iniciar los estudios de Graduado en Enfermería en esta Facultad, como resultado de la integración de la Universidad al Espacio Europeo de Educación Superior, lo que ha supuesto numerosos cambios en todos los aspectos relacionados con las metodologías docentes, resaltando la figura del estudiante como el máximo protagonista en el proceso de aprendizaje.Campus Mare Nostrum, Universidad Politécnica de Cartagena, Universidad de Murcia, Región de Murci

Use of metalloproteomics to access environmental stress in the free-living mice mus spretus

Comunicaciones a congreso

Surface chemistry and germination improvement of Quinoa seeds subjected to plasma activation

Plasma treatment is recognized as a suitable technology to improve germination efficiency of numerous seeds. In this work Quinoa seeds have been subjected to air plasma treatments both at atmospheric and low pressure and improvements found in germination rate and percentage of success. Seed water uptake by exposure to water vapor, although slightly greater for plasma treated seeds, did not justify the observed germination improvement. To identify other possible factors contributing to germination, the chemical changes experienced by outer parts of the seed upon plasma exposure have been investigated by X-ray photoemission spectroscopy (XPS) and scanning electron microscopy (SEM-EDX). XPS revealed that the outer layers of the Quinoa plasma treated seeds were highly oxidized and appeared enriched in potassium ions and adsorbed nitrate species. Simultaneously, SEM-EDX showed that the enrichment in potassium and other mineral elements extended to the seed pericarp and closer zones. The disappearance from the surface of both potassium ions and nitrate species upon exposure of the plasma treated seeds to water vapor is proposed as a factor favoring germination. The use of XPS to study chemical changes at seed surfaces induced by plasma treatments is deemed very important to unravel the mechanisms contributing to germination improvement