Effects of Thermal Radiation Using Wood Stoves on Population Health

The use of biomass for cooking food in the rural sector of the province of Manabí is very common. The present work analyzes the situation of families that use wood stoves for the cooking of food in the community of Casas Viejas, canton Jipipapa, province of Manabí. Thermography techniques have used to measure the level of emissivity to which users of traditional kitchens are exposed. It was determined that the exposure is direct and reaches temperatures up to 250 ° C, being able to raise its body temperature in the abdominal area up to 80 ° C. This periodic and prolonged exposure to thermal radiation can seriously affect the health of users

Management Model For University Cooperation At Universidad Técnica De Manabí, Ecuador

In researching a management model for university cooperation at the Universidad Técnica de Manabí, with its components, phases, stages, input, and output information as well as the premises of its practical application, thereby achieving qualitative and quantitative changes proposed in the conception of university cooperation for sustainable development. The model for the management of cooperation, the assumptions of the model and the components are exposed, and a map with universities that are currently on the network and the issues raised in the strategy, setting out the results at national and International levels

Photovoltaic Energy to Face an Earthquake

The application of photovoltaic technology is necessary to reduce the harmful effects of an intense earthquake in the city of Portoviejo. It is based on the information obtained about the occurrence of the earthquake on April 16 and considering data from other events of the same nature occurred in the territory, an assessment of the seismic risk for the city and by characterization of one of the zones is made subject to danger, the introduction of photovoltaic luminaires is proposed in order to provide certain strengths that can facilitate the work of the first urgency in the rescue and urgent repair of breakdowns, as well as the evacuation of the population to safer areas especially at night. An analysis is made of the technological structure of photovoltaic luminaires and the prices they have in the market, both internally and Internationally

Renewable Energy Sources on the Change of Energy Matrix in Manabí Province

The exploitation, distribution, and consumption of energy have caused the greatest environmental pollution on the planet and accelerated climate change; even though it has been the promoter of the social, economic development of many generations. Contemporary man can continue to increase his social development, but looking for alternatives to energy development. The work shows a model of energy development that will guarantee the sustainability of social development in the areas of the province of Manabí where energy arrives with low quality and in other places does not exist. The objective of the work is to propose the diversification of the energy matrix from the gradual and progressive introduction of technologies based on the use of renewable resources that it has was distributed in the territory of the province. This result will allow the use of indigenous renewable resources, reduce environmental pollution, and improve the quality of life of populations based on the principle of energy sustainability

Local Development Applied to Energy Scheme

Manabí is a province with great potential, either in the agri-food sector or in the renewable generation of energy. However, the limitations inherited from traditional development models prevent achieving the sustainable development of this territory. This paper proposes a development model at the local level, aimed at achieving equity and, through the use of renewable energy sources and other potentials present in specific territories, to improve the quality of life and reduce the risks of societies present there. Through geographic information systems, it was possible to generate and display on maps information related to the energy demand at the provincial and cantonal levels, as well as the province's energy behavior considering the population density

The Future of Micro-grids in Ecuador

An analysis is made on the development of power lines worldwide and that offer the approaches of the impacts that are generated in the economic and environmental, which justify the application of smart grids in Ecuador, as an effective way to raise the efficiency of the electric power service and to achieve a more efficient use of the energy that is generated by showing the different technologies used in electricity generation where renewable energy sources are incorporated. A comparative analysis of how the installed generation power has been increasing until 2016 is shown

New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type

Methylmalonic aciduria cblB type (MMA cblB) is caused by the impairment of ATP:cob(I)alamin adenosyltransferase (ATR), the enzyme responsible for the synthesis of adenosylcobalamin (AdoCbl) from cob(I)alamin. No definitive treatment is available for patients with this condition and novel therapeutic strategies are therefore much needed. Recently, we described a proof-of-concept regarding the use of pharmacological chaperones as a treatment. This work describes the effect of two potential pharmacological chaperones - compound V (N-{[(4-chlorophenyl)carbamothioyl]amino}-2-phenylacetamide) and compound VI (4-(4-(4-fluorophenyl)-5-methyl-1H-pyrazol-3-yl)benzene-1,3-diol) - on six ATR mutants, including the most common, p.Arg186Trp. Comprehensive functional analysis identified destabilizing (p.Arg186Gln, p.Arg190Cys, p.Arg190His, p.Arg191Gln and p.Glu193Lys) and oligomerization (p.Arg186Trp and p.Arg191Gln) mutations. In a cellular model overexpressing the destabilizing/oligomerization mutations, compounds V and VI had a positive effect on the stability and activity of all ATR variants. When provided in combination with hydroxocobalamin a more positive effect was obtained than with the compounds alone, even in mutations previously described as B12 non-responsive. In addition, a normal oligomerization profile was recovered after treatment of the p.Arg186Trp mutant with both compounds. These promising results confirm MMA cblB type as a conformational disorder and hence, pharmacological chaperones as a new therapeutic option alone or in combination with hydroxocobalamin for many patients with MMA cblBThis work was supported by Instituto de Salud Carlos III and (grant PI13/01239) plus grants from the Fundación Isabel Gemio and Obra Social de La Caixa to BP; the Research Council of Norway [nr. 185181 to AM], The KG Jebsen Foundation, and NovoSeeds (Novo Nordisk). AG was supported by a Ramón y Cajal grant from the Ministerio de Ciencia y Tecnología. This work was supported also by the European Regional Development Fund (PI13/01239

Iron–Gold Nanoflowers: A Promising Tool for Multimodal Imaging and Hyperthermia Therapy

The development of nanoplatforms prepared to perform both multimodal imaging and combined therapies in a single entity is a fast-growing field. These systems are able to improve diagnostic accuracy and therapy success. Multicomponent Nanoparticles (MCNPs), composed of iron oxide and gold, offer new opportunities for Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) diagnosis, as well as combined therapies based on Magnetic Hyperthermia (MH) and Photothermal Therapy (PT). In this work, we describe a new seed-assisted method for the synthesis of Au@Fe Nanoparticles (NPs) with a flower-like structure. For biomedical purposes, Au@Fe NPs were functionalized with a PEGylated ligand, leading to high colloidal stability. Moreover, the as-obtained Au@Fe-PEG NPs exhibited excellent features as both MRI and CT Contrast Agents (CAs), with high r2 relaxivity (60.5 mM−1⋅s−1) and X-ray attenuation properties (8.8 HU mM−1⋅HU). In addition, these nanoflowers presented considerable energy-to-heat conversion under both Alternating Magnetic Fields (AMFs) (∆T ≈ 2.5 °C) and Near-Infrared (NIR) light (∆T ≈ 17 °C). Finally, Au@Fe-PEG NPs exhibited very low cytotoxicity, confirming their potential for theranostics applications.Spanish Ministry of Economy, Industry and Competitiveness CTQ2017-86655-RSpanish Ministry of Science and Innovation PID2020-118448RB-C21Spanish Ministry of Science and Innovation PID2020-113108RB-I00MCIN/AEI/10.13039/501100011033Fondo Social de la DGA (grupos DGA) PGC2018-096016-B-I00Regional Ministry of Health of Andalusia OH-0026-2018Regional Ministry of Health of Andalusia PAIDI 2020. P20_0072

Lucro líquido do franqueado: um sinal para a escolha de franquia em época de crise

Este artículo aborda desde la perspectiva de la Teoría de Señales la elección de una franquicia por un potencial franquiciado que elige este canal de distribución por primera vez. El objetivo es analizar la relación entre algunas señales enviadas por el franquiciador y la elección de una franquicia por el potencial franquiciado. Concluimos que los efectos de las variables macroeconómicas de España en el periodo 2006-2013 influyeron en los ingresos netos de los franquiciados para que se convirtiera en una señal empleada por éstos a la hora de elegir la franquicia donde abrir un establecimiento.This paper adopts the perspective of Theory of Signals to discuss how someone starting a business as a franchisee for the first time can choose a suitable franchise brand. The aim was to analyze the relationship between certain signals sent by the franchisor and the choice of a franchise brand by the prospective franchisee. Using panel data, we found that the effects of macroeconomic variables in Spain for the 2006-2013 crisis period influenced franchisees' net income, which thus became a relevant signal in their process of choosing a franchise brand to start a business.Sob a perspectiva da Teoria de Sinais, este artigo aborda a seleção de uma franquia por um franqueado que elege esse potencial canal de distribuição pela primeira vez. O objetivo é analisar a relação entre alguns sinais enviados pelo franqueador e a escolha de uma franquia pelo potencial franqueado. Usando a metodologia de dados em painel, os resultados obtidos nos permitiram concluir que os efeitos das variáveis macroeconômicas da Espanha no período de crise econômica (2006-2013) influenciaram as receitas líquidas dos franqueados, tornando-se um sinal para eles elegerem onde abrir um estabelecimento franqueado