Bir Mimarî Sadânın Peşinde : Ahi Evran Külliyesi’nin Artikülasyonları

Bu çalışma, mimarlık pratiği içerisinde kendilerine mahsus anlamlar barındıran “sadâ” ve “artikülasyon” kavramlarının, mimari bir dilin üretiminde ne tür tanımlamalar ile karşılık bulduklarıyla alakalıdır. Bu doğrultuda, Türkiye’deki geleneksel yapı teknolojisine ait güncel uygulamaların artikülasyonları üzerinden, mekansâl üretimi meydana getiren form ve yapı detayları incelenmektedir. Hususi olarak, taş ve ahşap gibi geleneksel yapı malzemelerinin betonarme ile birlikte çözümlendiği Kırşehir’deki Ahi Evran Külliyesi, mekânsal oluşumunu mümkün kılan form ve yapı detaylarının üretiminde kullanılan malzemelerin olanaklarını değerlendirme şeklinden ötürü bu çalışmanın odak noktası konumundadır. Bu çalışmada, bahsi geçen yapının artikülasyonları bağlamında ele alınan malzemelerin ve bunlardan üretilen yapı detaylarının, mimarlık pratiği içerisinde geleneksel yapı teknolojisine ve üretimlerine eklemlenerek mevcut olan ürünlerin farklı mecralarda yeniden gündeme getirilmesi tartışılmaktadır. Bu çalışmayla hedeflenen, dilin ifade kabiliyetini oluşturan artiküler hareketlerin, mimarlığın üretiminde mekânsal bütünlüğü meydana getiren yapı detaylarıyla benzerliğini saptamaktır.This study related to how the concepts of “sadâ” and “articulation”, which have their own meaning in architectural practice, are used in the production of an architectural language. In this respect, articulations out of the current practices of traditional building technologies in Turkey, forming the spatial form and structure of production details are examined. In particular, the Ahi Evran Complex in Kırşehir, where traditional building materials such as stone and wood are used together with reinforced concrete, is the focus of this study because of the way in which it assesses the possibilities of the material usage in the production of the form and structure details that make the spatial formation possible. In this study, it is argued that the materials discussed in the context of articulation of said structure and the structural details produced there from are added to the traditional construction technology and production in the architectural practice and that the existing one is brought up again in different media. The aim of this study is to show the similarity of the articular movements, which constitute the expression ability of the language, with the structural details that create the spatial integrity in the production of architecture

Effects of sulfur supplementation on thyroid hormones in angora goats fed with a high-nitrate diet

Bu çalışma, yüksek diyetli nitrat alımı ve inorganik kükürt ilavesinin Ankara keçilerindeki tiroid hormonlarına etkisini belirlemek amacıyla yapıldı. Çalışmada, yaklaşık 14 aylık yaştaki 18 erkek Ankara keçisi 3 gruba bölündü: kontrol grup bazal diyetle beslendi, nitrat grubu 1500 ppm nitrat ilave edilen bazal diyetle beslendi ve nitrat+kükürt grubu 1500 ppm nitrat ve %1.8 sodyum sülfat ilave edilen bazal diyetle beslendi. Çalışmanın 45., 90., 135. ve 180. günlerinde serum örneklerinde tiroid uyarıcı hormon (TSH), total ve serbest triiyodotironin (TT3 veFT3) ve tetraiyodotironin (TT4 ve FT4) düzeyleri ölçüldü. 180. günde, TT4 hariç, serum TSH, total ve serbest T3 ve serbest T4 konsantrasyonları nitrat+kükürt grubunda kontrol ve nitrat grubundan daha yüksekti (P<0.01). Bu çalışma, Ankara keçilerinin tiroid hormonları dikkate alındığında 1500 ppm nitrat içeren bir beslemeyi tolere edebileceğini ve inorganik kükürdün doza bağlı olarak tiroid hormonları üzerine yüksek nitratlı diyetin olumsuz etkilerini hafifletmek için doğal bir kaynak görevi görebileceğini önermektedir.This study was to aimed for determination the effect of high dietary nitrate intake and inorganic sulphur supplementation on thyroids hormones in Angora goats. In this study, eighteen male Angora goats aged 14 months were divided into three groups (n = 6): control group fed with a basal diet, nitrate group fed with a basal diet supplemented with 1500 ppm nitrate, and nitrate + sulfur group fed with a basal diet supplemented with 1500 ppm nitrate and 1.8% sodium sulfate. On days 45, 90, 135, and 180 of the study, the concentrations of the thyroid-stimulating hormone (TSH), total and free triiodothyronine (TT3 and FT3), and tetraiodothyronine (TT4 and FT4) were measured in the serum samples. On day 180, except for TT4, the serum TSH and total and free T3 and free T4 concentrations were higher (P<0.05) in the nitrate + sulfur group than in the control and nitrate groups. This study suggested that Angora goats could tolerate a feed containing 1500 ppm nitrate with respect to the thyroid hormones, and inorganic sulfur might serve as a natural source for alleviating the negative effects of the high-nitrate diet on the thyroid gland in a dose-dependent manner

QUALITY OF LIFE AND THE FACTORS AFFECTING IT AMONG PEOPLE AGED 75 YEARS AND OVER LIVING IN A HEALTH CENTER REGION IN IZMIR

Esentepe Sağlık Ocağı Bölgesi\'nde yaşayan 75 yaş ve üzerindeki yaşlıların yaşamkalitesini ve etkileyen etmenleri belirlemektir.Gereç ve yöntem: Kesitsel tipteki çalışma Ekim 2006-Mayıs 2007 tarihleri arasındaİzmir Esentepe Sağlık Ocağı Bölgesi\'nde gerçekleştirildi. Araştırma evreni bu bölgedeyaşayan 75 yaş ve üzeri 851 kişiydi. Standart sapma 46, ± 5 hata, %95 güvendüzeyinde 235 kişi, sistematik örneklemeyle belirlendi. Araştırmanın bağımlı değişkeniyaşam kalitesi, bağımsız değişkenleri sosyo-demografik özellikler, sosyal destek, depresyon,günlük yaşam etkinlikleri bağımlılık durumuydu. Yaşam kalitesi için SF 12,günlük yaşam etkinlikleri için Barthel İndeksi, depresyon için Geriatrik DepresyonÖlçeğinin kısa formu kullanıldı. Veri yüz-yüze görüşme tekniğiyle toplandı, bağımsızgruplarda t testi, Mann-Whitney U Testi ve çoklu regresyon ile çözümlendi.Bulgular: Araştırma grubunun yaş ortalaması 79,1 ± 4,3 (75-98), %58,9\'u kadın, %51,4\'ü evli, %45,9\'u ilkokul mezunuydu. %92,5\'inin sağlık güvencesi vardı. Yaşlıların %24,7\'sinin GYE\'de bağımlı olduğu ve %24,0\'ında depresyon varlığı saptandı.İki değişkenli analizlerde Fiziksel Bileşen Özet Skor (FBÖS) ve Ussal Bileşen ÖzetSkor (UBÖS) kadınlarda anlamlı olarak daha düşükken ortaokul veya üstü eğitimlilerde,geliri giderine eşit veya fazla olanlarda anlamlı olarak daha yüksekti. Bastonkullananlarda hem FBÖS hem de UBÖS daha düşüktü (p<0,05). FBÖS evlilerde vesağlık güvencesi olanlarda daha yüksekken kronik hastalığı olanlarda daha düşüktü(p<0,05). FBÖS ve UBÖS, depresyon ve GYE\'de bağımlılık saptananlarda anlamlıolarak daha düşüktü. Çoklu regresyon analizi sonucunda cinsiyet, baston kullanımı,bağımlılık puanı ve kronik hastalık sayısı ile FBÖS, bağımlılık ve depresyon puanı ileUBÖS arasında anlamlı ilişki olduğu saptandı.Sonuç: Yaşlılarda bağımlılık, kronik hastalık, depresyon varlığı, baston kullanımı vecinsiyet yaşam kalitesi için önemli risk etmenleri olarak bulunmuştur. Risk grupları gözönünde bulundurularak yaşlı nüfusun YK\'lerini arttırmak önemli sağlık hedeflerindenolmalıdır.Objective: The aim of the study is to define the quality of life (QoL) and the factorsaffecting it in elderly people over 75 years living in Izmir Esentepe Health CenterRegion.Material and method: The cross-sectional study was conducted during October2006 and May 2007 in Izmir Esentepe Health Center Region. The study population ofthe research consisted of 851 elderly people of 75 years of age or over living in thisregion. Twohundredthirtyfive people were determined by systematic sampling, with astandard deviation of 46, ±5 error, and 95% confidence level. The dependent variableof the study was QoL, the independent variables were socio-demographic characteristics,social support, depression, and dependency on activity of daily living (ADL). TheSF-12 was used for QoL assessment, Barthel Index for ADL, and the short form ofGeriatric Depression Scale for depression assessment. The data were collected byface to face interviews and analyzed by t test, Mann-Whitney U test and multipleregression analysis.Results: The average age was 79.1 ± 4.3 (75-98), with a female proportion of 58.9%,51.4% of the study population were married, 45.9% of them primary school graduates,and 92.5% had health insurance. It was determined that 24.7% of the elderly peoplewere dependent on GYE and 24.0% of them had depression.In univariate analyses, Mental Component Summary Score (MCSS) and PhysicalComponent Summary Score (PCSS) were significantly lower in women, althoughMCSS and PCSS were significantly higher in elderly people with middle school orhigher education, in those with spending equal to income or more income thanspending. In the elderly people using the stick, both MCSS and PCSS were lower(p<0.05). MCSS were higher in married people and in the ones with health insurancealthough in the ones with a chronic disease were lower (p<0.05). MCSS and PCSSwere significantly lower in those with depression or dependency to ADL. At the end ofmultiple regression analysis, significant relations were found between sex, dependencyscore, number of chronic diseases and using stick and MCSS and betweendependency, depression score and PCSS.Conclusion: The presence of dependency, chronic disease, and depression, usingstick and gender were found as significant risk factors for QoL. Taking risk groups intoconsideration, improving the QoL\'s of the elderly population should be one of theimportant health goals

Demographic and clinical characteristics of patients with sustained and switching treatments using biological and targeted synthetic disease-modifying antirheumatic drugs: A multicenter, observational cross-sectional study for rheumatoid arthritis

Introduction Rheumatoid arthritis is a chronic inflammatory disease with different disease activity grades. Several registries have been designed to determine the appropriate regimens of disease-modifying antirheumatic drugs to obtain sustained clinical remission. We examined epidemiological and clinical characteristics of rheumatoid arthritis patients using a clinical registry database (BioSTaR) and analyzed the differences in patients with sustained and switched therapies. Methods A multicenter, observational cross-sectional study for rheumatoid arthritis was performed between February 2019 and September 2020 using the BioStaR-RA registry. Demographic and clinical characteristics were prospectively recorded into a specifically designed electronic database. The patients were divided into three groups due to the heterogeneity of the study cohort. Patients were grouped as Group I (Initial; within the first 6 months of treatment with biological/targeted synthetic drugs), Group ST (Sustained Treatment; any first drug lasting for at least 6 months without any change), and Group S (Switch; any switching to another drug). Comparative analysis was performed between sustained treatment (Group ST) and drug switching (Group S) groups. Results The study included a total of 565 patients. The mean age was 53.7 +/- 12.8 years, and the majority were female (80.4%). There were 104, 267, and 194 patients in Groups I, ST, and S, respectively. Erosive arthritis and hematological extra-articular involvement were more frequently detected in Group S than Group ST (p = 0.009 and p = 0.001). The patients in Group S had significantly higher disease activity scores (DAS28-CRP, CDAI, and SDAI) (p = 0.025, p = 0.010, and p = 0.003). There were significantly more patients with moderate disease activity in Group S (p < 0.05). Conclusions The groups with sustained treatment and switching included patients with different disease activity status, although higher disease activity was determined in switchers. Overall, moderate disease activity and remission were the most common disease activity levels. Lower disease activity scores, lower hematologic manifestations, better functional status, and lesser radiographic damage are associated with sustained treatment.Turkish Medicine and Medical Devices Agency ; Ankara Numune Egitim ve Arastirma Hastanes

Recent Advances in Health Biotechnology During Pandemic

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in 2019, cut the epoch that will make profound fluctuates in the history of the world in social, economic, and scientific fields. Urgent needs in public health have brought with them innovative approaches, including diagnosis, prevention, and treatment. To exceed the coronavirus disease 2019 (COVID-19) pandemic, various scientific authorities in the world have procreated advances in real time polymerase chain reaction (RT-PCR) based diagnostic tests, rapid diagnostic kits, the development of vaccines for immunization, and the purposing pharmaceuticals for treatment. Diagnosis, treatment, and immunization approaches put for- ward by scientific communities are cross-fed from the accrued knowledge of multidisciplinary sciences in health biotechnology. So much so that the pandemic, urgently prioritized in the world, is not only viral infections but also has been the pulsion in the development of novel approaches in many fields such as diagnosis, treatment, translational medicine, virology, mi- crobiology, immunology, functional nano- and bio-materials, bioinformatics, molecular biol- ogy, genetics, tissue engineering, biomedical devices, and artificial intelligence technologies. In this review, the effects of the COVID-19 pandemic on the development of various scientific areas of health biotechnology are discussed

Synthesis, characterization, and antimicrobial activity of a new pyrimidine Schiff base and its Cu(II), Ni(II), Co(II), Pt(II), and Pd(II) complexes

A new Schiff base, {1-[(5-bromo-2-hydroxy-benzylidene)- amino]-4-phenyl-2-thioxo-1,2-dihyro-pyrimidin-5-yl}-phenyl-methanone, was synthesized from N-amino pyrimidine-2-thione and 5-bromsalicylaldehyde. Metal complexes of the Schiff base were prepared from acetate salts of Cu(II), Ni(II), Co(II), Pd(II), and PtCl2 in methanol. The chemical structures of the Schiff base ligand and its metal complexes were confirmed by spectroscopic analysis. All of the compounds were evaluated for their antimicrobial against 4 gram-positive bacteria, 1 gram-negative bacterium, and 3 yeast strains. The Schiff base and the Cu(II) and Co(II) complexes showed good biological activity against all tested bacteria and yeast strains

Palladium(0) nanoparticles supported on metal organic framework as highly active and reusable nanocatalyst in dehydrogenation of dimethylamine-borane

Palladium(0) nanoparticles supported on the external surface of Cu-3(btc)(2) framework (PdNPs@Cu-3(btc)(2)) were in-situ generated from the reduction of Pd(acac)2 precursor impregnated on the Cu-3(btc)(2) support during the dehydrogenation of dimethylamine-borane in toluene at room temperature. The characterization of PdNPs@Cu-3(btc)(2) by using advanced analytical techniques shows the formation of well-dispersed palladium(0) nanoparticles supported on Cu-3(btc)(2) surface. These new palladium(0) nanoparticles were found to be the most active and the longest-lived nanocatalyst with superior reusability performance in the dehydrogenation of dimethylamine-borane at room temperature