Dominant/recessive behavior in the expression of molecular information: Self-assembly of inorganic macrocyclic architectures containing coordinatively unsaturated ligands

The polytopic ligand 1 contains three different metal ion binding subunits forming two substructures that code for the self-assembly of two different coordination structures (helicate and grid type) under metal ion complexation. Reaction with Cu(II) and Zn(II) ions generates the coordinatively unsaturated architectures 8 and 9 resulting from the formation of two double helicate arrangements. Their crystal structure has been determined by x-ray diffraction. These results show that the double helical motif is expressed at the expense of the grid type one, indicating the dominant/recessive behavior of the system. Together with earlier studies on the linear combination and crossover processing schemes, the dominant/recessive generation of 8 and 9 completes the demonstration of principle of the modes of multiple expression of molecular information in a multicode programmed chemical system

An original supramolecular helicate from a bipyridine-bipyrazine ligand strand and Ni-II by self-assembly

A new discrete supramolecular pseudo-helicate has been obtained from a saturated heterotopic methylbipyrazyl-methylbipyridyl ligand strand and NiCl2. The X-ray structure of the dinuclear complex shows the 2-oxapropylene bridge oxygen atoms are engaged in coordination to the octahedral metal centre and a selective ligand inter-strand orientation is promoted in the complex. The crystal packing shows a perfect regular linear arrangement of the asymmetric units giving a packing of interacting molecules having well-defined rectangular and polygonal open channels. Although a paramagnetic behaviour is observed above 10 K, below this temperature a significant deviation of this behaviour suggests the presence of an Ni-II-Ni-II magnetic coupling

Activity-based fingerprinting of proteases

10.1002/cbic.200500340ChemBioChem7132-36CBCH

Luminogenic "Clickable" Lanthanide Complexes for Protein Labeling.

International audienceDevelopment of lanthanide-based luminescent "switch-on" systems via azide-alkyne [3+2] cycloaddition is described. We used these for non-specific protein labeling and as tags for specific and selective activity-based protein labeling