1,536 research outputs found

    Economic sanctions against Russia: italian point of view

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    This article is devoted to the impact of economic sanctions against Russia imposed by the European Union on the economy of Italy and reflects the views of the Italians. Special attention is paid to the losses incurred by the economy of Italy

    Kinetic Solvers with Adaptive Mesh in Phase Space

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    An Adaptive Mesh in Phase Space (AMPS) methodology has been developed for solving multi-dimensional kinetic equations by the discrete velocity method. A Cartesian mesh for both configuration (r) and velocity (v) spaces is produced using a tree of trees data structure. The mesh in r-space is automatically generated around embedded boundaries and dynamically adapted to local solution properties. The mesh in v-space is created on-the-fly for each cell in r-space. Mappings between neighboring v-space trees implemented for the advection operator in configuration space. We have developed new algorithms for solving the full Boltzmann and linear Boltzmann equations with AMPS. Several recent innovations were used to calculate the discrete Boltzmann collision integral with dynamically adaptive mesh in velocity space: importance sampling, multi-point projection method, and the variance reduction method. We have developed an efficient algorithm for calculating the linear Boltzmann collision integral for elastic and inelastic collisions in a Lorentz gas. New AMPS technique has been demonstrated for simulations of hypersonic rarefied gas flows, ion and electron kinetics in weakly ionized plasma, radiation and light particle transport through thin films, and electron streaming in semiconductors. We have shown that AMPS allows minimizing the number of cells in phase space to reduce computational cost and memory usage for solving challenging kinetic problems

    Investigation of Using Natural Aromatizers of Lemon Essential Oil in Ayurvedic Culinary

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    There was considered a possibility of using natural aromatizers in ayurvedic culinary, namely fractions that act as a product of lemon essential oil. There was presented the component ratio and characteristic of a fragrance of a terpene fraction and terpenoid one, obtained by the gas-chromatographic analysis on a nozzle column with a stable dynonyl phthalate fraction by the standard method.A classic salad sauce β€œVinaigrette” was chosen as a research subject. The introduction of natural aromatizers was conducted at the final stage of mixing olive oil and other ingredients of the dish. The optimal amount of aromatizers was determined empirically by sensor analysis results. During the studies, it has been established, that a fraction of lemon essential oil No. 1 must be introduced in amount 0,1 g for 1000 g of the ready product, a fraction of lemon essential oil No. 2 – 0,125 g for 1000 g of the ready product.As far as terpenes and terpenoids of lemon essential oil are natural substances of the initial raw material, stimulating food juices extraction, it allows to state about the activation of so-called β€œdigestive fire” at using the aromatized sauce

    Implification of ephippium analysis (Cladocera, branchiopoda, crustacea) for reconstruction of past environmental changes in central yakutia, Russia

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    Β© SGEM2017. All Rights Reserved. The aim of our investigation is to reconstruct the local and regional palaeoenvironmental conditions and to highlight the rapid evolution of the thermokarst lake during the Holocene climate optimum. The investigated lake was located in Central Yakutia, Siberia, Russia. The investigated core was collected in a small pingo within a large Central Yakutian thermokarst Khara Bulgunnyakh basin (alas). According to ephippium analysis the formation of the lake coincided with the Holocene climatic optimum. Using cluster analysis we identified three statistically significant ecological zones that reflected changes in the species composition of sub-fossil cladoceran communities and sharp increase in concentrations of ephippia per sample. The period of optimal conditions for Cladocera that took place between 6500 and 6350 cal. yrs. BP is characterized by complex community structures and numerous resisting eggs of cladoceran remains deposited in sediments. Development of the lake ecosystem was rapid and it disappeared quite quickly

    Instructions for laboratory training in Special Microbiology and Virology for students of Faculty of Dentistry

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    ΠœΠ˜ΠšΠ ΠžΠ‘Π˜ΠžΠ›ΠžΠ“Π˜Π―ΠœΠ•Π’ΠžΠ”Π˜Π§Π•Π‘ΠšΠ˜Π• Π£ΠšΠΠ—ΠΠΠ˜Π―Π›ΠΠ‘ΠžΠ ΠΠ’ΠžΠ ΠΠ«Π• Π ΠΠ‘ΠžΠ’Π«Π’Π˜Π Π£Π‘ΠžΠ›ΠžΠ“Π˜Π―Π˜ΠΠžΠ‘Π’Π ΠΠΠΠ«Π• Π‘Π’Π£Π”Π•ΠΠ’Π«ΠŸΠ ΠΠšΠ’Π˜Π§Π•Π‘ΠšΠ˜Π• ΠΠΠ’Π«ΠšΠ˜Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Ρ‚ΡΡ ΠΏΠ»Π°Π½, ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ° практичСских занятий ΠΈ основныС практичСскиС Π½Π°Π²Ρ‹ΠΊΠΈ ΠΏΠΎ ΠΎΠ±Ρ‰Π΅ΠΉ ΠΌΠΈΠΊΡ€ΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ вирусологии

    ΠšΠΎΠΌΠΏΠ΅Ρ‚Π΅Π½Ρ†ΠΈΡ ΠΎΡ€Π³Π°Π½ΠΎΠ² мСстного самоуправлСния ΠΊΡ€ΡƒΠΏΠ½Π΅ΠΉΡˆΠΈΡ… Π³ΠΎΡ€ΠΎΠ΄ΠΎΠ² Π² сфСрС обСспСчСния ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-экономичСского развития

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    The subject of the article is legal issues of municipal authorities’ activities in the field of socioeconomic development.The purpose of the article is to identify trends in the legal regulation of socioeconomic issues of organizing local self-government in the largest cities of the Russian Federation. The methodology includes formal legal interpretation of Russian legislative acts, decisions of Russian Constitutional Court as well as systemic analysis of municipal acts.The main results, scope of application. The article analyzes the division of powers between regional and municipal authorities. At the present stage of development of Russian federalism, a rather complex and unstable model of delimitation of powers between levels of public authority has developed, which does not contribute to the socio-economic development of municipalities. distribution of powers between levels of public authority. The question of the delimitation of powers acquires new content in the formation of urban districts with intracity division and intracity districts in the largest cities. Based on the experience of organization and activities of urban districts with intracity division of Chelyabinsk and Samara, the problems and prospects of this approach to territorial planning and the distribution of powers between levels of public authority are outlined. Special attention is paid to the problem of finding a balance between centralization and decentralization of local self-government. In this aspect, the issue of a more effective delimitation of powers between different levels of public authority comes to the fore in order to maintain a unified urban policy in the field of ensuring the socio-economic development of the largest cities of the Russian Federation.Conclusions. A comprehensive approach is needed to delineate powers between levels of public authority, taking into account the importance of the largest cities in the spatial development of the Russian economy and their role in the formation of urban agglomerations. Only centralized administration makes it possible to develop a unified urban infrastructure. Therefore, improving the interaction of public authorities and local self-government is a necessary condition and the most important area of work in major cities that requires joint efforts. However, at the same time, it is necessary to avoid the degeneration of local self-government into a state one and the loss of the internal content of this institution of public power.На основС выявлСния Ρ‚Π΅Π½Π΄Π΅Π½Ρ†ΠΈΠΉ ΠΏΡ€Π°Π²ΠΎΠ²ΠΎΠ³ΠΎ рСгулирования вопросов ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ мСстного самоуправлСния Π² ΠΊΡ€ΡƒΠΏΠ½Π΅ΠΉΡˆΠΈΡ… Π³ΠΎΡ€ΠΎΠ΄Π°Ρ… Российской Π€Π΅Π΄Π΅Ρ€Π°Ρ†ΠΈΠΈ проводится Π°Π½Π°Π»ΠΈΠ· разграничСния ΠΏΠΎΠ»Π½ΠΎΠΌΠΎΡ‡ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹ΠΌΠΈ ΠΈ ΠΌΡƒΠ½ΠΈΡ†ΠΈΠΏΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ ΠΎΡ€Π³Π°Π½Π°ΠΌΠΈ власти. ΠžΡ‚Π΄Π΅Π»ΡŒΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ удСляСтся ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ΅ поиска баланса ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠ΅ΠΉ ΠΈ Π΄Π΅Ρ†Π΅Π½Ρ‚Ρ€Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠ΅ΠΉ мСстного самоуправлСния. Π’ этом аспСктС Π½Π° ΠΏΠ΅Ρ€Π²Ρ‹ΠΉ ΠΏΠ»Π°Π½ Π²Ρ‹Ρ…ΠΎΠ΄ΠΈΡ‚ вопрос Π±ΠΎΠ»Π΅Π΅ эффСктивного разграничСния ΠΏΠΎΠ»Π½ΠΎΠΌΠΎΡ‡ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌΠΈ уровнями ΠΏΡƒΠ±Π»ΠΈΡ‡Π½ΠΎΠΉ власти с Ρ†Π΅Π»ΡŒΡŽ сохранСния Π΅Π΄ΠΈΠ½ΠΎΠΉ городской ΠΏΠΎΠ»ΠΈΡ‚ΠΈΠΊΠΈ Π² сфСрС обСспСчСния ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-экономичСского развития ΠΊΡ€ΡƒΠΏΠ½Π΅ΠΉΡˆΠΈΡ… Π³ΠΎΡ€ΠΎΠ΄ΠΎΠ² Российской Π€Π΅Π΄Π΅Ρ€Π°Ρ†ΠΈΠΈ. Π‘Ρ„ΠΎΡ€ΠΌΡƒΠ»ΠΈΡ€ΠΎΠ²Π°Π½ Π²Ρ‹Π²ΠΎΠ΄ ΠΎ нСобходимости комплСксного ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° ΠΊ Ρ€Π°Π·Π³Ρ€Π°Π½ΠΈΡ‡Π΅Π½ΠΈΡŽ ΠΏΠΎΠ»Π½ΠΎΠΌΠΎΡ‡ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρƒ уровнями ΠΏΡƒΠ±Π»ΠΈΡ‡Π½ΠΎΠΉ власти с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ значимости ΠΊΡ€ΡƒΠΏΠ½Π΅ΠΉΡˆΠΈΡ… Π³ΠΎΡ€ΠΎΠ΄ΠΎΠ² Π² пространствСнном Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ российской экономики ΠΈ ΠΈΡ… Ρ€ΠΎΠ»ΠΈ Π² Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ городских Π°Π³Π»ΠΎΠΌΠ΅Ρ€Π°Ρ†ΠΈΠΉ

    The organization of the rating system for assessing the quality of university students training

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    In spite the universities use the rating system of assessing for a quite long time, this issue is still not fully considered. The article is based on the position of insufficient state of knowledge of the multifunctionality of the students rating. The rating helps to reveal the potential of students. It is mentioned that the rating system of assessment is a tool that will improve the quality of training and provide the required level of motivation. During the research, the following methods were used: analysis, synthesis, induction, deduction. As a result, the principles of the rating assessment system were revealed, a definition of the term "Rating" was given, its goals were indicated. As an example of the organization of the rating system of assessment, the Nyzhnii Novhorod State Pedagogical University and its "Regulations on the rating system for assessing the quality of student training" were used. It is noted that the rating includes: current check, midterm and final examinations. Further, all possible conditions under which the student receives points were identified and considered. On the example of the NSPU named after Kozma Minin transferring of the rating points into a five-point grading rating system is presented. Also, the types of violations for which points are discarded, are considered. As the study showed, comprehensive planned system yields productive results for students and the university.peer-reviewe

    Π‘ΠΈΠ½Ρ‚Π΅Π· Ρ‚Π° Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½Ρ– властивості Π°Π»ΠΊΡ–Π»-2-((5-(1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»-1-Ρ–Π»)ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»)Ρ‚Ρ–ΠΎ)Π΅Ρ‚Π°Π½(ΠΏΡ€ΠΎΠΏΠ°Π½,Π±Π΅Π½Π·)Ρ–ΠΌΡ–Π΄Π°Ρ‚Ρ–Π²

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    The synthesis of new biologically active compounds that will replace expensive foreign medicines at the pharmaceutical market of Ukraine is one of the most important directions in development of modern pharmacy and medicine. The synthesis, study of physicochemical and biological properties of new compounds containing 1,2,4-triazole and 1H-tetrazole cores are important tasks of modern synthetic chemistry.Aim. To synthesize new highly efficient and low-toxic substances, namely alkil-2-((5-(1Н-tetrazole-1-yl)methyl-4-R-1,2,4-triazole-3-yl)thio)etan(propan,benz)imidates, and study physicochemical properties of all compounds synthesized.Results and discussion. Twelve new compounds have been obtained as a result of synthetic transformations, the structure of compounds synthesized has been confirmed by modern complex of physicochemical methods of analysis (IR-spectrophotometry, 1H NMR-spectroscopy, elemental analysis), and their individuality has been proven on an Agilent 1260 Infinity HPLC high-performance liquid chromatograph equipped with an Agilent 6120 mass spectrometer.Experimental part. As starting materials for the synthesis of alkil-2-((5-(1Н-tetrazole-1-yl)methyl-4-R-1,2,4-triazole-3-yl)thio)etan(propan,benz)imidates the corresponding 2-((5-(1Н-tetrazole-1-yl)methyl-4-R-1,2,4-triazole-3-yl)thio)aceto(propane,benzo)nitriles were used. The synthesis was carried out in the absolute alcohol medium (propanol, butanol, octanol or allyl alcohol) with chloroform. Conclusions. During synthetic and physicochemical studies the preparative methods for the synthesis of alkil-2-((5-(1Н-tetrazole-1-yl)methyl-4-R-1,2,4-triazole-3-yl)thio)etan(propan,benz)imidates have been developed, the structure of the compounds synthesized has been determined and finally confirmed.Одним ΠΈΠ· ΠΏΡ€ΠΈΠΎΡ€ΠΈΡ‚Π΅Ρ‚Π½Ρ‹Ρ… Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΈΠΉ соврСмСнной Ρ„Π°Ρ€ΠΌΠ°Ρ†ΠΈΠΈ ΠΈ ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹ являСтся синтСз Π½ΠΎΠ²Ρ‹Ρ… отСчСствСнных биологичСски Π°ΠΊΡ‚ΠΈΠ²Π½Ρ‹Ρ… соСдинСний, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ Π±ΡƒΠ΄ΡƒΡ‚ Π·Π°ΠΌΠ΅Π½ΡΡ‚ΡŒ Π΄ΠΎΡ€ΠΎΠ³ΠΈΠ΅ Π·Π°Ρ€ΡƒΠ±Π΅ΠΆΠ½Ρ‹Π΅ Π°Π½Π°Π»ΠΎΠ³ΠΈ Π½Π° фармацСвтичСском Ρ€Ρ‹Π½ΠΊΠ΅. БСгодня Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌ являСтся синтСз, ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСских ΠΈ биологичСских свойств Π½ΠΎΠ²Ρ‹Ρ… соСдинСний, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ Π²ΠΊΠ»ΡŽΡ‡Π°ΡŽΡ‚ ядра 1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»Π° ΠΈ 1,2,3,4-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»Π°.ЦСль. Π¦Π΅Π»Π΅Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹ΠΉ синтСз соСдинСний, содСрТащих ядро1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»Π° ΠΈ ядро 1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»Π°, ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСских свойств синтСзированных соСдинСний.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π΅ синтСза ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½ΠΎ 12 Π½ΠΎΠ²Ρ‹Ρ… соСдинСний, строСниС ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½ΠΎ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ комплСкса соврСмСнных Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСских ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² Π°Π½Π°Π»ΠΈΠ·Π° (ИК-спСктрофотомСтрии, 1Н ЯМР-спСктроскопии, элСмСнтного Π°Π½Π°Π»ΠΈΠ·Π°), Π° ΠΈΡ… ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π° с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ Тидкостного Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Π° Agilent 1260 Infinity HPLC, ΠΎΠ±ΠΎΡ€ΡƒΠ΄ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ масс-спСктромСтром Agilent 6120.Π­ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Π°Ρ Ρ‡Π°ΡΡ‚ΡŒ. Для синтСза Π°Π»ΠΊΠΈΠ»-2-((5-(1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»-1-ΠΈΠ»)ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»)Ρ‚ΠΈΠΎ)этан(ΠΏΡ€ΠΎΠΏΠ°Π½,Π±Π΅Π½Π·)ΠΈΠΌΠΈΠ΄Π°Ρ‚ΠΎΠ² Π² качСствС исходных вСщСств использовали 2-((5-(1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»-1-ΠΈΠ»)ΠΌΠ΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»)Ρ‚ΠΈΠΎ)Π°Ρ†Π΅Ρ‚ΠΎ(ΠΏΡ€ΠΎΠΏΠ°Π½,Π±Π΅Π½Π·ΠΎ)Π½ΠΈΡ‚Ρ€ΠΈΠ»Ρ‹. Π‘ΠΈΠ½Ρ‚Π΅Π· ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π² срСдС ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰Π΅Π³ΠΎ Π°Π±ΡΠΎΠ»ΡŽΡ‚Π½ΠΎΠ³ΠΎ спирта (ΠΏΡ€ΠΎΠΏΠ°Π½ΠΎΠ»Π°, Π±ΡƒΡ‚Π°Π½ΠΎΠ»Π°, ΠΎΠΊΡ‚Π°Π½ΠΎΠ»Π° ΠΈΠ»ΠΈ Π°Π»Π»ΠΈΠ»ΠΎΠ²ΠΎΠ³ΠΎ спирта) Π² присутствии Ρ…Π»ΠΎΡ€ΠΎΡ„ΠΎΡ€ΠΌΠ°.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. Π’ΠΎ врСмя синтСтичСских ΠΈ Ρ„ΠΈΠ·ΠΈΠΊΠΎ-химичСских исслСдований Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Ρ‹ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΈΠ²Π½Ρ‹Π΅ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ синтСза Π°Π»ΠΊΠΈΠ»-2-((5-(1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»-1-ΠΈΠ»)ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-ΠΈΠ»)Ρ‚ΠΈΠΎ)этан(ΠΏΡ€ΠΎΠΏΠ°Π½,Π±Π΅Π½Π·)ΠΈΠΌΠΈΠ΄Π°Ρ‚ΠΎΠ², установлСно ΠΈ ΠΎΠΊΠΎΠ½Ρ‡Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½ΠΎ строСниС всСх синтСзированных соСдинСний.Одним Ρ–Π· ΠΏΡ€Ρ–ΠΎΡ€ΠΈΡ‚Π΅Ρ‚Π½ΠΈΡ… напрямків сучасної Ρ„Π°Ρ€ΠΌΠ°Ρ†Ρ–Ρ— Ρ‚Π° ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½ΠΈ Ρ” синтСз Π½ΠΎΠ²ΠΈΡ… вітчизняних Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΎ Π°ΠΊΡ‚ΠΈΠ²Π½ΠΈΡ… сполук, які Π±ΡƒΠ΄ΡƒΡ‚ΡŒ Π·Π°ΠΌΡ–Π½ΡŽΠ²Π°Ρ‚ΠΈ Π΄ΠΎΡ€ΠΎΠ³Ρ– Π·Π°ΠΊΠΎΡ€Π΄ΠΎΠ½Π½Ρ– Π°Π½Π°Π»ΠΎΠ³ΠΈ Π½Π° Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½ΠΎΠΌΡƒ Ρ€ΠΈΠ½ΠΊΡƒ. ΠΠ°Β Ρ‚Π΅ΠΏΠ΅Ρ€Ρ–ΡˆΠ½Ρ–ΠΉ час Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΈΠΌ Ρ” синтСз, вивчСння Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… Ρ‚Π° Π±Ρ–ΠΎΠ»ΠΎΠ³Ρ–Ρ‡Π½ΠΈΡ… властивостСй Π½ΠΎΠ²ΠΈΡ… сполук, які ΠΌΡ–ΡΡ‚ΡΡ‚ΡŒ ядра 1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»Ρƒ Ρ‚Π° 1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»Ρƒ.ΠœΠ΅Ρ‚Π°. ЦілСспрямований синтСз сполук, Ρ‰ΠΎ ΠΌΡ–ΡΡ‚ΡΡ‚ΡŒ ядро 1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»Ρƒ Ρ‚Π° ядро 1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»Ρƒ, вивчСння Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… властивостСй синтСзованих сполук.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. Π’ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ– синтСтичних ΠΏΠ΅Ρ€Π΅Ρ‚Π²ΠΎΡ€Π΅Π½ΡŒ ΠΎΡ‚Ρ€ΠΈΠΌΠ°Π½ΠΎ 12 Π½ΠΎΠ²ΠΈΡ… сполук, Π±ΡƒΠ΄ΠΎΠ²Ρƒ яких ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΠ΅Π½ΠΎ Π·Π° допомогою комплСксу сучасних Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ–Π² Π°Π½Π°Π»Ρ–Π·Ρƒ (Π†Π§-спСктрофотомСтрії, 1Н ЯМР-спСктроскопії, Π΅Π»Π΅ΠΌΠ΅Π½Ρ‚Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»Ρ–Π·Ρƒ), Π° Ρ—Ρ… Ρ–Π½Π΄ΠΈΠ²Ρ–Π΄ΡƒΠ°Π»ΡŒΠ½Ρ–ΡΡ‚ΡŒ ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΈΠ»ΠΈ Π½Π° Ρ€Ρ–Π΄ΠΈΠ½Π½ΠΎΠΌΡƒ Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„Ρ– Agilent 1260 Infinity HPLC, ΠΎΠ±Π»Π°Π΄Π½Π°Π½ΠΎΠ³ΠΎ мас-спСктромСтром Agilent 6120.Π•ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Π° частина. Для синтСзу Π°Π»ΠΊΡ–Π»-2-((5-(1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»-1-Ρ–Π»)ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»)Ρ‚Ρ–ΠΎ)Π΅Ρ‚Π°Π½(ΠΏΡ€ΠΎΠΏΠ°Π½,Π±Π΅Π½Π·)Ρ–ΠΌΡ–Π΄Π°Ρ‚Ρ–Π² як Π²ΠΈΡ…Ρ–Π΄Π½Ρ– Ρ€Π΅Ρ‡ΠΎΠ²ΠΈΠ½ΠΈ використали 2-((5-(1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»-1-Ρ–Π»)ΠΌΠ΅Ρ‚ΠΈΠ»-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»)Ρ‚Ρ–ΠΎ)Π°Ρ†Π΅Ρ‚ΠΎ(ΠΏΡ€ΠΎΠΏΠ°Π½,Π±Π΅Π½Π·ΠΎ)Π½Ρ–Ρ‚Ρ€ΠΈΠ»ΠΈ. Π‘ΠΈΠ½Ρ‚Π΅Π· ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρƒ сСрСдовищі Π²Ρ–Π΄ΠΏΠΎΠ²Ρ–Π΄Π½ΠΎΠ³ΠΎ Π°Π±ΡΠΎΠ»ΡŽΡ‚Π½ΠΎΠ³ΠΎ спирту (ΠΏΡ€ΠΎΠΏΠ°Π½ΠΎΠ»Ρƒ, Π±ΡƒΡ‚Π°Π½ΠΎΠ»Ρƒ, ΠΎΠΊΡ‚Π°Π½ΠΎΠ»Ρƒ Π°Π±ΠΎ Π°Π»Ρ–Π»ΠΎΠ²ΠΎΠ³ΠΎ спирту) Ρƒ присутності Ρ…Π»ΠΎΡ€ΠΎΡ„ΠΎΡ€ΠΌΡƒ. Висновки. ΠŸΡ–Π΄ час синтСтичних Ρ‚Π° Ρ„Ρ–Π·ΠΈΠΊΠΎ-Ρ…Ρ–ΠΌΡ–Ρ‡Π½ΠΈΡ… Π΄ΠΎΡΠ»Ρ–Π΄ΠΆΠ΅Π½ΡŒ Ρ€ΠΎΠ·Ρ€ΠΎΠ±Π»Π΅Π½Ρ– ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΈΠ²Π½Ρ– ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ синтСзу Π°Π»ΠΊΡ–Π»-2-((5-(1Н-Ρ‚Π΅Ρ‚Ρ€Π°Π·ΠΎΠ»-1-Ρ–Π»)ΠΌΠ΅Ρ‚ΠΈΠ»Π΅Π½-4-R-1,2,4-Ρ‚Ρ€ΠΈΠ°Π·ΠΎΠ»-3-Ρ–Π»)Ρ‚Ρ–ΠΎ)Π΅Ρ‚Π°Π½(ΠΏΡ€ΠΎΠΏΠ°Π½,Π±Π΅Π½Π·)Ρ–ΠΌΡ–Π΄Π°Ρ‚Ρ–Π², встановлСно Ρ‚Π° остаточно ΠΏΡ–Π΄Ρ‚Π²Π΅Ρ€Π΄ΠΆΠ΅Π½ΠΎ Π±ΡƒΠ΄ΠΎΠ²Ρƒ всіх синтСзованих сполук
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