92 research outputs found
Status Report on Education in the Economics of Animal Health: Results from a European Survey
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Comparação entre as técnicas de interpolação direta e dupla reciprocidade na solução do problema de autovalor : Comparison of direct interpolation and double reciprocity techniques for solving the eigenvalue problem
O presente trabalho apresenta os princípios matemáticos e compara duas técnicas do Método dos Elementos de Contorno que usam funções de base radial para resolver a integral relacionada ao termo reativo da Equação de Helmholtz. Assim, em um primeiro momento, apresenta-se a técnica da Dupla Reciprocidade, a qual usa procedimentos relacionados com a aplicação de princípios de reciprocidade para transformar a integração do domínio em integral de contorno. Em um segundo momento, a apresenta-se a técnica da Interpolação Direta, que se baseia em um procedimento de interpolação, no qual todo o núcleo do integral do domínio é aproximado. A comparação entre as duas técnicas é realizada por meio da análise de precisão das frequências naturais, encontradas pela solução dos problemas de autovalor. Um exemplo clássico foi escolhido para a avaliação dos resultados
Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome
Vaccine development is essential for pandemic preparedness. We previously conducted a Phase 1 clinical trial of the vector vaccine candidate MVA-MERS-S against the Middle East respiratory syndrome coronavirus (MERS-CoV), expressing its full spike glycoprotein (MERS-CoV-S), as a homologous two-dose regimen (Days 0 and 28). Here, we evaluate a third vaccination with MVA-MERS-S in a subgroup of trial participants one year after primary immunization. A booster vaccination with MVA-MERS-S is safe and well-tolerated. Both binding and neutralizing anti-MERS-CoV antibody titers increase substantially in all participants and exceed maximum titers observed after primary immunization more than 10-fold. We identify four immunogenic IgG epitopes, located in the receptor-binding domain (RBD, n=1) and the S2 subunit (n=3) of MERS-CoV-S. The level of baseline anti-human coronavirus antibody titers does not impact the generation of anti-MERS-CoV antibody responses. Our data support the rationale of a booster vaccination with MVA-MERS-S and encourage further investigation in larger trials
Iodine-125 brachytherapy for brain tumours - a review
Iodine-125 brachytherapy has been applied to brain tumours since 1979. Even though the physical and biological characteristics make these implants particularly attractive for minimal invasive treatment, the place for stereotactic brachytherapy is still poorly defined
Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials
An amendment to this paper has been published and can be accessed via the original article
Die nicht einrenkbaren angeborenen Hüftluxationen und ihre Behandlung mit der “Gabelung des oberen Femurendes” nach Lorenz-v. Baeyer
Die Entstehung eines hochgradigen Spitz-Hohlfusses durch Bänderezerreissung (operative Heilung)
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