12 research outputs found
PRÁTICAS NOS COMPONENTES CURRICULARES TÉCNICOS NA EJA: CASO PRODUÇÃO DE SANDUÍCHES
- Publication venue
- 'Instituto Federal Catarinense'
- Publication date
- 18/10/2018
- Field of study
A frequência do papilomavírus em uma população de mulheres da zona norte de Porto Alegre e características
- Author
- Publication venue
- Publication date
- 01/01/2004
- Field of study
17
Da roça para a escola: institucionalização e expansão das escolas primárias rurais no Paraná (1930-1960)
- Author
- BALHANA Altiva
- BAREIRO Edson
- BARREIRO Iraíde Marques de Freitas
- CAINELLI Marlene Rosa
- CANCIAN Nadir Aparecida
- CAPELO Maria Regina Clivati
- CAPELO Maria Regina Clivati
- CURY Jamil
- DAMASCENO Maria
- FAUSTO Boris
- GAUTHIER Pierre-Louis
- GRAÇA FILHO Afonso de Alencastro
- HALL Robert King
- HERVATINI Luciana
- HOFF Sandino
- LE GOFF Jacques
- MAGALHÃES Marion Brepohl de
- MARQUES Vera Regina Beltrão Marques
- MARTINIAK Vera Lucia
- MENEGUETTI Karin Schwabe
- MENNUCCI Sud.
- MIGUEL Maria Elisabeth Blanck
- MIGUEL Maria Elisabeth Blanck
- MIGUEL Maria Elisabeth Blanck
- MOTA Lucio Tadeu
- OLIVEIRA Dennilson de
- PASSADOR Cláudia Souza
- PEREIRA Roberval Eloy
- PILOTO Erasmo
- PRYJMA Marielda Ferreira
- TIBUCHESKI Jaqueline Kugler
- TOMAZI Nelson Dacio
- WACHOWICZ Rui Christovam
- ÁVILA Virgínia Pereira da Silva de
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Brazilian Flora 2020: Leveraging the power of a collaborative scientific network
- Author
- Abreu Fernanda
- Abreu Maria
- Abreu Vanessa H.R.
- Acuña‐castillo Rafael
- Afonso Edgar A.L.
- Agra Leandro A.N.N.
- Agra Maria
- Aguiar Daniel P.P.
- Aires Elisa
- Almeda Frank
- Almeida Eduardo
- Almeida Gracineide S.S.
- Almeida Mariana
- Almeida Nicolli B.C.
- Almeida Rafael
- Almeida Roberto B.P.
- Almeida Thaís
- Alves Daniela
- Alves Flávio
- Alves Karina N.L.
- Alves Maria B.B.
- Alves Rodolfo
- Amaral André L.S.
- Amaral Maria C.E.
- Amorim André M.A.
- Amorim Bruno
- Amorim Eduardo
- Amorim Vivian
- Amélio Leandro
- Andrade Ivanilza
- Andrade Ray
- Andreata Regina H.P.
- Andrino Caroline
- André Thiago
- Anjos Cassiane
- Antar Guilherme
- Antonicelli Mirian C.A.
- Antunes Lorena l.C.
- Aona Lidyanne Y.S.
- Arana Marcelo
- Aranha João L.M.
- Araujo Andréa
- Araujo Cintia A.T.
- Araujo Flávia
- Araújo Anderson G.A.
- Araújo Camila
- Araújo Mário H.T.
- Arbo Maria
- Arnou Emily
- Asprino Renata
- Assis Francine
- Assis Leandro C.S.
- Assis Marta
- Athayde Filho Francisco
- Athiê‐souza Sarah
- Azevedo Igor H.F.
- Bacci Lucas
- Barbosa Camilo V.O.
- Barbosa Juliana
- Barbosa Maria Regina V.
- Barbosa‐silva Rafael
- Barboza Gloria
- Barcellos Ian
- Barcelos Flávia R.B.
- Barcelos Laísa
- Barreto Kamilla l.
- Barros Fábio
- Barros Thamires l.A.
- Barros‐barreto Maria B.B.
- Bastos Cid J.P.
- Bastos Cláudia
- Batista João A.N.
- Batista Marcella M.I.
- Baumgratz José Fernando A.
- Bautista Hortencia
- Benelli Adarilda
- Berguecio Nicolás
- Bernacci Luís
- Beyer Maila
- Bezerra Andrea C.C.
- Bezerra Luísa M.P.A.
- Bezerra Yuri R.L.
- Bianchetti Luciano
- Bicudo Carlos E.M.
- Bigio Narcísio
- Biral Leonardo
- Bissoli Vinícius
- Bittencourt Felipe
- Bochorny Thuane
- Bohn Amabily
- Bohs Lynn
- Bojacá Gabriel F.P.
- Boldorini Abril
- Boldrini Ilsi
- Bolson Mônica
- Bordin Juçara
- Bordon Natali
- Borges Rafael A.X.
- Borges Rodrigo l.
- Bortoluzzi Roseli l.C.
- Bove Claudia
- Bovini Massimo
- Braga João M.A.
- Braga Nayara S.S.
- Branco Suema
- Brauner Laiana
- Braz Denise
- Bringel João B.A.
- Brito Antonio l.V.T.
- Brito Eliete
- Bruniera Carla
- Buchoski Monica
- Buck William
- Bueno Norma
- Bueno Vinicius
- Buril‐vital Maria T.A.
- Burton George
- Büneker Henrique
- Bünger Mariana
- Cabral Andressa
- Cabral Elsa l.
- Cabral Fernanda
- Cabral Tiara
- Caddah Mayara
- Caires Claudenir
- Caires Taiara
- Calazans Luana S.B.
- Caldas Diana K.D.
- Calió Maria
- Calvo Joel
- Camargo Rodrigo
- Camelo Mel
- Campos‐rocha Antonio
- Canestraro Bianca
- Canto‐dorow Thais
- Cantuária Patrick
- Cara Álison l.
- Cardoso Andréia
- Cardoso Domingos B.O.S.
- Cardoso Jesiane
- Cardoso Leandro J.T.
- Cardoso Pedro
- Cardozo Andrey l.
- Carmo Dimas
- Carmo João A.M.
- Carneiro Camila
- Carneiro Cláudia
- Carrijo Tatiana
- Caruzo Maria B.R.
- Carvalho Catarina
- Carvalho Dariane A.S.
- Carvalho Fernanda
- Carvalho Jefferson
- Carvalho Maria l.S.
- Carvalho‐silva Micheline
- Castello Ana C.D.
- Castro E Silva Isabella
- Castro Márcia
- Catenacci Fernanda
- Cavalcanti Laise
- Cavalcanti Taciana
- Cavalheiro Larissa
- Cervi Armando
- Chacon Roberta
- Chagas Aline
- Chagas Earl C.O.
- Chautems Alain
- Chauveau Olivier
- Chequín Renata
- Christ Anderson l.
- Christ Jheniffer
- Cidrão Bruno
- Clark Lynn
- Coelho Alexa A.O.P.
- Coelho Guilherme
- Coelho Marcus A.N.
- Coelho Rubens l.G.
- Colletta Gabriel
- Colli‐silva Matheus
- Conceição Adilva
- Conceição Tulio
- Condack João P.S.
- Contro Fernanda l.
- Cordeiro Inês
- Cordeiro Luciana
- Cordeiro Wesley P.F.S.
- Costa E Silva Maria
- Costa Andrea
- Costa Daniel
- Costa Denise
- Costa Fabiane
- Costa Fernanda S.N.
- Costa Francisco C.P.
- Costa Géssica A.G.
- Costa Isabelle G.C.M.
- Costa Itayguara
- Costa Jeferson
- Costa Jorge A.S.
- Costa José G.S.
- Costa Maria T.R.
- Costa Mitchel I.A.
- Costa Suzana
- Costa Thiago
- Costa Tiago
- Costa‐lima James l.
- Cota Matheus M.T.
- Couceiro Yuri S.V.
- Coutinho Thales
- Couto Dayvid
- Couto Ricardo
- Couvo Anielly
- Cyrillo Stephany
- Cárdenas Gabriela
- Câmara Paulo E.A.S.
- Cândido Elisa
- Côrtes Ana l.A.
- Dal Molin Luis
- Dalastra Claudenice
- Dalcin Eduardo Couto
- Damasceno Rafaella G.L.
- de Lazzari Lara R.P.
- Deble Leonardo
- Delfini Carolina
- Delgado Junior Geadelande
- Delgado‐salinas Alfonso
- Della Aline
- Delprete Piero
- Dematteis Massimiliano
- Dettke Greta
- Devecchi Marcelo
- Dewes Talita
- Di Maio Fernando
- Dias Kauê N.L.
- Dias Micheli
- Dias Pedro
- Dittrich Vinícius A.O.
- Domínguez Yoannis
- Dorneles Mariane
- Dressler Stefan
- Duarte Marilia
- Duran Juan D.T.
- Dutilh Julie H.A.
- Dutra Letícia l.
- Dutra Valquíria
- Díaz Yani C.A.
- Dórea Marcos
- Echternacht Livia
- Eggers Lilian
- Erkens Roy H.J.
- Eslabão Marcelo
- Espírito Santo Fábio
- Esser Hans‐joachim
- Essi Liliana
- Esteves Gerleni l.
- Esteves Roberto l.
- Everling Joel
- Ezcurra Cecilia
- Facco Marlon
- Fader Andrea A.C.
- Falcão Marcus J.A.
- Fantecelle Laura
- Farco Gabriela
- Faria Allan l.A.
- Faria Ana P.G.
- Faria Aparecida
- Faria Jair
- Faria Maria
- Farias Sabrina
- Farias‐singer Rosana
- Farinaccio Maria
- Fernandes Aluisio
- Fernandes Ana
- Fernandes Fernando
- Fernandes José
- Fernandes Rozijane
- Fernandes Thiago
- Fernandes Ulisses
- Fernando Emanoel M.P.
- Ferreira Carlos D.M.
- Ferreira Fabrício
- Ferreira Gabriel
- Ferreira João P.R.
- Ferreira Priscila P.A.
- Ferreira Silvana
- Ferrucci María
- Fiaschi Pedro
- Fidanza Karina
- Filardi Fabiana L.R.
- Filgueiras Tarciso
- Firetti Fabiana
- Fleischmann Andreas
- Florentín Javier
- Florentín Mariela
- Flores Andréia
- Flores Jerônimo M.M.
- Flores Thiago
- Fonseca Luiz H.M.
- Fontelas Jean
- Fontella‐pereira Jorge
- Forster Wellington
- Forzza Rafaela
- Fraga Claudio
- Fraga Fernanda R.M.
- Fraga Santiago
- Francisco Jéssica N.C.
- França Flávio
- França Juliana R.K.G.
- Freire‐fierro Alina
- Freitas Fernanda
- Freitas Joelcio
- Freitas Maria
- Fritsch Peter
- Funez Luís
- Furtado Samyra
- Gaem Paulo
- Gaglioti André l.
- Gagnon Edeline
- Gama Beatriz R.A.
- Garcia Flávia C.P.
- Gasper André l.
- Gerace Samuele
- Giacomin Leandro l.
- Giaretta Augusto
- Gil André S.B.
- Gissi Danilo
- Giuffre Pamela M.W.
- Giulietti Ana
- Giussani Liliana
- Goebel Gabriela
- Goes Monique
- Goldenberg Renato
- Gomes Beatriz
- Gomes Fernanda
- Gomes Mario
- Gomes‐da‐silva Janaína
- Gomes‐klein Vera l.
- Gonella Paulo
- Gonzaga Augusto F.N.
- Gonzaga Diego
- Gonzatti Felipe
- González Favio
- Gonçalez Victor
- Gonçalves Ana P.S.
- Gonçalves Deise J.P.
- Gouvêa Yuri
- Graham Shirley A.T.
- Gregório Bernarda
- Grings Martin
- Groppo Milton
- Grossi Mariana
- Guarçoni Elidio A.E.
- Guedes Felipe
- Guedes Juliana
- Guerra Ethiéne
- Guimarães Elsie
- Guimarães Leonardo R.S.
- Guimarães Paulo J.F.
- Gurgel Ely S.C.
- Gutiérrez Diego
- Góes Luiz A.A.
- Hall Climbiê
- Harley Raymond
- Hassemer Gustavo
- Hattori Eric K.O.
- Hechenleitner Paulina
- Hefler Sonia
- Heiden Gustavo
- Henning Tilo
- Henriques Diego
- Hensold Nancy
- Hinoshita Lucas K.R.
- Hirai Regina
- Hirao Yasmin
- Hiriart Florencia
- Hopkins Michael J.G.
- Hoyos‐gómez Saúl
- Huamantupa Isau
- Hurbath Fernanda
- Iganci João R.V.
- Ilkiu‐borges Anna l.
- Imig Daniela
- Indriunas Alexandre
- Inácio Camila
- Jacques Eliane l.
- Jacques Suara S.A.
- Jaimes Juliana
- Jardim Jomar
- Jesus Jôane
- Jesus Priscila
- Jiménez‐mejías Pedro
- Johnson David
- Jordão Lucas S.B.
- Jordão Valner M.M.
- Jorge Taciane
- Kaehler Miriam
- Kameyama Cíntia
- Kataoka Eric
- Kessous Igor
- Kilipper Julia
- Kinoshita Luiza
- Klein Viviane
- Klitgaard Bente
- Knapp Sandra
- Koch Ana
- Koch Ingrid
- Kochanovski Fábio
- Kominami Gabriel F.G.
- Konno Tatiana U.P.
- Koschnitzke Cristiana
- Kotovski Emília
- Kriebel Ricardo
- Külkamp Josimar
- Labiak Paulo
- Leal Brígida
- Leal Eduardo
- Leite Wellerson
- Leite Áurea C.F.
- Leitman Paula
- Lewis Gwilym
- Lima Adriana
- Lima Alexandre
- Lima Duane F.S.
- Lima Eliene
- Lima Haroldo
- Lima Jessica
- Lima Laura C.P.
- Lima Laíce F.G.
- Lima Letícia
- Lima Lucas
- Lima Luis F.P.
- Lima Rita
- Lima Vanessa l.
- Link‐perez Melanie
- Lirio Elton
- Lobão Adriana
- Loeuille Benoit F.P.
- Lohmann Lúcia
- Loiola Maria I.B.
- Lombardi Julio
- Longhi‐wagner Hilda
- Lopes Gabriel S.R.
- Lopes Jenifer
- Lopes Letícia
- Lopes Raimundo
- Lopes Rosana
- Lorencini Tiago
- Lorenzi Harri
- Lourenço Ana R.L.
- Lourenço Arthur
- Louzada Rafael
- Lovo Juliana
- Lozano Eduardo
- Luber Jaquelini
- Lucas Dióber
- Lucas Eve
- Luebert Federico
- Lughadha Eimear Nic
- Luizi‐ponzo Andrea
- Luna Bruna
- Luna Naédja K.M.
- Luz Cíntia l.S.
- López Maria
- Lüdtke Raquel
- M.D. Cardozo Nállarett
- Machado Anderson F.P.
- Machado Evandro
- Machado Talita
- Maciel Jefferson
- Maciel Sebastião
- Magalhães Rodrigo
- Magenta Mara A.G.
- Maia Leonor
- Maia Talita
- Mamede Maria C.H.
- Mansano Vidal
- Marchioretto Maria
- Margalho Luciano
- Marinho Lucas
- Marques Danilo
- Marquete Ronaldo
- Marra Raquel
- Martins Angela
- Martins Marcos B.S.
- Martins Milena
- Martins Márcio l.L.
- Martins Renata
- Martins Suzana
- Masson Victória
- Matias Ligia
- Matos Agnes M.M.V.
- Matos Andreza
- Matos Fernando
- Matozinhos Carolina
- Mattos Cilene M.J.
- Mattos Leticia
- Matzenauer William
- Mauad Anna V.S.R.
- Maya‐lastra Carlos
- Mayo Simon
- Mazine Fiorella
- Medeiros Débora
- Medeiros Erika V.S.S.
- Medeiros Herison
- Medeiros Maria C.M.P.
- Meerow Alan
- Meireles Jose
- Meireles Leonardo
- Meirelles Julia
- Melchor‐castro Briggitthe
- Mello Zelia
- Mello‐silva Renato
- Melo André l.
- Melo Caio V.V.D.
- Melo Efigenia
- Melo José I.M.
- Mendes Jone C.R.
- Mendes Maria C.Q.
- Mendes‐silva Ingrid
- Meneguzzo Thiago E.C.
- Menezes Cristine
- Menezes Felipe G.P.
- Menezes Mariângela
- Menini Neto Luiz
- Mentz Lilian
- Mesquita Antônio l.
- Messias Patrícia
- Mezzonato‐pires Ana
- Michelangeli Fabián
- Miguel João
- Miguel Laila
- Milward‐de‐azevedo Michaele
- Miotto Silvia T.S.
- Miranda Cecília
- Miranda Vitor F.O.
- Mitchell John
- Molina José M.P.
- Mondin Cláudio
- Monge Marcelo
- Monteiro Daniele
- Monteiro Fernanda K.S.
- Monteiro Raquel
- Monteiro Silvana H.N.
- Monteiro Thiago
- Monzoli João V.L.
- Moore Paloma G.P.
- Mora Martha
- Moraes Marta
- Moraes Mónica
- Morales Juan
- Morales Matías
- Moran Robbin
- Moreira Andréia D.R.
- Moreira André l.C.
- Moreira Ariane
- Moreira Bianca
- Moreira Giselle l.
- Moreira Kassio V.C.
- Moreira Pablo F.F.
- Morim Marli
- Morokawa Rosemeri
- Moroni Pablo
- Mota Aline
- Mota Michelle C.A.
- Mota Nara F.O.
- Moura Beryl E.L.
- Moura Carlos Wallace N.
- Moura Ingridy
- Moura Luíza
- Moura Ricardo l.
- Moura Tania
- Mundim Júlia
- Muniz Filho Eduardo
- Muniz Francisca
- Muniz Leticia
- Mynssen Claudine
- Nakajima Jimi
- Nascimento Janaina G.A.
- Nascimento José
- Nascimento Silvia
- Nepomuceno Francisco A.A.
- Nervo Michelle
- Nery Eduardo
- Neves Beatriz
- Nogueira Matheus G.C.
- Nunes Annelise
- Nunes Clebiana
- Nunes Teonildes
- Nóbrega Giseli
- O'Leary Nataly
- Oellgaard Benjamin
- Oliveira Adriana l.R.
- Oliveira Ana C.S.
- Oliveira Andreza G.S.
- Oliveira Aron
- Oliveira Bárbara
- Oliveira Caetano
- Oliveira Fernanda M.C.
- Oliveira Filipe G.A.
- Oliveira Gleison
- Oliveira Gustavo
- Oliveira Hermeson
- Oliveira Iasmin l.C.
- Oliveira José F.C.
- Oliveira Joésili C.P.
- Oliveira Juliana
- Oliveira Juliana R.P.M.
- Oliveira Leticia G.R.
- Oliveira Lilian F.A.
- Oliveira Lorena
- Oliveira Luciana S.D.
- Oliveira Marcia C.R.
- Oliveira Marcos G.M.
- Oliveira Marise H.V.
- Oliveira Marla I.U.
- Oliveira Márcio l.B.
- Oliveira Regina
- Oliveira Renata
- Oliveira Reyjane
- Oliveira Rodrigo C.G.
- Oliveira Sylvia
- Oliveira Ykaro
- Orlandini Priscila
- Orsolano Guilherme
- Pacífico Ricardo
- Paglia Isis
- Paiva Gabrielle C.P.
- Paixão Liliane
- Pastore José F.B.
- Pastore Mayara
- Pastori Tamara
- Paucar Jenny O.A.
- Paula‐souza Juliana
- Pederneiras Leandro
- Peichoto Myriam
- Peixoto Ariane l.
- Pell Susan
- Pellegrini Marco O.O.
- Pena Nelson T.L.
- Pennington Richard
- Peralta Denilson
- Pereira Amanda P.N.
- Pereira Andreza S.S.
- Pereira Jovani B.S.
- Pereira Maria
- Pereira Paulo E.E.
- Pereira Sidney
- Pereira‐silva Rafaela
- Perez Ana P.F.
- Pessoa Cleiton
- Pessoa Clenia
- Pessoa Edlley
- Pessoa Maria C.R.
- Petrongari Fernanda
- Philbrick Thomas
- Pignal Marc
- Pimenta Karena
- Pinto Rafael
- Pioner Natália
- Pirani José
- Pizzardo Raquel
- Plos Anabela
- Ponce Marta
- Pontes Juliana
- Pontes Ricardo A.S.
- Pontes Tiago
- Pontes‐pires Aline
- Pott Vali
- Prado Jefferson
- Prado Thainá
- Praia Talita
- Prance Ghillean
- Prange Carolina
- Prata Ana P.N.
- Prochazka Luana
- Proença Carolyn E.B.
- Prudêncio Renato X.A.
- Pscheidt Allan
- Quaresma Aclebia
- Quaresma Aline
- Queiroz George
- Queiroz Luciano
- Queiroz Rubens
- Quinet Alexandre
- Ramos Eliana
- Ramos Geraldo J.P.
- Rando Juliana
- Rebouças Natanael
- Reginato Marcelo
- Reis Miguel M.R.
- Reis Priscila
- Reis‐silva Genilson
- Ribas Osmar
- Ribeiro André R.O.
- Ribeiro Carolina l.
- Ribeiro José E.L.S.
- Ribeiro Michel
- Ribeiro Pétala
- Ribeiro Rayane T.M.
- Ribeiro Ricardo
- Ribeiro Rogério
- Riina Ricarda
- Ritter Mara
- Rivadavia Fernando
- Rivera Vanessa l.
- Rizzo Beatriz
- Rocha Antônio E.S.
- Rocha Lamarck
- Rocha Maria J.R.
- Rodrigues Carine
- Rodrigues Christchellyn
- Rodrigues Izabella M.C.
- Rodrigues Marianna
- Rodrigues Rodrigo Sampaio
- Rodrigues Rodrigo Schütz
- Rodríguez Juan F.C.
- Rodríguez Pedro
- Rollim Isis
- Romanini Rebeca
- Romero María
- Romero Rosana
- Romão Gerson
- Romão Marcos V.V.
- Roque Nádia
- Rosa Bárbara
- Rosa Patrícia
- Rosa Priscila
- Rossa Iago
- Rossetto Elson F.S.
- Rossi Lucia
- Rossini Josiene
- Rosário Alessandro
- Royer Carla
- Rua Gabriel
- Saavedra Mariana
- Saka Mariana
- Sakuragui Cassia
- Salas Roberto
- Sales Margareth
- Salgado Vanina
- Salimena Fátima R.G.
- Salino Alexandre
- Salvador Rafael
- Sampaio Daniela
- Sancho Gisela
- Sano Paulo
- Santana Jéssica C.O.
- Santana Karoline
- Santana Mariana
- Santiago Augusto C.P.
- Santos Alessandra
- Santos Amanda P.B.
- Santos Ana C.A.S.
- Santos Andrea K.A.
- Santos Carlos A.G.
- Santos Emanuelle l.
- Santos Felipe
- Santos Fernanda
- Santos João U.M.
- Santos Karin
- Santos Leidiana l.
- Santos Matheus
- Santos Otilene
- Santos Rafaela
- Santos Renata G.P.
- Santos Thaíla V.A.
- Santos Thiago
- Santos Vanessa
- Santos‐silva Fernanda
- Santos‐silva Juliana
- Saraiva Deisy
- Sarkinen Tiina
- Sartori Ângela l.B.
- Sassone Agostina
- Sauthier Luana
- Scalon Viviane
- Scatigna André
- Schaefer Juliana
- Scheidegger Najla M.B.
- Schliewe Marcos
- Schmidt Eduard D.L.
- Schneider Angelo
- Schneider Layla J.C.
- Schuettpelz Eric
- Schwartsburd Pedro
- Schwarz Elizabeth
- Scudeler Ana l.
- Sebastiani Renata
- Secco Ricardo
- Secretti Elisangela
- Segalla Rosane
- Seleme Elidiene
- Semir João
- Senna Luisa
- Setubal Robberson
- Shimizu Gustavo
- Shirasuna Regina
- Silva Filho Pedro J.S.
- Silva Adaíses S.M.
- Silva Aline V.M.
- Silva Amanda l.
- Silva Anádria
- Silva Caroline C.A.
- Silva Cassio
- Silva Christian
- Silva Cintia
- Silva Diego
- Silva Dilana
- Silva Fabio
- Silva Fernanda
- Silva Francismeire
- Silva Gabriel
- Silva Gledson
- Silva Guilherme
- Silva Gustavo H.L.
- Silva João P.S.
- Silva Juliana l.
- Silva Juliene F.M.
- Silva Leonardo
- Silva Lucas
- Silva Luciana
- Silva Luiza
- Silva Marcio R.P.
- Silva Marcos
- Silva Marcus F.O.
- Silva Maria S.D.
- Silva Maria l.B.
- Silva Márcio
- Silva Nilda M.F.
- Silva Otávio l.M.
- Silva Rafael
- Silva Raphael
- Silva Renata S.A.
- Silva Renato
- Silva Ronaldo
- Silva Saura
- Silva Suelma
- Silva Tatiane
- Silva Thaynara
- Silva Tânia R.S.
- Silva Wanderson l.S.
- Silva‐castro Milene
- Silva‐cobra Gisele
- Silva‐gonçalves Kelly
- Silveira Fernanda
- Silveira João
- Silveira Thamyres
- Simon Marcelo
- Simão‐bianchini Rosangela.
- Simões Ana
- Simões André
- Siniscalchi Carolina
- Siqueira Carlos
- Smidt Eric
- Smith Alan
- Smith Nathan
- Snak Cristiane
- Soares Abel E.R.
- Soares Arthur
- Soares Edson l.C.
- Soares Kelen
- Soares Luanda
- Soares Marcos V.B.
- Soares Maria l.C.
- Soares Polyana
- Soares Raimundo
- Sobrado Sandra
- Sobral Marcos
- Somner Genise
- Sothers Cynthia
- Sousa Ana A.C.
- Sousa Danilo J.L.
- Sousa Francisco
- Sousa Gardene
- Sousa Hian C.F.
- Sousa Leandro O.F.
- Sousa Mayco W.S.
- Sousa Valdeci
- Souza Aline
- Souza Bruno
- Souza Elnatan
- Souza Filipe
- Souza Luzia
- Souza Marcelo
- Souza Maria A.D.
- Souza Raquel M.B.S.
- Souza Vinicius
- Souza Élvia
- Souza‐buturi Fátima
- Spina Andréa
- Stadnik Aline M.S.
- Staggemeier Vanessa
- Stapf María N.S.
- Stefano Rodrigo
- Stehmann João Renato
- Stern Stephen
- Streher Nathália
- Suchoronczek Andréia
- Sundue Michael
- Sylvestre Lana
- Sá Cyl F.C.
- São‐mateus Wallace M.B.
- Takeuchi Cátia
- Tardivo Rosângela
- Taylor Nigel
- Teixeira Michella D.R.
- Teles Aristônio
- Temponi Livia
- Thode Verônica
- Thomas William
- Tierno Lorena
- Tissot‐squalli Mara
- Toledo Cássio A.P.
- Torke Benjamin
- Torres Alicia
- Torres Daniela S.C.
- Torres‐leite Filipe
- Tozzi Ana M.G.A.
- Trad Rafaela
- Trevisan Rafael
- Trierveiler‐pereira Larissa
- Trovó Marcelo
- Tuler Amélia
- Tyrrell Christopher
- Udulutsch Renata
- Uribbe Fernando
- Vahl Daiane
- Valadares Rodrigo
- Valdemarin Karinne
- Valduga Eduardo
- Valente Emilia
- Valls Jose F.M.
- van den Berg Cássio
- Vasconcelos Liziane
- Vasconcelos Thaís N.C.
- Vasques Diego
- Vaz Angela M.S.F.
- Versiane Ana F.A.
- Versieux Leonardo
- Via Do Pico Gisela
- Viana Pedro l.
- Vianna Filho Marcelo D.M.
- Vianna Suelen
- Vidal João
- Vidal Kaio V.A.
- Vieira Fábio C.S.
- Vieira Jaqueline
- Vieira João P.S.
- Vieira Lucas l.A.
- Vieira Tamara A.F.
- Vieira Tiago l.
- Viera‐barreto Jéssica
- Vignoli‐silva Márcia
- Vilas Bôas‐bastos Silvana
- Villarreal Juan
- Vincent Michael
- Vita Marcela
- Vitta Fabio
- Viveros Raquel
- Viviurka Fernanda
- Vogel Ely Cleusa
- Volet Danilo
- Völtz Rafael
- Wallnöfer Bruno
- Walter Bruno M.T.
- Wanderley Maria G.L.
- Watanabe Mauricio T.C.
- Weber Philipy A.P.
- Weigend Maximilian
- Welker Cassiano A.D.
- Windisch Paulo
- Yoshikawa Vania
- Zamengo Henrique
- Zanatta Maria R.V.
- Zannin Ana
- Zappi Daniela
- Zeferino Laís
- Zelenski Andréia
- Zimbrão Geraldo
- Zuloaga Fernando
- Zuntini Alexandre
- Ângulo María
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora
Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
- Author
- Abdrakhmanov Olzhas
- Abely Michel
- Al-Iede Montaha
- Aleksejeva Elina
- Alghisi Federico
- Altenburg Josje
- Amato Annalisa
- Amelina Elena
- Amorim Adelina
- Aparicio Marina, Blanco
- Asensi José, R Villa
- Asfuroğlu Pelin
- Aslan Ayse, Tana
- Athanazio Rodrigo, Abensur
- Badolato Raffaele
- Bakkeheim Egil
- Bambir Ivan
- Banki Adrienn
- Bannier Michiel
- Battistini Fiorella
- Behl Eva-Susanne
- Belleguic Chantal
- Bignamini Elisabetta
- Bihouee Tiphaine
- Bilkova Alena
- Billon Yves
- Bingöl Ayşen
- Bližnáková Nina
- Boboli Hedwige
- Boitсova Evgeniya
- Boucher Isabelle, Danner
- Brinkmann Folke
- Bui Stéphanie
- Burgel Pierre-Régis
- Burghart Sabine
- Bérešová Eva
- Camara Boubou
- Cancelo Isabel, Ramos
- Carnovale Vincenzo
- Carr Siobhán, B
- Casciaro Rosaria
- Castanhinha Susana
- Castellani Carlo
- Castro Enrique, Blitz
- Charatsi Anna-Maria
- Charman Susan, C
- Cheng Stephanie, Y
- Cheraud Marie-Christine
- Chernyavskaya Anastasia
- Chiron Raphael
- Ciciriello Fabiana
- Cimino Giuseppe
- Cipolli Marco
- Ciuca Ioana
- Clarenbach Christian
- Claßen Martin
- Cohen-Cymberknoh Malena
- Collura Mirella
- Colombo Carla
- Colomer Jordi, Costa I
- Cortell-Aznar Isidoro
- Corullón Silvia, Castillo
- Corvol Harriet
- Cosgriff Rebecca
- Cosson Laure
- Cox Des
- Csilla-Enikö Szabo
- Cáceres Layla, Diab
- da Silva-Filho Luiz, Vicente Rf
- Daccò Valeria
- Dalphin Marie-Laure
- Daneau Géraldine
- Danevska Ivana, Arnaudova
- de Fuccio Marcelo, Bicalho
- de Miranda Sandra
- de Monestrol Isabelle
- de Valbuena Marta, Ruiz
- de Vincente Carlos, Martin
- de Wachter Elke
- de Winter Karin
- Deneuville Eric
- Diamantea Filia
- Dogru Deniz
- Donati Valentina
- Drali Ouardia
- Drevinek Pavel
- Duarte Marta, Cristina
- Dubus Jean-Christophe
- Duet Emmanuelle, Coirier
- Dugac Andrea, Vukić
- Dupont Lieven
- Durieu Isabelle
- Dziecichowicz-Latała Daria
- Eder Johannes
- Elbert Alexander
- Elnazir Basil
- Epaud Ralph
- Eyüboğlu Tuğba, Şişmanlar
- Faro Albert
- Fernandes Flavia, Fonseca
- Fernandez Antonio, José Aguilar
- Fernàndez Antonio, Alvarez
- Ferrari Gianluca
- Ferreiro Adelaida, Lamas
- Ficili Francesca
- Filho Eduardo, Piacentini
- Fischer Reta
- Fletcher Godfrey
- Folino Anna
- Fouda Eman, Mahmoud
- Francalanci Michela
- Fuster Casilda, Olveira
- Fustik Stojka
- Gagliano Vanessa
- Galarraga Laura, Moreno
- Gamboa Fernanda
- García Félix, Baranda
- García Patricia, Fernández
- Gartner Silvia
- Gerardin Michèle
- Gilljam Marita
- Girón-Moreno Rosa, Maria
- Gohy Sophie
- Gonçalves Fabienne
- Gorinova Yuliya
- Goss Christopher, H
- Graepler-Mainka Ute
- Grenet Dominique
- Griese Matthias
- Grübl Armin
- Gunaratnam Cedric
- Gur Michal
- Gutierrez Hector, H
- Gökdemir Yasemin
- Hage René
- Hammermann Jutta
- Hamouda Samia
- Hanssens Laurence
- Harutyunyan Satenik
- Hatziagorou Elpis
- Hebestreit Helge
- Heijerman Harry
- Heinzmann Andrea
- Herz Alexander
- Houdouin Véronique
- Huet Frédéric
- Jaksch Peter
- Janssens Hettie
- Jung Andreas
- Kainz Katharina
- Kallinger Margit
- Kamalaporn Harutai
- Karadag Bulent
- Kashirskaya Nataliya
- Kasmi Irena
- Kayserová Hana
- Kessler Romain
- Kiefer Alexander
- Kinder Birte
- Kirwan Laura
- Knabben Adriana, de Siqueira Carvalho
- Knoop Christiane
- Kondratyeva Elena
- Koppelman Gerard
- Krantz Christina
- Krasovskiy Stanislav
- Krivec Uroš
- Kuhnert Stefan
- Kusche Rachel
- Köse Mehmet
- Köster Holger
- La Barrière Hélène, De
- Labarga Inés, Herrero
- Laezza Caterina
- Lakatos-Krepcik Andrea
- Lammertyn Elise
- Languepin Jeanne
- Laurans Muriel
- Leitner Alexander
- Lemonnier-Videau Lydie
- Leonardi Salvatore
- Leonetti Giuseppina
- Leroy Sylvie
- Lindberg Ulrika
- Lindblad Anders
- Livnat Galit
- Llerena Cathie
- Lucanto Maria, Cristina
- Lucca Francesca
- Lucidi Vincenzina
- Macek Milan
- Macey Julie
- Mainz Jochen
- Majo Fabio
- Malakauskas Kestutis
- Manca Antonio
- Manika Katerina
- Mankikian Julie
- Maretti Tatjana, Jakovska
- Marguet Christophe
- Marshall Bruce, C
- Martin Clémence
- Martins Valéria, de Carvalho
- Martínez José, Ramón Gutiérrez
- Maschio Massimo
- Mayer Angelika
- Mckone Edward, F
- Mei-Zahav Meir
- Melloti Roberta
- Mely Laurent
- Mencarini Valeria
- Meneses Daniela, Gois
- Merkus Peter
- Messore Barbara
- Middleton Peter, G
- Misevičiene Valdone
- Mittaine Marie
- Mondejar-Lopez Pedro
- Monte Luciana, de Freitas Velloso
- Mozdzen Marta
- Mukhina Maria
- Murris-Espin Marlène
- Naehrig Susanne
- Naehrlich Lutz
- Naito Yumi
- Nasr Samya
- Navarro Silvia, Merlos
- Neyra Alejandro, López
- Niehues Tim
- Nieto-Royo Rosa
- Nogueira Esperanza, Jiménez
- Nowé Vicky
- Nuijsink Marianne
- Nuriyev Emil
- Nüßlein Thomas
- Olesen Hanne, Vebert
- Orenti Annalisa
- Ozcan Gizem
- Ozcelik Ugur
- Padoan Rita
- Palladino Nicola
- Pantano Stefano
- Paredes Carmen, Luna
- Pastor Maria, Dolores
- Pecellín Isabel, Delgado
- Pekcan Sevgi
- Pereira Luísa
- Perisson Caroline
- Petrova Guergana
- Pfleger Andreas
- Piccini Carole, Bailly
- Pirson Jessica
- Pisi Giovanna
- Pizzamiglio Giovanna
- Plant Barry, J
- Poli Piercarlo
- Poplawska Krystyna
- Prados-Sánchez Concepción
- Pressler Tania
- Prevotat Anne
- Pérez Inés
- Pérez-Ruiz Estela
- Quattromano Ester
- Raia Valeria
- Ramel Sophie
- Rames Cinthia
- Reem Kanaan
- Reix Philippe
- Renner Sabine
- Revillon Marine
- Reynaud-Gaubert Martine
- Richaud-Thiriez Bénédicte
- Ringshausen Felix
- Rittie Jean-Luc
- Rochat Isabelle
- Roig María, Cols
- Ros Mirco
- Rose Markus
- Rosenecker Josef
- Rotolo Novella
- Ruppel Renate
- Ruseckaite Rasa
- Salobir Barbara
- Salvatore Donatello
- Salvatore Marco
- Santiago Veronica, Sanz
- Santos Ana, Sofia Araújo
- Scalbert-Dujardin Manuëla
- Scharschinger Anette
- Schropp Christian
- Schuurmans Macé
- Schuurmans Macé
- Schwarz Carsten
- Semenchuk Julie
- Sermet-Gaudelus Isabelle
- Sherman Victoria
- Silva Sónia
- Silva Teresa, Reis
- Simonova Olga
- Smaczny Christina
- Sommerburg Olaf
- Spaggiari Cinzia
- Stadlinger Martin
- Stan Iustina
- Steinack Carolin
- Stephenson Anne, L
- Stolz Simone
- Storni Véronique
- Sutharsan Sivagurunathan
- Taccetti Giovanni
- Tatopoulos Aurélie
- Tawfeeq Reem, Mustafa
- Terheggen Suzanne
- Thimmesch Matthieu
- Thir Christina
- Thomas Wolfgang
- Thouvenin Guillaume
- Tješić-Drinković Duška
- Troussier Françoise
- Tural Dilber, Ademhan
- van Braeckel Eva
- van der Meer Renske
- van der Vaart Hester
- van Hoorenbeeck Kim
- van Rens Jacqui
- Vanderhelst Eef
- Vitullo Pamela
- Walter Anna-Lena
- Wege Sabine
- Weiss Laurence
- Weldetsadik Abate, Yeshidinber
- Welzenbach Britta
- Wesseling Geert-Jan
- Wizla Nathalie
- Wojsyk-Banaszak Irena
- Wollschläger Bettina
- Wozniacki Lukasz
- Yiallouros Panayiotis
- Zampoli Marco
- Zolin Anna
- Zomer-van Ommen Domenique
- Çobanoğlu Nazan
- Šelb Julij
- Publication venue
- Elsevier
- Publication date
- 01/01/2024
- Field of study
International audienceBackground: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF).Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV 1 ) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV 1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection.Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV 1 pre-and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre-and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection.Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF
The PLATO Mission
- Author
- Aboudan Alessio
- Abreu Manuel
- Acuña Lorena
- Adams Moritz
- Adibekyan Vardan
- Aerts Conny
- Affer Laura
- Agneray François
- Agnor Craig
- Ahmed Saad
- Aigrain Suzanne
- Al-Bahlawan Ashraf
- Alei Eleonora
- Alencar Silvia
- Alexander Richard
- Alfonso-Garzón Julia
- Aliaga Jose Aroca
- Alibert Yann
- Almeida Leonardo
- Altavilla Giuseppe
- Althaus Christian
- Amarsi Anish
- Amôres Eduardo
- Andrade Laerte
- Antoniadis-Karnavas Alexandros
- António Carlos
- Aparicio Marcos Villaverde
- Appolloni Matteo
- Appourchaux Thierry
- Arena Claudio
- Armstrong David
- Asplund Martin
- Audenaert Jeroen
- Auricchio Natalia
- Avelino Pedro
- Baeke Ann
- Baillié Kevin
- Balado Ana
- Balestra Andrea
- Ball Warrick
- Ballans Herve
- Ballot Jerome
- Barban Caroline
- Barbary Gaële
- Barbieri Mauro
- Barker Adrian
- Barklem Paul
- Barnes Sydney
- Barragan Oscar
- Baruteau Clément
- Basu Sarbani
- Baudin Frederic
- Baumeister Philipp
- Bayliss Daniel
- Bazot Michael
- Beck Paul
- Bedding Tim
- Belkacem Kevin
- Bellinger Earl
- Benatti Serena
- Benomar Othman
- Benz Willy
- Bergemann Maria
- Bergomi Maria
- Bernardo Pierre
- Biazzo Katia
- Bignamini Andrea
- Bigot Lionel
- Billot Nicolas
- Binet Martin
- Biondi David
- Biondi Federico
- Birch Aaron
- Bitsch Bertram
- Bognár Zsófia
- Boisse Isabelle
- Bolmont Emeline
- Bonanno Alfio
- Bonavita Mariangela
- Bonfanti Andrea
- Bonfils Xavier
- Bonito Rosaria
- Bonomo Aldo Stefano
- Borsa Francesco
- Borsato Luca
- Bossini Diego
- Bouchy Francois
- Boufleur Rodrigo
- Boumier Patrick
- Bourrier Vincent
- Boué Gwenaël
- Bowman Dominic
- Bozzo Enrico
- Bradley Louisa
- Brandeker Alexis
- Bray John
- Bressan Alessandro
- Breton Sylvain
- Brienza Daniele
- Brito Ana
- Brogi Matteo
- Brown Beverly
- Brown David
- Brun Allan Sacha
- Bruno Giovanni
- Bruns Michael
- Buchhave Lars
- Bugnet Lisa
- Buldgen Gaël
- Burgess Patrick
- Busatta Andrea
- Busso Giorgia
- Buzasi Derek
- Bérard Diane
- Bódi Attila
- Börner Anko
- Børsen-Koch Victor Aguirre
- Caballero José
- Cabral Alexandre
- Cabrera Juan
- Calderone Flavia
- Cameron Andrew
- Cameron Robert
- Campante Tiago
- Cara Christophe
- Carone Ludmila
- Carrasco Josep Manel
- Carrasco Miguel Andrés Sánchez
- Casagrande Luca
- Casewell Sarah
- Cassisi Santi
- Castellani Marco
- Castro Matthieu
- Catala Claude
- Catelan Márcio
- Ceballos Paz Victoria Bluhm
- Cegla Heather
- Cerruti Chiara
- Cessa Virginie
- Chadid Merieme
- Chagas Maria Liduina Das
- Chaplin William
- Charpinet Stephane
- Chiappini Cristina
- Chiarucci Simone
- Chiavassa Andrea
- Chinellato Simonetta
- Chirulli Giovanni
- Christensen-Dalsgaard Jorgen
- Church Ross
- Claret Antonio
- Clarke Cathie
- Claudi Riccardo
- Clermont Lionel
- Coelho Hugo
- Coelho Joao
- Cogato Fabrizio
- Colomé Josep
- Condamin Mathieu
- Conseil Simon
- Corbard Thierry
- Correia Alexandre
- Corsaro Enrico
- Cosentino Rosario
- Costes Jean
- Cottinelli Andrea
- Covone Giovanni
- Creevey Orlagh
- Crida Aurelien
- Csizmadia Szilard
- Cunha Margarida
- Curry Patrick
- d'Orazi Valentina
- da Costa Jefferson
- da Silva Francys
- da Silva João Gomes
- da Silva Lucas Franco
- da Silva Tiago Sanches
- Dalal Shweta
- Damasso Mario
- Damiani Cilia
- Damiani Francesco
- Davies Ben
- Davies Guy
- Davies Melvyn
- Davison Gary
- de Almeida Leandro
- de Angeli Francesca
- de Barros Susana Cristina Cabral
- de Freitas Daniel Brito
- de Freitas Marcia Cristina
- de Galarreta Claudia Ruiz
- de Martino Domitilla
- de Mascarenhas David Vaz
- de Medeiros José Renan
- de Mello Gustavo Frederico Porto
- de Paula Luiz Alberto
- de Plaa Jelle
- de Ridder Joris
- Deal Morgan
- Decin Leen
- Deeg Hans
- Degl'Innocenti Scilla
- Deheuvels Sebastien
- del Burgo Carlos
- del Moral Beatriz Aparicio
- del Sordo Fabio
- Deleuil Magali
- Delgado-Mena Elisa
- Demangeon Olivier
- Denk Tilmann
- Derekas Aliz
- Desidera Silvano
- Dexet Marc
- Di Criscienzo Marcella
- Di Giorgio Anna Maria
- Di Mauro Maria Pia
- Dima Marco
- Dinuzzi Giacomo
- Dionatos Odysseas
- Distefano Elisa
- Domingo Albert
- Dorn Caroline
- Doyle Lauren
- Duarte Elena
- Ducellier Florent
- Dumaye Luc
- Dumusque Xavier
- Dupret Marc-Antoine
- Díaz Luisa Fernanda Rodríguez
- Díaz-García José-Javier
- Eggenberger Patrick
- Ehrenreich David
- Eiff Matthias Ammler-Von
- Eigmüller Philipp
- Eising Johannes
- Emilio Marcelo
- Erikson Anders
- Eriksson Kjell
- Ermocida Marco
- Eschen Yoshi
- Estrela Inês
- Etangs Alain Lecavelier Des
- Evans Dafydd Wyn
- Fabbian Damian
- Fabrizio Michele
- Faria João Pedro
- Farina Maria
- Farinato Jacopo
- Feliz Dax
- Feltzing Sofia
- Fenouillet Thomas
- Fernández Irene Catalán
- Ferrari Lorenza
- Ferraz-Mello Sylvio
- Fialho Fabio
- Fienga Agnes
- Figueira Pedro
- Figueiredo Ana Carolina Mattiuci
- Fiori Laura
- Flaccomio Ettore
- Focardi Mauro
- Foley Steve
- Fontignie Jean
- Ford Dominic
- Fornazier Karin
- Forteza Sebastià Barceló
- Forveille Thierry
- Fossati Luca
- Franca Rodrigo de Marca
- Frasca Antonio
- Fridlund Malcolm
- Furlan Marco
- Gabler Sarah-Maria
- Gaido Marco
- Gallagher Andrew
- Galli Emanuele
- Garcia Juan Pablo Rodriguez
- Garcia Rafael
- García-Vázquez Hugo
- Gaulme Patrick
- Gauthier Nicolas
- Gehan Charlotte
- Gent Matthew
- Georgieva Iskra
- Ghigo Mauro
- Giana Edoardo
- Gil M de los Angeles Alcacera
- Gill Samuel
- Girardi Leo
- Giribaldi Riano Isidoro Escate
- Giusi Giovanni
- Gizon Laurent
- Gomez-Lopez Juan Manuel
- Gorius Nicolas
- Gouel Pierre-Vincent
- Goulty Duncan
- Goupil Mariejo
- Granado Javier Pascual
- Granata Valentina
- Grenfell John Lee
- Grießbach Denis
- Grolleau Emmanuel
- Grouffal Salomé
- Grziwa Sascha
- Guarcello Mario Giuseppe
- Gueguen Loïc
- Guenther Eike Wolf
- Guijarro Ángel Luis Valverde
- Guilhem Terrasa
- Guillerot Lucas
- Guiot Pierre
- Guterman Pascal
- Gutiérrez Antonio
- Gutiérrez-Canales Fernando
- Güdel Manuel
- Haba Rafael Garrido
- Hagelberg Janis
- Haldemann Jonas
- Hall Cassandra
- Handberg Rasmus
- Harrison Diana
- Harrison Ian
- Hasiba Johann
- Haswell Carole
- Hatalova Petra
- Hatzes Artie
- Haywood Raphaelle
- Heckes Frank
- Heiter Ulrike
- Hekker Saskia
- Heller René
- Helling Christiane
- Helminiak Krzysztof
- Hemsley Simon
- Heng Kevin
- Heras Ana
- Hermans Aline
- Hermes Jj
- Hernández Antonio García
- Hernández Jonay Isai González
- Hidalgo David Pena
- Hinkel Natalie
- Hobbs David
- Hodgkin Simon
- Hofmann Karl
- Hojjatpanah Saeed
- Houdek Günter
- Huber Daniel
- Huesler Joseph
- Hui-Bon-Hoa Alain
- Huygen Rik
- Huynh Duc-Dat
- Hébrard Guillaume
- Iro Nicolas
- Irwin Jonathan
- Irwin Mike
- Izidoro André
- Jacquinod Sophie
- Jannsen Nicholas Emborg
- Janot-Pacheco Eduardo
- Janson Markus
- Jeszenszky Harald
- Jiang Chen
- Jofre Paula
- Johansen Anders
- Johnston Cole
- Jones Geraint
- Kabath Petr
- Kallinger Thomas
- Kanitz Thomas
- Karjalainen Marie
- Karjalainen Raine
- Karoff Christoffer
- Kawaler Steven
- Kawata Daisuke
- Keereman Arnoud
- Keiderling David
- Kennedy Tom
- Kenworthy Matthew
- Kerschbaum Franz
- Kidger Mark
- Kiefer Flavien
- Kintziger Christian
- Kislyakova Kristina
- Kiss László
- Kjeldsen Hans
- Klagyivik Peter
- Klahr Hubert
- Klevas Jonas
- Kochukhov Oleg
- Kolb Ulrich
- Koncz Alexander
- Korth Judith
- Kostogryz Nadiia
- Kovács Gábor
- Kovács József
- Kozhura Oleg
- Krivova Natalie
- Kuhlemann Ilyas
- Kupka Friedrich
- Kučinskas Arunas
- Kálmán Szilárd
- Köhler Ulrich
- Laauwen Wouter
- Labiano Alvaro
- Lagarde Nadege
- Laget Philippe
- Laky Gunter
- Lam Kristine Wai Fun
- Lambrechts Michiel
- Lammer Helmut
- Lanza Antonino Francesco
- Lanzafame Alessandro
- Laskar Jacques
- Latter Henrik
- Lavanant Tony
- Lawrenson Alastair
- Lazzoni Cecilia
- Lebre Agnes
- Lebreton Yveline
- Leinhardt Zoe
- Leleu Adrien
- Lendl Monika
- Leto Giuseppe
- Levillain Yves
- Leão Izan de Castro
- Libert Anne-Sophie
- Lichtenberg Tim
- Ligi Roxanne
- Lignieres Francois
- Lillo-Box Jorge
- Linsky Jeffrey
- Liu John Scige
- Loidolt Dominik
- Longval Yuying
- Lopes Ilídio
- Lorenzani Andrea
- Lorenzo-Alvarez Jose
- Ludwig Hans-Guenter
- Lund Mikkel
- Lundkvist Mia Sloth
- Luri Xavier
- Maceroni Carla
- Madden Sean
- Madhusudhan Nikku
- Maggio Antonio
- Magliano Christian
- Magrin Demetrio
- Mahy Laurent
- Maibaum Olaf
- Malac-Allain Leeroy
- Malapert Jean-Christophe
- Malavolta Luca
- Maldonado Jesus
- Mamonova Elena
- Mancebo Antonio José Jimenez
- Manchon Louis
- Mann Andrew
- Mantovan Giacomo
- Marafatto Luca
- Marconi Marcella
- Mardling Rosemary
- Marigo Paola
- Marinoni Silvia
- Marliani Filippo
- Marques Joao Pedro
- Marques Érico
- Marrese Paola Maria
- Marshall Douglas
- Martin-Garcia Cesar
- Martinez Tobias Vicanek
- Martins Bruno Leonardo Canto
- Martiz Mariel Lares
- Martín Elisa Borreguero
- Mary David
- Marzari Francesco
- Mas-Hesse J. Miguel
- Masana Eduard
- Mascher Andrina
- Mastropasqua Sergio Rufini
- Mathis Stéphane
- Mathur Savita
- Maxted Pierre
- Mazeh Tsevi
- Mazevet Stephane
- Mazzei Francesco
- Mccormac James
- Mcmillan Paul
- Menou Lucas
- Merle Thibault
- Meru Farzana
- Mesa Dino
- Mesa Rosario Sanz
- Messina Sergio
- Meunier Jean-Charles
- Meunier Nadége
- Micela Giuseppina
- Michaelis Harald
- Michel Eric
- Michielsen Mathias
- Michtchenko Tatiana
- Miglio Andrea
- Miguel Yamila
- Milligan David
- Min Michiel
- Mirouh Giovanni
- Mitchell Morgan
- Moedas Nuno
- Molendini Francesca
- Molnár László
- Mombarg Joey
- Montalban Josefina
- Montalto Marco
- Monteiro Mário
- Morales Juan Carlos
- Morales-Calderon Maria
- Morbidelli Alessandro
- Mordasini Christoph
- Moreau Chrystel
- Morel Thierry
- Morello Guiseppe
- Morin Julien
- Moroni Pier Giorgio Prada
- Mortier Annelies
- Mosser Benoît
- Mourard Denis
- Mousis Olivier
- Moutou Claire
- Mowlavi Nami
- Moya Andrés
- Muehlmann Prisca
- Muirhead Philip
- Munari Matteo
- Munoz Antonio Garcia
- Murillo Kevin Gonzalez
- Musella Ilaria
- Mustill Alexander James
- Mészáros Szabolcs
- Napoli Ricardo Simoyama
- Nardetto Nicolas
- Nardiello Domenico
- Narita Norio
- Nascimbeni Valerio
- Nascimento Jose-Dias Do
- Nash Anna
- Navascues David Barrado
- Neiner Coralie
- Nelson Richard
- Nettelmann Nadine
- Nicolini Gianalfredo
- Nielsen Martin
- Niemi Sami-Matias
- Noack Lena
- Noels-Grotsch Arlette
- Noll Anthony
- Norazman Azib
- Norton Andrew
- Nsamba Benard
- Nunez Marina Vela
- O'Rourke Laurence
- Ofir Aviv
- Ogilvie Gordon
- Olander Terese
- Olivetto Christian
- Olofsson Göran
- Ong Joel
- Ortolani Sergio
- Osborn Hugh
- Oshagh Mahmoudreza
- Osorio María Rosa Zapatero
- Ottacher Harald
- Ottensamer Roland
- Ouazzani Rhita-Maria
- Paardekooper Sijme-Jan
- Pace Emanuele
- Pagano Isabella
- Pajas Miriam
- Palacios Ana
- Palandri Gaelle
- Palle Enric
- Paproth Carsten
- Parro Vanderlei
- Parviainen Hannu
- Passegger Vera Maria
- Pastor-Morales Carmen
- Pedersen May Gade
- Pepe Francesco
- Perales Silvia Martínez
- Pereira Filipe
- Persson Carina
- Pertenais Martin
- Peter Gisbert
- Petit Antoine
- Petit Pascal
- Pezzuto Stefano
- Pichierri Gabriele
- Pietrinferni Adriano
- Pinheiro Fernando
- Pinsonneault Marc
- Piotto Giampaolo
- Plachy Emese
- Plasson Philippe
- Plez Bertrand
- Pollacco Don
- Poppenhaeger Katja
- Poretti Ennio
- Portaluri Elisa
- Portell Jordi
- Poyatos Julien
- Pozuelos Francisco
- Pricopi Dumitru
- Prieto Carlos Allende
- Prisinzano Loredana
- Pätzold Martin
- Quade Matthias
- Ragazzoni Roberto
- Raimondo Gabriella
- Rainer Monica
- Ramsay Gavin
- Ramón-Ballesta Alejandro
- Rauer Heike
- Rauterberg Christoph
- Redman Bob
- Redmer Ronald
- Reese Daniel
- Regibo Sara
- Reiners Ansgar
- Reinhold Timo
- Renie Christian
- Rial Federico Jose Diaz
- Ribas Ignasi
- Ribeiro Sergio
- Ricciardi Thiago Pereira
- Rice Ken
- Richard Olivier
- Riello Marco
- Rieutord Michel
- Ripepi Vincenzo
- Rixon Guy
- Rockstein Steve
- Rodriguez-Gomez Julio
- Rodríguez María Teresa Rodrigo
- Rodón Jose Ramón
- Roehlly Yannick
- Roig Fernando
- Rojas-Ayala Bárbara
- Rolf Tobias
- Rosado Hugo
- Rosotti Giovanni
- Roth Markus
- Roth Olivier
- Rousseau Alex
- Roxburgh Ian
- Roy Fabrice
- Royer Pierre
- Ruane Kirk
- Russi Andrea
- Rätz Stefanie
- Rørsted Jakob Lysgaard
- Saar Steven
- Saikia Sudeshna Boro
- Saillenfest Melaine
- Salaris Maurizio
- Salmon Sebastien
- Saltas Ippocratis
- Samadi Aunia
- Samadi Réza
- Samra Dominic
- Sanchez Ricardo Zanmar
- Sanmartin Maria Angeles Sierra
- Santerne Alexandre
- Santoli Francesco
- Santos Nuno
- Santos Ângela
- Sarro Luis Manuel
- Scandariato Gaetano
- Schlafly Edward
- Schmider François-Xavier
- Schneider Jean
- Schou Jesper
- Schunker Hannah
- Schwarzkopf Gabriel Jörg
- Schäfer Martin
- Serenelli Aldo
- Seynaeve Dries
- Shan Yutong
- Shapiro Alexander
- Shipman Russel
- Sicilia Daniela
- Sigot Axelle
- Silliman Kyle
- Silvotti Roberto
- Simon Attila
- Skarka Marek
- Smalley Barry
- Smiljanic Rodolfo
- Smit Samuel
- Smith Alan
- Smith Alexis
- Smith Leigh
- Snellen Ignas
- Soares Maria Cristina Rabello
- Sobrino Roi Alonso
- Sohl Frank
- Solanki Sami
- Sortino Francesca
- Sousa Sérgio
- Southworth John
- Souto Diogo
- Sozzetti Alessandro
- Stamatellos Dimitris
- Stassun Keivan
- Steller Manfred
- Stello Dennis
- Stelzer Beate
- Stiebeler Ulrike
- Stokholm Amalie
- Storelvmo Trude
- Strassmeier Klaus
- Strugarek Antoine
- Strøm Paul Anthony
- Suarez Juan-Carlos
- Sulis Sophia
- Szabados László
- Szabó Gyula
- Szabó Róbert
- Szuszkiewicz Ewa
- Sódor Ádám
- Talens Geert Jan
- Teti Daniele
- Theisen Tom
- Thoul Anne
- Thévenin Frédéric
- Tiphene Didier
- Titz-Weider Ruth
- Tkachenko Andrew
- Tomecki Daniel
- Tonfat Jorge
- Torres Nadia Hidalgo
- Tosi Nicola
- Trallero Isabel Vera
- Trampedach Regner
- Traven Gregor
- Triaud Amaury
- Trujillo Luis Alonso Alvarez
- Trønnes Reidar
- Tsantaki Maria
- Tschentscher Matthias
- Turin Arnaud
- Tvaruzka Adam
- Udry Stéphane
- Ulmer Bernd
- Ulmer-Moll Solène
- Ulusoy Ceren
- Umbriaco Gabriele
- Valencia Diana
- Valentini Marica
- Valio Adriana
- van Eylen Vincent
- van Grootel Valerie
- van Kempen Tim
- van Reeth Timothy
- van Zelst Iris
- Vandenbussche Bart
- Vasiliou Konstantinos
- Vasilyev Valeriy
- Vazan Allona
- Velloso Eduardo Nunes
- Ventura Paolo
- Ventura Rita
- Venturini Julia
- Veras Dimitri
- Verdugo Eva
- Verma Kuldeep
- Vibert Didier
- Vida Krisztián
- Vigan Arthur
- Villacorta Antonio
- Villaver Eva
- Viotto Valentina
- Vorobyov Eduard
- Vorontsov Sergey
- Wagner Frank
- Walloschek Thomas
- Walton Dave
- Walton Nicholas
- Wang Haiyang
- Waters Rens
- Watson Christopher
- Wedemeyer Sven
- Weeks Angharad
- Weingril Jörg
- Weiss Annita
- Wendler Belinda
- Werner Stephanie
- West Richard
- Westerdorff Karsten
- Westphal Pierre-Amaury
- Wheatley Peter
- White Tim
- Whittaker Amadou
- Wickhusen Kai
- Wilson Thomas
- Windsor James
- Winter Othon
- Winter Silvia Giuliatti
- Winther Mark Lykke
- Winton Alistair
- Witteck Ulrike
- Witzke Veronika
- Woitke Peter
- Wolter David
- Wuchterl Günther
- Wyatt Mark
- Yang Dan
- Yu Jie
- Zapata Gonzalo Ramos
- Zazo Luis Jorge Gómez
- Zechmeister Mathias
- Zhou Yixiao
- Ziemke Claas
- Zwintz Konstanze
- Švanda Michal
- Publication venue
- HAL CCSD
- Publication date
- 01/01/2024
- Field of study
International audiencePLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases
Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis
- Author
- Abad-Santos Francisco
- Adegunsoye Ayodeji
- Al-Beidh Farah
- Aleman Soo
- ALMEIDA THIAGO M.L.
- Almuedo Alex
- Alonso Pérez Tamara
- Altice Frederick
- ANDRADE LUIS E.C.
- Angus Derek
- Annane Djillali
- Arabi Yaseen
- Arip Masita
- Asensi Victor
- Asgeirsson Hilmir
- Avendaño Solá Cristina
- AVEZUM ALVARO
- Axelrod Matthew
- AZEVEDO LUCIANO C.P.
- Azoulay Elie
- Baillie J Kenneth
- Baillie Kenneth J
- Baron Gabriel
- Barrios Ana
- Basri Sazali
- Bautista-Hernández Azucena
- Beane Abigail
- Beasley Richard
- Benbenishty Julie S.
- Bensaci Ana Maria
- Berry Lindsay
- Berry Lindsay R.
- Berry Scott
- BERWANGER OTÁVIO
- Bhimani Zahra
- Bidin Farah Nadiah
- Blennow Ola
- Bonten Marc
- Bosteels Cedric
- Bradbury Charlotte
- Broman Niklas
- Brunkhorst Frank
- Buch Maya H
- Bureau Serge
- Buxton Meredith
- Cadranel Jacques
- Campos Esteban José
- Carbonell Cristina
- CARCEL SHEILA
- CARVALHO JULIO CESAR
- CASTRO CLAUDIO G.
- Castro Pedro
- Castán Clara
- CAVALCANTI ALEXANDRE B.
- Cavalcanti Alexandre Biasi
- Chappell Lucy C
- Chatzidionysiou Katerina
- Cheng Allen
- Chidambaram Suresh
- Chong Meng Li
- Chun Geok Ying
- COELHO JULIANA C.
- Colman Roos
- CONCEIÇÃO FABIO G.
- Cooper Nichola
- Corbacho Noemí
- COSTA ANDRÉ N.
- Cove Matt
- Dalmau David
- DAMIANI LUCAS P.
- Day Jeremy N
- de Benito Natividad
- De Buyser Stefanie
- De Jong Menno
- De Leeuw Elisabeth
- DE SOUZA DENISE
- Declercq Jozefien
- Derde Lennie
- Derde Lennie P. G.
- Diaz Janet V.
- Domingo Pere
- Domingo Pere
- Dougados Maxime
- DOURADO LETICIA K.
- Emmerich Joseph
- Espinosa Gerard
- Estcourt Lise
- Estrada Vicente
- FARIAS DANIELLE L.C.
- Fartoukh Muriel
- Faust Saul N
- Fernandes Ana
- Fernandez-Cruz Ana
- Feuth Thijs
- Fisher David
- Fleisher Jorge
- Fortun Jesús
- Foulkes Andrea S
- Fowler Robert
- FREITAS FLAVIO G.R.
- Frigault Matthew J
- Galea James
- Galun Eitan
- Garcia Felipe
- Garcia-Vicuna Rosario
- García-Fraile Lucio
- GARRIDO JOSE CARLOS
- GEBARA OTAVIO C.E.
- Godolphin Peter J.
- Gonzalez-Alvaro Isidoro
- Goossens Herman
- Gordon Anthony
- Gordon Anthony C.
- Green Cameron
- Guidet Bertrand
- Gutierrez Felix
- Gutierrez Maria del Mar
- Gutiérrez Liarte Ángela
- Halid Luqman Alhakim
- Haniffa Rashan
- Harvey Liam
- Hasan Mohd Shahnaz
- Haynes Richard
- Haynes Richard
- Healy Brian C
- Henter Jan-Inge
- Hermine Olivier
- Hermine Olivier
- Herrera Silvia
- Higgins Alisa
- Higgins Julian P. T.
- Hills Thomas
- Hohenthal Ulla
- Horby Peter W
- Horby Peter W.
- Horcajada Juan Pablo
- Horick Nora K.
- Horne Anna Carin
- Huckins David S.
- Humbert Marc
- Ibrahim Nur Munirah
- Ichihara Nao
- ISHIHARA LUCIANA M.
- Jaki Thomas
- Janols Helena
- Jeffery Katie
- Juszczak Edmund
- Kamarulzaman Adeeba
- Karrison Theodore
- King Andrew
- Koh Hui Moon
- Kukreja Anjanna
- Kumar Kuldeep
- Lacombe Karine
- Lambrecht Bart
- Lamontagne Francois
- Lampa Jon
- Landray Martin J
- Landray Martin J.
- Lawler Patrick
- Leal Lorna
- Lederer David J.
- Lee Cheng Siang
- LEITE RODRIGO T.
- Leon Rafael
- LEON RAFAEL
- Lim Wei Shen
- Lin Nina
- LISBOA THIAGO C.
- Litton Ed
- LOPES RENATO D.
- Lorenzi Elizabeth
- Lorenzi Elizabeth
- MACHADO DAVID J.B.
- MACHADO FLAVIA R.
- Maes Bastiaan
- Mafham Marion
- Mahevas Matthieu
- Malinis Maricar
- Malouf Jorge
- Mansour Michael K
- Mariette Xavier
- Mariette Xavier
- Marshall John
- Marshall John C.
- MARTIN JOSIANE
- Marttila Harri
- Martínez José Antonio
- Mateo Gracia María
- McArthur Colin
- McAuley Daniel
- McGuinness Shay
- McVerry Bryan
- Megat Johari Bushra
- Mejía-Abril Gina
- MERCHANTE NICOLAS
- Merchante Nicolas
- Millan Lucia
- Misnan Nor Arisah
- Misnan Nor Arisah
- Mohamed Gani Yasmin
- Mohan Shalini V.
- Mohd Abd Rahim Mohd Abd Hafiz
- Mohd Thabit Alif Adlan
- Molas Maria Ema
- Montgomery Alan
- Montgommery Stephanie
- Morpeth Susan
- Mouncey Paul
- Mukri Mohd Noor Azreet
- Mumford Andrew
- Mur Isabel
- Murthy Srinivas
- Murthy Srinivas
- Muñez Rubio Elena
- Muñoz Jessica
- Muñóz José
- Neelamegam Malinee
- Netea Mihai
- Ng Rong Xiang
- Nichol Alistair
- Nikiforow Sarah
- Nivens Michael C.
- Niward Katarina F
- Nordberg Marika
- Nowak Piotr
- Ogungbenro Kayode
- Oksi Jarmo
- Omar Sharifah Faridah
- Ong Hang Cheng
- PACHECO EDUARDO S.
- Pacheco Iván
- Paredes Roger
- Parke Rachael
- Parke Åsa
- Parker Jane
- Patel Naomi J
- Pene Frédéric
- Perez-Molina Jose A
- Perez-Molina Jose A.
- Pettila Ville
- Pincus Michael D
- PINTÃO MARIA CAROLINA T.
- Pisano Jennifer
- Pizov Reuven
- Pizov Reuven
- Pomar Virginia
- Ponnampalavanar Sasheela
- Porcher Raphael
- Porcher Raphael
- Postma Simone
- Pourchet-Martinez Valérie
- PRATS JOÃO G.
- Price Christina
- Prieto Jose Carlos
- Prieto Sergio
- Raja Azwa Raja Iskandar Syah
- Raja Sureja Letchumi
- Rajasuriar Reena
- Rajasuriar Reena
- Ramanan Athimalaipet V.
- Ramos Martínez Antonio
- Rasmuson Johan
- Ratain Mark
- Ravaud Philippe
- Ravaud Philippe
- Reid Pankti D.
- Resche Rigon Matthieu
- Reyes Felipe
- Rodríguez-García Sebastian C
- ROJAS SALOMÓN S.O.
- ROSA REGIS G.
- Rosas Ivan O.
- Rowan Kathryn
- Ruiz-Antorán Belén
- Rutgers Abraham
- Sagar Manish
- Saito Hiroki
- Salama Carlos
- Sancho-Lopez Aranzazu
- SANDES ALEX R.
- Santos Marlene
- SANTOS SUELI V.
- Sanz Sanz Jesus
- Saravanamuttu Sujana
- Savovic Jelena
- SCHEINBERG PHILLIP
- Schlemmer Frédéric
- SCHNEIDER DANIEL
- Seto Todd B.
- Seymour Chris
- Shah Ruta
- Shankar-Hari Manu
- Shankar-Hari Manu
- Shrager Harry
- Sim Benedict
- SIQUEIRA SUELLEN R.R.
- Sivapalasingam Sumathi
- Skorup Paul
- Soin Arvinder Singh
- Soriano Alex
- Spiga Francesca
- Staplin Natalie
- Sterne Jonathan A. C.
- Stone John H.
- Strek Mary
- Strohbehn Garth W.
- Sulaiman Helmi
- Sunden-Cullberg Jonas
- Svensson Anna-Karin
- Syed Badaruddin Syarifah Nurul Ain
- Syed Mansor Syed Mukhtar
- Syed Omar Sharifah Faridah
- Sönnerborg Anders
- Tan Kok Tong
- Tay Kim Heng
- Thangavelu Suvintheran
- Tharaux Pierre Louis
- The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group [missing]
- Thwaites Guy
- Tibi Annick
- Tierney Jayne
- Tong Steve
- TORRE-CISNEROS JULIAN
- Torre-Cisneros Julian
- Torres Ferran
- Tsai Larry W.
- Tuang Wei Xuan
- Turgeon Alexis
- Turner Anne
- Uyeki Tim
- Vale Claire L.
- Valtonen Mika
- van Bentum-Puijk Wilma
- Van Damme Karel
- van de Veerdonk Frank
- van Hoogstraten Hubert
- van Meerten Tom
- VEIGA VIVIANE C.
- Veiga Viviane Cordeiro
- Vesterbacka Jan C.
- Villar Luisa M
- Vuorinen Tytti
- Webb Steve
- Westerweel Peter E.
- Wong Chee Kuan
- Wong Pui Li
- Woolley Ann E.
- Yazdanpanah Yazdan
- Youngstein Taryn
- ZAMPIERI FERNANDO G.
- Zarychanski Ryan
- Zulhaimi Nurul Syuhada
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2021
- Field of study
IMPORTANCE Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm.
OBJECTIVE To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes.
DATA SOURCES Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts.
STUDY SELECTION Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria.
DATA EXTRACTION AND SYNTHESIS In this prospectivemeta-analysis, risk of biaswas assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I-2 statistic. The primary analysis was an inverse variance-weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality.
MAIN OUTCOMES AND MEASURES The primary outcome measurewas all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days.
RESULTS A total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P =.003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P <.001) for tocilizumab and 1.08 (95% CI, 0.86-1.36; P =.52) for sarilumab. The summary ORs for the association with mortality compared with usual care or placebo in those receiving corticosteroids were 0.77 (95% CI, 0.68-0.87) for tocilizumab and 0.92 (95% CI, 0.61-1.38) for sarilumab. The ORs for the association with progression to invasive mechanical ventilation or death, compared with usual care or placebo, were 0.77 (95% CI, 0.70-0.85) for all IL-6 antagonists, 0.74 (95% CI, 0.66-0.82) for tocilizumab, and 1.00 (95% CI, 0.74-1.34) for sarilumab. Secondary infections by 28 days occurred in 21.9% of patients treated with IL-6 antagonists vs 17.6% of patients treated with usual care or placebo (OR accounting for trial sample sizes, 0.99; 95% CI, 0.85-1.16).
CONCLUSIONS AND RELEVANCE In this prospectivemeta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
- Author
- Abu-Manneh Rana
- Adams David
- Agathangelou Petros
- Ajroud-Driss Senda Ajroud-Driss
- Al-Salameh Abdallah
- Aldinc Emre
- Algalarrondo Vincent
- Allen Adriane C.
- Altinkurt Emre
- Alves Cristina
- Anan Intissar
- Ando Rina
- Arrouasse Raphaele
- Attarian Shahram
- aus dem Siepen Fabian
- Ayache Samar S.
- Balaya-Gouraya Line
- Barroso Fabio
- Baskin Amber
- Bauer Ralf
- Beaudonnet Guillemette
- Becquemont Laurent
- Berber Erhan
- Berk John L.
- Bernardo Daniela
- Berthelot Emeline
- Bisogni Giulia
- Blasco Pelicano Josep Miquel
- Blume Brianna
- Borrachero Cristina
- Boubrit Yasmine
- Bournane Halima
- Boyer Leslie
- Brannagan III Thomas H.
- Brice Sylvie
- Brueckner Caitlin
- Bulthuis-Kuiper Janita
- Burks Kathleen L.
- Cakar Arman
- Campana-Salort Emmanuelle
- Campistol Josep M.
- Cantú Brito Carlos Gerardo
- Cardoso Berensztejn Amanda
- Cardoso Marcio
- Carrillo Esmeralda
- Casey Patricia
- Castro Isabel
- Castro Jose
- Cauquil-Michon Cécile
- Chacko Liza
- Chahine Ilonah
- Chamova Teodora
- Chan Soo Looi
- Chao Chi-Chao
- Charlin Cyril
- Chaudhry Vinay
- Cherneva Zheyna
- Cherninkova-Gopina Sylvia
- Cho Eun Bin
- Choi Kyomin
- Choumert Ariane
- Chu Hanh
- Cioroiu Comana
- Cisneros Barroso Eugenia
- Coelho Teresa
- Cohen Oliver
- Conceição Isabel M.
- Correia Nuno
- Cortese Andrea
- Coskun Derya J.
- Criollo Mora Elia
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- Gamez Martinez Jose M
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- Itoya Amenze
- Jack Kristin
- Jarrett Raquel
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- Jeon Eun-Seok
- Jiménez López Brenda Poled
- Jose Vega Francisco
- Joslin Benjamin C.
- Jozefowicz Elsa
- Judge Daniel P.
- Kabar Iyad
- Kapoor Prashant
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- Katanazaka Kimitaka
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- Marques Júnior Wilson
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- Oh Jeeyoung
- Orellana Lucas G.
- Oshita Tomohiko
- Overcash J. Scott
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- Perez Javier M.
- Pessoa Bernardete
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- Pinto Marcus Vinicius
- Planté-Bordeneuve Violaine
- Polydefkis Michael
- Pouget Jean
- Pu Helen
- Pytel Cordoba Vanesa
- Pérez-Castañeda Sandra Lorena
- Quan Dianna
- Rajkumar Vincent S.
- Rakotondratafika Fetra
- Ramalho Joana
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- Schilling Matthias
- Schmidt Hartmut H.
- Schubert Friederike
- Segawa Akiko
- Sekijima Yoshiki
- Sellers Peter
- Seok Jin Myoung
- Serbest Nail G.
- Shah Syed Mahmood
- Shije Jeffrey
- Shimomura Masahiro
- Shin Hyun Jin
- Signate Aissatou
- Sirin Inan Nermin G.
- Slama Michel S.
- Smith Ashley
- Soderberg Karin
- Sommerville R. Brian
- Stephant Maeva
- Stewart Graeme
- Stone Paula
- Su Jen-Jen
- Suan Daniel
- Suhr Ole
- Sweetser Marianne T.
- Tada Satoshi
- Takahashi Tetsuya
- Taniguchi Ikuko
- Taniwaki Takayuki
- Tard Celine
- Taylor Lenka
- Taylor Mark
- Thai Desmond
- Théaudin-Saliou Marie
- Tournev Ivaylo
- Tran Leyla
- Truong Nghi
- Tsai Li-Kai
- Tsang Steven
- Tsuruhisa Seiko
- Tugal Tutkun Nuriye Ilknur
- Ueda Akihiko
- Ueda Mitsuharu
- Ueno Hiroki
- Ulane Christina
- Ulbricht Hannah
- Uson Mercedes
- Valdrez Katia
- Verschueren Annie
- Vervoitte Laetitia
- Vest John
- Victory Jennifer
- Viera Lima Ana Flavia
- Vinas Maita
- Vista Geno
- Vorona Elena
- Vuong Thao
- Waddington-Cruz Márcia
- Wade N. Kevin
- Wajnsztajn Fernanda
- Walter Doreen
- Wang Jing Jing
- Waters Michael
- Waucquier Nawal
- Weimer Louis
- Wells Karen
- White Matthew T.
- Wiesman Janice
- Witzig Thomas E.
- Wixner Jonas
- Yamanishi Yuki
- Yamashita Taro
- Yang Chih-Chao
- Ye Jing
- Yeh Shin-Joe
- Yorita Akiko
- Yoshinaga Tsuneaki
- Zamba-Papanicolaou Eleni
- Zeldenrust Steven R
- Zepeda Karla A.
- Zhelyazkova-Glaveeva Sashka
- Zibert Andree
- Zueiter Andreas
- Zwijack Brittany
- Özdemir Betül
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
© 2020 Elsevier Ltd. All rights reserved.Background: Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR production, in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy.
Methods: This multicentre, open-label extension (OLE) trial enrolled patients at 43 hospitals or clinical centres in 19 countries as of Sept 24, 2018. Patients were eligible if they had completed the phase 3 APOLLO or phase 2 OLE parent studies and tolerated the study drug. Eligible patients from APOLLO (patisiran and placebo groups) and the phase 2 OLE (patisiran group) studies enrolled in this global OLE trial and received patisiran 0·3 mg/kg by intravenous infusion every 3 weeks with plans to continue to do so for up to 5 years. Efficacy assessments included measures of polyneuropathy (modified Neuropathy Impairment Score +7 [mNIS+7]), quality of life, autonomic symptoms, nutritional status, disability, ambulation status, motor function, and cardiac stress, with analysis by study groups (APOLLO-placebo, APOLLO-patisiran, phase 2 OLE patisiran) based on allocation in the parent trial. The global OLE is ongoing with no new enrolment, and current findings are based on the interim analysis of the patients who had completed 12-month efficacy assessments as of the data cutoff. Safety analyses included all patients who received one or more dose of patisiran up to the data cutoff. This study is registered with ClinicalTrials.gov, NCT02510261.
Findings: Between July 13, 2015, and Aug 21, 2017, of 212 eligible patients, 211 were enrolled: 137 patients from the APOLLO-patisiran group, 49 from the APOLLO-placebo group, and 25 from the phase 2 OLE patisiran group. At the data cutoff on Sept 24, 2018, 126 (92%) of 137 patients from the APOLLO-patisiran group, 38 (78%) of 49 from the APOLLO-placebo group, and 25 (100%) of 25 from the phase 2 OLE patisiran group had completed 12-month assessments. At 12 months, improvements in mNIS+7 with patisiran were sustained from parent study baseline with treatment in the global OLE (APOLLO-patisiran mean change -4·0, 95 % CI -7·7 to -0·3; phase 2 OLE patisiran -4·7, -11·9 to 2·4). Mean mNIS+7 score improved from global OLE enrolment in the APOLLO-placebo group (mean change from global OLE enrolment -1·4, 95% CI -6·2 to 3·5). Overall, 204 (97%) of 211 patients reported adverse events, 82 (39%) reported serious adverse events, and there were 23 (11%) deaths. Serious adverse events were more frequent in the APOLLO-placebo group (28 [57%] of 49) than in the APOLLO-patisiran (48 [35%] of 137) or phase 2 OLE patisiran (six [24%] of 25) groups. The most common treatment-related adverse event was mild or moderate infusion-related reactions. The frequency of deaths in the global OLE was higher in the APOLLO-placebo group (13 [27%] of 49), who had a higher disease burden than the APOLLO-patisiran (ten [7%] of 137) and phase 2 OLE patisiran (0 of 25) groups.
Interpretation: In this interim 12-month analysis of the ongoing global OLE study, patisiran appeared to maintain efficacy with an acceptable safety profile in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy. Continued long-term follow-up will be important for the overall assessment of safety and efficacy with patisiran.info:eu-repo/semantics/publishedVersio
Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
- AlBsoul Ahmad
- Albsoul Nader
- Alcorta Rodrigo
- Alejandre Villalobos Cristina
- Alemdag Gökçe nur
- Alexander Philip
- Alfarra Nada
- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
- Ali Asmaa
- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
- Aljaberi Loay
- Aljanfi Asma
- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
- Amorim Edgar
- Amro Adham
- Anandan Premkumar
- Anas khalifa Rawda
- Anastasio Lorenzo
- Andersson Yvette
- Andreotti Dario
- Andrew David
- André Benoît
- Ang Sue Ean
- Angel Miguel
- Anggita Gultom Phebe
- Annapureddy Naga
- Anokhin Evgeny
- Ansaloni Luca
- Ansarei Dhirar
- Ansari Abdul Basit
- Antaky Marco
- Anthony Natasha
- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
- Argentou Maria-Ioanna
- Argudo Nuria
- Argyriou Eleftherios Orestis
- Arias Madrid Natalia
- Aribi Sarra
- Arifin Ghafur Rasyid
- Arizpe Daniel
- Arnaud Alexis P
- Arora Bharti
- Arora Deeksha
- Arowolo Olukayode
- Arrangoiz Rodrigo
- Arslan Ekin
- Artigau Eva
- Ashfaq Ahsan
- Ashour Dina
- Ashour Firas
- Ashoushan Hana
- Ashraf Ahmed
- Ashraf Alaa
- Asif Ashar
- Asnel Dorisme
- Asok Anjitha
- Assa Rawan
- Assalhi Mohamed
- Asta Martina
- Asti Emanuele Luigi Giuseppe
- Atakul Onur
- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
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- Banks Alexander
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- Barbosa Camacho Francisco José
- Barbosa José
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- Barendegere Venerand
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- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
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- Belvedere Angela
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- Bengur Fuat Baris
- Benkabbou Amine
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- Bhandare Manish
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- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
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- Budzynski Piotr
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- Burke Daniel
- Burman Shivang
- Bury Pawel
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- Butt Eman
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- Buzaite Kristina
- C S Archana
- Caballero Díaz Yurena
- Cabrera Rivera Paulo Andrés
- Cagigas Fernandez Carmen
- Calik Adnan
- Calleja Thomas
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- Veale Kelly
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- Winter Des
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- Wisselink Daan
- Wogensen Fredrik
- Wondoh Paul M.
- Wong Florence
- Wong Hsu Ven
- Wong Jane J
- Wong Jeremy
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- Wong Sui-Weng
- Wong Tsz Lun Ernest
- Wood Lauren
- Woon-Shoo-Tong Xiao-Ming Sarah
- Wren Sherry
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- Xanthopoulou Georgia
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- Yacoub Aseel
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- Yahia Mohamed Ali Mohamed
- Yakushkina Al'ona
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- Yang P Zichu
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- Yates Charlotte
- Ye Geoffrey
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- Zabiyaka Mikhail
- Zachariah Sanoop Koshy
- Zafar Syed Nabeel
- Zaffaroni Gloria
- Zahra Baryab
- Zahran Diaaaldin
- Zakaria Andee Dzulkarnaen
- Zakaria Mai
- Zakaria Omar
- Zakaria Zaidi
- Zambrana Campos Vanesa
- Zammit Matthew
- Zanini Nicola
- Zara Vlu Jean
- Zara Vlu Jean
- Zarti Heba
- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Šatkauskas Mindaugas
- Škimelyte Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 30/01/2021
- Field of study
© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
- Author
- A Yacoub Mina
- A. Adam Mohammed
- A. Nassar Mahmoud
- A.Nemer Ayoob
- Aahlin Eirik Kjus
- Ab Rahim Mohd Fadliyazid
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abang Jamari Dyg Zahratul Hamrak
- Abantanga Francis
- Abarca Sol
- Abazid Eias
- Abbas Abbas
- Abbas Khalid
- Abbas Mohammad Monir
- Abbasy Jibran
- Abbosh Ali
- Abd Karim Muhammad Fairuz Shah
- Abd Wahab Haidar Hadri
- Abd Barook
- Abdalei Abdulwahab
- Abdalla Ahmed Elkamel Ahmed
- Abdallah Aya
- AbdAllah Mostafa Salim Mohamed
- Abdel Malik Abu Baker
- Abdelhady Mousa Heba
- Abdelhady Samar
- Abdelhakim Ahmed
- Abdelkader Muhammad
- Abdelkawy Shaza
- Abdelkhalek Mohamed
- Abdellatif Esraa
- Abdelmaksoud Tawakel Noura
- Abdelmohsen Naglaa
- Abdelmotaleb Ibrahem
- Abdelrazek Aly
- Abdelsalam Israa
- Abdelshakour Mahmoud
- Abdelwahed Ahmed Mohamed
- Abdou Abdulrahman Osama
- Abdou Alrawy
- Abdou Hossam
- Abdul Aziz Mohamed Rezal
- Abdul Aziz Nora
- Abdulgawad Almogy Mariam
- Abdulla Mazin A.
- Abdullah Muhammad Tariq
- Abdullahi Lawal
- Abdullayev Seymur
- Abed Saeed
- Abelló David
- Abiola Olajide
- Abo mahadi Asmaa'
- Abo-khammash Areej
- Abou Chaar Mohamad K.
- Abou El.soud Moustafa Ramadan
- Abouelsoad Nervana
- Abraham Joyner
- Abreu da Silva Alberto
- Abu Ahammala Ayman B.
- Abu Al Amrain Mahmoud
- Abu Al-saleem Hasan
- Abu Alamrain Abdulwhhab
- Abu Alqumboz Amjad
- Abu Ataya Ahmed
- Abu hallalah Muad fathi khalleefah
- Abu Jamie Najlaa
- Abu Jayyab Israa
- Abu shua'ib Rana
- Abu Zainah Baraa
- Abu-Nimeh Samar
- Abu-Rous Mohammed R.
- Abu-srour Abrar
- Abuelhatal Hasan
- Abuelqomboz Ayham
- Abuhilal Baseel
- Abuhlaiga Ma'aly
- Abujamra Saleh
- Abukhalaf Sadi A.
- Abusalem Lana
- AbuSirrees Mahmoud
- Acevedo Veronica
- Acharya Rajgopal
- Achkasov Sergey
- Acosta Eric
- Adamo Karin
- Adamou Harissou
- Adams Jamie
- Adams Lawrence
- Adawi Samer
- Adebanjo Ademola
- Adel Marina
- Adel Sawsan
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adenuga Adedire
- Aderounmu Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adesunkanmi Abdul-Rashid
- Adeyeye Ademola
- Adidharma Peter
- Adisa Adewale
- Adisa Adewale O
- Adnan Nour
- Afifi Amr Abdelghani
- Afifi Eman
- Afolayan Michael Olatunji
- Afzal Asma
- Agarwal Arnav
- Agarwal Raksheeth
- Agbakwuru Augustine
- Agbeko Anita Eseenam
- Aguilar Martinez Maria Del Mar
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlqvist Sandra
- Ahmad Izzuddin Ahmad Imran
- Ahmad Kasim
- Ahmad Sarwat
- Ahmed Ahmedgaber
- Ahmed Hazem Abdelkarem
- Ahmed Mariam
- Ahmed Nabila
- Ahmed Zahra
- Ainoa Eppu
- Aithie Joanna M S
- Ajani Costanza
- Ajao Akinlabi
- Ajiboye Anthony
- Ajmera Ankit
- Akande Oluwatosin
- Akaydin Elif
- Akbaba Ata Cem
- Akbar Sana Amir
- Akeel Nouf
- Akeem Aderogba Adeleke
- Akin Alp
- Akinkuolie Akinbolaji
- Akisheva Aygulya
- Akitikori Mabel Temisanren
- Akrida Ioanna
- Aktas Melik Kagan
- Al basos Iyad
- Al Farsi Maryam
- Al Nassrallah Majdi
- Al Sagheir Eman
- Al Saqqa Sara
- Al Saqqa Sara
- Al-Allaf Omar
- Al-Busaidi Ibrahim S.
- Al-Dhufri Ali
- Al-Himyari Hamza S.
- Al-Masri Mahmoud
- Al-Najjar Hani
- Al-Sabbagh Yusra
- Al-Shwaikh Samar
- Al-Slaibi Ibrahim
- Al-Taher Raed
- Al-Tammam Hiba
- Alabuzidi Aya
- Alagha Othman
- Alammarin Mohammad
- Alapatt John
- Alasttal Mohammed
- Alatise Olusegun Isaac
- Albaggar Marwa
- Albahnasawi Moath A.
- Albati Naif
- Alberga Anna
- Alberts Justin
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- Alemdağ Gökçe nur
- Alexander Philip
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- Alfitory Asma
- Alhabil Belal
- Alhaj Ahmad
- Alherz Mohammad
- Alhimyar Maryam
- Ali Ahmad Syed Mustafa
- Ali SANI Samuel
- Ali Amr
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- Ali Mahmoud
- Ali Shabina
- Alimi Marjan
- Aliosin Oleg
- Aliyu Halima
- Aljaafreh Almoutuz
- Aljaber Dana
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- Aljiffry Murad
- Aljohmani Lylas
- Alkhaledi Ahmad
- Alkhatib Ala'a Aldeen
- Alkhatib Haya
- Alkhatib Mo'min
- Allen Ingabire J.C.
- Almasri Murad
- Almeida Braga Sara
- Almeida Filipe
- Almigheerbi Alabas
- Almoqayyad Abdelrahman
- Almuzghi Fakhruddin
- Alnoury Mostafa
- Alonso Batanero Ester
- Alqadi Mohammad
- Alsaid Bayan
- Alsalameh Barah
- Alsallaq Osama
- Alser Osaid
- Alshaar Muhammad
- Alsharef Tagwa
- Alsharqawi Nourah
- Alswerki Mohammad
- Altaf Amna
- Altaf Rabiya
- AlTaweel Mohammed
- Althini Abdulmunem Ahmed Mustafa
- Altibi Ahmed M.
- Altinel Yuksel
- Altiner Saygin
- Altomare Donato Francesco
- Altumei Zohoor
- Alvarez Rivera Alvaro Eduardo
- Alvarez-Cano Alethia
- Alves do Canto Brum Homero
- Alves Daniela Macedo
- Alves Magda
- Alvi Abdul
- Alwaheidi Malak
- Alwali Abdallah
- Alwerfally AbdulMawlay
- Alwhaidi Noor
- Alyafi Amr
- Alzabti Fatima
- Alzahaf Ahmed
- AlZohour Mohammad
- Amadou Magagi Ibrahim
- Amandito Radhian
- Amarin Justin Z.
- Amaro Margarida
- Ambrazevicius Marijus
- Amendola Alfonso
- Amin Leila
- Amine Souadka
- Amjad Talal
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- Anas khalifa Rawda
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- Anthoulakis Christos
- Antonopoulou Maria Ioanna
- Anwar Mohamed
- Anwer Abdul Wahid
- Anyanwu Chikamuche
- Anyanwu Lofty-John
- Anyanwu Mercy Chinemerem
- Anyomih Theophilus Teddy Kojo
- Appukuttan Akhila
- Aquilino Fabrizio
- Archibald Jess
- Arciénega Yañez María del pilar
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- Argudo Nuria
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- Arifin Ghafur Rasyid
- Arizpe Daniel
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- Arora Bharti
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- Asti Emanuele Luigi Giuseppe
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- Atallah Khalid
- Atanasov Boyko
- Atawneh Mohammad
- Athamneh Sarah
- Ather Muaaz
- Athisayaraj Thomas
- Atkociunas Aivaras
- Attia Mohamed
- Au Angela
- Awad Israa
- Awadallah Haneen
- Awaji Kholoud
- Awesat Eman
- Awolowo Ajibola
- Ayandipo Omobolaji
- Ayash Mohammad
- Ayau Fernanda
- Ayesh Kholoud
- Ayman El-sawy Esraa
- Ayoub Rami
- Aytac Erman
- Ayub Bushra
- Ayub Saima
- Ayyad Rawan
- Azevedo José
- Azodo Ijeoma
- Azzubia Joma
- B L Ashika
- Ba Mouhamadou Bachir
- Babaa Basheer
- Babirye Lilian
- Bacic Ivan
- Badr Esraa Tarek
- Badr Helmy
- Badran Abdul
- Badwe Rajendra
- Bafford Andrea Chao M.D.
- Baggaley Caitlin
- Bahroun Sumayyah Ghayth
- Baiao José Miguel
- Baiocchi Daniella
- Bairos Menezes Maria
- Baiu Ioana
- Bajilan Mohammad
- Bajomo Oreoluwa
- Bake Jacques
- Baki Bahadir Emre
- Bakoleas Panagiotis
- Balaawi Reem
- Balalis Dimitrios
- Balata Mohamed
- Balkarov Artem
- Ballouhey Quentin
- Balogun Olanrewaju
- Baloyiannis Ioannis
- Baltaci Ege
- Bamaca Ixcajoc Elvis Benjamin
- Banaz Tuba
- Banda Bitiel
- Banglani Muntaha
- Bani Hani Farah
- Bani hani Mohammad
- Bani hani Zeina
- Baniowda Muath
- Banks Alexander
- Bannister Sharon
- Baranyai Zsolt
- Barati Nastaran
- Barbosa Camacho Francisco José
- Barbosa José
- Bardos David
- Barendegere Venerand
- Barghuthi Lutfi
- Barhoush Ola
- Barnes Nicole
- Baronio Gianluca
- Barreda Zelaya Lilian Elizabeth
- Barrera López Francisco Javier
- Barsic Neven
- Barter Charlotte
- Bartosiak Katarzyna
- Basarab Maksym
- Basso Stefano Maria Massimiliano.
- Bastiaenen Vivian
- Batashki Ilia
- Bath Michael
- Beattie Miriam
- Bedada Alemayehu Ginbo
- Belais Fanny
- Belal qadomi Asef
- Belev Nikolay
- Belli Andrea
- Beltrán de Heredia Juan
- Belvedere Angela
- Ben Dallah Najah
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- Bengur Fuat Baris
- Benkabbou Amine
- Benke Marton
- Benyaiche Chaymae
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- Bhandare Manish
- Bhangu Aneel
- Bhatti Muhammad Iqbal
- Bianchini Stefania
- Bianco Francesco
- Bibas Fatma
- Biccard Bruce M
- Bielosludtsev Oleksii
- Bienfait Mumbere
- Billy Matthew
- Bin Mohamad Sithik Muhammad Navid
- Binetti Margherita
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- Zarzycki Piotr
- Zattoni Davide
- Zavala Gabriela
- Zawahrah Hassan
- Zeiton Asaid
- Zeko Amanda
- Zeng Zhi
- Zeromskas Paulius
- Zhang Geoffrey
- Zhivkov Evgeni
- Zid Esraa
- Zidan Ahmed Mohy
- Zielasek Christian
- Zilinskas Justas
- Zimmermann Bernd
- Ziprin Paul
- Zizzo Maurizio
- Zografos George
- Zoikas Athanasios
- Zorrilla Matilla Laura Patricia
- Zoulamoglou Menelaos
- Zreeg Dafer
- Zub-Pokrowiecka Anna
- Zubiaurre Vanessa
- Zuhdy Mohammed
- Zuikyte Diana
- Zuloaga Fernandez del Valle Carlos Jose
- Zulu Stanley
- Ângelo Miguel
- Älgå Andreas
- Çolak Elif
- Ümarik Toomas
- Čepuliené Daiva
- Şahin Can
- Šatkauskas Mindaugas
- Škimelytè Monika
- Šlenfuktas Vygintas
- Šuman Oliver
- Žatecký Jan
- Žumbakys Žygimantas
- Župan Domagoj
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research