A participação da pessoa com deficiência no processo eleitoral sob a interpretação dos ideais da democracia e da cidadania

A relação da democracia e cidadania, se remete na análise de legitima representação social e da garantia da inclusão de todos no processo eleitoral. Este estudo tem como objetivo demonstrar e discutir, através de pesquisa bibliográfica, a relação entre democracia e cidadania como dois polos intrínsecos que se complementam para garantir direitos de todos, inclusive das pessoas com deficiência em um Estado Democrático de Direito com realce ao direito da pessoa com deficiência mental de participar do processo eleitoral, segundo o novo paradigma do Estatuto da Pessoa com Deficiência, lei 13.146/2015, que resgatou os ideais da Convenção sobre direitos da Pessoa com Deficiência. O resultado desta discussão nos leva a acreditar que desta relação de democracia e cidadania, a inclusão social no processo eleitoral deve ser a mais abrangente possível de participantes, sem discriminação ou exclusão

Funcionamiento familiar y su relación con el consumo de alcohol en adultos jóvenes

Family functionality plays a leading role when dealing with health problems, being a factor that, depending on the existing dynamics within the family system, will be a protective factor or in turn represent a risk factor for alcohol use in the person. The objective of the study was to determine the relationship between family functioning and alcohol use in young adults through a study methodology with a quantitative approach, correlational scope, non-experimental design, and cross section with a sample made up of 159 young adults (50.6% women and 49.4% men). The Family Functioning Test (FF-SIL) and The Alcohol Use Disorders Identification Test (AUDIT) were used. As results, the prevalence of perception of moderately functional family structures was identified with 55.3%, with respect to alcohol use it was determined at 74.2% with a low level of risk, there being a statistically significant difference between the sexes, being men who tend to consume more. Finally, it is concluded that there is no correlation between the study variables, which makes it possible to demonstrate the importance of continuing with studies that address the problem.La funcionalidad familiar juega un rol protagónico al tratarse de problemas de salud, siendo un factor que, dependiendo de la dinámica existente dentro del sistema familiar será un factor protector o a su vez representará un factor de riesgo para el consumo de alcohol en la persona. El objetivo del estudio fue determinar la relación entre el funcionamiento familiar y el consumo de alcohol en adultos jóvenes mediante una metodología de investigación con enfoque cuantitativo, de alcance correlacional, diseño no experimental y corte transversal, en una muestra conformada por 159 adultos jóvenes (50,6% mujeres y 49,4% hombres). Se empleó el Test de Funcionamiento Familiar (FF-SIL) y el Test de identificación de los Trastornos debido al consumo de alcohol (AUDIT). Como resultados se identificó la prevalencia de percepción de estructuras familiares moderadamente funcionales con el 55.3 %, respecto al consumo de alcohol se determinó al 74.2 % con un nivel bajo de riesgo, existiendo una diferencia estadísticamente significativa entre sexos, siendo los hombres quienes tienden a consumir más. Finalmente, se concluye en que no existe una correlación entre las variables de estudio, lo que permite evidenciar la importancia de continuar con estudios que aborden la problemátic

Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles

Virus-like particles (VLPs) constitute a promising platform in vaccine development and targeted drug delivery. To date, most applications use simple nonenveloped VLPs as human papillomavirus or hepatitis B vaccines, even though the envelope is known to be critical to retain the native protein folding and biological function. Here, we present tagged enveloped VLPs (TagE-VLPs) as a valuable strategy for the downstream processing and monitoring of the in vivo production of specific-site-functionalized enveloped influenza VLPs. This two-step procedure allows bioorthogonal functionalization of azide-tagged nascent influenza type A hemagglutinin proteins in the envelope of VLPs through a strain-promoted [3 + 2] alkyne-azide cycloaddition reaction. Importantly, labeling does not influence VLP production and allows for construction of functionalized VLPs without deleterious effects on their biological function. Refined discrimination and separation between VLP and baculovirus, the major impurity of the process, is achieved when this technique is combined with flow cytometry analysis, as demonstrated by atomic force microscopy. TagE-VLPs is a versatile tool broadly applicable to the production, monitoring, and purification of functionalized enveloped VLPs for vaccine design trial runs, targeted drug delivery, and molecular imaging.The authors acknowledge funding from the European Union (EDUFLUVAC project FP7-HEALTH-2013-INNOVATION), the Fundação para a Ciência e Tecnologia (FCT, Portugal; project HIVERA/0002/2013 and FCT Investigator to G.J.L.B.), EPSRC (to G.J.L.B.), the European Commission, Marie Skłodowska-Curie Actions (MSCA), and RISE project grant 644167. S. B. C., J. M. F., F. M., and D. G. acknowledge FCT for fellowships SFRH/BD/52302/2013, SFRH/BD/70423/2010, SFRH/BD/70139/2010, and SFRH/BPD/73500/2010, respectively. The authors acknowledge Ricardo Silva for all his help in fluorescence analysis implementation and fruitful discussions. The authors also acknowledge Patrícia Gomes-Alves for her help for mass spectrometry analysis. Mass spectrometry data was obtained by the Mass Spectrometry Unit (UniMS), ITQB/iBET, Oeiras, Portugal. G. J. L. B. is a Royal Society University Research Fellow and the recipient of a European Research Council Starting Grant (TagIt)

Valorisation of red beet waste: one-step extraction and separation of betalains and chlorophylls using thermoreversible aqueous biphasic systems

Globally, up to 50% of root crops, fruits and vegetables produced is wasted. Beetroot stems and leaves fit into this scenario, with only a small fraction being used in cattle food. One way of approaching this problem is through their valorisation, by extracting and recovering valuable compounds present in this type of waste that could be used in other applications, while contributing towards a circular economy. In this work, a new integrated process using thermoreversible aqueous biphasic systems (ABS) composed of quaternary ammonium-based ionic liquids (ILs) and polypropyleneglycol 400 g mol−1 (PPG) is shown to allow the one-step extraction and separation of two pigment classes—betalains and chlorophylls—from red beet stems and leaves. The pigment extraction was carried out with a monophasic aqueous solution of the IL and PPG, whose phase separation was then achieved by a temperature switch, resulting in the simultaneous separation of chlorophylls and betalains into opposite phases. A central composite design was used to optimise the extraction parameters (time, temperature, and solid : liquid (S/L) ratio) of both pigment extraction yields, reaching at 20 °C, 70 min and a S/L ratio of 0.12 a maximum extraction yield of 6.67 wt% for betalains and 1.82 wt% for chlorophylls (per weight of biomass). Moreover, it is shown that aqueous solutions of ILs better stabilise betalains than the gold standard solvent used for the extraction method. Among the studied systems, the ABS comprising the IL N-ethyl-N-methyl-N,N-bis(2-hydroxyethyl) bromide ([N21(2OH)(2OH)]Br) presented the best separation performance, with an extraction efficiency of 92% and 95% for chlorophylls and betalains, respectively, for opposite phases. The pigments were removed from the respective phases using affinity resins, with high recoveries: 96% for betalains and 98% for chlorophylls, further allowing the IL reuse. Finally, the cyto- and ecotoxicities of the quaternary ammonium-based ILs were determined. The obtained results disclosed low to negligible toxicity in the thousands of mg L−1 range, with [N21(2OH)(2OH)]Br being harmless from an ecotoxicological point of view. Overall, it is shown here that the developed process is an innovative approach for the one-step extraction and selective separation of pigments contributing to the valorisation of waste biomass

Thermoreversible (Ionic-Liquid-Based) Aqueous Biphasic Systems

The ability to induce reversible phase transitions between homogeneous solutions and biphasic liquid-liquid systems, at pre-defined and suitable operating temperatures, is of crucial relevance in the design of separation processes. Ionic-liquid-based aqueous biphasic systems (IL-based ABS) have demonstrated superior performance as alternative extraction platforms, and their thermoreversible behaviour is here disclosed by the use of protic ILs. The applicability of the temperature-induced phase switching is further demonstrated with the complete extraction of two value-added proteins, achieved in a single-step. It is shown that these temperature-induced mono(bi)phasic systems are significantly more versatile than classical liquid-liquid systems which are constrained by their critical temperatures. IL-based ABS allow to work in a wide range of temperatures and compositions which can be tailored to fit the requirements of a given separation process

Desarrollo Hibrido con Flutter

This article contains relevant and summarized information related to the "Hybrid Development with Flutter" the same based on an investigation which allows collecting from different bibliographic sources, the main aspects for the application and execution of a computer project based on Flutter, within the The document shows the analysis of several texts, in order to present the reader with a structured overview of the processes to be carried out for a correct development and implementation of hybrid applications, this research is based on the need to publicize this new Development Framework. which allows new programmers to design and code mobile applications that complement the great evolutionary environment of mobile applications todayEl presente articulo contiene informacion relevante y resumida relacionada con el “Desarrollo Hibrido con Flutter” el mismo basado en una investigación la cual permite recolectar de distintas fuentes bibliográficas, los principales aspectos para la aplicación y ejecución de un proyecto informático basado en Flutter, dentro del documento se muestra el análisis de varios textos, con la finalidad de presentar al lector un panorama estructurado sobre los procesos a realizar para un correcto desarrollo eh implementación de aplicaciones hibridas, esta investigación parte de la necesidad de dar a conocer este nuevo Framework de desarrollo el cual permita a nuevos programadores diseñar y codificar aplicativos móviles que permitan complementar el gran entorno evolutivo de las aplicaciones móviles en la actualidad

New perspectives for sustainable resource and energy use, management and transformation: approaches from green and sustainable chemistry and engineering

The special volume on green and sustainable chemistry and engineering has fourteen papers that were considered relevant to the present day issues and discussion, such as adequate use of raw materials and efficient energy, besides considering renewable sources for materials and energy; and changing economical canons towards circular economy. Businesses, governments and Society are facing a number of challenges to tread the sustainability path and provide wellbeing for future generations. This special volume relevance provides discussions and contributions to foster that desirable future. Chemicals are ubiquitous in everyday activities. Their widespread presence provides benefits to societies’ wellbeing, but can have some deleterious effects. To counteract such effect, green engineering and sustainable assessment in industrial processes have been gathering momentum in the last thirty years. Green chemistry, green engineering, eco-efficiency, and sustainability are becoming a necessity for assessing and managing products and processes in the chemical industry. This special volume presents fourteen articles related to sustainable resource and energy use (five articles), circular economy (one article), cleaner production and sustainable process assessment (five article), and innovation in chemical products (three articles). Green and sustainable chemistry, as well as sustainable chemical engineering and renewable energy sources are required to foster and consolidate a transition towards more sustainable societies. This special volume present current trends in chemistry and chemical engineering, such as sustainable resource and energy use, circular economy, cleaner production and sustainable process assessment, and innovation in chemical products. This special volume provides insights in this direction and complementing other efforts towards such transition

Feeding spectra and activity of the freshwater crab Trichodactylus kensleyi (Decapoda: Brachyura: Trichodactylidae) at La Plata basin

Background: In inland water systems, it is important to characterize the trophic links in order to identify the ‘trophic species’ and, from the studies of functional diversity, understand the dynamics of matter and energy in these environments. The aim of this study is to analyze the natural diet of Trichodactylus kensleyi of subtropical rainforest streams and corroborate the temporal variation in the trophic activity during day hours. Results: A total of 15 major taxonomic groups were recognized in gut contents. The index of relative importance identified the following main prey items in decreasing order of importance: vegetal remains, oligochaetes, chironomid larvae, and algae. A significant difference was found in the amount of full stomachs during day hours showing a less trophic activity at midday and afternoon. The index of relative importance values evidenced the consumption of different prey according to day moments. Results of the gut content indicate that T. kensleyi is an omnivorous crab like other trichodactylid species. Opportunistic behavior is revealed by the ingestion of organisms abundant in streams such as oligochaetes and chironomid larvae. The consumption of allochthonous plant debris shows the importance of this crab as shredder in subtropical streams. However, the effective assimilation of plant matter is yet unknown in trichodactylid crabs. Conclusions: This research provides knowledge that complements previous studies about trophic relationships of trichodactylid crabs and supported the importance of T. kensleyi in the transference of energy and matter from benthic community and riparian sources to superior trophic levels using both macro- and microfauna.Fil: Williner, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias; ArgentinaFil: de Azevedo Carvalho, Debora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; ArgentinaFil: Collins, Pablo Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentin