1,730 research outputs found
Controlled Contact to a C60 Molecule
The conductance of C60 on Cu(100) is investigated with a low-temperature
scanning tunneling microscope. At the transition from tunneling to the contact
regime the conductance of C60 adsorbed with a pentagon-hexagon bond rises
rapidly to 0.25 conductance quanta G0. An abrupt conductance jump to G0 is
observed upon further decreasing the distance between the instrument's tip and
the surface. Ab-initio calculations within density functional theory and
non-equilibrium Green's function techniques explain the experimental data in
terms of the conductance of an essentially undeformed C60. From a detailed
analysis of the crossover from tunneling to contact we conclude that the
conductance in this region is strongly affected by structural fluctuations
which modulate the tip-molecule distance.Comment: 4 pages, 3 figure
Engineering Negative Differential Conductance with the Cu(111) Surface State
Low-temperature scanning tunneling microscopy and spectroscopy are employed
to investigate electron tunneling from a C60-terminated tip into a Cu(111)
surface. Tunneling between a C60 orbital and the Shockley surface states of
copper is shown to produce negative differential conductance (NDC) contrary to
conventional expectations. NDC can be tuned through barrier thickness or C60
orientation up to complete extinction. The orientation dependence of NDC is a
result of a symmetry matching between the molecular tip and the surface states.Comment: 5 pages, 4 figures, 1 tabl
Bayesian Error Estimation in Density Functional Theory
We present a practical scheme for performing error estimates for Density
Functional Theory calculations. The approach which is based on ideas from
Bayesian statistics involves creating an ensemble of exchange-correlation
functionals by comparing with an experimental database of binding energies for
molecules and solids. Fluctuations within the ensemble can then be used to
estimate errors relative to experiment on calculated quantities like binding
energies, bond lengths, and vibrational frequencies. It is demonstrated that
the error bars on energy differences may vary by orders of magnitude for
different systems in good agreement with existing experience.Comment: 5 pages, 3 figure
Evolution of Global Relativistic Jets: Collimations and Expansion with kKHI and the Weibel Instability
One of the key open questions in the study of relativistic jets is their
interaction with the environment. Here, we study the initial evolution of both
electron-proton and electron-positron relativistic jets, focusing on their
lateral interaction with the ambient plasma. We trace the generation and
evolution of the toroidal magnetic field generated by both kinetic
Kelvin-Helmholtz (kKH) and Mushroom instabilities (MI). This magnetic field
collimates the jet. We show that in electron-proton jet, electrons are
perpendicularly accelerated with jet collimation. The magnetic polarity
switches from the clockwise to anti-clockwise in the middle of jet, as the
instabilities weaken. For the electron-positron jet, we find strong mixture of
electron-positron with the ambient plasma, that results in the creation of a
bow shock. Merger of magnetic field current filaments generate density bumps
which initiate a forward shock. The strong mixing between jet and ambient
particles prevents full development of the jet on the studied scale. Our
results therefore provide a direct evidence for both jet collimation and
particle acceleration in the created bow shock. Differences in the magnetic
field structures generated by electron-proton and electron-positron jets may
contribute to observable differences in the polarized properties of emission by
electrons.Comment: 25 pages, 12 figures, ApJ, accepte
Associations between objective measures of physical activity, sleep and stress levels among preschool children
Radiation from accelerated particles in relativistic jets with shocks, shear-flow, and reconnection
We have investigated particle acceleration and shock structure associated
with an unmagnetized relativistic jet propagating into an unmagnetized plasma.
Strong magnetic fields generated in the trailing jet shock lead to transverse
deflection and acceleration of the electrons. We have self-consistently
calculated the radiation from the electrons accelerated in the turbulent
magnetic fields. We find that the synthetic spectra depend on the bulk Lorentz
factor of the jet, the jet temperature, and the strength of the magnetic fields
generated in the shock. We have also begun study of electron acceleration in
the strong magnetic fields generated by kinetic shear (Kelvin-Helmholtz)
instabilities. Our calculated spectra should lead to a better understanding of
the complex time evolution and/or spectral structure from gamma-ray bursts,
relativistic jets, and supernova remnants.Comment: 6 pages, 4 figures, 2012 Fermi Symposium proceedings - eConf C12102
Adherence to subcutaneous interferon beta-1a treatment using an electronic injection device:a prospective open-label Scandinavian noninterventional study (the ScanSmart study)
Background: Disease modifying drugs help control the course of relapsing remitting multiple sclerosis (RRMS); however, good adherence is needed for long-term outcomes.
Objective: To evaluate patient adherence to treatment with subcutaneous interferon beta-1a using RebiSmart® and assess injection-site reactions and treatment satisfaction.
Methods: This prospective, single-arm, open-label, noninterventional multicenter Phase IV trial included disease modifying drug-experienced mobile patients with RRMS. Adherence was measured over 12 weeks. Items 13–23, 35, 37, and 38 of the Multiple Sclerosis Treatment Concerns Questionnaire (injection-site reactions and treatment satisfaction) were recorded at 12 weeks.
Results: Sixty patients were recruited (mean age 43.7 [±SD 7.9] years; 83% female; mean years since multiple sclerosis diagnosis 6.7 [SD 4.5]). Adherence data were obtained in 54 patients only due to technical problems with six devices. Over 12 weeks, 89% (n=48) of patients had ≥90% adherence to treatment. Most patients experienced mild influenza-like symptoms and injection-site reactions, and global side effects were minimal. Most patients (78%) rated the convenience as the most important aspect of the device, and most experienced no or mild pain.
Conclusion: RRMS patients treated with subcutaneous interferon beta-1a, administered with RebiSmart, demonstrated generally good adherence, and the treatment was generally well tolerated
Clinical trialist perspectives on the ethics of adaptive clinical trials: a mixed-methods analysis
Abstract
Background
In an adaptive clinical trial (ACT), key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also may involve ethical considerations that differ from more traditional randomized trials. Better understanding of clinical trial experts’ views about the ethical aspects of adaptive designs could assist those planning ACTs. Our aim was to elucidate the opinions of clinical trial experts regarding their beliefs about ethical aspects of ACTs.
Methods
We used a convergent, mixed-methods design employing a 22-item ACTs beliefs survey with visual analog scales and open-ended questions and mini-focus groups. We developed a coding scheme to conduct thematic searches of textual data, depicted responses to visual analog scales on box-plot diagrams, and integrated findings thematically. Fifty-three clinical trial experts from four constituent groups participated: academic biostatisticians (n = 5); consultant biostatisticians (n = 6); academic clinicians (n = 22); and other stakeholders including patient advocacy, National Institutes of Health, and U.S. Food and Drug Administration representatives (n = 20).
Results
The respondents recognized potential ethical benefits of ACTs, including a higher probability of receiving an effective intervention for participants, optimizing resource utilization, and accelerating treatment discovery. Ethical challenges voiced include developing procedures so trial participants can make informed decisions about taking part in ACTs and plausible, though unlikely risks of research personnel altering enrollment patterns.
Conclusions
Clinical trial experts recognize ethical advantages but also pose potential ethical challenges of ACTs. The four constituencies differ in their weighing of ACT ethical considerations based on their professional vantage points. These data suggest further discussion about the ethics of ACTs is needed to facilitate ACT planning, design and conduct, and ultimately better allow planners to weigh ethical implications of competing trial designs.http://deepblue.lib.umich.edu/bitstream/2027.42/111302/1/12910_2015_Article_22.pd
Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial.
An international network to monitor the structure, composition and dynamics of Amazonian forests (RAINFOR)
The Amazon basin is likely to be increasingly affected by environmental changes: higher temperatures, changes in precipitation, CO2 fertilization and habitat fragmentation. To examine the important ecological and biogeochemical consequences of these changes, we are developing an international network, RAINFOR, which aims to monitor forest biomass and dynamics across Amazonia in a co-ordinated fashion in order to understand their relationship to soil and climate. The network will focus on sample plots established by independent researchers, some providing data extending back several decades. We will also conduct rapid transect studies of poorly monitored regions. Field expeditions analysed local soil and plant properties in the first phase (2001–2002). Initial results suggest that the network has the potential to reveal much information on the continental-scale relations between forest and environment. The network will also serve as a forum for discussion between researchers, with the aim of standardising sampling techniques and methodologies that will enable Amazonian forests to be monitored in a coherent manner in the coming decades
- …