Caracteres geoquímicos y mineralógicos del yacimiento de Sn y Au de Montejo (Salamanca)

[Resumen] El yacimiento situado al S. E. de la Provincia de Salamanca está constituido por una serie de filones de cuarzo brechificado de dirección E-W, subverticales y encajados en materiales pertenecientes al Complejo Esquistograuváquico (Formación Monterrubio, dominando en esta zona esquistos, grauvacas y microconglomerados). Fue explotado durante los años 40 y 50 para Sn y esporádicamente para Au. Se han estudiado al microscopio 80 preparaciones pulidas y transparentes seleccionadas en cuatro sondeos de 250 metros, calicatas y antiguas escombreras, con el fin de caracterizar paragénesis, sucesión de la mineralización y alteraciones hidrotermales relacionadas. También se ha realizado un muestréo en las zonas mineralizadas y con alteración hidrotermal para su estudio geoquímico. Se han analizado: Au, As, Sb, Bi, Cu, Pb, Zn, Sn, Rb, Sr y Ba en 40 muestras. Las relaciones intereleme~ntales más evidentes son: Au-Sn-Bi y Cu-Sb. Por otro lado, se correlacionan los resultados geoquímicos con los diversos tipos de alteraciones hidrotermales.[Abstract] This tin-gold deposit is located in the SE Salamanca province. Mineralization is associated with several quartz-veins and breccias in metamorphic terrains of Precambrian-Cambrian ages (<<Complejo Esquistograuváquico»). Were studied microscopically 80 samples of four drillings (250 m deep) and other surface sampIes. It is presented mineral paragenesis and wall-rocks alterations relationed with mineralization. The geochemical stady include determinations of Au, As, Sb, Bi, Cu, Pb, Zn, Sn, Rb, Sr and Ba. A factor analysis on the geochemical data stablished the fo11owing associations: Au-Sn-Bi and Cu-Sb

Lesiones en el manguito rotador tras luxación anterior de hombro en pacientes mayores de 40 años.

Se ha realizado un estudio prospectivo de la evolución de 32 luxaciones anteriores de hombro en pacientes de más de 40 años con el objetivo de establecer la incidencia, localización y tipo de rotura del manguito rotador a causa de la luxación, conocer evolución clínica y establecer los criterios clínicos que nos permitan sospechar una rotura del manguito rotador, sin necesidad de recurrir a resonancia magnética (RM) de entrada. Los pacientes fueron sometidos a estudio mediante RM, clasificando las lesiones observadas en cinco grados en función de la extensión de la rotura, siendo el grupo 1 la integridad del manguito. El 90% de los casos presentó una rotura del manguito rotador asociada a la luxación. Tras un periodo de rehabilitación se demostró una diferencia significativa en la recuperación de la abducción en los pacientes con manguito íntegro, siendo un signo clínico de importancia para valorar el estado del manguito rotador.A prospective study of the evolution of 32 anterior dislocations of the shoulder in patients older than forty years has been done with the objective of establishing the incidence, location and kind of tear caused by the dislocation, to know the evolution and to establish the clinical parameters that allow us to suspect an injury of the rotator cuff without the help of magnetic resonance (MR) in the beginning. All the patients were studied with MR, doing a classification of the tears in five degrees, depending on the extension of the tears, being the group 1 the integrity of the rotator cuff. In 90% of the cases a rotator cuff tear has been found to be associated with the dislocation. After the rehabilitation, a significative difference in the recovery of the abduction has been demonstrated in the patients with integrity of the rotator cuff, being an important clinical sign to know the state of the rotator cuff

Parrel, vinífera aragonesa de la depresión del Ebro. Adaptación a terroir semiáridos de cultivo

En el marco del proyecto VALOVITIS (Programa POCTEFA 2014-2020) de identificación y evaluación de variedades minoritarias en el Piedemonte Pirenaico, se está trabajando y sometiendo a estudio la variedad PARREL. Tras los resultados obtenidos en sucesivas campañas de vendimia y vinificación semi-industrial, la variedad Parrel destaca como una de las variedades autóctonas de la región de Aragón con mayor potencial para su posterior desarrollo comercial atendiendo a sus propiedades agronómicas, enológicas a su resistencia a enfermedades como el oídio y a su capacidad de adaptación a condiciones climáticas continentales caracterizadas por elevadas oscilaciones térmicas a lo largo del año

Elastografía cuantitativa en la evaluación de nódulos tiroideos

Objective To retrospectively assess the diagnostic capacity of quantitative elastography to determine the odds between benign and malignant thyroid nodules, and determine its usefulness in deciding which nodules should be subjected to fine needle aspiration puncture (FNA). Patients and methods 203 thyroid nodules from 195 patients referred by the Endocrinology Service for cytological study during the year 2018 were analyzed. All of them underwent conventional ultrasound, quantitative elastography and FNA. A statistical analysis was performed using logistic regression that relates the probability that a nodule is suspected of malignancy and the elasticity value measured in kilopascals (kPa) and the elastographic ratio. Results There is a significant and positive relationship between the cytological result of Bethesda V / VI and the kPas / elastographic ratio. FNA is recommended for those nodules with values greater than 25kPa and / or elastographic ratio greater than 1.5. Conclusion Quantitative elastography is a useful tool that, together with other ultrasound parameters, would help to predict the malignancy of a thyroid nodule and to better select for FNA. © 2021 Georg Thieme Verlag. All rights reserved

Human papillomavirus infection in honduran women with normal cytology

Contains fulltext : 80440.pdf (publisher's version ) (Closed access)OBJECTIVE: This study was aimed at estimating type-specific HPV prevalence and its cofactors among Honduran women with normal cytology in order to provide valuable information to health policymakers about the epidemiology of this important sexually transmitted infection. METHODS: A total of 591 women with normal cytology from Tegucigalpa, Honduras were interviewed and tested for HPV using the SPF10 LiPA25. A structured epidemiological questionnaire was administered to each woman. RESULTS: The overall HPV prevalence was 51%. Twenty-three types of HPV were detected; HPV 16, 51, 31, 18, and 11 were the most common. The highest prevalence of cancer associated HPV types (15.0%) was found in the women less than 35 years. Besides the association with age, the main independent predictors of HPV infection were the lifetime number of sexual partners and having a low socioeconomic status and less than 5 previous Pap smears. CONCLUSIONS: In the population studied, there was a broad diversity of HPV infections, with high-risk types being the most common types detected. The establishment of a well-characterized population with regard to the community prevalence of type-specific HPV infection will provide a valuable baseline for monitoring population effectiveness of an HPV vaccine

Chikungunya virus infections among travellers returning to Spain, 2008 to 2014

Since the first documented autochthonous transmission of chikungunya virus in the Caribbean island of Saint Martin in 2013, the infection has been reported within the Caribbean region as well as North, Central and South America. The risk of autochthonous transmission of chikungunya virus becoming established in Spain may be elevated due to the large numbers of travellers returning to Spain from countries affected by the 2013 epidemic in the Caribbean and South America, as well as the existence of the Aedes albopictus vector in certain parts of Spain. We retrospectively analysed the laboratory diagnostic database of the National Centre for Microbiology, Institute of Health Carlos III (CNM-ISCIII) from 2008 to 2014. During the study period, 264 confirmed cases, of 1,371 suspected cases, were diagnosed at the CNM-ISCIII. In 2014 alone, there were 234 confirmed cases. The highest number of confirmed cases were reported from the Dominican Republic (n = 136), Venezuela (n = 30) and Haiti (n = 11). Six cases were viraemic in areas of Spain where the vector is present. This report highlights the need for integrated active case and vector surveillance in Spain and other parts of Europe where chikungunya virus may be introduced by returning travellers

Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution

<p>Abstract</p> <p>Background</p> <p>In gene expression analysis, statistical tests for differential gene expression provide lists of candidate genes having, individually, a sufficiently low <it>p</it>-value. However, the interpretation of each single <it>p</it>-value within complex systems involving several interacting genes is problematic. In parallel, in the last sixty years, <it>game theory </it>has been applied to political and social problems to assess the power of interacting agents in forcing a decision and, more recently, to represent the relevance of genes in response to certain conditions.</p> <p>Results</p> <p>In this paper we introduce a Bootstrap procedure to test the null hypothesis that each gene has the same relevance between two conditions, where the relevance is represented by the Shapley value of a particular coalitional game defined on a microarray data-set. This method, which is called <it>Comparative Analysis of Shapley value </it>(shortly, CASh), is applied to data concerning the gene expression in children differentially exposed to air pollution. The results provided by CASh are compared with the results from a parametric statistical test for testing differential gene expression. Both lists of genes provided by CASh and t-test are informative enough to discriminate exposed subjects on the basis of their gene expression profiles. While many genes are selected in common by CASh and the parametric test, it turns out that the biological interpretation of the differences between these two selections is more interesting, suggesting a different interpretation of the main biological pathways in gene expression regulation for exposed individuals. A simulation study suggests that CASh offers more power than t-test for the detection of differential gene expression variability.</p> <p>Conclusion</p> <p>CASh is successfully applied to gene expression analysis of a data-set where the joint expression behavior of genes may be critical to characterize the expression response to air pollution. We demonstrate a synergistic effect between coalitional games and statistics that resulted in a selection of genes with a potential impact in the regulation of complex pathways.</p

Cost-effectiveness of human papillomavirus vaccination for prevention of cervical cancer in Taiwan

<p>Abstract</p> <p>Background</p> <p>Human papillomavirus (HPV) infection has been shown to be a major risk factor for cervical cancer. Vaccines against HPV-16 and HPV-18 are highly effective in preventing type-specific HPV infections and related cervical lesions. There is, however, limited data available describing the health and economic impacts of HPV vaccination in Taiwan. The objective of this study was to assess the cost-effectiveness of prophylactic HPV vaccination for the prevention of cervical cancer in Taiwan.</p> <p>Methods</p> <p>We developed a Markov model to compare the health and economic outcomes of vaccinating preadolescent girls (at the age of 12 years) for the prevention of cervical cancer with current practice, including cervical cytological screening. Data were synthesized from published papers or reports, and whenever possible, those specific to Taiwan were used. Sensitivity analyses were performed to account for important uncertainties and different vaccination scenarios.</p> <p>Results</p> <p>Under the assumption that the HPV vaccine could provide lifelong protection, the massive vaccination among preadolescent girls in Taiwan would lead to reduction in 73.3% of the total incident cervical cancer cases and would result in a life expectancy gain of 4.9 days or 8.7 quality-adjusted life days at a cost of US$324 as compared to the current practice. The incremental cost-effectiveness ratio (ICER) was US$23,939 per life year gained or US$13,674 per quality-adjusted life year (QALY) gained given the discount rate of 3$30,000 per QALY under most conditions, even when vaccine efficacy was suboptimal or when vaccine-induced immunity required booster shots every 13 years.</p> <p>Conclusions</p> <p>Although gains in life expectancy may be modest at the individual level, the results indicate that prophylactic HPV vaccination of preadolescent girls in Taiwan would result in substantial population benefits with a favorable cost-effectiveness ratio. Nevertheless, we should not overlook the urgency to improve the compliance rate of cervical screening, particularly for older individuals.</p

Population-based prevalence of cervical infection with human papillomavirus genotypes 16 and 18 and other high risk types in Tlaxcala, Mexico

This study was supported by the National Institute of Public Health of Mexico, the Coordinación de Investigación en Salud del Instituto Mexicano del Seguro Social, the Secretaría de Salud Tlaxcala, the Instituto Nacional de las Mujeres, and the Consejo Nacional de Ciencia y Tecnología [FOSISS 2013 202468]. Additional support has been provided by Roche Diagnostics, BD Diagnostics, DICIPA and Arbor Vita Corporation. The study sponsors did not played a role in designing the study, collecting, analyzing or interpreting the data, writing the report, or submitting this paper for publication. UC Berkeley Center for Global Public Health, Schoeneman Grant, Joint Medical Program Thesis Grant, and Cancer Research UK (C569/A10404)