Fatores limitadores à reabilitação da musculatura do assoalho pélvico em pacientes com incontinência urinária de esforço

A reabilitação da musculatura do assoalho pélvico tem sido preconizada por diversos autores como uma terapia de primeira linha para o tratamento da incontinência urinária de esforço. Apresenta vantagens por ser não invasiva, de baixo custo e sem efeitos colaterais. Porém, fatores como aderência, motivação, compreensão da terapia e deficiência esfincteriana podem interferir nos resultados dessa abordagem terapêutica. A fim de se conhecer o impacto dos fatores citados acima e se investigar o efeito de cada um destes na intervenção fisioterápica foi feita uma revisão da literatura.The rehabilitation of the pelvic floor muscles has been postulated by many authors as a firstline therapy for the treatment of stress urinary incontinence. It has advantages, such as being a noninvasive, lowcost therapy without side effects. However, factors such as adherence, motivation, therapy understanding and intrinsic sphincter deficiency can interfere with the results of this therapeutic approach. A literature review was carried out to understand the impact of aforementioned factors and investigate the effect of each one of them on the physical therapy intervention

DIABETES GESTACIONAL ASSISTIDA: PERFIL E CONHECIMENTO DAS GESTANTES

Pregnancy is a condition that can cause intolerance to carbohydrates when diagnosed during pregnancy is called Gestational Diabetes Mellitus. The presence of Gestational Diabetes Mellitus (GDM) implies high risk for mother and newborn. The study aims to: describe the socioeconomic, clinical and epidemiological profile of pregnant women with gestational diabetes; Understand the knowledge of pregnant women with gestational diabetes treated at a referral institution in women's health in the state of Ceará, about his condition. This is a study of qualitative and quantitative, qualitative predominance conducted in a public hospital in Fortaleza / Ce in the period August to October 2011, through a questionnaire. Quantitative data were analyzed using SPSS and qualitative data through the phenomenological method Amedeo Giorgi (1985). The results indicate that the diagnosis of 6 (35.4%) of participants DMG occurred before the 20th week of gestation; that the women surveyed, 11 (64.7%) reported that they had diabetic relatives, worrying evidence, given that family history is a risk factor for triggering DMG. It was also observed that 12 (70.06%) had prenatal consultation with the amount recommended by the Ministry of Health, yet the majority reported that it was not warned about DMG. We conclude that pregnant women interviewed did not have much information about their condition and possible complications.http://dx.doi.org/10.5902/2236583413504 A gravidez é um estado que pode provocar uma intolerância aos carboidratos e à Diabetes Mellitus (DM). Quando essa doença é diagnosticada durante a gravidez é denominada Diabetes Mellitus Gestacional (DMG). A presença de DMG implica alto risco para mãe e para o recém-nascido. O estudo tem como objetivos: descrever o perfil socioeconômico, epidemiológico e clínico das gestantes portadoras de DMG; Compreender o conhecimento das gestantes portadoras de DMG, atendidas em uma instituição de referência em saúde da mulher no Estado do Ceará, sobre sua patologia. Trata-se de um estudo de natureza qualitativa e quantitativa, com predominância qualitativa, realizado em um hospital público de Fortaleza/Ce, no período de agosto a outubro de 2011, através da aplicação de um questionário. Os dados quantitativos foram analisados através do programa estatístico SPSS e os dados qualitativos através do Método Fenomenológico de Amedeo Giorgi (1985).    Os resultados apontam que o diagnóstico de 6 (35,4%) das participantes DMG ocorreu antes da 20a semana de gestação; que das gestantes pesquisadas, 11 (64,7%) relataram que tinham parentes diabéticos, indício preocupante, tendo em vista que o histórico familiar é um fator de risco para desencadear DMG. Observou-se também que 12 (70,06%) tiveram o pré-natal com quantidade de consulta preconizada pelo Ministério da Saúde, mesmo assim a maioria informou que não foi alertada quanto a DMG. Conclui-se que as gestantes entrevistadas não possuem muita informação sobre sua patologia e possíveis complicações.Descritores: Saúde da Mulher; Diabetes Gestacional; Perfil de Saúde.

Targeted sequencing identifies novel variants in common and rare MODY genes

Background: Maturity-onset diabetes of the young (MODY) is a form of monogenic diabetes with autosomal dominant inheritance. To date, mutations in 11 genes have been frequently associated with this phenotype. In Brazil, few cohorts have been screened for MODY, all using a candidate gene approach, with a high prevalence of undiagnosed cases (MODY-X). Methods: We conducted a next-generation sequencing target panel (tNGS) study to investigate, for the first time, a Brazilian cohort of MODY patients with a negative prior genetic analysis. One hundred and two patients were selected, of which 26 had an initial clinical suspicion of MODY-GCK and 76 were non-GCK MODY. Results: After excluding all benign and likely benign variants and variants of uncertain significance, we were able to assign a genetic cause for 12.7% (13/102) of the probands. Three rare MODY subtypes were identified (PDX1/NEUROD1/ABCC8), and eight variants had not been previously described/mapped in genomic databases. Important clinical findings were evidenced in some cases after genetic diagnosis, such as MODY-PDX1/HNF1B. Conclusion: A multiloci genetic approach allowed the identification of rare MODY subtypes, reducing the large percentage of MODY-X in Brazilian cases and contributing to a better clinical, therapeutic, and prognostic characterization of these rare phenotypes

MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue

The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability

Chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. Its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) ≈500 ORFs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) wide-spread utilization of quorum sensing for control of inducible systems, all of which underpin the versatility and adaptability of the organism. The genome also contains extensive but incomplete arrays of ORFs coding for proteins associated with mammalian pathogenicity, possibly involved in the occasional but often fatal cases of human C. violaceum infection. There is, in addition, a series of previously unknown but important enzymes and secondary metabolites including paraquat-inducible proteins, drug and heavy-metal-resistance proteins, multiple chitinases, and proteins for the detoxification of xenobiotics that may have biotechnological applications