PID_16_17_LPA5_Anexo

Innovación EducativaPresenta un análisis del taller realizado CARDBOARD PROJECT por el profesor JAVIER BLANCO MARTÍN y la propuesta ganadora del concurso público para “CARDBOARD PROJECT. Workshop de investigación del cartón como elemento arquitectónico”. Residencia para instalación arquitectónica/escultórica, consistente en la investigación de un prototipo de refugio para damnificados en situaciones de emergencia con cartón “nido de abeja”. EfímerARQ WORKSHOP Exposición: “LA IN.REVERBERANCIA DEL CARTÓN Y OTRAS LUCES. EfímerARQ”. Realizada en diciembre de 2016. Lugar: LABORATORIO DE LAS ARTES DEL AYUNTAMIENTO DE VALLADOLID. ORGANIZADO POR: LAVA y E.T.S. ARQUITECTURA DE VALLADOLID. Profesor: JAVIER BLANCO MARTÍNDepartamento de Teoría de la Arquitectura y Proyectos Arquitectónico

X-ray microtomography analysis of the damage micromechanisms in 3D woven composites under low-velocity impact

3D woven composites reinforced with either S2 glass, carbon or a hybrid combination of both and containing either polyethylene or carbon z-yarns were tested under low-velocity impact. Different impact energies (in the range of 21–316 J) were used and the mechanical response (in terms of the impact strength and energy dissipated) was compared with that measured in high-performance, albeit standard, 2D laminates. It was found that the impact strength in both 2D and 3D materials was mainly dependent on the in-plane fiber fracture. Conversely, the energy absorption capability was primarily influenced by the presence of z-yarns, having the 3D composites dissipated over twice the energy than the 2D laminates, irrespective of their individual characteristics (fiber type, compaction degree, porosity, etc.). X-ray microtomography revealed that this improvement was due to the z-yarns, which delayed delamination and maintained the structural integrity of the laminate, promoting energy dissipation by tow splitting, intensive fiber breakage under the tup and formation of a plug by out-of-plane shear

Regulatory dispersion and the possibilities of electronic articulation of international private law with xml: The experience of the Team of Valladolid

El presente trabajo expone la funcionalidad del lenguaje XML en el tratamiento de documentos jurídicos y la experiencia del Grupo de Valladolid en dos proyectos de investigación relacionados con documentos del Derecho internacional privado de la Unión Europea. El trabajo, que se remonta al año 2003 y que llega hasta la actualidad, se materializó en varios prototipos de aplicaciones que permiten la gestión documental de un conjunto de normas europeas de Derecho Internacional Privado. El último capítulo se plantea la pregunta de si la tecnología digital puede ayudar a resolver los problemas actuales de dispersión normativa y de quiebra del sistema en el Derecho internacional privado español o si la tecnología no es capaz de resolver.The work presents the functionality of the XML language in the treatment of legal documents and the experience of the Team of Valladolid in two research projects dealing with documents of Private International Law of the European Union. The work, which started in 2003 and continues nowadays, has produced as result several applications that support the management of a set of International Private Law European rules. The paper concludes with the question of whether digital technology can help solve the current problems due to regulatory dispersion and the failure of the system in the Spanish Private International Law.Fil: Vicente Blanco, Dámaso Francisco Javier. Universidad de Valladolid; EspañaFil: Martínez González, Mercedes. Universidad de Valladolid; España. Institut National de Recherche en Informatique et en Automatique; FranciaFil: Alvite Díez, María Luisa. Universidad de León; EspañaFil: Dabove, Maria Isolina. Universidad Nacional de Rosario. Facultad de Derecho; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Towards an MDE-based approach to test entity reconciliation applications

The management of large volumes of data has given rise to significant challenges to the entity reconciliation problem (which refers to combining data from different sources for a unified vision) due to the fact that the data are becoming more unstructured, unclean and incomplete, need to be more linked, etc. Testing the applications that implement the entity reconciliation problem is crucial to ensure both the correctness of the reconciliation process and the quality of the reconciled data. In this paper, we present a first approach, based on MDE, which allows the creation of test models for the integration testing of entity reconciliation applications.Ministerio de Ciencia y Tecnología TIN2013-46928-C3-1-RMinisterio de Ciencia y Tecnología TIN2013-46928-C3-3-RMinisterio de Ciencia y Tecnología TIN2015-71938-REDTPrincipado de Asturias GRUPIN14-00

Early Integration Testing for Entity Reconciliation in the Context of Heterogeneous Data Sources

Entity reconciliation (ER) aims to combine data from different sources for a unified vision. The management of large volumes of data has given rise to significant challenges to the ER problem due to facts such as data becoming more unstructured, unclean, and incomplete or the existence of many datasets that store information about the same topic. Testing the applications that implement the ER problem is crucial to ensure both the correctness of the reconciliation process and the quality of the reconciled data. This paper presents an approach based on model-driven engineering that allows the creation of test models for the early integration testing of ER applications, contributing in three main aspects: the description of the elements of the proposed framework, the definition of the testing model, and the validation of the proposal through two real-world case studies. This validation verifies that the early integration testing of the ER application is capable of detecting a series of deficiencies, which a priori are not known and that will help to improve the final result that the ER application offers.Ministerio de Ciencia y Tecnología TIN2013-46928-C3-1-RMinisterio de Ciencia y Tecnología TIN2013-46928-C3-3-RMinisterio de Ciencia y Tecnología TIN2016-76956-C3-1-RMinisterio de Ciencia y Tecnología TIN2016-76956-C3-2-RMinisterio de Ciencia y Tecnología TIN2015-71938-RED

Hsp90 beta inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytes

Background: Hsp90 beta is a member of the Hsp90 family of protein chaperones. This family plays essential roles in the folding, maturation and activity of many proteins that are involved in signal transduction and transcriptional regulation. The role of this protein in chondrocytes is not well understood, although its increase in osteoarthritic cells has been reported. The present study aimed to explore the role of Hsp90 beta in key aspects of OA pathogenesis. Methods: Human OA chondrocytes were isolated from cartilage obtained from patients undergoing joint replacement surgery, and primary cultured. Cells were stimulated with proinflammatory cytokines (IL-1 beta or TNF-alpha) and nitric oxide donors (NOC-12 or SNP). For Hsp90 beta inhibition, two different chemical inhibitors (Geldanamycin and Novobiocin) were employed, or siRNA transfection procedures were carried out. Gene expression was determined by real-time PCR, apoptosis was quantified by flow cytometry and ELISA, and nitric oxide (NO) production was evaluated by the Griess method. Indirect immunofluorescence assays were performed to evaluate the presence of Hsp90 beta in stimulated cells. Results: Hsp90 beta was found to be increased by proinflammatory cytokines. Inhibition of Hsp90 beta by the chemicals Geldanamycin (GA) and Novobiocin (NB) caused a dose-dependent decrease of the NO production induced by IL-1 beta in chondrocytes, up to basal levels. Immunofluorescence analyses demonstrate that the NO donors NOC-12 and SNP also increased Hsp90 beta. Chemical inhibition or specific gene silencing of this chaperone reduced the DNA condensation and fragmentation, typical of death by apoptosis, that is induced by NO donors in chondrocytes. Conclusions: The present results show how Hsp90 beta modulates NO production and NO-mediated cellular death in human OA chondrocytes

Academic engagement: A diary study on the mediating role of academic support

© 2020 Elsevier Inc. Based on the Job Demands-Resources (JD-R) model, this diary study investigated the mediator role of academic resources in the relationship between personal resources and variables of well-being. The study postulates that the perceived level of academic support received by students during the day mediates the relationship between the levels of self-efficacy and curiosity, measured early in the day, and the level of academic engagement measured at the end of the day. Ninety-four undergraduates filled in a general questionnaire and subsequently completed a daily questionnaire, for 5 consecutive academic days (470 diary entries). The multilevel analysis showed a positive relationship between self-efficacy and curiosity and academic engagement. In addition, the results revealed a positive relationship between academic support and academic engagement. Finally, the results showed partial mediation of academic support in the relationship between self-efficacy and academic engagement and in the relationship between curiosity and academic engagement. The results can be used to improve teaching and learning programs in colleges and universities.This research was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES (Brazil), through a scholarship granted to the first author (process n° 99999.004301/2015-03

Active and healthy aging. How to promote it at work?

Revisión[ES] Introducción: Actualmente se está produciendo un acusado cambio demográfico en el que se observa un envejecimiento en la población activa, debido principalmente al aumento de la esperanza de vida y la disminución en las tasas de fecundidad. Resulta un desafío para nuestra sociedad el tratar de mejorar la calidad de vida del trabajador mayor.Objetivo: Identificar y evaluar las intervenciones más actuales en la promoción de la salud del trabajador mayor, fomentando el envejecimiento activo y saludable en su entorno laboral.Metodología: Se ha realizado una revisión bibliográfica basada en la literatura publicada durante el periodo de 2006-2016 en varias bases de datos científicas: MEDLINE, SCOPUS, IBECS, LILACS, y WOK.Resultados: La búsqueda produjo un total de 63 registros y tras la aplicación de filtros y criterios de exclusión e inclusión, se seleccionaron un total de 8 artículos (3 estudios transversales, 3 ensayos clínicos controlados aleatorizados y 2 ensayos clínicos cuasi-experimentales). Se evidenciaron resultados estadísticamente significativos en distintas estrategias de promoción de la salud en el trabajador mayor, repercutiendo positivamente en su desempeño laboral. Conclusiones: Se obtuvieron hallazgos positivos en determinados parámetros de salud (actividad física diaria, hábitos alimenticios, peso, BMI, etc.) en los programas cuyo objetivo era mantener la salud y bienestar del trabajador mayor. Además se ha constatado la falta de estudios longitudinales de calidad, existiendo la necesidad de generar evidencia para el ajuste de los actuales programas en función de la franja de edad, patología predominante en cada sector laboral y su correspondiente análisis coste efectividad. [EN] Introduction: The aging of the active workforce explains the strong demographic change which is nowadays taking place mainly due to both increasing longevity and decreasing fertility rates. It seems to be a challenge to improve the life quality of the older worker.Objective: To identify and evaluate the modern interventions in the health promotion of the older worker by encouraging an active and healthy aging at the workplace. Methods: A systematic review based on the literature published between 2006-2016 in different scientific databases has been carried out: MEDLINE, SCOPUS, IBECS, LILACS and WOK. Results: The search produced a total of 63 registers. After applying filters and inclusion and exclusion criteria a total of 8 original articles were selected: 3 cross-sectional studies, 3 randomised controlled studies and 2 non randomised control trials.Statistically significant results were observed in different health promotion strategies of the older worker improving the workplace activities. Conclusions: The articles aiming for the maintenance of health, well-being in active aging obtained positive results regarding several health indicators (daily physical activity, food habits, body weight, BMI, etc.). Still, quality longitudinal studies are scarce. There is a clear necessity to generate evidence adjusting the existing programmes according to the age, the predominant pathology in each labour sector and the corresponding cost-effectiveness analysis.N

Mechanomyographic Measures of Muscle Contractile Properties are Infuenced by Electrode Size and Stimulation Pulse Duration

The aim was to determine the efects of changing pulse duration and electrode size on muscle contractile properties. Thirty-six healthy young male participated in the study (age 24.8±5.8 years; height 178.2±0.6cm; body mass 71.8±7.3kg; self-reported weekly moderate intensity activity 3.5±1.2h·week−1). Tensiomyography was used to assess rectus femoris (RF) and vastus medialis (VM) muscles neuromuscular properties of the dominant leg according to the electrode size (3.2–5cm) and the stimulus length (0.2, 0.5, and 1ms). Maximal radial displacement (Dm); Contraction time (Tc); Delay time (Td); Sustained time (Ts) and Half relaxation time (Tr) were measured. Relative and absolute reliability was quantifed. To analyze the efects of the electrode and the stimulus length, a repeated-measures analysis of variance was used. Dm and Tc parameters showed for both muscles an excellent relative (0.95–0.99) and absolute reliability (1.6–4.2%). However, Ts and Tr showed low values of absolute reliability (4.4–40.9%). The duration of the stimulus length applied to the RF and VM and electrode size signifcantly infuences muscle’s contractile properties (p<0.05; η2 p=0.09–0.60). The Dm increases substantially as the duration of the stimulus increases and with the use of the larger electrode in both muscles. However, Tc and Td are less afected by both conditions and not entirely clear. Practically, our study suggests that a stimulus pulse duration of 1ms together with a 5 × 5cm electrode is necessary to reach a reliable and reproducible assessment of both RF and VM muscles contractile properties.Ciencias de la Actividad Física y del Deport

Monitoring the performance of wastewater treatment plants for organic matter removal using excitation-emission matrix fluorescence

This study has assessed the usefulness of excitation-emission matrix fluorescence (EEMF) as a fast and simple analytical technique to track changes in dissolved organic matter (DOM) during the sequence of treatment in wastewater treatment plants (WWTPs). Three different industrial wastewaters and treatment plants have been studied in this work: an industrial park wastewater treated in an independent line at the Burgos WWTP (Spain), a food industry wastewater (crisps and snacks manufacturing) that was treated in a MBR (Membrane Biological Reactor) pilot plant (University of Burgos) and a municipal landfill leachate treated in a physicochemical treatment plant within the same landfill. Removal percentages for the wastewater organic matter at each stage of the treatment plants were successfully obtained by monitoring the main fluorescence peaks: protein-like peaks (tryptophan-like peaks T1, T2 and tyrosine-like peaks B1, B2), humic-like peaks (fulvic-like peak A and humic-like peak C) and microbially-derived peak M. Therefore, EEMF readily allows the assessment of the reactivity of the different types of organic matter towards specific treatments, such as clarification, biodegradation, filtration, etc. Among the wastewaters studied, the food industry wastewater exhibited the greater diversity of fluorescence peaks (B1, B2, T1, T2, A1, A2 and M) whereas the landfill leachate only showed the presence of humic substances (mainly humic-like peak C). This study has demonstrated that EEMF is a useful and user-friendly technique to monitor the performance of wastewater treatment plants for organic matter removal, allowing a rapid response to potential problems in the treatment