Eugenol mitigated acute lung but not spermatic toxicity of C60 fullerene emulsion in mice

C60 fullerene (C60) is a nano-pollutant that can damage the respiratory system. Eugenol exhibits significant anti-inflammatory and antioxidant properties. We aimed to investigate the time course of C60 emulsion-induced pulmonary and spermatic harms, as well as the effect of eugenol on C60 emulsion toxicity. The first group of mice (protocol 1) received intratracheally C60 emulsion (1.0 mg/kg BW) or vehicle and were tested at 12, 24, 72 and 96 h (F groups) thereafter. The second group of mice (protocol 2) received intratracheally C60 emulsion or vehicle, 1 h later were gavaged with eugenol (150 mg/kg) or vehicle, and experiments were done 24 h after instillation. Lung mechanics, morphology, redox markers, cytokines and epididymal spermatozoa were analyzed. Protocol 1: Tissue damping (G) and elastance (H) were significantly higher in F24 than in others groups, except for H in F72. Morphological and inflammatory parameters were worst at 24 h and subsequently declined until 96 h, whereas redox and spermatic parameters worsened over the whole period. Eugenol eliminated the increase in G, H, cellularity, and cytokines, attenuated oxidative stress induced by C60 exposure, but had no effect on sperm. Hence, exposure to C60 emulsion deteriorated lung morphofunctional, redox and inflammatory characteristics and increased the risk of infertility. Furthermore, eugenol avoided those changes, but did not prevent sperm damage

Micropolíticas: devir, cooperação dissonante e experiência pura

This article traces the definition of the concept of micropolitics in a singular perspective of Critical Semiotics. It seeks supplements in the theories of Deleuze and Guattari to think of it as an underlying force to alliances that produce zones of becoming. Regarding the propositions of Rolnik and Guattari, it proposes the understanding of micropolitics as a process of dissonant cooperation among subjects positioned in distinct subjectivities, a process that makes these existential models deterritorialize themselves. Concerning the phenomenal characteristics of this process, it uses the thought of James and Lapoujade to understand that micropolitics is produced and intensified based on what these thinkers called pure experience.O artigo traça um percurso de definição do conceito de micropolítica em uma visada singular da Semiótica Crítica. Busca suplementos nas teorizações de Deleuze e Guattari para pensá-la enquanto força subjacente a alianças que produzem zonas de devir. Em relação às proposições de Rolnik e Guattari, projeta a compreensão da micropolítica enquanto processo de cooperação dissonante entre sujeitos posicionados em subjetividades distintas, processo que faz esses modelos existenciais desterritorializarem-se. Já considerando as características fenomênicas desse processo, recorre ao pensamento de James e de Lapoujade para compreender que a micropolítica é produzida e intensificada a partir do que esses filósofos chamaram de experiência pura

Physiological and biochemical evaluation of different types of recovery in national level Paralympic powerlifting

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Cartografia e diplomacia: usos geopolíticos da informação toponímica (1750-1850)

O artigo explora dimensões geopolíticas da toponímia, registradas em documentos cartográficos, desde as reformas empreendidas pelo consulado pombalino em meados do século XVIII, até às primeiras décadas do século XIX, em meio ao processo de afirmação do Estado imperial pós-colonial.This paper explores the geopolitical dimensions of toponymy as registered in cartographic documents dating from the reforms pushed through by the consulate of Marquis of Pombal in the mid 18th century to the early decades of the 19th century, as the post-colonial imperial State established itself

Data standardization of plant-pollinator interactions

Background: Animal pollination is an important ecosystem function and service, ensuring both the integrity of natural systems and human well-being. Although many knowledge shortfalls remain, some high-quality data sets on biological interactions are now available. The development and adoption of standards for biodiversity data and metadata has promoted great advances in biological data sharing and aggregation, supporting large-scale studies and science-based public policies. However, these standards are currently not suitable to fully support interaction data sharing. Results: Here we present a vocabulary of terms and a data model for sharing plant–pollinator interactions data based on the Darwin Core standard. The vocabulary introduces 48 new terms targeting several aspects of plant–pollinator interactions and can be used to capture information from different approaches and scales. Additionally, we provide solutions for data serialization using RDF, XML, and DwC-Archives and recommendations of existing controlled vocabularies for some of the terms. Our contribution supports open access to standardized data on plant–pollinator interactions. Conclusions: The adoption of the vocabulary would facilitate data sharing to support studies ranging from the spatial and temporal distribution of interactions to the taxonomic, phenological, functional, and phylogenetic aspects of plant–pollinator interactions. We expect to fill data and knowledge gaps, thus further enabling scientific research on the ecology and evolution of plant–pollinator communities, biodiversity conservation, ecosystem services, and the development of public policies. The proposed data model is flexible and can be adapted for sharing other types of interactions data by developing discipline-specific vocabularies of terms.Fil: Salim, José A. Universidade de Sao Paulo; BrasilFil: Saraiva, Antonio M.. Universidade de Sao Paulo; BrasilFil: Zermoglio, Paula Florencia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Patagonia Norte. Instituto de Investigaciones En Recursos Naturales, Agroecologia y Desarrollo Rural. - Universidad Nacional de Rio Negro. Instituto de Investigaciones En Recursos Naturales, Agroecologia y Desarrollo Rural.; ArgentinaFil: Agostini, Kayna. Universidade Federal do São Carlos; BrasilFil: Wolowski, Marina. Universidade Federal de Alfenas; BrasilFil: Drucker, Debora P.. Empresa Brasileira de Pesquisa Agropecuaria (embrapa);Fil: Soares, Filipi M.. Universidade de Sao Paulo; BrasilFil: Bergamo, Pedro J.. Jardim Botânico do Rio de Janeiro; BrasilFil: Varassin, Isabela G.. Universidade Federal do Paraná; BrasilFil: Freitas, Leandro. Jardim Botânico do Rio de Janeiro; BrasilFil: Maués, Márcia M.. Empresa Brasileira de Pesquisa Agropecuaria (embrapa);Fil: Rech, Andre R.. Universidade Federal dos Vales do Jequitinhonha e Mucuri; BrasilFil: Veiga, Allan K.. Universidade de Sao Paulo; BrasilFil: Acosta, Andre L.. Instituto Tecnológico Vale; BrasilFil: Araujo, Andréa C. Universidade Federal do Mato Grosso do Sul; BrasilFil: Nogueira, Anselmo. Universidad Federal do Abc; BrasilFil: Blochtein, Betina. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Freitas, Breno M.. Universidade Estadual do Ceará; BrasilFil: Albertini, Bruno C.. Universidade de Sao Paulo; BrasilFil: Maia Silva, Camila. Universidade Federal Rural Do Semi Arido; BrasilFil: Nunes, Carlos E. P.. University of Stirling; BrasilFil: Pires, Carmen S. S.. Empresa Brasileira de Pesquisa Agropecuaria (embrapa);Fil: Dos Santos, Charles F.. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Queiroz, Elisa P.. Universidade de Sao Paulo; BrasilFil: Cartolano, Etienne A.. Universidade de Sao Paulo; BrasilFil: de Oliveira, Favízia F. Universidade Federal da Bahia; BrasilFil: Amorim, Felipe W.. Universidade Estadual Paulista Julio de Mesquita Filho; BrasilFil: Fontúrbel, Francisco E.. Pontificia Universidad Católica de Valparaíso; ChileFil: da Silva, Gleycon V.. Ministério da Ciência, Tecnologia, Inovações. Instituto Nacional de Pesquisas da Amazônia; BrasilFil: Consolaro, Hélder. Universidade Federal de Catalão; Brasi

Nascidos vivos com hemangioma e linfangioma no Brasil: estudo epidemiológico.

Introduction: Hemangiomas and lymphangiomas represent congenital vascular conditions affecting the circulatory and lymphatic systems, respectively. Hemangiomas consist of abnormal blood vessels, while lymphangiomas are composed of altered lymphatic vessels. Both conditions are typically identified in newborns or young children, though they can manifest at any age. Methodology: This study constitutes a descriptive epidemiological analysis focused on investigating cases of hemangioma and lymphangioma in live births in Brazil. Data collection will be conducted through the Live Birth Information System (SINASC) during the period from 2017 to 2021. Results: In the Northern region, 25 cases were recorded, representing 4.86% of the total live births with hemangioma and lymphangioma in the sample. In the Northeast region, this proportion is slightly higher, with 76 cases, accounting for 14.79% of the total. The Southeast holds the highest proportion, with 316 cases, representing a significant 61.48% of the sample. In the Southern region, 69 cases were recorded, comprising 13.42% of the total. Finally, in the Central-West region, 28 cases were counted, representing 5.45% of the sample. Conclusion: This meticulous analysis of variables related to live births with these conditions provides valuable insights that go beyond mere numerical understanding. The relevance of this profile is evident when considering various aspects.Introdução: Hemangiomas e linfangiomas representam condições vasculares congênitas que afetam o sistema circulatório e linfático, respectivamente. Os hemangiomas são formados por vasos sanguíneos anormais, enquanto os linfangiomas são compostos por vasos linfáticos alterados. Ambas as condições são geralmente identificadas em recém-nascidos ou crianças pequenas, embora possam se manifestar em qualquer idade. Metodologia: Esta pesquisa configura uma análise epidemiológica descritiva voltada para a investigação de casos de hemangioma e linfangioma em nascidos vivos no Brasil. A coleta de dados será conduzida por meio do Sistema de Informações sobre Nascidos Vivos (SINASC) no período compreendido entre 2017 e 2021. Resultado: Na região Norte, foram registrados 25 casos, representando 4,86% do total de nascidos vivos com hemangioma e linfangioma na amostra. Já na região Nordeste, essa proporção é um pouco maior, com 76 casos, correspondendo a 14,79% do total. O Sudeste detém a maior proporção, com 316 casos, representando expressivos 61,48% da amostra. Na região Sul, foram registrados 69 casos, compreendendo 13,42% do total. Por fim, na região Centro-Oeste, foram contabilizados 28 casos, representando 5,45% da amostra. Conclusão: Essa análise minuciosa das variáveis relacionadas a nascidos vivos com essas condições proporciona insights valiosos que transcendem a simples compreensão numérica. A relevância desse perfil é evidente ao considerar vários aspectos

Data standardization of plant–pollinator interactions

Background: Animal pollination is an important ecosystem function and service, ensuring both the integrity of natural systems and human well-being. Although many knowledge shortfalls remain, some high-quality data sets on biological interactions are now available. The development and adoption of standards for biodiversity data and metadata has promoted great advances in biological data sharing and aggregation, supporting large-scale studies and science-based public policies. However, these standards are currently not suitable to fully support interaction data sharing. Results: Here we present a vocabulary of terms and a data model for sharing plant–pollinator interactions data based on the Darwin Core standard. The vocabulary introduces 48 new terms targeting several aspects of plant–pollinator interactions and can be used to capture information from different approaches and scales. Additionally, we provide solutions for data serialization using RDF, XML, and DwC-Archives and recommendations of existing controlled vocabularies for some of the terms. Our contribution supports open access to standardized data on plant–pollinator interactions. Conclusions: The adoption of the vocabulary would facilitate data sharing to support studies ranging from the spatial and temporal distribution of interactions to the taxonomic, phenological, functional, and phylogenetic aspects of plant–pollinator interactions. We expect to fill data and knowledge gaps, thus further enabling scientific research on the ecology and evolution of plant–pollinator communities, biodiversity conservation, ecosystem services, and the development of public policies. The proposed data model is flexible and can be adapted for sharing other types of interactions data by developing discipline-specific vocabularies of termsinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio