Pela via dos afetos: experiência universitária na trajetória política de jovens liberais

This paper deals with the impact of college experience regarding the identification of young students with political, economic, and social liberalism. The relevance of this experience in their paths is directly related to the affective dimension that links friendships to the construction of political affinities. The results we present here are part of an ethnographic investigation of two and a half years, and in-depth interviews with young liberals from Campina Grande, Paraíba, Brazil, that formed the Luís Gama Collective and showed how the arrival at the university allowed these young group of people to negotiate knowledge, dispositions and political preferences in a socio-political context of transition between the left-wing and extreme right-wing (2016-2018).Este artículo discute el impacto de la vivencia universitaria en la trayectoria de identificación de jóvenes estudiantes al liberalismo político, económico y social. La importancia de esta experiencia en sus trayectorias se relaciona a la dimensión afectiva que interconecta relaciones de amistad y construcción de afinidades políticas. Los resultados son parte de una investigación etnográfica de dos años y medio de duración, y de entrevistas en profundidad a jóvenes liberales de Campina Grande, Paraíba, Brasil, que conforman el colectivo Luis Gama, y muestran como la llegada a la universidad les permitió negociar saberes, disposiciones y preferencias políticas, en un contexto socio-político de transición entre izquierda y extrema derecha (2016-2018).Este artigo aborda o impacto da vivência universitária na trajetória de adesão de jovens estudantes até o liberalismo político, econômico e social. A importância que esta experiência assume em suas trajetórias está diretamente relacionada à dimensão afetiva que interconecta relações de amizade e construção de afinidades políticas. Os resultados aqui discutidos baseiam-se em dois anos e meio de pesquisa etnográfica e entrevistas em profundidade junto a jovens liberais em Campina Grande, Paraíba, que compõem o coletivo Luis Gama, e mostram como a chegada à universidade permitiu aos jovens interlocutores negociarem saberes, disposições e preferências políticas em um contexto sócio-político de transição entre esquerda e extrema direita (2016-2018)

Efficacy of Insulin Titration Driven by SMS in Improving Glycemic Control in People with Type 2 Diabetes

Insulin treatment; Text messaging; Type 2 diabetesTractament amb insulina; Missatge de text; Diabetis tipus 2Tratamiento con insulina; Mensaje de texto; Diabetes tipo 2Aim: To evaluate the efficacy of the self-management of insulin titration based on information received by the Short Message Service (SMS). Methods: A case-control study including 59 subjects in each arm with 16 weeks of follow-up was performed. The inclusion criteria were: (1) Subjects with type 2 diabetes (T2D) under basal insulin treatment; (2) Suboptimal glycemic control: HbA1c ≥ 7.5% and fasting capillary blood glucose (FCBG) > 140 mg/dL (>3 times per week). Subjects were invited to use an insulin titration service based on SMS feedback aimed at optimizing glycemic control depending on fasting blood glucose levels. Psychological aspects were evaluated in the interventional group by means of validated questionnaires (DDS, HADS and SF-12). Results: The intervention group achieved a lower mean FCBG (126 mg/dL ± 34 vs. 149 mg/dL ± 46, p = 0.001) and lower HbA1c (7.5% ± 1.3 vs. 7.9% ± 0.9, p = 0.021) than the control group. In addition, the intervention group showed a significant improvement in psychological aspects related to Emotional Burden (p = 0.031), Regimen Distress (p < 0.001), Depression (p = 0.049) and Mental Health (p < 0.01). Conclusions: The SMS-guided titration was effective in terms of improving glucometric parameters in comparison with the standard of care and improved significant psychological aspects—mainly, the stress associated with insulin treatmentThis research was funded by a Roche Diabetes Care unrestricted grant

HST/ACS Photometry of Old Stars in NGC 1569: The Star Formation History of a Nearby Starburst

(abridged) We used HST/ACS to obtain deep V- and I-band images of NGC 1569, one of the closest and strongest starburst galaxies in the Universe. These data allowed us to study the underlying old stellar population, aimed at understanding NGC 1569's evolution over a full Hubble time. We focus on the less-crowded outer region of the galaxy, for which the color-magnitude diagram (CMD) shows predominantly a red giant branch (RGB) that reaches down to the red clump/horizontal branch feature (RC/HB). A simple stellar population analysis gives clear evidence for a more complicated star formation history (SFH) in the outer region. We derive the full SFH using a newly developed code, SFHMATRIX, which fits the CMD Hess diagram by solving a non-negative least squares problem. Our analysis shows that the relative brightnesses of the RGB tip and RC/HB, along with the curvature and color of the RGB, provide enough information to ameliorate the age-metallicity-extinction degeneracy. The distance/reddening combination that best fits the data is E(B-V) = 0.58 +/- 0.03 and D = 3.06 +/- 0.18 Mpc. Star formation began ~ 13 Gyr ago, and this accounts for the majority of the mass in the outer region. However, the initial burst was followed by a relatively low, but constant, rate of star formation until ~ 0.5-0.7 Gyr ago when there may have been a short, low intensity burst of star formation.Comment: 50 pages, including 17 figures. Accepted for publication in A

Extrasinus Zygomatic Implants: Three Year Experience from a New Surgical Approach for Patients with Pronounced Buccal Concavities in the Edentulous Maxilla

Background: The surgical protocol for zygomatic fixtures prescribes an intrasinus approach ideally maintaining the sinus membrane intact and the implant body inside the sinus while gaining access to the zygomatic bone. In the presence of a pronounced buccal concavity, the implant head has to be placed far from the alveolar crest in a palatal direction, which results in a bulky bridge construction. Purpose: The aim of this study was to report on the preliminary experiences with zygomatic implants placed with an extrasinus approach in order to have the implant head emerging at or near the top of the alveolar crest. Materials and Methods: Twenty consecutive patients with pronounced buccal concavities in the edentulous posterior maxilla were treated with 104 regular and 36 zygomatic implants as support of fixed dental bridges. Sixteen patients were treated bilaterally and four patients were treated unilaterally. The zygomatic implants were inserted by using an extrasinus surgical approach with the implant body passing from the alveolar crest through the buccal concavity into the zygomatic bone. This enabled placement of the implant head at or close to the alveolar crest. The patients were followed from 36 to 48 months after occlusal loading with a mean follow-up of 41 months. The relation of the zygomatic implants to the crest was measured and compared with a control group of 20 patients treated with conventional placement of zygomatic implants. Results: No implants were lost during the study period. No pain, discomfort, or complications related to the extrasinus path of the zygomatic implants were recorded after the initial healing period and up to the 36th-month checkup. The zygomatic implants emerged, on average, 3.8 mm (SD 2.6) palatal to the top of the crest compared with 11.2 mm (SD 5.3) to the conventional technique. Conclusion: The present 3-year clinical study shows that an extrasinus approach can be utilized when placing zygomatic implants in patients with pronounced buccal concavities in the posterior maxilla. Moreover, the technique results in an emergence of the zygomatic fixture close to the top of the crest, which is beneficial from a cleaning and patient-comfort point of view.2.803 JCR (2010) Q1, 8/77 Dentistry, oral surgery & medicin

Distinct molecular signature of murine fetal liver and adult hematopoietic stem cells identifies novel regulators of hemapoietic stem cell function

During ontogeny, fetal liver (FL) acts as a major site for hematopoietic stem cell (HSC) maturation and expansion, whereas HSCs in the adult bone marrow (ABM) are largely quiescent. HSCs in the FL possess faster repopulation capacity as compared with ABM HSCs. However, the molecular mechanism regulating the greater self-renewal potential of FL HSCs has not yet extensively been assessed. Recently, we published RNA sequencing-based gene expression analysis on FL HSCs from 14.5-day mouse embryo (E14.5) in comparison to the ABM HSCs. We reanalyzed these data to identify key transcriptional regulators that play important roles in the expansion of HSCs during development. The comparison of FL E14.5 with ABM HSCs identified more than 1,400 differentially expressed genes. More than 200 genes were shortlisted based on the gene ontology (GO) annotation term "transcription." By morpholino-based knockdown studies in zebrafish, we assessed the function of 18 of these regulators, previously not associated with HSC proliferation. Our studies identified a previously unknown role for tdg, uhrf1, uchl5, and ncoa1 in the emergence of definitive hematopoiesis in zebrafish. In conclusion, we demonstrate that identification of genes involved in transcriptional regulation differentially expressed between expanding FL HSCs and quiescent ABM HSCs, uncovers novel regulators of HSC function.status: publishe

On-growth and in-growth osseointegration enhancement in PM porous Ti-scaffolds by two different bioactivation strategies: alkali thermochemical treatment and RGD peptide coating

A lack of primary stability and osteointegration in metallic implants may result in implant loosening and failure. Adding porosity to metallic implants reduces the stress shielding effect and improves implant performance, allowing the surrounding bone tissue to grow into the scaffold. However, a bioactive surface is needed to stimulate implant osteointegration and improve mechanical stability. In this study, porous titanium implants were produced via powder sintering to create different porous diameters and open interconnectivity. Two strategies were used to generate a bioactive surface on the metallic foams: (1) an inorganic alkali thermochemical treatment, (2) grafting a cell adhesive tripeptide (RGD). RGD peptides exhibit an affinity for integrins expressed by osteoblasts, and have been reported to improve osteoblast adhesion, whereas the thermochemical treatment is known to improve titanium implant osseointegration upon implantation. Bioactivated scaffolds and control samples were implanted into the tibiae of rabbits to analyze the effect of these two strategies in vivo regarding bone tissue regeneration through interconnected porosity. Histomorphometric evaluation was performed at 4 and 12 weeks after implantation. Bone-to-implant contact (BIC) and bone in-growth and on-growth were evaluated in different regions of interest (ROIs) inside and outside the implant. The results of this study show that after a long-term postoperative period, the RGD-coated samples presented higher quantification values of quantified newly formed bone tissue in the implant's outer area. However, the total analyzed bone in-growth was observed to be slightly greater in the scaffolds treated with alkali thermochemical treatment. These results suggest that both strategies contribute to enhancing porous metallic implant stability and osteointegration, and a combination of both strategies might be worth pursuing

On-Growth and In-Growth Osseointegration Enhancement in PM Porous Ti-Scaffolds by Two Different Bioactivation Strategies : Alkali Thermochemical Treatment and RGD Peptide Coating

A lack of primary stability and osteointegration in metallic implants may result in implant loosening and failure. Adding porosity to metallic implants reduces the stress shielding effect and improves implant performance, allowing the surrounding bone tissue to grow into the scaffold. However, a bioactive surface is needed to stimulate implant osteointegration and improve mechanical stability. In this study, porous titanium implants were produced via powder sintering to create different porous diameters and open interconnectivity. Two strategies were used to generate a bioactive surface on the metallic foams: (1) an inorganic alkali thermochemical treatment, (2) grafting a cell adhesive tripeptide (RGD). RGD peptides exhibit an affinity for integrins expressed by osteoblasts, and have been reported to improve osteoblast adhesion, whereas the thermochemical treatment is known to improve titanium implant osseointegration upon implantation. Bioactivated scaffolds and control samples were implanted into the tibiae of rabbits to analyze the effect of these two strategies in vivo regarding bone tissue regeneration through interconnected porosity. Histomorphometric evaluation was performed at 4 and 12 weeks after implantation. Bone-to-implant contact (BIC) and bone in-growth and on-growth were evaluated in different regions of interest (ROIs) inside and outside the implant. The results of this study show that after a long-term postoperative period, the RGD-coated samples presented higher quantification values of quantified newly formed bone tissue in the implant's outer area. However, the total analyzed bone in-growth was observed to be slightly greater in the scaffolds treated with alkali thermochemical treatment. These results suggest that both strategies contribute to enhancing porous metallic implant stability and osteointegration, and a combination of both strategies might be worth pursuing

Two different strategies to enhance osseointegration in porous titanium : Inorganic thermo-chemical treatment versus organic coating by peptide adsorption

In this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability