The use of satellite data, meteorology and land use data to define high resolution temperature exposure for the estimation of health effects in Italy

Introduction. Despite the mounting evidence on heat-related health risks, there is limited evidence in suburban and rural areas. The limited spatial resolution of temperature data also hinders the evidence of the differential heat effect within cities due to individual and area-based characteristics. Methods. Satellite land surface temperature (LST), observed meteorological and spatial and spatio-temporal land use data were combined in mixed-effects regression models to estimate daily mean air temperature with a 1x1km resolution for the period 2000-2010. For each day, random intercepts and slopes for LST were estimated to capture the day-to-day temporal variability of the Ta–LST relationship. The models were also nested by climate zones to better capture local climates and daily weather patterns across Italy. The daily exposure data was used to estimate the effects and impacts of heat on cause-specific mortality and hospital admissions in the Lazio region at municipal level in a time series framework. Furthermore, to address the differential effect of heat within an urban area and account for potential effect modifiers a case cross-over study was conducted in Rome. Mean temperature was attributed at the individual level to the Rome Population Cohort and the urban heat island (UHI) intensity using air temperature data was calculated for Rome. Results. Exposure model performance was very good: in the stage 1 model (only on grid cells with both LST and observed data) a mean R2 value of 0.96 and RMSPE of 1.1°C and R2 of 0.89 and 0.97 for the spatial and temporal domains respectively. The model was also validated with regional weather forecasting model data and gave excellent results (R2=0.95 RMSPE=1.8°C. The time series study showed significant effects and impacts on cause-specific mortality in suburban and rural areas of the Lazio region, with risk estimates comparable to those found in urban areas. High temperatures also had an effect on respiratory hospital admissions. Age, gender, pre-existing cardiovascular disease, marital status, education and occupation were found to be effect modifiers of the temperature-mortality association. No risk gradient was found by socio-economic position (SEP) in Rome. Considering the urban heat island (UHI) and SEP combined, differential effects of heat were observed by UHI among same SEP groupings. Impervious surfaces and high urban development were also effect modifiers of the heat-related mortality risk. Finally, the study found that high resolution gridded data provided more accurate effect estimates especially for extreme temperature intervals. Conclusions. Results will help improve heat adaptation and response measures and can be used predict the future heat-related burden under different climate change scenarios.Open Acces

Dichiarazione dei diritti della donna e della cittadina

Traduzione italiana della " Déclaration des droits de la femme et de la citoyenne" scritta da Olympe de Gouges nel 179

Realistic estimation for the detectability of dark matter subhalos using Fermi-LAT catalogs

Numerical simulations of structure formation have made remarkable progress in recent years, in particular due to the inclusion of baryonic physics evolving with the dark matter component. We generate Monte Carlo realizations of the dark matter subhalo population based on the results of the recent hydrodynamical simulation suite of Milky Way–sized galaxies [F. Marinacci, R. Pakmor, and V. Springel, Mon. Not. R. Astron. Soc. 437, 1750 (2014).MNRAA40035-871110.1093/mnras/stt2003]. We then simulate the gamma-ray sky for both the setup of the 3FGL and 2FHL Fermi Large Area Telescope (LAT) catalogs, including the contribution from the annihilation of dark matter in the subhalos. We find that the flux sensitivity threshold strongly depends on the particle dark matter mass and, more mildly, also on its annihilation channel and the observation latitude. The results differ for the 3FGL and 2FHL catalogs, given their different energy thresholds. We also predict that the number of dark matter subhalos among the unassociated sources is very small. A null number of detectable subhalos in the Fermi-LAT 3FGL catalog would imply upper limits on the dark matter annihilation cross section into bb[over ¯] of 2×10^{-26}(5×10^{-25})  cm^{3}/s with M_{DM}=50(1000)  GeV. We find less than one extended subhalo in the Fermi-LAT 3FGL catalog. As a matter of fact, the differences in the spatial and mass distribution of subhalos between hydrodynamic and dark matter–only runs do not have significant impact on the detectability of dark subhalos in gamma rays

Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update meta-analysis on phase III trials

Background: To analyze the efficacy and toxicity of bevacizumab on survival outcomes in recurrent ovarian cancer. Results: Bevacizumab was associated with significant improvement of PFS and OS compared with standard treatment with HRs of 0.53 (95% CI 0.44 - 0.63; p < 0.00001) and 0.87 (95% CI, 0.77 to 0.99; p = 0.03), respectively. Bevacizumab increased the incidence of G3/G4 hypertension (RR 19.01, 95% CI 7.77 - 46.55; p < 0.00001), proteinuria (RR 17.31, 95% CI 5.42 - 55.25; p < 0.00001), arterial thromboembolic events (ATE) (RR 4.99, 95% CI 1.29 - 19.27; p = 0.02) and bleeding (RR 3.14, 95% CI 1.35 - 7.32; p = 0.008). Materials and Methods: Three randomized phase III trials representing 1502 patients were identified. Pooled hazard ratio (HR), odd ratio (OR), risk ratio (RR) with 95% confidence interval (CI) were calculated using fixed or random effects model. Conclusions: Adding bevacizumab to standard chemotherapy improved ORR, PFS and OS, and it had a higher, but manageable, incidence of toxicities graded 3 to 4

Insights into the Structure of Dot@Rod and Dot@Octapod CdSe@CdS Heterostructures

CdSe@CdS dot@rods with diameter around 6 nm and length of either 20, 27, or 30 nm and dot@octapods with pod diameters of ?15 nm and lengths of ?50 nm were investigated by X-ray absorption spectroscopy. These heterostructures are prepared by seed-mediated routes, where the structure, composition, and morphology of the CdSe nanocrystals used as a seed play key roles in directing the growth of the second semiconducting domain. The local structural environment of all the elements in the CdSe@CdS heterostructures was investigated at the Cd, S, and Se K-edges by taking advantage of the selectivity of X-ray absorption spectroscopy, and was compared to pure reference compounds. We found that the structural features of dot@rods are independent of the size of the rods. These structures can be described as made of a CdSe dot and a CdS rod, both in the wurtzite phase with a high crystallinity of both the core and the rod. This result supports the effectiveness of high temperature colloidal synthesis in promoting the formation of core@shell nanocrystals with very low defectivity. On the other hand, data on the CdSe@CdS with octapod morphology suggest the occurrence of a core composed of a CdSe cubic sphalerite phase with eight pods made of CdS wurtzite phase. Our findings are compared to current models proposed for the design of functional heterostructures with controlled nanoarchitecture

Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps

This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic transformation and regeneration in Italy during the 1980s. Following his scientific interests as guiding principles, this review summarizes the recent advances obtained in plant biotechnology and fundamental research aiming to: (i) Exploit in vitro plant cell and tissue cultures to induce genetic variability and to produce useful metabolites; (ii) gain new insights into the biochemical function of Agrobacterium rhizogenes rol genes and their application to metabolite production, fruit tree transformation, and reverse genetics; (iii) improve genetic transformation in legume species, most of them recalcitrant to regeneration; (iv) untangle the potential of KNOTTED1-like homeobox (KNOX) transcription factors in plant morphogenesis as key regulators of hormonal homeostasis; and (v) elucidate the molecular mechanisms of the transition from juvenility to the adult phase in Prunus tree species

Through-and-through femorofemoral wire retrograde technique for the E-nside precannulated inner branch thoracoabdominal stent graft

The E-nside multibranched stent graft (Jotec GmbH, Hechingen, Germany) is the first and only off-the-shelf thoracoabdominal prosthesis with precannulated inner branches. Usually, after the device deployment, target vessel stenting will be facilitated by antegrade inner branch cannulation to retrieve the precannulated guide. In the literature, the use of antegrade access has been associated with the potential risk of cerebral and systemic embolization. Therefore, other retrograde techniques have been described. We have reported a new retrograde approach using a precannulated through-and-through femorofemoral wire technique for target vessel catheterization

Defining discovery:is Google Scholar a discovery platform? An essay on the need for a new approach to scholarly discovery

This essay discusses the concept of discovery, intended as content discovery, and defines it in the new context of Open Science, with a focus on Social Sciences and Humanities (SSH). Starting from the example of Google Scholar, the authors show that this well established service does not address the current needs, practices, and variety of discovery. Alternatives in terms of technical choices, features, and governance, do however exist, offering richer and more open discovery. The paper presents in particular the implementations and research work of the H2020 project TRIPLE (Transforming Research through Innovative Practices for Linked Interdisciplinary Exploration). Dedicated to the building of a discovery platform for the SSH, the project is meant to address the specificities and evolution of discovery in this field. Prevailing scholarly resource platforms like Google Scholar limit discovery by focussing only on publications, and favouring through their algorithm well-cited papers, English content, and discipline-specific resources. A limitation in the context of cross-disciplinary and collaborative Open Science, such a service more specifically hinders discovery in the SSH. Characterized by a fragmented landscape, a variety of languages, data types, and outputs, research in the SSH requires services that fully exploit discovery potentialities. Moreover, a survey conducted within the TRIPLE project showed that most SSH researchers use Google Scholar as their starting point, and that they recognise the lack of control they have with this system. Beyond the extension of features and content, transparency is the other important criterion for the building of an Open Infrastructure actually serving the research community. In light of this, we present in some detail the GoTriple platform, which exploits today's technological potential and incorporates the best known functionalities in order to unveil more and innovative scholarly outputs and lead to international and interdisciplinary research project collaborations

The Balance Between the Therapeutic Efficacy and Safety of [¹⁷⁷Lu]Lu-NeoB in a Preclinical Prostate Cancer Model

Purpose: Radiolabeled NeoB is a promising gastrin-releasing peptide receptor (GRPR)–targeting radiopharmaceutical for theranostics of GRPR-expressing malignancies, e.g., prostate cancer (PCa). The aim of this study was to evaluate the effect of different doses of [177Lu]Lu-NeoB on the balance between therapeutic efficacy and safety in a preclinical PCa model. Procedures: To determine the efficacy of [177Lu]Lu-NeoB, PC-3 xenografted mice received 3 sham injections (control group) or 3 injections of 30 MBq/300 pmol, 40 MBq/400 pmol, or 60 MBq/600 pmol [177Lu]Lu-NeoB (groups 1, 2, and 3, respectively) 1 week apart. To quantify tumor uptake, single-photon emission computed tomography/computed tomography (SPECT/CT) imaging was performed 4 h after the first, second, and third injection on a separate group of animals. For safety evaluations, pancreatic and renal tissues of non-tumor-bearing mice treated with the abovementioned [177Lu]Lu-NeoB doses were evaluated 12 and 24 weeks post-treatment. Results: Treatment of PC-3 tumors with all three studied [177Lu]Lu-NeoB doses was effective. Median survival times were significantly (p &lt; 0.0001) improved for treatment groups 1, 2, and 3 versus the control group (82 days, 89 days, 99 days versus 19 days, respectively). However, no significant differences were observed between treatment groups. Quantification of SPECT/CT images showed minimal differences in the average absolute radioactivity uptake, especially after the third injection. Histopathological analysis revealed no clear signs of treatment-related pancreatic toxicity. For the kidneys, atrophy and fibrosis were observed for one animal from group 1 and a chronic inflammatory response was observed for both animals from group 3 at 24 weeks post-treatment. Conclusions: Treatment with [177Lu]Lu-NeoB is effective in a preclinical PCa model. Adjusting the administered dose could positively impact the risk-benefit balance as a higher dose might not lead to an increased therapeutic effect, but it may lead to an increase in toxicological effects in healthy organs such as the kidneys.</p