3,863 research outputs found
The Protostellar Mass Function
The protostellar mass function (PMF) is the Present-Day Mass Function of the
protostars in a region of star formation. It is determined by the initial mass
function weighted by the accretion time. The PMF thus depends on the accretion
history of protostars and in principle provides a powerful tool for
observationally distinguishing different protostellar accretion models. We
consider three basic models here: the Isothermal Sphere model (Shu 1977), the
Turbulent Core model (McKee & Tan 2003), and an approximate representation of
the Competitive Accretion model (Bonnell et al. 1997, 2001a). We also consider
modified versions of these accretion models, in which the accretion rate tapers
off linearly in time. Finally, we allow for an overall acceleration in the rate
of star formation. At present, it is not possible to directly determine the PMF
since protostellar masses are not currently measurable. We carry out an
approximate comparison of predicted PMFs with observation by using the theory
to infer the conditions in the ambient medium in several star-forming regions.
Tapered and accelerating models generally agree better with observed
star-formation times than models without tapering or acceleration, but
uncertainties in the accretion models and in the observations do not allow one
to rule out any of the proposed models at present. The PMF is essential for the
calculation of the Protostellar Luminosity Function, however, and this enables
stronger conclusions to be drawn (Offner & McKee 2010).Comment: 16 pages, 8 figures, published in Ap
A History of Falls is Associated with a Significant Increase in Acute Mortality in Women after Stroke
Background and Purpose: The risks of falls and fractures increase after stroke. Little is known about the prognostic significance of previous falls and fractures after stroke. This study examined whether having a history of either event is associated with poststroke mortality. Methods: We analyzed stroke register data collected prospectively between 2003 and 2015. Eight sex-specific models were analyzed, to which the following variables were incrementally added to examine their potential confounding effects: age, type of stroke, Oxfordshire Community Stroke Project classification, previous comorbidities, frailty as indicated by the prestroke modified Rankin Scale score, and acute illness parameters. Logistic regression was applied to investigate in-hospital and 30-day mortality, and Cox proportional-hazards models were applied to investigate longer-term outcomes of mortality. Results: In total, 10,477 patients with stroke (86.1% ischemic) were included in the analysis. They were aged 77.7±11.9 years (mean±SD), and 52.2% were women. A history of falls was present in 8.6% of the men (n=430) and 20.2% of the women (n=1,105), while 3.8% (n=189) of the men and 12.9% of the women (n=706) had a history of both falls and fractures. Of the outcomes examined, a history of falls alone was associated with increased in-hospital mortality [odds ratio (OR)=1.33, 95% confidence interval (CI)=1.03–1.71] and 30-day mortality (OR=1.34, 95% CI=1.03–1.73) in women in the fully adjusted models. The Cox proportional-hazards models for longer-term outcomes and the history of falls and fractures combined showed no significant results. Conclusions: The history of falls is an important factor for acute stroke mortality in women. A previous history of falls may therefore be an important factor to consider in the short-term stroke prognosis, particularly in women
A Remarkable Three Hour Thermonuclear Burst From 4U 1820-30
We present a detailed observational and theoretical study of a ~3 hr long
X-ray burst (the ``super burst'') observed by the Rossi X-ray Timing Explorer
(RXTE) from the low mass X-ray binary (LMXB) 4U 1820-30. This is the longest
X-ray burst ever observed from this source, and perhaps one of the longest ever
observed in great detail from any source. We show that the super burst is
thermonuclear in origin. The level of the accretion driven flux as well as the
total energy release of ~1.5 x 10^{42} ergs indicate that helium could not be
the energy source for the super burst. We outline the physics relevant to
carbon production and burning on helium accreting neutron stars and present
calculations of the thermal evolution and stability of a carbon layer and show
that this process is the most likely explanation for the super burst. We show
that for large columns of accreted carbon fuel, a substantial fraction of the
energy released in the carbon burning layer is radiated away as neutrinos, and
the heat that is conducted from the burning layer in large part flows inward,
only to be released on timescales longer than the observed burst. Thus the
energy released possibly exceeds that observed in X-rays by more than a factor
of ten. Spectral analysis during the super burst reveals the presence of a
broad emission line between 5.8 - 6.4 keV and an edge at 8 - 9 keV likely due
to reflection of the burst flux from the inner accretion disk in 4U 1820-30. We
believe this is the first time such a signature has been unambiguously detected
in the spectrum of an X-ray burst.Comment: AASTEX, 44 pages, 14 figures. Accepted for publication in the
Astrophysical Journa
Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer
A fluorescence in situ hybridisation (FISH) assay has been used to screen for ETV1 gene rearrangements in a cohort of 429 prostate cancers from patients who had been diagnosed by trans-urethral resection of the prostate. The presence of ETV1 gene alterations (found in 23 cases, 5.4%) was correlated with higher Gleason Score (P=0.001), PSA level at diagnosis (P=<0.0001) and clinical stage (P=0.017) but was not linked to poorer survival. We found that the six previously characterised translocation partners of ETV1 only accounted for 34% of ETV1 re-arrangements (eight out of 23) in this series, with fusion to the androgen-repressed gene C15orf21 representing the commonest event (four out of 23). In 5′-RACE experiments on RNA extracted from formalin-fixed tissue we identified the androgen-upregulated gene ACSL3 as a new 5′-translocation partner of ETV1. These studies report a novel fusion partner for ETV1 and highlight the considerable heterogeneity of ETV1 gene rearrangements in human prostate cancer
Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer.
BACKGROUND: Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy. METHODS: A tissue microarray (TMA) series of 596 hormone-naive prostate cancers (HNPCas) was screened for chromosome X and AR-gene locus-specific copy number alterations using four-colour fluorescence in situ hybridisation. RESULTS: Both high level gain in chromosome X (≥4 fold; n=4, 0.7%) and locus-specific amplification of the AR-gene (n=6, 1%) were detected at low frequencies in HNPCa TMAs. Fluorescence in situ hybridisation mapping whole sections taken from the original HNPCa specimen blocks demonstrated that AR-gene amplifications exist in small foci of cells (≤ 600 nm, ≤1% of tumour volume). Patients with AR gene-locus-specific copy number gains had poorer prostate cancer-specific survival. CONCLUSION: Small clonal foci of cancer containing high level gain of the androgen receptor (AR)-gene develop before hormone deprivation therapy. Their small size makes detection by TMA inefficient and suggests a higher prevalence than that reported herein. It is hypothesised that a large proportion of AR-amplified CRPCa could pre-date hormone deprivation therapy and that these patients would potentially benefit from early total androgen ablation
Electrospun amplified fiber optics
A lot of research is focused on all-optical signal processing, aiming to
obtain effective alternatives to existing data transmission platforms.
Amplification of light in fiber optics, such as in Erbium-doped fiber
amplifiers, is especially important for an efficient signal transmission.
However, the complex fabrication methods, involving high-temperature processes
performed in highly pure environment, slow down the fabrication and make
amplified components expensive with respect to an ideal, high-throughput and
room temperature production. Here, we report on near infrared polymer fiber
amplifiers, working over a band of about 20 nm. The fibers are cheap, spun with
a process entirely carried out at room temperature, and show amplified
spontaneous emission with good gain coefficients as well as low optical losses
(a few cm^-1). The amplification process is favoured by the high fiber quality
and low self-absorption. The found performance metrics promise to be suitable
for short-distance operation, and the large variety of commercially-available
doping dyes might allow for effective multi-wavelength operation by electrospun
amplified fiber optics.Comment: 27 pages, 8 figure
Metabolic Rift or Metabolic Shift? Dialectics, Nature, and the World-Historical Method
Abstract In the flowering of Red-Green Thought over the past two decades, metabolic rift thinking is surely one of its most colorful varieties. The metabolic rift has captured the imagination of critical environmental scholars, becoming a shorthand for capitalism’s troubled relations in the web of life. This article pursues an entwined critique and reconstruction: of metabolic rift thinking and the possibilities for a post-Cartesian perspective on historical change, the world-ecology conversation. Far from dismissing metabolic rift thinking, my intention is to affirm its dialectical core. At stake is not merely the mode of explanation within environmental sociology. The impasse of metabolic rift thinking is suggestive of wider problems across the environmental social sciences, now confronted by a double challenge. One of course is the widespread—and reasonable—sense of urgency to evolve modes of thought appropriate to an era of deepening biospheric instability. The second is the widely recognized—but inadequately internalized—understanding that humans are part of nature
Measurement of the p\bar{p}\sqrt{s}$ = 1.8 TeV
We update the measurement of the top production cross section using the CDF
detector at the Fermilab Tevatron. This measurement uses decays to
the final states +jets and +jets. We search for quarks from
decays via secondary-vertex identification or the identification of
semileptonic decays of the and cascade quarks. The background to the
production is determined primarily through a Monte Carlo simulation.
However, we calibrate the simulation and evaluate its uncertainty using several
independent data samples. For a top mass of 175 , we measure
pb and pb using
the secondary vertex and the lepton tagging algorithms, respectively. Finally,
we combine these results with those from other decay channels and
obtain pb.Comment: The manuscript consists of 130 pages, 35 figures and 42 tables in
RevTex. The manuscript is submitted to Physical Review D. Fixed typo in
author lis
Search for Narrow Diphoton Resonances and for gamma-gamma+W/Z Signatures in p\bar p Collisions at sqrt(s)=1.8 TeV
We present results of searches for diphoton resonances produced both
inclusively and also in association with a vector boson (W or Z) using 100
pb^{-1} of p\bar p collisions using the CDF detector. We set upper limits on
the product of cross section times branching ratio for both p\bar
p\to\gamma\gamma + X and p\bar p\to\gamma\gamma + W/Z. Comparing the inclusive
production to the expectations from heavy sgoldstinos we derive limits on the
supersymmetry-breaking scale sqrt{F} in the TeV range, depending on the
sgoldstino mass and the choice of other parameters. Also, using a NLO
prediction for the associated production of a Higgs boson with a W or Z boson,
we set an upper limit on the branching ratio for H\to\gamma\gamma. Finally, we
set a lower limit on the mass of a `bosophilic' Higgs boson (e.g. one which
couples only to \gamma, W, and Z$ bosons with standard model couplings) of 82
GeV/c^2 at 95% confidence level.Comment: 30 pages, 11 figure
A CLUSTER IN THE MAKING: ALMA REVEALS THE INITIAL CONDITIONS FOR HIGH-MASS CLUSTER FORMATION
G0.253+0.016 is a molecular clump that appears to be on the verge of forming a high mass, Arches-like cluster. Here we present new ALMA observations of its small-scale (�0.07 pc) 3mm dust continuum and molecular line emission. The data reveal a complex network of emission features, the morphology of which { 3 { ranges from small, compact regions to extended, �lamentary structures that are
seen in both emission and absorption. The dust column density is well traced by molecules with higher excitation energies and critical densities, consistent with a clump that has a denser interior. A statistical analysis supports the idea that turbulence shapes the observed gas structure within G0.253+0.016. We find a clear break in the turbulent power spectrum derived from the optically thin dust continuum emission at a spatial scale of �0.1 pc, which may correspond to the spatial scale at which gravity has overcome the thermal pressure. We suggest that G0.253+0.016 is on the verge of forming a cluster from hierarchical,
�lamentary structures that arise from a highly turbulent medium. Although the stellar distribution within Arches-like clusters is compact, centrally condensed and smooth, the observed gas distribution within G0.253+0.016 is extended, with no high-mass central concentration, and has a complex, hierarchical structure. If this clump gives rise to a high-mass cluster and its stars are formed from this
initially hierarchical gas structure, then the resulting cluster must evolve into a centrally condensed structure via a dynamical process
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