A microstructured wavefront filter for the Darwin nulling interferometer

The European Space Agency's space-based Darwin mission aims to directly detect extrasolar Earth-like planets using nulling interferometry. However, in order to accomplish this using current optical technology, the interferometer input beams must be filtered to remove local wavefront errors. Although short lengths of single-mode fibre are ideal wavefront filters, Darwin's operating wavelength range of 4 - 20µm presents real challenges for optical fibre technology. In addition to the fact that step-index fibres only offer acceptable coupling efficiency over about one octave of optical bandwidth, very few suitable materials are transparent within this wavelength range. Microstructured optical fibres offer two unique properties that hold great promise for this application; they can be made from a single-material and offer endlessly single-mode guidance. Here we explore the advantages of using a microstructured fibre as a broadband wavefront filter for 4 - 20 µm

Using Electronic Institutions to secure Grid environments

Abstract. As the technical infrastructure to support Grid environments matures, attention must be focused on integrating such technical infrastructure with technologies to support more dynamic access to services, and ensuring that such access is appropriately monitored and secured. Such capabilities will be key in providing a safe environment that allow the creation of virtual organisations at run time. This paper addresses this issue by analysing how work from within the field of Electronic Institutions (EIs) can be employed to provide security support for Grid environments, and introduces the notion of a Semantic Firewall (SFW) responsible for mediating interactions with protected services given a set of access policies. An overarching guideline is that such integration should be pragmatic, taking into account the real-life lessons learned whilst developing, deploying and using the GRIA infrastructure for Grid environments

A hydrochemical modelling framework for combined assessment of spatial and temporal variability in stream chemistry: application to Plynlimon, Wales

Recent concern about the risk to biota from acidification in upland areas, due to air pollution and land-use change (such as the planting of coniferous forests), has generated a need to model catchment hydro-chemistry to assess environmental risk and define protection strategies. Previous approaches have tended to concentrate on quantifying either spatial variability at a regional scale or temporal variability at a given location. However, to protect biota from ‘acid episodes’, an assessment of both temporal and spatial variability of stream chemistry is required at a catchment scale. In addition, quantification of temporal variability needs to represent both episodic event response and long term variability caused by deposition and/or land-use change. Both spatial and temporal variability in streamwater chemistry are considered in a new modelling methodology based on application to the Plynlimon catchments, central Wales. A two-component End-Member Mixing Analysis (EMMA) is used whereby low and high flow chemistry are taken to represent ‘groundwater’ and ‘soil water’ end-members. The conventional EMMA method is extended to incorporate spatial variability in the two end-members across the catchments by quantifying the Acid Neutralisation Capacity (ANC) of each in terms of a statistical distribution. These are then input as stochastic variables to a two-component mixing model, thereby accounting for variability of ANC both spatially and temporally. The model is coupled to a long-term acidification model (MAGIC) to predict the evolution of the end members and, hence, the response to future scenarios. The results can be plotted as a function of time and space, which enables better assessment of the likely effects of pollution deposition or land-use changes in the future on the stream chemistry than current methods which use catchment average values. The model is also a useful basis for further research into linkage between hydrochemistry and intra-catchment biological diversity.</p> <p style='line-height: 20px;'><b>Keywords:</b> hydrochemistry, End-Member Mixing Analysis (EMMA), uplands, acidificatio

Matching Lenses: Alignment and View Update

Bidirectional programming languages have been proposed as a practical approach to the view update problem. Programs in these languages, often called lenses, can be read in two ways— from left to right as functions mapping sources to views, and from right to left as functions mapping updated views back to updated sources. Lenses address the view update problem by making it possible to define a view and its associated update policy together. One issue that has not received sufficient attention in the design of bidirectional languages is alignment. In general, to correctly propagate an update to a view, a lens needs to match up the pieces of the edited view with corresponding pieces of the underlying source. Unfortunately, existing bidirectional languages are extremely limited in their treatment of alignment—they only support simple strategies that do not suffice for many examples of practical interest. In this paper, we propose a novel framework of matching lenses that extends basic lenses with new mechanisms for calculating and using alignments. We enrich the types of lenses with “chunks” that identify the locations of data that should be re-aligned after updates, and we formulate refined behavioral laws that capture essential constraints on the handling of chunks. To demonstrate the utility of our approach, we develop a core language of matching lenses for string data, and we extend it with primitives for describing a number of useful alignment heuristics

Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis

Mycophenolate mofetil (CellCept®), a commonly used immunosuppressive drug in solid organ transplantation, has recently been shown to cause graft-versus-host disease (GVHD)-like changes in the gastrointestinal tract. On rare occasions, true GVHD has also been documented in the gastrointestinal tract of solid organ transplant patients. Because the treatment for these two entities is different, i.e. removal of the offending agent versus the administration of steroids, proper identification of the cause is imperative. We present a case of mycophenolate mofetil colitis mimicking grade I GVHD of the gut. In our study, we used fluorescence in situ hybridization for the Y chromosome to document the lack of male donor lymphocytes in the female recipient colon biopsy. We suggest that molecular techniques including fluorescence in situ hybridization could be used to discriminate between MMF-related colitis and true GVHD in order to help guide therapy

Entanglement and four wave mixing effects in the dissipation free nonlinear interaction of two photons at a single atom

We investigate the nonlinear interaction between two photons in a single input pulse at an atomic two level nonlinearity. A one dimensional model for the propagation of light to and from the atom is used to describe the precise spatiotemporal coherence of the two photon state. It is shown that the interaction generates spatiotemporal entanglement in the output state similar to the entanglement observed in parametric downconversion. A method of generating photon pairs from coherent pump light using this quantum mechanical four wave mixing process is proposed.Comment: 10 pages, including 3 figures, correction in eq.(7), updated references, final version for publication in PR

Finding largest small polygons with GloptiPoly

A small polygon is a convex polygon of unit diameter. We are interested in small polygons which have the largest area for a given number of vertices $n$. Many instances are already solved in the literature, namely for all odd $n$, and for $n=4, 6$ and 8. Thus, for even $n\geq 10$, instances of this problem remain open. Finding those largest small polygons can be formulated as nonconvex quadratic programming problems which can challenge state-of-the-art global optimization algorithms. We show that a recently developed technique for global polynomial optimization, based on a semidefinite programming approach to the generalized problem of moments and implemented in the public-domain Matlab package GloptiPoly, can successfully find largest small polygons for $n=10$ and $n=12$. Therefore this significantly improves existing results in the domain. When coupled with accurate convex conic solvers, GloptiPoly can provide numerical guarantees of global optimality, as well as rigorous guarantees relying on interval arithmetic

Fantastic plastic? Experimental evaluation of polyurethane bone substitutes as proxies for human bone in trauma simulations

Recent years have seen steady improvements in the recognition and interpretation of violence related injuries in human skeletal remains. Such work has at times benefited from the involvement of biological anthropologists in forensic casework and has often relied upon comparison of documented examples with trauma observed in skeletal remains. In cases where no such example exists investigators must turn to experimentation. The selection of experimental samples is problematic as animal proxies may be too dissimilar to humans and human cadavers may be undesirable for a raft of reasons. The current article examines a third alternative in the form of polyurethane plates and spheres marketed as viable proxies for human bone in ballistic experiments. Through subjecting these samples to a range of impacts from both modern and archaic missile weapons it was established that such material generally responds similarly to bone on a broad, macroscopic scale but when examined in closer detail exhibits a range of dissimilarities that call for caution in extrapolating such results to real bone

Can invasions occur without change? A comparison of G-matrices and selection in the peach-potato aphid, Myzus persicae

Most evolutionary research on biological invasions has focused on changes seen between the native and invaded range for a particular species. However, it is likely that species that live in human-modified habitats in their native range might have evolved specific adaptations to those environments, which increase the likelihood of establishment and spread in similar human-altered environments. From a quantitative genetic perspective, this hypothesis suggests that both native and introduced populations should reside at or near the same adaptive peak. Therefore, we should observe no overall changes in the G (genetic variance–covariance) matrices between native and introduced ranges, and stabilizing selection on fitness-related traits in all populations. We tested these predictions comparing three populations of the worldwide pest Myzus persicae from the Middle East (native range) and the UK and Chile (separately introduced ranges). In general, our results provide mixed support for this idea, but further comparisons of other species are needed. In particular, we found that there has been some limited evolution in the studied traits, with the Middle East population differing from the UK and Chilean populations. This was reflected in the structure of the G-matrices, in which Chile differed from both UK and Middle East populations. Furthermore, the amount of genetic variation was massively reduced in Chile in comparison with UK and Middle East populations. Finally, we found no detectable selection on any trait in the three populations, but clones from the introduced ranges started to reproduce later, were smaller, had smaller offspring, and had lower reproductive fitness than clones from the native range

Is long term physical activity safe for older adults with knee pain: a systematic review

ObjectiveTo determine whether long-term physical activity is safe for older adults with knee pain.DesignA comprehensive systematic review and narrative synthesis of existing literature was conducted using multiple electronic databases from inception until May 2013. Two reviewers independently screened, checked data extraction and carried out quality assessment.Inclusion criteria for study designs were randomised controlled trials (RCTs), prospective cohort studies or case control studies, which included adults of mean age over 45 years old with knee pain or osteoarthritis (OA), undertaking physical activity over at least 3 months and which measured a safety related outcome (adverse events, pain, physical functioning, structural OA imaging progression or progression to total knee replacement (TKR)).ResultsOf the 8614 unique references identified, 49 studies were included in the review, comprising 48 RCTs and one case control study. RCTs varied in quality and included an array of low impact therapeutic exercise interventions of varying cardiovascular intensity. There was no evidence of serious adverse events, increases in pain, decreases in physical function, progression of structural OA on imaging or increased TKR at group level. The case control study concluded that increasing levels of regular physical activity was associated with lower risk of progression to TKR.ConclusionsLong-term therapeutic exercise lasting 3 to 30 months is safe for most older adults with knee pain. This evidence supports current clinical guideline recommendations. However, most studies investigated selected, consenting older adults carrying out low impact therapeutic exercise which may affect result generalizability