Hyperresponsiveness in the human nasal airway: new targets for the treatment of allergic airway disease.

Allergic rhinitis is a condition which affects over 15% of the population in the United Kingdom. The pathological process involves two stages: nasal inflammation, and the development of nasal airway hyperresponsiveness (AHR) to allergen and a number of other stimuli. This results in the amplification of any subsequent allergic reaction, contributing to the chronic allergic state. A number of different hypotheses have been proposed to explain the underlying mechanism of AHR, including a role for eosinophil-derived proteins, free radicals and neuropeptides. While there may be a number of independent pathways which can result in AHR, evidence obtained from both animal models and in vivo experiments in humans indicate that some mediators may interact with one another, resulting in AHR. Further research into these interactions may open new avenues for the pharmacological treatment of chronic allergic rhinitis, and possibly other allergic airway diseases

High power femtosecond source based on passively mode-locked 1055nm VECSEL and Yb-fibre power amplifier

We report 5 ns pulses at 160 W average power and 910 repetition rate from a passively mode-locked VECSEL source seeding an Yb-doped fibre power amplifier. The amplified pulses were compressed to 291 fs duration

Quadratic response theory for spin-orbit coupling in semiconductor heterostructures

This paper examines the properties of the self-energy operator in lattice-matched semiconductor heterostructures, focusing on nonanalytic behavior at small values of the crystal momentum, which gives rise to long-range Coulomb potentials. A nonlinear response theory is developed for nonlocal spin-dependent perturbing potentials. The ionic pseudopotential of the heterostructure is treated as a perturbation of a bulk reference crystal, and the self-energy is derived to second order in the perturbation. If spin-orbit coupling is neglected outside the atomic cores, the problem can be analyzed as if the perturbation were a local spin scalar, since the nonlocal spin-dependent part of the pseudopotential merely renormalizes the results obtained from a local perturbation. The spin-dependent terms in the self-energy therefore fall into two classes: short-range potentials that are analytic in momentum space, and long-range nonanalytic terms that arise from the screened Coulomb potential multiplied by a spin-dependent vertex function. For an insulator at zero temperature, it is shown that the electronic charge induced by a given perturbation is exactly linearly proportional to the charge of the perturbing potential. These results are used in a subsequent paper to develop a first-principles effective-mass theory with generalized Rashba spin-orbit coupling.Comment: 20 pages, no figures, RevTeX4; v2: final published versio

Structured evaluation of virtual environments for special-needs education

This paper describes the development of a structured approach to evaluate experiential and communication virtual learning environments (VLEs) designed specifically for use in the education of children with severe learning difficulties at the Shepherd special needs school in Nottingham, UK. Constructivist learning theory was used as a basis for the production of an evaluation framework, used to evaluate the design of three VLEs and how they were used by students with respect to this learning theory. From an observational field study of student-teacher pairs using the VLEs, 18 behaviour categories were identified as relevant to five of the seven constructivist principles defined by Jonassen (1994). Analysis of student-teacher behaviour was used to provide support for, or against, the constructivist principles. The results show that the three VLEs meet the constructivist principles in very different ways and recommendations for design modifications are put forward

Statics and Dynamics of an Inhomogeneously-Nonlinear Lattice

We introduce an inhomogeneously-nonlinear Schr{\"o}dinger lattice, featuring a defocusing segment, a focusing segment and a transitional interface between the two. We illustrate that such inhomogeneous settings present vastly different dynamical behavior than the one expected in their homogeneous counterparts in the vicinity of the interface. We analyze the relevant stationary states, as well as their stability by means of perturbation theory and linear stability analysis. We find good agreement with the numerical findings in the vicinity of the anti-continuum limit. For larger values of the coupling, we follow the relevant branches numerically and show that they terminate at values of the coupling strength which are larger for more extended solutions. The dynamical development of relevant instabilities is also monitored in the case of unstable solutions.Comment: 14 pages, 4 figure

Tidal energy in the Bering Sea

Tidal harmonics computed from TOPEX/POSEIDON altimetry are assimilated into a barotropic, finite element model of the Bering Sea whose accuracy is evaluated though comparisons with independent bottom pressure gauges. The model is used to estimate energy fluxes through each of the Aleutian Passes and Bering Strait and to construct an energy budget for the major tidal constituents. The finite element model does not conserve mass locally and this is shown to give rise to an additional term in the energy budget whose contribution is significant for the prior model, but which is reduced substantially with the assimilation technique. Though the M2 constituent is estimated to have the largest net energy flux into the Bering Sea at 31.2 GW, the K1 constituent is not far behind at 24.9 GW and the sum for the three largest diurnal constituents is found to be greater than the sum for the largest three semi-diurnals. Samalga and Amutka Passes are found to be the primary conduits for influx of semi-diurnal energy while Amchitka Pass is the primary conduit for diurnal energy. A significant portion of the diurnal energy is seen to exist in the form of continental shelf waves trapped along Bering Sea slopes.The effect of the 18.6-year nodal modulation is estimated and found to cause basin-wide variations of approximately 19% in the net incoming tidal energy flux. Larger variations in the dissipation occur in subregions that are strongly dominated by the diurnal constituents, such as Seguam Pass and south of Cape Navarin. These variations should correlate with tidal mixing and may have important consequences for biological productivity, similar to those previously found for Pacific halibut recruitment (Parker et al., 1995) and shrimp, capelin, herring, cod, and haddock biomass in the Barents Sea (Yndestad, 2004)

Brexit: Modes of Uncertainty and Futures in an Impasse

Alongside the emergence of various populisms, Brexit and other contemporary geopolitical events have been presented as symptomatic of a generalizing and intensifying sense of uncertainty in the midst of a crisis of (neo)liberalism. In this paper we describe what kind of event Brexit is becoming in the impasse between the UK’s EU referendum in 2016 and its anticipated exit from the EU in 2019. Based on 108 interviews with people in the North‐East of England, we trace how Brexit is variously enacted and felt as an end, advent, a harbinger of worse to come, non‐event, disaster, and betrayed promise. By following how these incommensurate versions of Brexit take form and co‐exist we supplement explanatory and predictive approaches to the geographies of Brexit and exemplify an approach that traces what such geopolitical events become. Specifically, we use the concept of ‘modes of uncertainty’ as a way of discerning patterns in how present uncertainties are lived. A ‘mode of uncertainty’ is a shared set of practices animated by a distinctive mood through which futures are made present and felt. Rather than treat uncertainty as a static, explanatory context, we thus follow how different versions of Brexit are constituted through specific ‘modes of (un)certainty’ – negative hope, national optimisms, apprehensive hopefulness and fantasies of action ‐ that differentiate within a seemingly singular, shared sense of uncertainty

Lattice Resistance and Peierls Stress in Finite-size Atomistic Dislocation Simulations

Atomistic computations of the Peierls stress in fcc metals are relatively scarce. By way of contrast, there are many more atomistic computations for bcc metals, as well as mixed discrete-continuum computations of the Peierls-Nabarro type for fcc metals. One of the reasons for this is the low Peierls stresses in fcc metals. Because atomistic computations of the Peierls stress take place in finite simulation cells, image forces caused by boundaries must either be relaxed or corrected for if system size independent results are to be obtained. One of the approaches that has been developed for treating such boundary forces is by computing them directly and subsequently subtracting their effects, as developed by V. B. Shenoy and R. Phillips [Phil. Mag. A, 76 (1997) 367]. That work was primarily analytic, and limited to screw dislocations and special symmetric geometries. We extend that work to edge and mixed dislocations, and to arbitrary two-dimensional geometries, through a numerical finite element computation. We also describe a method for estimating the boundary forces directly on the basis of atomistic calculations. We apply these methods to the numerical measurement of the Peierls stress and lattice resistance curves for a model aluminum (fcc) system using an embedded-atom potential.Comment: LaTeX 47 pages including 20 figure

You Can’t Always Get What You Want: Using “Broken Lotteries” to Check the Validity of Charter School Evaluations using Matching Designs

We consider situations in which public charter school lotteries are neither universally conducted nor consistently documented. Such lotteries produce “broken” Randomized Control Trials, but provide opportunities to assess the internal validity of quasi-experimental research designs. Here, we present the results of a statewide charter school evaluation using a broad-based student matching evaluation design, and run two additional analyses using the charter application wait-lists as robustness checks. Our additional models, which address concerns of self-selection by using only charter applicants as matched comparison students, yield similar effect estimates and thus provide support for the use of matching designs in charter school evaluations

Long-distance frequency transfer over an urban fiber link using optical phase stabilization

We transferred the frequency of an ultra-stable laser over 86 km of urban fiber. The link is composed of two cascaded 43-km fibers connecting two laboratories, LNE-SYRTE and LPL in Paris area. In an effort to realistically demonstrate a link of 172 km without using spooled fiber extensions, we implemented a recirculation loop to double the length of the urban fiber link. The link is fed with a 1542-nm cavity stabilized fiber laser having a sub-Hz linewidth. The fiber-induced phase noise is measured and cancelled with an all fiber-based interferometer using commercial off the shelf pigtailed telecommunication components. The compensated link shows an Allan deviation of a few 10-16 at one second and a few 10-19 at 10,000 seconds