Difficult encounters around "monkey cheeks": Farmers' interests and the design of flood retention areas in Thailand

Flood retention areas are being increasingly promoted for flood risk management. People living in these areas will accept them if their interests are taken into account. The present study analyses the extent to which farmers' interests were taken into account in two flood retention projects in Thailand. A feasibility study was conducted in preparation for the first project which included public participation. The second project was a pilot project implemented in the same zone at a small scale. Participants in the public participation process and farmers living in proposed flood retention areas were interviewed for the purpose of the present study. Agreement could have been reached between the farmers and the public agencies concerning the flood retention areas. However, the participation process did not enable frank discussion about the conditions under which farmers would accept the project. The second project was designed without public participation and offered very little compensation to farmers. In countries marked by power imbalances in water resources management, public agencies may impose flood retention areas, but the absence of agreements with farmers can reduce the effectiveness of the measure. Reaching such agreements requires challenging the imbalanced power relationships between farmers and public agencies

The galactic population of white dwarfs

Original paper can be found at: http://www.iop.org/EJ/conf DOI: 10.1088/1742-6596/172/1/012004 [16th European White Dwarfs Workshop]The contribution of white dwarfs of the different Galactic populations to the stellar content of our Galaxy is only poorly known. Some authors claim a vast population of halo white dwarfs, which would be in accordance with some investigations of the early phases of Galaxy formation claiming a top-heavy initial– mass– function. Here, I present a model of the population of white dwarfs in the Milky Way based on observations of the local white dwarf sample and a standard model of Galactic structure. This model will be used to estimate the space densities of thin disc, thick disc and halo white dwarfs and their contribution to the baryonic mass budget of the Milky Way. One result of this investigation is that white dwarfs of the halo population contribute a large fraction of the Galactic white dwarf number count, but they are not responsible for the lion's share of stellar mass in the Milky Way. Another important result is the substantial contribution of the – often neglected – population of thick disc white dwarfs. Misclassification of thick disc white dwarfs is responsible for overestimates of the halo population in previous investigations.Peer reviewe

Proteome Profiling of Breast Tumors by Gel Electrophoresis and Nanoscale Electrospray Ionization Mass Spectrometry

We have conducted proteome-wide analysis of fresh surgery specimens derived from breast cancer patients, using an approach that integrates size-based intact protein fractionation, nanoscale liquid separation of peptides, electrospray ion trap mass spectrometry, and bioinformatics. Through this approach, we have acquired a large amount of peptide fragmentation spectra from size-resolved fractions of the proteomes of several breast tumors, tissue peripheral to the tumor, and samples from patients undergoing noncancer surgery. Label-free quantitation was used to generate protein abundance maps for each proteome and perform comparative analyses. The mass spectrometry data revealed distinct qualitative and quantitative patterns distinguishing the tumors from healthy tissue as well as differences between metastatic and non-metastatic human breast cancers including many established and potential novel candidate protein biomarkers. Selected proteins were evaluated by Western blotting using tumors grouped according to histological grade, size, and receptor expression but differing in nodal status. Immunohistochemical analysis of a wide panel of breast tumors was conducted to assess expression in different types of breast cancers and the cellular distribution of the candidate proteins. These experiments provided further insights and an independent validation of the data obtained by mass spectrometry and revealed the potential of this approach for establishing multimodal markers for early metastasis, therapy outcomes, prognosis, and diagnosis in the future. © 2008 American Chemical Society

Modelling direct and indirect water requirements of construction

Water consumed directly by the construction industry is known to be of little importance. However, water consumed in the manufacture of goods and services required by construction may be significant in the context of a building\u27s life cycle water requirements and the national water budget. This paper evaluates the significance of water embodied in the construction of individual buildings. To do this, an input-output-based hybrid embodied water analysis was undertaken on 17 Australian non-residential case studies. It was found that there is a considerable amount of water embodied in construction. The highest value was 20.1 kilolitres (kL)/m2 gross floor area (GFA), representing many times the enclosed volume of the building, and many years worth of operational water. The water required by the main construction process is minimal. However, the water embodied in building materials is considerable. These findings suggest that the selection of elements and materials has a great impact on a building\u27s embodied water. This research allows the construction industry to evaluate design and construction in broad environmental terms to select options that might be cost neutral or possibly cost positive while retaining their environmental integrity. The research suggests policies focused on operational water consumption alone are inadequate. <br /

Managing emotions through eating

Emotional eating plays a significant role in the aetiology of eating disorders and obesity, and has been observed in healthy, non-restrained individuals. Despite this, research that examines emotional eating has mainly focused on females, obese populations and individuals who have a formal diagnosis of an eating disorder, the studies of which have been mainly involved surveys, experimental, observational or quantitative methods. Research has also found significant gender differences in emotional eating, yet there has been limited investigation into emotional eating in men. This research attempted to understand the process of emotional eating in men using constructivist grounded theory. The purpose of this study was to understand the way in which men use food in response to emotions and the impact it has on their psychological well-being. Semi-structured interviews were conducted with thirteen male participants aged between 23-61 years of age. All participants were fluent in English, half of the participants were from the UK, 4 were from Europe, and the remaining three were from Mexico, Egypt and Malaysia. Four main categories were developed from the data: Negotiating Masculinity, Emotional Eating Serving a Function, Seeking Control and Stuck in the Cycle. One core category encompassed all of the categories: Navigating Emotions and Masculinity through Eating. The categories were complex and linked to one another, demonstrating the cyclical nature of emotional eating. An emergent theory was developed and mapped onto a conceptualisation that attempts to explain the process of emotional eating in men, demonstrating the way masculinity affects the way that these men cope with their emotions through eating. The findings of this study provide an insight for Counselling Psychologists and other mental health practitioners working with men who struggle with managing their emotions and turn to food in attempt to cope

The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma.

Receptor tyrosine kinases-based autocrine loops largely contribute to activate the MAPK and PI3K/AKT pathways in melanoma. However, the molecular mechanisms involved in generating these autocrine loops are still largely unknown. In the present study, we examine the role of the transcription factor RUNX2 in the regulation of receptor tyrosine kinase (RTK) expression in melanoma. We have demonstrated that RUNX2-deficient melanoma cells display a significant decrease in three receptor tyrosine kinases, EGFR, IGF-1R and PDGFRβ. In addition, we found co-expression of RUNX2 and another RTK, AXL, in both melanoma cells and melanoma patient samples. We observed a decrease in phosphoAKT2 (S474) and phosphoAKT (T308) levels when RUNX2 knock down resulted in significant RTK down regulation. Finally, we showed a dramatic up regulation of RUNX2 expression with concomitant up-regulation of EGFR, IGF-1R and AXL in melanoma cells resistant to the BRAF V600E inhibitor PLX4720. Taken together, our results strongly suggest that RUNX2 might be a key player in RTK-based autocrine loops and a mediator of resistance to BRAF V600E inhibitors involving RTK up regulation in melanoma

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

Comment in Lowering the High Cost of Cancer Drugs--III. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--I. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--IV. [Mayo Clin Proc. 2016] In Reply--Lowering the High Cost of Cancer Drugs. [Mayo Clin Proc. 2016] US oncologists call for government regulation to curb drug price rises. [BMJ. 2015

DNA Fingerprinting of Pearls to Determine Their Origins

We report the first successful extraction of oyster DNA from a pearl and use it to identify the source oyster species for the three major pearl-producing oyster species Pinctada margaritifera, P. maxima and P. radiata. Both mitochondrial and nuclear gene fragments could be PCR-amplified and sequenced. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay in the internal transcribed spacer (ITS) region was developed and used to identify 18 pearls of unknown origin. A micro-drilling technique was developed to obtain small amounts of DNA while maintaining the commercial value of the pearls. This DNA fingerprinting method could be used to document the source of historic pearls and will provide more transparency for traders and consumers within the pearl industry

The structure of ultrathin Langmuir-Blodgett films of cadmium behenate

Grazing incidence x-ray-diffraction investigations of the structures of Langmuir-Blodgett films of cadmium behenate with 1, 2, 3, 5, and 21 monolayers are reported. The single monolayer film, deposited on a hydrophilic substrate, showed a hexagonal structure, whereas the bilayer film, deposited on a hydrophobic substrate, had a rectangular structure with herringbone orientation of the acyl chains. With multilayer films formed on a hydrophilic substrate, it was possible to detect that the hexagonal structure of the first layer was retained when additional layers were deposited and that the additional layers had the same rectangular structure as the bilayer. (c) 2005 American Institute of Physics

Opening and closing the future: climate change, adaptation, and scenario planning

The gales of climate change blow the future open and closed. In response, we are having to learn to live with a renewed notion of limits and a novel level of uncertainty. One emerging governance response is a turn to scenario planning, which generates narratives about multiple futures refracted out from the present. Like climate change itself, scenario planning, and the broader field of futures studies it is part of, is historically and socially positioned, belying its application as a mere method or tool. This paper discusses the growing turn to scenario planning within government climate change adaptation initiatives in light of parallel shifts in governance (eg, interest in efficiency and wicked problems) and adaptation efforts (eg, framed as risk management or resilience) and their shared roots in the ambiguities of sustainable development. It provides an extended introduction to a theme issue that provides, overall, a nested discussion of the role of scenario planning by government for climate change adaptation, noting how governance, climate change adaptation, and scenario planning all fold together the motifs of openness and closedness. This paper engages with the emerging field of future geographies and critical interest in future orientations to highlight the way society’s growing engagement on climate change adaptation exposes, critiques, replicates, and amplifies our existing orientations to the future and time and their politically contested and embedded character. It points to the way the motif of open futures can be both progressive and conservative, as political and economic interests seek to open up some futures while closing down others in the name of the ambivalent goals of adaptation and sustainable development