3,774 research outputs found

    Biomarkers in Kidney Transplantation: Translating to clinical practice

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    Improving long-term graft survival is a major challenge in kidney transplantation. Ischaemia-reperfusion injury is a critical early allograft insult that enhances the risk of delayed graft function, which is common in deceased-donor transplantation. Delayed graft function complicates the post-transplant management and has a negative impact on both short and long-term outcomes. The development of effective interventions to prevent and attenuate the injury caused by ischaemia-reperfusion is constricted by the limited ability of early detection of kidney damage. In recent years, clinical and translational research has focused on improvements in the diagnosis of acute kidney injury and provided prognostic information that is helpful in the post-transplant care. Numerous biomarkers in kidney transplantation have been evaluated in the past decade, but, so far, evidence to support their use in routine practice is limited. The purpose of this review is to examine the current status of three biomarkers for early diagnosis and prognosis of delayed graft function, namely urinary neutrophil gelatinase-associated lipocalin, oxidative stress and cystatin C. In addition, the concept of a biomarker is addressed, as well as the existing challenges and perspectives for developing a biomarker. This review discusses current literature and reflects the author’s own interpretation and experience

    Philip Morris International, Inc. : equity valuation

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    This dissertation is focused on the equity valuation of Philip Morris International, Inc., the leading publicly traded tobacco company. In other words, the work done on this paper aims at determining how much the company is worth given its current assets and position in the market. Such analysis is of great importance for shareholders and potential investors, since the market is not always able to reflect the assets’ true value. Underlying this challenge is an overview of the main equity valuation methodologies and theories, along with other aspects considered as essential in a valuation process. In this context, three methodologies were considered suitable. However, the conclusions were more influenced by the adjusted present value methodology. Philip Morris Int’ is found to be undervalued with 28.32% upside potential, a BUY recommendation. Finally, the methodologies used and results obtained were contrasted to those of UBS Investment Bank, in their report published on April 19th 2012. For a more detailed overview of the dissertation main findings, read the executive summary on appendix O

    O encontro clínico [Política Nacional de Saúde Integral da População Negra]

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    Unidade 2 do curso Saúde da População Negra, contendo 3 atividades. Tem como objetivo atuar pela perspectiva do cuidado centrado na pessoa e na família, para implementação da Política Nacional de Saúde Integral da População Negra, promovendo o acesso ao SUS e o cuidado de saúde equânime e culturalmente pertinentes às necessidades da população negra na relação profissional da saúde-paciente
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