Re-wiring the brain: Increased functional connectivity within primary somatosensory cortex following synchronous co-activation

AbstractThe primary somatosensory cortex shows precise topographical organisation, but can be quickly modified by alterations to sensory inputs. Temporally correlated sensory inputs to the digits can result in the merging of digit representations on the cortical surface. Underlying mechanisms driving these changes are unclear but the strengthening of intra-cortical synaptic connections via Hebbian mechanisms has been suggested. We use fMRI measures of temporal coherence to infer alterations in the relative strength of neuronal connections between digit regions 2 and 4 following 3hours of synchronous and asynchronous co-activation. Following synchronous co-activation we find a 20% increase in temporal coherence of the fMRI signal (p=0.0004). No significant change is seen following asynchronous co-activation suggesting that temporal coincidence between the two digit inputs during co-activation is driving this coherence change. In line with previous work we also find a trend towards reduced separation of the digit representations following synchronous co-activation and significantly increased separation for the asynchronous case. Increased coherence is significantly correlated with reduced digit separation for the synchronous case. This study shows that passive synchronous stimulation to the digits strengthens the underlying cortical connections between the digit regions in only a few hours, and that this mechanism may be related to topographical re-organisation

Disposal of hypergolic propellants. Phase 6, task 1: The cryogenic scrubber prototype

A cryogenic scrubber prototype (CSP) was evaluated as a means of removing monomethylhydrazine (MMH) vapor and dinitrogen textroxide (NTO) vapor from nitrogen or helium vent gas stream. The concept, laboratory data, design, construction and experimentation are discussed

Effects of the N-methyl-D-Aspartate receptor antagonist dextromethorphan on vibrotactile adaptation

<p>Abstract</p> <p>Background</p> <p>Previous reports have demonstrated that short durations of vibrotactile stimuli (less than or equal to 2 sec) effectively and consistently modify both the perceptual response in humans as well as the neurophysiological response in somatosensory cortex. The change in cortical response with adaptation has been well established by a number of studies, and other reports have extended those findings in determining that both GABA- and NMDAR-mediated neurotransmission play a significant role in the dynamic response of somatosensory cortical neurons. In this study, we evaluated the impact that dextromethorphan (DXM), an NMDAR antagonist, had on two distinct vibrotactile adaptation tasks.</p> <p>Results</p> <p>All subjects, both those that ingested 60 mg DXM and those that ingested placebo, were evaluated for their amplitude discriminative capacity between two simultaneously delivered vibrotactile stimuli both with and without 3 conditions of pre-exposure to adapting stimulation. The results demonstrated that the perceptual metrics of subjects who ingested 60 mg DXM were significantly altered from that of controls when the amplitude discrimination task followed one of the conditions of adapting stimulation. Without the condition of pre-exposure to an adapting stimulus (or stimuli), there was little difference between the observations obtained from the subjects that ingested DXM and controls. Peak impact on subject response occurred at 60 min post-ingestion, whereas the scores of controls who ingested placebo were not impacted.</p> <p>Conclusion</p> <p>The results – that DXM blocks vibrotactile adaptation – is consistent with the suggestion that NMDAR-mediated neurotransmission plays a significant role in the perceptual adaptive response. This finding is also consistent with neurophysiological findings that report observations of the effects of NMDAR block on the SI cortical response to repetitive vibrotactile stimulation.</p

Fairness, envy, guilt and greed: building equity considerations into agency theory

In this article we examine the extent to which fairness considerations are salient to senior executives, and consider the implications for agency theory, tournament theory and the design of top-management incentives. We look for patterns in a unique data set of senior executive preferences and seek explanations for these patterns using a model of fairness first advanced by Fehr and Schmidt in 1999. We propose a number of amendments to Fehr and Schmidt’s model. We challenge some of the standard tenets of agency theory and tournament theory, demonstrating why equity considerations should be taken into account. We add to the growing literature on behavioural agency theory

Comparison of Geant4 hadron generation with data from the interactions with beryllium nuclei of +8.9 GeV/c protons and pions, and of -8 GeV/c pions

Hadron generation in the Geant4 simulation tool kit is compared with inclusive spectra of secondary protons and pions from the interactions with beryllium nuclei of +8.9 GeV/c protons and pions, and of -8.0 GeV/c pions. The data were taken in 2002 at the CERN Proton Synchrotron with the HARP spectrometer. We report on significant disagreements between data and simulated data especially in the polar-angle distributions of secondary protons and pions.Comment: 15 pages, 13 figure

Development of Integrated Programs for Aerospace-Vehicle Design (IPAD)

Integrated Programs for Aerospace Vehicle Design (IPAD) system design requirements are given. The information is based on the IPAD User Requirements Document (D6-IPAD-70013-D) and the Integrated Information Processing Requirements Document (D6-IPAD-70012-D). General information about IPAD and a list of the system design requirements that are to be satisfied by the IPAD system are given. The system design requirements definition is to be considered as a baseline definition of the IPAD system design requirements

Methane Capture: Options for Greenhouse Gas Emission Reduction

This report discusses legislative alternatives for addressing methane capture, sources of methane, opportunities and challenges for methane capture, and current federal programs that support methane recovery

How fair versus how long: An integrative theory‐based examination of procedural justice and procedural timeliness

Although studies have linked procedural justice to a range of positive attitudes and behaviors, the focus on justice has neglected other aspects of decision‐making procedures. We explore one of those neglected aspects: procedural timeliness—defined as the degree to which procedures are started and completed within an acceptable time frame. Do employees react to how long a procedure takes, not just how fair it seems to be? To explore that question, we examined the potential effects of procedural timeliness using six theories created to explain the benefits of procedural justice. This integrative theory‐based approach allowed us to explore whether “how long” had unique effects apart from “how fair.” The results of a three‐wave, two‐source field study showed that procedural timeliness had a significant indirect effect on citizenship behavior through many of the theory‐based mechanisms, even when controlling for procedural justice. A laboratory study then replicated those effects while distinguishing procedures that were too fast versus too slow. We discuss the implications of our results for research on fostering citizenship behavior and improving supervisors’ decision‐making procedures

Forward production of charged pions with incident π±\pi^{\pm} on nuclear targets measured at the CERN PS

Measurements of the double-differential $\pi^{\pm}$ production cross-section in the range of momentum 0.5 \GeVc \leq p \le 8.0 \GeVc and angle 0.025 \rad \leq \theta \le 0.25 \rad in interactions of charged pions on beryllium, carbon, aluminium, copper, tin, tantalum and lead are presented. These data represent the first experimental campaign to systematically measure forward pion hadroproduction. The data were taken with the large acceptance HARP detector in the T9 beam line of the CERN PS. Incident particles, impinging on a 5% nuclear interaction length target, were identified by an elaborate system of beam detectors. The tracking and identification of the produced particles was performed using the forward spectrometer of the HARP detector. Results are obtained for the double-differential cross-sections ${{\mathrm{d}^2 \sigma}}/{{\mathrm{d}p\mathrm{d}\Omega}}$ mainly at four incident pion beam momenta (3 \GeVc, 5 \GeVc, 8 \GeVc and 12 \GeVc). The measurements are compared with the GEANT4 and MARS Monte Carlo simulationComment: to be published on Nuclear Physics