HIV-2 infection in a migrant from Gambia: the history of the disease combined with phylogenetic analysis revealed the real source of infection

Human immunodeficiency virus type 2 (HIV-2) infection prevalence is increasing in some European countries. The increasing migratory flow from countries where HIV-2 is endemic has facilitated the spread of the virus into Europe and other regions. We describe a case of HIV-2 infection in a migrant individual in the Asylum Seeker Centre (ASC) in Italy. The patient's virus was sequenced, and found to be a typical HIV-2 genotype A virus. Bayesian evolutionary analysis revealed that the HIV-2 sequence from migrant dated back to 1986 in a subcluster including sequences from Guinea Bissau. This was coherent with the migrant history who lived in Guinea Bissau from his birth until 1998 when he was 13 years old. Monitoring for HIV-2 infection in migrants from western Africa is necessary using adequate molecular tools to improve the diagnosis and understand the real origin of infection

Early massive clusters and the bouncing coupled dark energy

The abundance of the most massive objects in the Universe at different epochs is a very sensitive probe of the cosmic background evolution and of the growth history of density perturbations, and could provide a powerful tool to distinguish between a cosmological constant and a dynamical dark energy field. In particular, the recent detection of very massive clusters of galaxies at high redshifts has attracted significant interest as a possible indication of a failure of the standard LCDM model. Several attempts have been made in order to explain such detections in the context of non-Gaussian scenarios or interacting dark energy models, showing that both these alternative cosmologies predict an enhanced number density of massive clusters at high redshifts, possibly alleviating the tension. However, all the models proposed so far also overpredict the abundance of massive clusters at the present epoch, and are therefore in contrast with observational bounds on the low-redshift halo mass function. In this paper we present for the first time a new class of interacting dark energy models that simultaneously account for an enhanced number density of massive clusters at high redshifts and for both the standard cluster abundance at the present time and the standard power spectrum normalization at CMB. The key feature of this new class of models is the "bounce" of the dark energy scalar field on the cosmological constant barrier at relatively recent epochs. We present the background and linear perturbations evolution of the model, showing that the standard amplitude of density perturbations is recovered both at CMB and at the present time, and we demonstrate by means of large N-body simulations that our scenario predicts an enhanced number of massive clusters at high redshifts without affecting the present halo abundance. (Abridged)Comment: 11 pages, 6 figures, 2 tables. Minor changes, references added. Accepted for publication in MNRA

Health and wellbeing under COVID-19: The green covid survey

Given the impact of COVID-19 on populations, especially under lockdown conditions, there has been more attention than ever focused on the role of nature, including green and blue spaces, to act as a form of health-enabler across societies. Access to green space, with its potential for physical activity and mental health support has been specifically identified within the literature as an important asset for neighbourhood and citizen health and wellbeing. With the advent of the COVID-19 pandemic, most countries have developed as part of their public health strategies, a series of lockdown measures in which citizens have either been confined to home, or at best, a small catchment area immediately surrounding their homes. AS part of a flurry of recent research on such relationships, the GreenCOVID study was carried out by a group of researchers in Spain, the UK and Ireland, all broadly operating to a similar framework and collecting information from the general adult population in each of the three countries. This short commentary introduces the survey alongside preliminary Irish results specifically focused on household characteristics, access to nearby green space as well as a measure of psychological wellbeing

Associations of the natural and built environment with mental health and wellbeing during COVID-19: Irish perspectives from the GreenCOVID study

Background In several countries public health efforts to contain the COVID-19 pandemic have included movement restrictions that confine residents to their home or to reduced catchment areas. Household characteristics and assets of nearby spaces may be particularly relevant to support wellbeing and mental health in this context. The aim of this study was to explore wellbeing and mental health associations with factors of the immediate natural and built environment among adults in Ireland during the first wave of the COVID-19 pandemic

In-flight calibration and verification of the Planck-LFI instrument

In this paper we discuss the Planck-LFI in-flight calibration campaign. After a brief overview of the ground test campaigns, we describe in detail the calibration and performance verification (CPV) phase, carried out in space during and just after the cool-down of LFI. We discuss in detail the functionality verification, the tuning of the front-end and warm electronics, the preliminary performance assessment and the thermal susceptibility tests. The logic, sequence, goals and results of the in-flight tests are discussed. All the calibration activities were successfully carried out and the instrument response was comparable to the one observed on ground. For some channels the in-flight tuning activity allowed us to improve significantly the noise performance.Comment: Long technical paper on Planck LFI in flight calibration campaign: 109 pages in this (not final) version, 100 page in the final JINST versio

Predation effects on mean time to extinction under demographic stochasticity

Methods for predicting the probability and timing of a species' extinction are typically based on a combination of theoretical models and empirical data, and focus on single species population dynamics. Of course, species also interact with each other, forming more or less complex networks of interactions. Models to assess extinction risk often lack explicit incorporation of these interspecific interactions. We study a birth and death process in which the death rate includes an effect from predation. This predation rate is included via a general nonlinear expression for the functional response of predation to prey density. We investigate the effects of the foraging parameters (e.g. attack rate and handling time) on the mean time to extinction. Mean time to extinction varies by orders of magnitude when we alter the foraging parameters, even when we exclude the effects of these parameters on the equilibrium population size. In particular we observe an exponential dependence of the mean time to extinction on handling time. These findings clearly show that accounting for the nature of interspecific interactions is likely to be critically important when estimating extinction risk.Comment: 11 pages, 4 figures; Typos removed. For further discussion about the paper go to http://purl.org/net/extinctio

Radioactive stents delay but do not prevent in-stent neointimal hyperplasia

BACKGROUND: Restenosis after conventional stenting is almost exclusively caused by neointimal hyperplasia. Beta-particle-emitting radioactive stents decrease in-stent neointimal hyperplasia at 6-month follow-up. The purpose of this study was to evaluate the 1-year outcome of (32)P radioactive stents with an initial activity of 6 to 12 microCi using serial quantitative coronary angiography and volumetric ECG-gated 3D intravascular ultrasound (IVUS). METHODS AND RESULTS: Of 40 patients undergoing initial stent implantation, 26 were event-free after the 6-month follow-up period and 22 underwent repeat catheterization and IVUS at 1 year; they comprised half of the study population. Significant luminal deterioration was observed within the stents between 6 months and 1 year, as evidenced by a decrease in the angiographic minimum lumen diameter (-0.43+/-0.56 mm; P:=0.028) and in the mean lumen diameter in the stent (-0.55+/-0. 63 mm; P:=0.001); a significant increase in in-stent neointimal hyperplasia by IVUS (18.16+/-12.59 mm(3) at 6 months to 27.75+/-11. 99 mm(3) at 1 year; P:=0.001) was also observed. Target vessel revascularization was performed in 5 patients (23%). No patient experienced late occlusion, myocardial infarction, or death. By 1 year, 21 of the initial 40 patients (65%) remained event-free. CONCLUSIONS: Neointimal proliferation is delayed rather than prevented by radioactive stent implantation. Clinical outcome 1 year after the implantation of stents with an initial activity of 6 to 12 microCi is not favorable when compared with conventional stenting

Gender Differences in Russian Colour Naming

In the present study we explored Russian colour naming in a web-based psycholinguistic experiment (http://www.colournaming.com). Colour singletons representing the Munsell Color Solid (N=600 in total) were presented on a computer monitor and named using an unconstrained colour-naming method. Respondents were Russian speakers (N=713). For gender-split equal-size samples (NF=333, NM=333) we estimated and compared (i) location of centroids of 12 Russian basic colour terms (BCTs); (ii) the number of words in colour descriptors; (iii) occurrences of BCTs most frequent non-BCTs. We found a close correspondence between females’ and males’ BCT centroids. Among individual BCTs, the highest inter-gender agreement was for seryj ‘grey’ and goluboj ‘light blue’, while the lowest was for sinij ‘dark blue’ and krasnyj ‘red’. Females revealed a significantly richer repertory of distinct colour descriptors, with great variety of monolexemic non-BCTs and “fancy” colour names; in comparison, males offered relatively more BCTs or their compounds. Along with these measures, we gauged denotata of most frequent CTs, reflected by linguistic segmentation of colour space, by employing a synthetic observer trained by gender-specific responses. This psycholinguistic representation revealed females’ more refined linguistic segmentation, compared to males, with higher linguistic density predominantly along the redgreen axis of colour space

Incidence, Predictors, and Significance of Abnormal Cardiac Enzyme Rise in Patients Treated With Bypass Surgery in the Arterial Revascularization Therapies Study (ARTS)

BACKGROUND: Although it has been suggested that elevation of CK-MB after percutaneous coronary intervention is associated with adverse clinical outcomes, limited data are available in the setting of coronary bypass grafting. The aim of the present study was to determine the incidence, predictors, and prognostic significance of CK-MB elevation following multivessel coronary bypass grafting (CABG). METHODS AND RESULTS: The population comprises 496 patients with multivessel coronary disease assigned to CABG in the Arterial Revascularization Therapies Study (ARTS). CK-MB was prospectively measured at 6, 12, and 18 hours after the procedure. Thirty-day and 1-year clinical follow-up were performed. Abnormal CK-MB elevation occurred in 61.9% of the patients. Patients with increased cardiac-enzyme levels after CABG were at increased risk of both death and repeat myocardial infarction within the first 30 days (P=0.001). CK-MB elevation was also independently related to late adverse outcome (P=0.009, OR=0.64). CONCLUSIONS: Increased concentrations of CK-MB, which are often dismissed as inconsequential in the setting of multivessel CABG, appear to occur very frequently and are associated with a significant increase in both repeat myocardial infarction and death beyond the immediate perioperative period