Comparing Hospital Costs & Length of Stay for Cancer Patients in New York State Comprehensive Cancer Centers vs. Non-Designated Academic Centers & Community Hospitals

Ryan Fodero ’23Major: Economics and BiologyFaculty Mentor: Dr. James Bailey, Economics This paper explores differences in costs and lengths of stay for cancer patients admitted to National Cancer Institute designated Comprehensive Cancer Centers, non-designated academic medical centers, and community hospitals in New York State. Using patient-level data from the New York State Statewide Planning and Research Cooperative System Hospital Inpatient Discharges dataset for the years 2017-2019, I employ ordinary least squares and Poisson regressions to determine that inpatient costs were 27% higher, but length of stay was 12% shorter, in comprehensive cancer centers than in non-designated academic medical centers and community hospitals. The results imply that, in New York State, comprehensive cancer centers may be a magnet for more complex oncology cases and administer more expensive treatments. That expertise, however, is probably responsible for more efficient care delivery and thorough discharge planning, allowing for shorter average lengths of stay

Comparing Hospital Costs & Lengths of Stay for Cancer Patients in New York State Comprehensive Cancer Centers vs. Non-Designated Academic Centers & Community Hospitals

This paper explores differences in costs and lengths of stay for cancer patients admitted to National Cancer Institute-designated Comprehensive Cancer Centers, non-designated academic medical centers, and community hospitals in New York State using patient-level data from the New York State Statewide Planning and Research Cooperative System Hospital Inpatient Discharges dataset from 2017-2019. We employ ordinary least squares and Poisson regressions to compare hospital costs and length of stay for cancer patients, controlling for hospital type, patient demographics, and patient health. Inpatient costs were 27% higher, but length of stay was 12% shorter, in comprehensive cancer centers relative to community hospitals. In New York State, comprehensive cancer centers are a magnet for more complex oncology cases and administer more expensive treatments. That expertise, however, seems to be responsible for more efficient care delivery and thorough discharge planning, allowing for shorter average lengths of stay

An analysis of achievement motivation and motivational tendencies among men and women collegiate gymnasts

The purpose of this study was to analyse the levels of achievement motivation and the motivational tendencies of male and female collegiate gymnasts. Three broad questions were posed: 1) What differences, if any, are there in the levels of achievement motivation among and between male and female gymnasts classified as high-level and lower-level performers on high-performing collegiate competitive teams and measured by the Lynn Achievement Motivation Questionnaire? 2) What differences, if any, are there among and between male and female gymnasts with respect to their motivational tendencies of a) mastery of skill, b) dynamic interaction, and c) self-regard as revealed from their individual sport motivation sorts via the Berlin Q Sort? and 3) What is the relationship, if any, between male and female gymnasts' motivational tendency toward mastery of skill when adjusting for differences in their scores for achievement motivation

Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer's disease

The identification of biochemical markers of Alzheimer's disease (AD) may help in the diagnosis of the disease. Previous studies have shown that Aβ1–42 is decreased, and tau and phospho-tau are increased in AD cerebrospinal fluid (CSF). Our own studies have identified glycosylated isoforms of acetylcholinesterase (Glyc-AChE) and butyrylcholinesterase (Glyc-BuChE) that are increased in AD CSF. Glyc-AChE is increased in APP (SW) Tg2576 transgenic mice prior to amyloid plaque deposition, which suggests that Glyc-AChE may be an early marker of AD. The aim of this study was to determine whether Glyc-AChE or Glyc-BuChE is increased in CSF at early stages of AD and to compare the levels of these markers with those of Aβ1–42, tau and phospho-tau. Lumbar CSF was obtained ante mortem from 106 non-AD patients, including 15 patients with mild cognitive impairment (MCI), and 102 patients with probable AD. Glyc-AChE, tau and phospho-tau were significantly increased in the CSF of AD patients compared to non-neurological disease (NND) controls. Aβ1–42 was lower in the AD patients than in NND controls. A positive correlation was found between the levels of Glyc-AChE or Glyc-BuChE and disease duration. However, there was no clear correlation between the levels of tau, phospho-tau or Aβ1–42 and disease duration. The results suggest that Glyc-AChE and Glyc-BuChE are unlikely to be early markers of AD, although they may have value as markers of disease progression.This work was supported by research grants from the National Health and Medical Research Council of Australia, the RL Cooper Medical Research Foundation of Australia, by a sponsored research agreement with Axonyx Inc. (New York), Innogenetics (Belgium), and by the Swedish Medical Research Council. J. S.-V. was partially sponsored by a fellowship from Navarro Tripodi Foundation of Spain and Innogentics (Belgium) and by a grant from the MCyT of Spain (Ramón y Cajal Program).Peer reviewe

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

AbstractBackgroundEvaluation of brain β-amyloid by positron emission tomography (PET) imaging can assist in the diagnosis of Alzheimer disease (AD) and other dementias.MethodsOpen-label, nonrandomized, multicenter, phase 3 study to validate the 18F-labeled β-amyloid tracer florbetaben by comparing in vivo PET imaging with post-mortem histopathology.ResultsBrain images and tissue from 74 deceased subjects (of 216 trial participants) were analyzed. Forty-six of 47 neuritic β-amyloid-positive cases were read as PET positive, and 24 of 27 neuritic β-amyloid plaque-negative cases were read as PET negative (sensitivity 97.9% [95% confidence interval or CI 93.8–100%], specificity 88.9% [95% CI 77.0–100%]). In a subgroup, a regional tissue-scan matched analysis was performed. In areas known to strongly accumulate β-amyloid plaques, sensitivity and specificity were 82% to 90%, and 86% to 95%, respectively.ConclusionsFlorbetaben PET shows high sensitivity and specificity for the detection of histopathology-confirmed neuritic β-amyloid plaques and may thus be a valuable adjunct to clinical diagnosis, particularly for the exclusion of AD.Trial registrationClinicalTrials.gov NCT01020838

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease

status: publishe

Pair-Wise Regulation of Convergence and Extension Cell Movements by Four Phosphatases via RhoA

Various signaling pathways regulate shaping of the main body axis during early vertebrate development. Here, we focused on the role of protein-tyrosine phosphatase signaling in convergence and extension cell movements. We identified Ptpn20 as a structural paralogue of PTP-BL and both phosphatases were required for normal gastrulation cell movements. Interestingly, knockdowns of PTP-BL and Ptpn20 evoked similar developmental defects as knockdown of RPTPα and PTPε. Co-knockdown of RPTPα and PTP-BL, but not Ptpn20, had synergistic effects and conversely, PTPε and Ptpn20, but not PTP-BL, cooperated, demonstrating the specificity of our approach. RPTPα and PTPε knockdowns were rescued by constitutively active RhoA, whereas PTP-BL and Ptpn20 knockdowns were rescued by dominant negative RhoA. Consistently, RPTPα and PTP-BL had opposite effects on RhoA activation, both in a PTP-dependent manner. Downstream of the PTPs, we identified NGEF and Arhgap29, regulating RhoA activation and inactivation, respectively, in convergence and extension cell movements. We propose a model in which two phosphatases activate RhoA and two phosphatases inhibit RhoA, resulting in proper cell polarization and normal convergence and extension cell movements