641 research outputs found
The stream volume of fluid advection algorithm
The Volume of Fluid (VOF) method is a powerful tool for modelling the movement of free surface fluid flows. In this paper, a new VOF advection algorithm is presented, termed the Stream scheme. The algorithm uses a linear piecewise method for free surface reconstruction, coupled to a unique fully multidimensional method of cell boundary flux integration. Comparisons with other VOF advection algorithms show the performance of the new scheme to be good
Isolation and structural determination of non-racemic tertiary cathinone derivatives
The racemic tertiary cathinones N,N-dimethylcathinone (1), N,N-diethylcathinone (2) and 2-(1-pyrrolidinyl)-propiophenone (3) have been prepared in reasonable yield and characterized using NMR and mass spectroscopy. HPLC indicates that these compounds are isolated as the anticipated racemic mixture. These can then be co-crystallized with (+)-O,O′-di-p-toluoyl-D-tartaric, (+)-O,O′-dibenzoyl-D-tartaric and (−)-O,O′-dibenzoyl-L-tartaric acids giving the single enantiomers S and R respectively of 1, 2 and 3, in the presence of sodium hydroxide through a dynamic kinetic resolution. X-ray structural determination confirmed the enantioselectivity. The free amines could be obtained following basification and extraction. In methanol these are reasonably stable for the period of several hours, and their identity was confirmed by HPLC and CD spectroscopy
Effect of intersubband scattering on weak localization in 2D systems
The theory of weak localization is generalized for multilevel 2D systems
taking into account intersubband scattering. It is shown that weak intersubband
scattering which is negligible in a classical transport, affects strongly the
weak-localization correction to conductivity. The anomalous magnetoresistance
is calculated in the whole range of classically low magnetic fields. This
correction to conductivity is shown to depend strongly on the ratios of
occupied level concentrations. It is demonstrated that at relatively low
population of the excited subband, it is necessary to use the present theory
because the high-field limit asimptotics is shown to be achieved only in
classical magnetic fields.Comment: 18 pages, 4 figures. Accepted to Phys. Rev. B 6
Nanoscale Mechanical Characterisation of Amyloid Fibrils Discovered in a Natural Adhesive
Using the atomic force microscope, we have investigated the nanoscale mechanical response of the attachment adhesive of the terrestrial alga Prasiola linearis (Prasiolales, Chlorophyta). We were able to locate and extend highly ordered mechanical structures directly from the natural adhesive matrix of the living plant. The in vivo mechanical response of the structured biopolymer often displayed the repetitive sawtooth force-extension characteristics of a material exhibiting high mechanical strength at the molecular level. Mechanical and histological evidence leads us to propose a mechanism for mechanical strength in our sample based on amyloid fibrils. These proteinaceous, pleated β-sheet complexes are usually associated with neurodegenerative diseases. However, we now conclude that the amyloid protein quaternary structures detected in our material should be considered as a possible generic mechanism for mechanical strength in natural adhesives
Transient Magnetic and Doppler Features Related to the White-light Flares in NOAA 10486
Rapidly moving transient features have been detected in magnetic and Doppler
images of super-active region NOAA 10486 during the X17/4B flare of 28 October
2003 and the X10/2B flare of 29 October 2003. Both these flares were extremely
energetic white-light events. The transient features appeared during impulsive
phases of the flares and moved with speeds ranging from 30 to 50 km s.
These features were located near the previously reported compact acoustic
\cite{Donea05} and seismic sources \cite{Zharkova07}. We examine the origin of
these features and their relationship with various aspects of the flares, {\it
viz.}, hard X-ray emission sources and flare kernels observed at different
layers - (i) photosphere (white-light continuum), (ii) chromosphere (H
6563\AA), (iii) temperature minimum region (UV 1600\AA), and (iv) transition
region (UV 284\AA).Comment: 26 pages, 13 figures, 2 tables, accepted for publication in Solar
Physic
Multiwavelength Observations of Supersonic Plasma Blob Triggered by Reconnection Generated Velocity Pulse in AR10808
Using multi-wavelength observations of Solar and Heliospheric Observatory
(SoHO)/Michelson Doppler Imager (MDI), Transition Region and Coronal Explorer
(TRACE) 171 \AA, and H from Culgoora Solar Observatory at Narrabri,
Australia, we present a unique observational signature of a propagating
supersonic plasma blob before an M6.2 class solar flare in AR10808 on 9th
September 2005. The blob was observed between 05:27 UT to 05:32 UT with almost
a constant shape for the first 2-3 minutes, and thereafter it quickly vanished
in the corona. The observed lower bound speed of the blob is estimated as
215 km s in its dynamical phase. The evidence of the blob with
almost similar shape and velocity concurrent in H and TRACE 171 \AA\
supports its formation by multi-temperature plasma. The energy release by a
recurrent 3-D reconnection process via the separator dome below the magnetic
null point, between the emerging flux and pre-existing field lines in the lower
solar atmosphere, is found to be the driver of a radial velocity pulse outwards
that accelerates this plasma blob in the solar atmosphere. In support of
identification of the possible driver of the observed eruption, we solve the
two-dimensional ideal magnetohydrodynamic equations numerically to simulate the
observed supersonic plasma blob. The numerical modelling closely match the
observed velocity, evolution of multi-temperature plasma, and quick vanishing
of the blob found in the observations. Under typical coronal conditions, such
blobs may also carry an energy flux of 7.0 ergs cm
s to re-balance the coronal losses above active regions.Comment: Solar Physics; 22 Pages; 8 Figure
Improved Machine Tool Linear Axis Calibration Through Continuous Motion Data Capture
Machine tool calibration is becoming recognised as an important part of the manufacturing process. The current international standards for machine tool linear axes calibration support the use of quasi-static calibration techniques. These techniques can be time consuming but more importantly a compromise in quality due to the practical restriction on the spatial resolution of target positions on the axis under test. Continuous motion calibration techniques have the potential to dramatically increase calibration quality. Through taking several measurement values per second while the axis under test is in motion, it is possible to measure in far greater detail. Furthermore, since machine tools normally operate in dynamic mode, the calibration data can be more representative if it is captured while the machine is in motion. The drawback to measuring the axis while in motion is the potential increase in measurement uncertainty. In the following paper, different methods of continuous motion calibration are discussed. A time-based continuous motion solution is proposed as well as a novel optimisation and correlation algorithm to accurately fuse the data taken from quasi-static and continuous motion measurements. The measurement method allows for minimal quasi-static measurements to be taken while using a continuous motion measurement to enhance the calibration process with virtually no additional time constraints. The proposed method does not require any additional machine interfacing, making it a more readily accessible solution for widespread machine tool use than other techniques which require hardware links to the CNC. The result of which means a shorter calibration routine and enhanced results. The quasi-static and continuous motion measurements showed correlation to within one micrometre at the quasi-static measurement targets. An error of 13 μm was detailed on the continuous motion, but was missed using the standard test. On a larger, less accurate machine, the quasi-static and continuous motion measurements were on average within 3 μm of each other however, showed a standard deviation of 4 μm which is less than 1% of the overall error. Finally, a high frequency cyclic error was detected in the continuous motion measurement but was missed in the quasi-static measuremen
Extreme Ultra-Violet Spectroscopy of the Lower Solar Atmosphere During Solar Flares
The extreme ultraviolet portion of the solar spectrum contains a wealth of
diagnostic tools for probing the lower solar atmosphere in response to an
injection of energy, particularly during the impulsive phase of solar flares.
These include temperature and density sensitive line ratios, Doppler shifted
emission lines and nonthermal broadening, abundance measurements, differential
emission measure profiles, and continuum temperatures and energetics, among
others. In this paper I shall review some of the advances made in recent years
using these techniques, focusing primarily on studies that have utilized data
from Hinode/EIS and SDO/EVE, while also providing some historical background
and a summary of future spectroscopic instrumentation.Comment: 34 pages, 8 figures. Submitted to Solar Physics as part of the
Topical Issue on Solar and Stellar Flare
A shooting algorithm for problems with singular arcs
In this article we propose a shooting algorithm for a class of optimal
control problems for which all control variables appear linearly. The shooting
system has, in the general case, more equations than unknowns and the
Gauss-Newton method is used to compute a zero of the shooting function. This
shooting algorithm is locally quadratically convergent if the derivative of the
shooting function is one-to-one at the solution. The main result of this paper
is to show that the latter holds whenever a sufficient condition for weak
optimality is satisfied. We note that this condition is very close to a second
order necessary condition. For the case when the shooting system can be reduced
to one having the same number of unknowns and equations (square system) we
prove that the mentioned sufficient condition guarantees the stability of the
optimal solution under small perturbations and the invertibility of the
Jacobian matrix of the shooting function associated to the perturbed problem.
We present numerical tests that validate our method.Comment: No. RR-7763 (2011); Journal of Optimization, Theory and Applications,
published as 'Online first', January 201
FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.
Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.
Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95 confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2.
Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2. © 2014 Cancer Research UK
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