What is the nature of morality? A response to Casebeer, Railton and Ruse

A response to comments by William Casebeer, Peter Railton, and Michael Ruse on "Naturalizing Ethics" (2007)

Characteristics of Mergers and Aquisitions by Small Manufacturing Firms

While acquisitions by large firms receive a great deal of media and researcher attention, acquisitions by small firms tend to be overlooked.   This study compares a sample of M&As by small U.S. manufacturing firms that occurred between 1992 and 1999 with a sample of M&As conducted  by  large  U.S.  manufacturing firms   that  occurred  during  the  same  period Characteristics examined include the type of transaction, the type of ownership of the target firm and the relationship between the target and acquirer's primary products and geographic locations.  Results indicate that many small firms are active acquirers and are involved in a wide range of M&A activities that are often quite similar to that undertaken by large firms. There are, however, several important differences.  Small firms are found to be more likely to purchase privately  held targets and to make acquisitions of targets that were primarily involved in industries outside of manufacturing.  Large acquirers are more likely to make acquisitions of partial interest in a target and to make cross-border transactions. Implications for researchers and practitioners are discussed

Analysis of the Cost of Emergency Managers\u27 Meeting Load: A Hampton Road Case-Study

Preparation for a disaster is not something that can be done by a single organization thus there is a need for coordination between them. Meetings and joint exercises are one means of coordination used by the emergency management community. Meetings and exercises take time, including transportation of personnel and arrangements, and time is money. With limited budgets, emergency managers need to make hard decisions about how their time is allocated. This paper describes a cost model for meeting analysis and discusses a case study that looks at the holistic time spent on meetings and exercises, by personnel, for the Hampton Roads Region of Virginia. A novel way is used to display this expenditure, e.g., it is shown in terms of monetary cost instead of temporal cost. This analysis highlighted some unexpected results, i.e., the small number of personnel involved in multiple working group meetings and high level of travel costs between the HR and the state capital, Richmond. This cost model approach may provide emergency managers with better mechanisms to show their meetings costs to senior leadership

Law School Intentions Of Undergraduate Business Students

The purpose of this paper is to examine factors that influence business students’ intentions to enroll in law school. Scant research has focused on factors that influence business students’ decisions to enroll in law school. This paper attempts to fill that gap. Hypotheses about student intentions are based on Ajzen & Fishbein’s (1977) Theory of Planned Behavior. A sample of students enrolled in a business law class at a large Midwestern university is used to examine the hypotheses. Results indicate that law school intentions are driven by whether students feel they would enjoy the work of a lawyer, whether they feel having a law degree would provide them with job opportunities, and whether they feel they have the skills and abilities to get a law degree. Surprisingly, perceptions about future wealth are not associated with law school intentions. The sample may generalize to business student populations at other large state universities; however, it is important for future researchers to similarly investigate student law school intentions at other types of universities and colleges. The paper encourages undergraduate teachers of business law, as well as administrators of law schools, to consider the determinants of student intentions to study law. We particularly encourage law schools to work with undergraduate law faculty and periodically survey their target undergraduate populations to better understand student perceptions about attending law school

Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase.

UnlabelledMigalastat HCl (AT1001, 1-Deoxygalactonojirimycin) is an investigational pharmacological chaperone for the treatment of α-galactosidase A (α-Gal A) deficiency, which leads to Fabry disease, an X-linked, lysosomal storage disorder. The currently approved, biologics-based therapy for Fabry disease is enzyme replacement therapy (ERT) with either agalsidase alfa (Replagal) or agalsidase beta (Fabrazyme). Based on preclinical data, migalastat HCl in combination with agalsidase is expected to result in the pharmacokinetic (PK) enhancement of agalsidase in plasma by increasing the systemic exposure of active agalsidase, thereby leading to increased cellular levels in disease-relevant tissues. This Phase 2a study design consisted of an open-label, fixed-treatment sequence that evaluated the effects of single oral doses of 150 mg or 450 mg migalastat HCl on the PK and tissue levels of intravenously infused agalsidase (0.2, 0.5, or 1.0 mg/kg) in male Fabry patients. As expected, intravenous administration of agalsidase alone resulted in increased α-Gal A activity in plasma, skin, and peripheral blood mononuclear cells (PBMCs) compared to baseline. Following co-administration of migalastat HCl and agalsidase, α-Gal A activity in plasma was further significantly increased 1.2- to 5.1-fold compared to agalsidase administration alone, in 22 of 23 patients (95.6%). Importantly, similar increases in skin and PBMC α-Gal A activity were seen following co-administration of migalastat HCl and agalsidase. The effects were not related to the administered migalastat HCl dose, as the 150 mg dose of migalastat HCl increased α-Gal A activity to the same extent as the 450 mg dose. Conversely, agalsidase had no effect on the plasma PK of migalastat. No migalastat HCl-related adverse events or drug-related tolerability issues were identified.Trial registrationClinicalTrials.gov NCT01196871

Examining the Relationship between Clinical Decision Support and Performance Measurement

In concept and practice, clinical decision support (CDS) and performance measurement represent distinct approaches to organizational change, yet these two organizational processes are interrelated. We set out to better understand how the relationship between the two is perceived, as well as how they jointly influence clinical practice. To understand the use of CDS at benchmark institutions, we conducted semistructured interviews with key managers, information technology personnel, and clinical leaders during a qualitative field study. Improved performance was frequently cited as a rationale for the use of clinical reminders. Pay-for-performance efforts also appeared to provide motivation for the use of clinical reminders. Shared performance measures were associated with shared clinical reminders. The close link between clinical reminders and performance measurement causes these tools to have many of the same implementation challenges

Interplay between ferromagnetism, surface states, and quantum corrections in a magnetically doped topological insulator

The breaking of time-reversal symmetry by ferromagnetism is predicted to yield profound changes to the electronic surface states of a topological insulator. Here, we report on a concerted set of structural, magnetic, electrical and spectroscopic measurements of \MBS thin films wherein photoemission and x-ray magnetic circular dichroism studies have recently shown surface ferromagnetism in the temperature range 15 K $\leq T \leq 100$ K, accompanied by a suppressed density of surface states at the Dirac point. Secondary ion mass spectroscopy and scanning tunneling microscopy reveal an inhomogeneous distribution of Mn atoms, with a tendency to segregate towards the sample surface. Magnetometry and anisotropic magnetoresistance measurements are insensitive to the high temperature ferromagnetism seen in surface studies, revealing instead a low temperature ferromagnetic phase at $T \lesssim 5$ K. The absence of both a magneto-optical Kerr effect and anomalous Hall effect suggests that this low temperature ferromagnetism is unlikely to be a homogeneous bulk phase but likely originates in nanoscale near-surface regions of the bulk where magnetic atoms segregate during sample growth. Although the samples are not ideal, with both bulk and surface contributions to electron transport, we measure a magnetoconductance whose behavior is qualitatively consistent with predictions that the opening of a gap in the Dirac spectrum drives quantum corrections to the conductance in topological insulators from the symplectic to the orthogonal class.Comment: To appear in Phys. Rev.

Tapering practices of New Zealand's elite raw powerlifters

Pritchard, HJ, Tod, DA, Barnes, MJ, Keogh, JW, and McGuigan, MR. Tapering practices of New Zealand's elite raw powerlifters. J Strength Cond Res 30(7): 1796-1804, 2016-The major aim of this study was to determine tapering strategies of elite powerlifters. Eleven New Zealand powerlifters (28.4 ± 7.0 years, best Wilks score of 431.9 ± 43.9 points) classified as elite were interviewed, using semistructured interviews, about their tapering strategies. Interviews were transcribed verbatim and content analyzed. Total training volume peaked 5.2 ± 1.7 weeks from competition while average training intensity (of 1 repetition maximum) peaked 1.9 ± 0.8 weeks from competition. During tapering, volume was reduced by 58.9 ± 8.4% while intensity was maintained (or slightly reduced) and the final weight training session was performed 3.7 ± 1.6 days out from competition. Participants generally stated that tapering was performed to achieve full recovery; that accessory work was removed around 2 weeks out from competition; and deadlifting takes longer to recover from than other lifts. Typically participants stated that trial and error, and changes based on "feel" were the sources of tapering strategies; equipment used and movements performed during tapering are the same as in competition; nutrition was manipulated during the taper (for weight cutting or performance aims); and poor tapering occurred when too long (1 week or more) was taken off training. These results suggest that athletes may benefit from continuing to strength train before important events with reduced volume and maintained intensity. Only exercises that directly assist sports performance should remain in the strength program during tapering, to assist with reductions in fatigue while maintaining/improving strength expression and performance