Retail sales and retail real estate : an economic analysis of the trends in neighborhood and community shopping center market

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Architecture, 1998.Includes bibliographical references.An economic analysis was carried out to determine trends and patterns in the neighborhood and community shopping center market. Economic analysis was performed to determine whether the current retail market is overbuilt. This analysis was based on sales performance of goods common to shopping centers, income per square foot performance of shopping center Real Estate Investment Trusts, and the movement of national sales as a share of personal income. The results from a sales per square foot test of the retail market revealed that the relationship of sales per square foot is declining. Upon further analysis, the changes in sales per square foot over the changes in square footage reveal an inconsistency with the conclusion and that the retail market may not be overbuilt. Further, a sample of shopping center Real Estate Investment Trusts reveal that they are currently outperforming their respective markets on an income per square foot basis. Finally, results from the national sales as a percentage of personal income test conclude that purchases as a share of personal income have fallen more slowly in recent years.by John Joseph Fiore.S.M

The many faces of ubiquitinated histone H2A: insights from the DUBs

Monoubiquitination of H2A is a major histone modification in mammalian cells. Understanding how monoubiquitinated H2A (uH2A) regulates DNA-based processes in the context of chromatin is a challenging question. Work in the past years linked uH2A to transcriptional repression by the Polycomb group proteins of developmental regulators. Recently, a number of mammalian deubiquitinating enzymes (DUBs) that catalyze the removal of ubiquitin from H2A have been discovered. These studies provide convincing evidence that H2A deubiquitination is connected with gene activation. In addition, uH2A regulatory enzymes have crucial roles in the cellular response to DNA damage and in cell cycle progression. In this review we will discuss new insights into uH2A biology, with emphasis on the H2A DUBs

A review of urban computing for mobile phone traces

In this work, we present three classes of methods to extract information from triangulated mobile phone signals, and describe applications with different goals in spatiotemporal analysis and urban modeling. Our first challenge is to relate extracted information from phone records (i.e., a set of time-stamped coordinates estimated from signal strengths) with destinations by each of the million anonymous users. By demonstrating a method that converts phone signals into small grid cell destinations, we present a framework that bridges triangulated mobile phone data with previously established findings obtained from data at more coarse-grained resolutions (such as at the cell tower or census tract levels). In particular, this method allows us to relate daily mobility networks, called motifs here, with trip chains extracted from travel diary surveys. Compared with existing travel demand models mainly relying on expensive and less-frequent travel survey data, this method represents an advantage for applying ubiquitous mobile phone data to urban and transportation modeling applications. Second, we present a method that takes advantage of the high spatial resolution of the triangulated phone data to infer trip purposes by examining semantic-enriched land uses surrounding destinations in individual's motifs. In the final section, we discuss a portable computational architecture that allows us to manage and analyze mobile phone data in geospatial databases, and to map mobile phone trips onto spatial networks such that further analysis about flows and network performances can be done. The combination of these three methods demonstrate the state-of-the-art algorithms that can be adapted to triangulated mobile phone data for the context of urban computing and modeling applications.BMW GroupAustrian Institute of TechnologySingapore. National Research FoundationMassachusetts Institute of Technology. School of EngineeringMassachusetts Institute of Technology. Dept. of Urban Studies and PlanningSingapore-MIT Alliance for Research and Technology (Center for Future Mobility

The Grizzly, September 26, 1986

Mary Ann Unger\u27s Temple is the Gift of Muriel and Philip I. Berman • Kane Evaluates Alcohol Policy • Myrin Hires $20,000 Security Guard • Going a Little Haywire • Letters: Majestically situated?; My Hey Echoes • Bears Buried in Season Opener Against Franklin & Marshall • Lady Bears Fight to 2-2 • Booters Jump to 4-1 • Trauger Sweeps Up Her Opponents • Blowing the Call • Grizzly Captains • Athlete of the Week: Gwen O\u27Donohue • Bio Head Makes Small Move from Dean\u27s Office to Laboratories • Tim Ail Becomes New Food Director • Education Moveshttps://digitalcommons.ursinus.edu/grizzlynews/1169/thumbnail.jp

Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of Fe65 with Wild-type and Mutant Alzheimer's β-Amyloid Precursor Proteins

The two tandem phosphotyrosine interaction/phosphotyrosine binding (PID/PTB) domains of the Fe65 protein interact with the intracellular region of the Alzheimer's beta-amyloid precursor protein (APP). This interaction, previously demonstrated in vitro and in the yeast two hybrid system, also takes place in vivo in mammalian cells, as demonstrated here by anti-Fe65 co-immunoprecipitation experiments. This interaction differs from that occurring between other PID/PTB domain-containing proteins, such as Shc and insulin receptor substrate 1, and activated growth factor receptors as follows: (i) the Fe65-APP interaction is phosphorylation-independent; (ii) the region of the APP intracellular domain involved in the binding is larger than that of the growth factor receptor necessary for the formation of the complex with Shc; and (iii) despite a significant similarity the carboxyl-terminal regions of PID/PTB of Fe65 and of Shc are not functionally interchangeable in terms of binding cognate ligands. A role for Fe65 in the pathogenesis of familial Alzheimer's disease is suggested by the finding that mutant APP, responsible for some cases of familial Alzheimer's disease, shows an altered in vivo interaction with Fe65

The XMM-Newton wide-field survey in the COSMOS field II: X-ray data and the logN-logS

We present the data analysis and the X-ray source counts for the first season of XMM-Newton observations in the COSMOS field. The survey covers ~2 deg^2 within the region of sky bounded by 9^h57.5^m<R.A.<10^h03.5^m; 1^d27.5^m<DEC<2^d57.5^m with a total net integration time of 504 ks. A maximum likelihood source detection was performed in the 0.5-2 keV, 2-4.5 keV and 4.5-10 keV energy bands and 1390 point-like sources were detected in at least one band. Detailed Monte Carlo simulations were performed to fully test the source detection method and to derive the sky coverage to be used in the computation of the logN-logS relations. The 0.5--2 keV and 2--10 keV differential logN-logS were fitted with a broken power-law model which revealed a Euclidean slope (alpha~2.5) at the bright end and a flatter slope (alpha~1.5) at faint fluxes. In the 5--10 keV energy band a single power-law provides an acceptable fit to the observed source counts with a slope alpha~2.4. A comparison with the results of previous surveys shows good agreement in all the energy bands under investigation in the overlapping flux range. We also notice a remarkable agreement between our logN-logS relations and the most recent model of the XRB. The slightly different normalizations observed in the source counts of COSMOS and previous surveys can be largely explained as a combination of low counting statistics and cosmic variance introduced by the large scale structure

Your: Your Unified Reader

The advancement in signal processing and GPU based systems has enabled new transient detectors at various telescopes to perform much more sensitive searches than their predecessors. Typically the data output from the telescopes is in one of the two commonly used formats: psrfits and Sigproc filterbank. Software developed for transient searches often only works with one of these two formats, limiting their general applicability. Therefore, researchers have to write custom scripts to read/write the data in their format of choice before they can begin any data analysis relevant for their research. \textsc{Your} (Your Unified Reader) is a python-based library that unifies the data processing across multiple commonly used formats. \textsc{Your} implements a user-friendly interface to read and write in the data format of choice. It also generates unified metadata corresponding to the input data file for a quick understanding of observation parameters and provides utilities to perform common data analysis operations. \textsc{Your} also provides several state-of-the-art radio frequency interference mitigation (RFI) algorithms, which can now be used during any stage of data processing (reading, writing, etc.) to filter out artificial signals.Comment: 3 pages, Published in JOSS, Github: https://github.com/thepetabyteproject/you

Outbreak of Antiviral Drug–Resistant Influenza A in Long-Term Care Facility, Illinois, USA, 2008

An outbreak of oseltamivir-resistant influenza A (H1N1) occurred in a long-term care facility. Eight (47%) of 17 and 1 (6%) of 16 residents in 2 wards had oseltamivir-resistant influenza A virus (H1N1) infections. Initial outbreak response included treatment and prophylaxis with oseltamivir. The outbreak abated, likely because of infection control measures

Strategy to Enhance Influenza Surveillance Worldwide1

Sentinel surveillance for severe acute respiratory infection and influenza-like illness is effective in resource-limited settings

Exploring the future of data-driven product design

Connected devices present new opportunities to advance design through data collection in the wild, similar to the way digital services evolve through analytics. However, it is still unclear how live data transmitted by connected devices informs the design of these products, going beyond performance optimisation to support creative practices. Design can be enriched by data captured by connected devices, from usage logs to environmental sensors, and data about the devices and people around them. Through a series of workshops, this paper contributes industry and academia perspectives on the future of data-driven product design. We highlight HCI challenges, issues and implications, including sensemaking and the generation of design insight. We further challenge current notions of data-driven design and envision ways in which future HCI research can develop ways to work with data in the design process in a connected, rich, human manner