Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein

Aim. We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice. Methods. A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. At the end of the experiment, the lung, liver, kidney, and stomach were removed for histopathologic assessment. Results. Histopathologic investigation revealed a statistically significant difference between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P<0.001, P<0.001, P<0.001, P<0.001, and P=0.048, respectively); mean congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P<0.001, P<0.001, P<0.001, P=0.030, and P<0.001, respectively); mean congestion, edema, and neutrophil inflammation scores in the stomach (P=0.008, P=0.014, and P<0.001, respectively); and mean congestion and hydropic degeneration scores in the liver (P=0.029 and P=0.002, respectively). Conclusion. Diclofenac sodium alone ameliorates lung edema due to caerulin-induced acute pancreatitis

Predictive and prognostic value of preoperative complete blood count in prostate cancer

Aim: The predictive and prognostic value of complete blood count (CBC) In different types of cancer has been frequently demonstrated in recent years. Prostate cancer is the second most common cancer in men worldwide and is one of the most leading causes of death. In our study, we sought to find out whether CBC parameters could distinguish patients with prostate cancer from patients with benign prostatic hyperplasia. Material and Method: Laboratory findings and histopathological findings of totally 93 patients were retrospectively re-evaluated. The absolute neutrophil count (ANC), the absolute lymphocyte count (ALC), platelet count, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and mean platelet volume (MPV) values were noted. In patients with prostate cancer, pathological parameters such as prostate weight, tumor percentage. Gleason score perineural invasion, seminal vesicle involvement, apical and radial margin involvement, extra-prostatic extension were determined. Results: In our study, we found that ANC, NLR, PLR, and MPV were significantly different between patients with benign prostatic hyperplasia and with prostate cancer (p < 0.05). We found that ANC and MPV were much more successful in discriminating these patients (p < 0.001). We have shown that ANC has higher specificity and MPV value has higher sensitivity. However, we didn't find any correlation between blood parameters and pathological parameters in patients with prostate cancer. Discussion: Our study has shown that ANC, NLR, PLR, and MPV have the ability to discriminate malignant lesions from benign lesions. Although no correlation with pathologic parameters can be determined, we think that CBC might be evaluated as an auxiliary tool for prostate cancer diagnosis

Epidemiological and localization characteristics of non-melanoma skin cancers: Retrospective analysis of 400 cases

Aim: In this study, it was aimed to investigate the epidemiological and localization characteristics of the patients diagnosed with nonmelanocytic skin cancer (NMSC). Materials and Methods: Histopathologic results of patients diagnosed with NMSC in the Pathology Department of Necmettin Erbakan University, Meram School of Medicine, between 2007 and 2017 were retrospectively reviewed. The age, sex, tumor type, and localization of the patients were investigated. Results: A totals of 400 patients diagnosed with NMSC were identified. 220 of the patients were male (55%) and 180 were female (45%). The male to female ratio was 220/180 (1.22). The age range was 10–105-year-old and the mean age was 67.8. Basal cell carcinoma (BCC) was found in 263 patients (65%), squamous cell carcinoma (SCC) in 114 patients (28%) and baso SCC (BSCC) in 12 patients (3%). BCC and SCC were observed together in 9 patients. BCC was most commonly detected in the nasal region with (31%) 82 patients (50%). SHC was most commonly detected in the lower lip region with 26 patients (22%). The localization of the BSCC was most common in the nasal region with 6 patients (%50). The rate of BCC/SCC in the nasal region was 82/11. The BCC/SCC ratio in the extremity region was 4/14. Conclusion: In our region, the most frequent histopathologic diagnosis was found BCC in patients prediagnosed with NMSC, and most cases were seen in male patients. In cases of BCC a BSCC, the most common tumor localization was nose area while it was lower lip area in SCC cases. In addition, BCC and BSCC were not detected in the lower lip

Cutaneous Metastases of the Synchronous Primary Endometrial and Bilateral Ovarian Cancer: An Infrequent Presentation and Literature Review

There are limited data about the cutaneous metastases of gynecological malignancies in the literature. Based on this limited number of studies, cutaneous metastases from gynecological malignancies are uncommon occurrences. Cutaneous metastases from the synchronous endometrioid carcinoma of the uterine corpus and bilateral ovaries arising from endometriosis are extremely rare. Herein, we report a 51-year-old woman with FIGO Stage 1A Grade 1 endometrial endometrioid-type adenocarcinoma and synchronous bilateral Stage 1B ovarian endometrioid-type adenocarcinoma who presented 34 months following total abdominal hysterectomy and bilateral salpingo-oophorectomy with skin metastases. After the patient underwent an excisional biopsy, we applied a palliative radiotherapy. The patient received the combination therapy with cisplatin and doxorubicin after the completion of radiotherapy but the disease evolution was rapidly fatal and the patient died 4 months after her admission to our department due to widely disseminated disease

Ürogenital sistem yerleşimli soliter fibröz tümör: iki olgu sunumu

Soliterfibröz tümörler (SFT), genellikle plevra yerleşimli, nadir görülen spindle hücreli neoplazmlardır. Fakat bu tümörler ekstraplevral bölgelerde de nadir olarak görülebilirler. Ürogenital lokalizasyon ise oldukça nadirdir. Biz, ürogenital yerleşimli 2 olgu sunacağız. İlk olgumuz, 33yaşında erkek hastada ürogenital sistemde mesane yerleşimli, ikinci olgumuz ise 49 yaşında bayan hastada böbrekte perirenal yağ doku yerleşimlidir. Her iki olguda da tümör iyi sınırlı olup, spindle hücrelerden oluşmakta idi. Bu tümörler immünhistokimyasal olarak CD-34, BCL-2 ve CD-99 ile pozitif, sitokeratin, CD-117, S-100 ve kas markerları ile negatif ekspresyon göstermekte idi. %90 olgu benign seyirli olup, immünhistokimyasal çalışmalar tanıda anahtar rol oynamaktadır.A solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm that usually occurs in the pleura, but may occur in extrapleural sites. Its occurrence in the urogenital system is rare. We report a two cases arising in the urogenital system. The first case, 33-year-old male patient bladder located in the urogenital system, while the second case is a 49-year- old female patient with kidney perirenal fat tissue localization. In the two cases the tumor was well-circumscribed and composed of a spindle cells. Immunohistochemical studies revealed reactivity for CD34, CD99, and Bcl-2 protein, with no staining for keratin or muscle markers, confirming the diagnosis. This tumors are benign in up to 90% of cases. The immunohistochemical study is the key to diagnosis

Type I Ifn-Related Netosis In Ataxia Telangiectasia And Artemis Deficiency

Background: Pathological inflammatory syndromes of unknown etiology are commonly observed in ataxia telangiectasia (AT) and Artemis deficiency. Similar inflammatory manifestations also exist in patients with STING-associated vasculopathy in infancy (SAVI). Objective: We sought to test the hypothesis that the inflammation-associated manifestations observed in patients with AT and Artemis deficiency stem from increased type I IFN signature leading to neutrophil-mediated pathological damage. Methods: Cytokine/protein signatures were determined by ELISA, cytometric bead array, or quantitative PCR. Stat1 phosphorylation levels were determined by flow cytometry. DNA species accumulating in the cytosol of patients' cells were quantified microscopically and flow cytometrically. Propensity of isolated polymorhonuclear granulocytes to form neutrophil extracellular traps (NETs) was determined using fluorescence microscopy and picogreen assay. Neutrophil reactive oxygen species levels and mitochondrial stress were assayed using fluorogenic probes, microscopy, and flow cytometry. Results: Type I and III IFNsignatures were elevated in plasma and peripheral blood cells of patients with AT, Artemis deficiency, and SAVI. Chronic IFN production stemmed fromthe accumulation of DNA in the cytoplasm of ATand Artemis-deficient cells. Neutrophils isolated from patients spontaneously produced NETs and displayed indicators of oxidative and mitochondrial stress, supportive of theirNETotic tendencies. Asimilar phenomenonwas also observed in neutrophils from healthy controls exposed to patient plasma samples or exogeneous IFN-alpha. Conclusions: Type I IFN-mediated neutrophil activation and NET formation may contribute to inflammatory manifestations observed in patients with AT, Artemis deficiency, and SAVI. Thus, neutrophils represent a promising target to manage inflammatory syndromes in diseases with active type I IFN signature.Wo