Hydrodynamical Survey of First Overtone Cepheids

A hydrodynamical survey of the pulsational properties of first overtone Galactic Cepheids is presented. The goal of this study is to reproduce their observed light- and radial velocity curves. The comparison between the models and the observations is made in a quantitative manner on the level of the Fourier coefficients. Purely radiative models fail to reproduce the observed features, but convective models give good agreement. It is found that the sharp features in the Fourier coefficients are indeed caused by the P1/P4 = 2 resonance, despite the very large damping of the 4th overtone. For the adopted mass-luminosity relation the resonance center lies near a period of 4.2d +/- 0.2 as indicated by the observed radial velocity data, rather than near 3.2d as the light-curves suggest.Comment: ApJ, 12 pages, (slightly) revise

A test of time-dependent theories of stellar convection

Context: In Cepheids close to the red edge of the classical instability strip, a coupling occurs between the acoustic oscillations and the convective motions close to the surface.The best topical models that account for this coupling rely on 1-D time-dependent convection (TDC) formulations. However, their intrinsic weakness comes from the large number of unconstrained free parameters entering in the description of turbulent convection. Aims: We compare two widely used TDC models with the first two-dimensional nonlinear direct numerical simulations (DNS) of the convection-pulsation coupling in which the acoustic oscillations are self-sustained by the kappa-mechanism. Methods: The free parameters appearing in the Stellingwerf and Kuhfuss TDC recipes are constrained using a chi2-test with the time-dependent convective flux that evolves in nonlinear simulations of highly-compressible convection with kappa-mechanism. Results: This work emphasises some inherent limits of TDC models, that is, the temporal variability and non-universality of their free parameters. More importantly, within these limits, Stellingwerf's formalism is found to give better spatial and temporal agreements with the nonlinear simulation than Kuhfuss's one. It may therefore be preferred in 1-D TDC hydrocodes or stellar evolution codes.Comment: 7 pages, 5 figures, 2 tables, accepted for publication in A&

Association between adenovirus viral load and mortality in pediatric allo-hct recipients. the multinational advance study

This multivariable analysis from the AdVance multicenter observational study assessed adenovirus (AdV) viremia peak, duration, and overall AdV viral burden—measured as time-averaged area under the viremia curve over 16 weeks (AAUC0-16)—as predictors of all-cause mortality in pediatric allo-HCT recipients with AdV viremia. In the 6 months following allo-HCT, 241 patients had AdV viremia ≥ 1000 copies/ml. Among these, 18% (43/241) died within 6 months of first AdV ≥ 1000 copies/ml. Measures of AdV viral peak, duration, and overall burden of infection consistently correlate with all-cause mortality. In multivariable analyses, controlling for lymphocyte recovery, patients with AdV AAUC0-16 in the highest quartile had a hazard ratio of 11.1 versus the lowest quartile (confidence interval 5.3–23.6); for peak AdV viremia, the hazard ratio was 2.2 for the highest versus lowest quartile. Both the peak level and duration of AdV viremia were correlated with short-term mortality, independent of other known risk factors for AdV-related mortality, such as lymphocyte recovery. AdV AAUC0-16, which assesses both peak and duration of AdV viremia, is highly correlated with mortality under the current standard of care. New therapeutic agents that decrease AdV AAUC0-16 have the potential of reducing mortality in this at-risk patient population

RR Lyrae Variables in the Globular Cluster M55. The First Evidence for Non Radial Pulsations in RR Lyr Stars

We present the results of a photometric study of RR Lyrae variables in the field of the globular cluster M55. We have discovered nine new RR Lyrae stars, increasing the number of known variables in this cluster to 15 objects. Five of the newly discovered variables belong to Bailey type RRc and two to type RRab. Two background RRab stars are probable members of the Sagittarius dwarf galaxy. Fourier decomposition of the light curves was used to derive basic properties of the present sample of RR Lyrae variables. From an analysis of the RRc variables we obtain a mean mass of $M=0.53\pm0.03 M_\odot$, luminosity $\log L=1.75\pm0.01$, effective temperature $T_{eff}=7193\pm27$ K, and helium abundance $Y=0.27\pm0.01$. Based on the $B-V$ colors, periods and metallicities of the RRab stars we estimate the value of the color excess for M55 to be equal to $E(B-V)=0.11\pm0.03$. Using this value we derive the colors of the blue and red edges of the instability strip in M55. The blue edge lies at $(B-V)_0=0.20$ mag and the red edge lies at $(B-V)_0=0.38$ mag. We estimate the values of the visual apparent and dereddened distance moduli to be $13.65\pm0.11$ and $13.31\pm0.11$, respectively. The light curves of three of the RRc variables exhibit changes in amplitude of over 0.1 mag on the time scale of less than a week, rather short for the Blazhko effect, but with no evidence for another radial pulsational frequency. However we do detect other periodicities which are clearly visible in the light curve after removing variations with the first overtone radial frequency. This is strong evidence for the presence of non-radial pulsations, a behavior common for $\delta$ Scuti stars but not yet observed among RR Lyr variables.Comment: submitted to Astronomical Journal, 33 pages with 11 figure

V440 Per: the longest period overtone Cepheid

V440 Per is a Population I Cepheid with the period of 7.57 day and low amplitude, almost sinusoidal light and radial velocity curves. With no reliable data on the 1st harmonic, its pulsation mode identification remained controversial. We obtained a radial velocity curve of V440 Per with our new high precision and high throughput Poznan Spectroscopic Telescope. Our data reach the accuracy of 130 m/s per individual measurement and yield a secure detection of the 1st harmonic with the amplitude of A_2= 140+/- 15 m/s. The velocity Fourier phase \phi_21 of V440 Per is inconsistent at the 7.25 \sigma level with those of the fundamental mode Cepheids, implying that the star must be an overtone Cepheid, as originally proposed by Kienzle et al.(1999). Thus, V440 Per becomes the longest period Cepheid with the securely established overtone pulsations. We show, that the convective nonlinear pulsation hydrocode can reproduce the Fourier parameters of V440 Per very well. Requirement to match the observed properties of V440 Per constrains free parameters of the dynamical convection model used in the pulsation calculations, in particular the radiative losses parameter.Comment: Submitted to MNRA

Variable turbulent convection as the cause of the Blazhko effect - testing the Stothers model

The amplitude and phase modulation observed in a significant fraction of the RR Lyrae variables - the Blazhko effect - represents a long-standing enigma in stellar pulsation theory. No satisfactory explanation for the Blazhko effect has been proposed so far. In this paper we focus on the Stothers (2006) idea, in which modulation is caused by changes in the structure of the outer convective zone, caused by a quasi-periodically changing magnetic field. However, up to this date no quantitative estimates were made to investigate whether such a mechanism can be operational and whether it is capable of reproducing the light variation we observe in Blazhko variables. We address the latter problem. We use a simplified model, in which the variation of turbulent convection is introduced into the non-linear hydrodynamic models in an ad hoc way, neglecting interaction with the magnetic field. We study the light curve variation through the modulation cycle and properties of the resulting frequency spectra. Our results are compared with Kepler observations of RR Lyr. We find that reproducing the light curve variation, as is observed in RR Lyr, requires a huge modulation of the mixing length, of the order of +/-50 per cent, on a relatively short time-scale of less than 40 days. Even then, we are not able to reproduce neither all the observed relations between modulation components present in the frequency spectrum, nor the relations between Fourier parameters describing the shape of the instantaneous light curves.Comment: 17 pages, 13 figures, accepted for publication in MNRAS; for associated animation, see http://homepage.univie.ac.at/radek.smolec/publications/KASC11a

Observing and modeling the dynamic atmosphere of the low mass-loss C-star R Sculptoris at high angular resolution

We study the circumstellar environment of the carbon-rich star R Scl using the near- and mid-infrared high spatial resolution observations from the ESO-VLTI instruments VINCI and MIDI. These observations aim at increasing our knowledge of the dynamic processes in play within the very close circumstellar environment where the mass loss of AGB stars is initiated. Data are interpreted using a self-consistent dynamic model. Interferometric observations do not show any significant variability effect at the 16 m baseline between phases 0.17 and 0.23 in the K band, and for both the 15 m baseline between phases 0.66 and 0.97 and the 31 m baseline between phases 0.90 and 0.97 in the N band. We find fairly good agreement between the dynamic model and the spectrophotometric data from 0.4 to 25 $\mu$m. The model agrees well with the time-dependent flux data at 8.5 $\mu$m, whereas it is too faint at 11.3 and 12.5 $\mu$m. The VINCI visibilities are reproduced well, meaning that the extension of the model is suitable in the K-band. In the mid-infrared, the model has the proper extension to reveal molecular structures of C2H2 and HCN located above the stellar photosphere. However, the windless model used is not able to reproduce the more extended and dense dusty environment. Among the different explanations for the discrepancy between the model and the measurements, the strong nonequilibrium process of dust formation is one of the most probable. The complete dynamic coupling of gas and dust and the approximation of grain opacities with the small-particle limit in the dynamic calculation could also contribute to the difference between the model and the data

Dusp8 affects hippocampal size and behavior in mice and humans

Dual-specificity phosphatase 8 (Dusp8) acts as physiological inhibitor for the MAPKs Jnk, Erk and p38 which are involved in regulating multiple CNS processes. While Dusp8 expression levels are high in limbic areas such as the hippocampus, the functional role of Dusp8 in hippocampus morphology, MAPK-signaling, neurogenesis and apoptosis as well as in behavior are still unclear. It is of particular interest whether human carriers of a DUSP8 allelic variant show similar hippocampal alterations to mice. Addressing these questions using Dusp8WT and KO mouse littermates, we found that KOs suffered from mildly impaired spatial learning, increased locomotor activity and elevated anxiety. Cell proliferation, apoptosis and p38 and Jnk phosphorylation were unaffected, but phospho-Erk levels were higher in hippocampi of the KOs. Consistent with a decreased hippocampus size in Dusp8 KO mice, we found reduced volumes of the hippocampal subregions subiculum and CA4 in humans carrying the DUSP8 allelic variant SNP rs2334499:C > T. Overall, aberrations in morphology and behavior in Dusp8 KO mice and a decrease in hippocampal volume of SNP rs2334499:C > T carriers point to a novel, translationally relevant role of Dusp8 in hippocampus function that warrants further studies on the role of Dusp8 within the limbic network

Infrared Light Curves of Mira Variable Stars from COBE DIRBE Data

We have used the COBE DIRBE database to derive near- and mid-infrared light curves for a well-defined sample of 38 infrared-bright Mira variable stars, and compared with optical data from the AAVSO. In general, the 3.5 micron and 4.9 micron DIRBE bandpasses provide the best S/N light curves, with S/N decreasing with wavelength at longer wavelengths. At 25 microns, good light curves are only available for ~10 percent of our stars, and at wavelengths >= 60 microns, extracting high quality light curves is not possible. The amplitude of variability is typically less in the near-infrared than in the optical, and less in the mid-infrared than in the near-infrared, with decreasing amplitude with increasing wavelength. On average, there are 0.20 +/- 0.01 magnitudes variation at 1.25 microns and 0.14 +/- 0.01 magnitudes variation at 4.9 micron for each magnitude variation in V. The observed amplitudes are consistent with results of recent theoretical models of circumstellar dust shells around Mira variables. For a few stars in our sample, we find clear evidence of time lags between the optical and maxima of phase ~ 0.05 - 0.13, with no lags in the minima. For three stars, mid-infrared maximum appears to occur slightly before that in the near-infrared,but after optical maximum. We find three examples of secondary maxima in the rising portions of the DIRBE light curves, all of which have optical counterparts in the AAVSO data, supporting the hypothesis that they are due to shocks rather than newly-formed dust layers. We find no conclusive evidence for rapid (hours to days) variations in the infrared brightnesses of these stars.Comment: 16 pages, Astronomical Journal, in press, to be publishe

Comparison of Human Memory CD8 T Cell Responses to Adenoviral Early and Late Proteins in Peripheral Blood and Lymphoid Tissue

Treatment of invasive adenovirus (Ad) disease in hematopoietic stem cell transplant (SCT) recipients with capsid protein hexon-specific donor T cells is under investigation. We propose that cytotoxic T cells (CTLs) targeted to the late protein hexon may be inefficient in vivo because the early Ad protein E3-19K downregulates HLA class I antigens in infected cells. In this study, CD8+ T cells targeted to highly conserved HLA A2-restricted epitopes from the early regulatory protein DNA polymerase (P-977) and late protein hexon (H-892) were compared in peripheral blood (PB) and tonsils of naturally infected adults. In tonsils, epitope-specific pentamers detected a significantly higher frequency of P-977+CD8+ T cells compared to H-892+CD8+ T cells; this trend was reversed in PB. Tonsil epitope-specific CD8+ T cells expressed IFN-γ and IL-2 but not perforin or TNF-α, whereas PB T cells were positive for IFN-γ, TNF-α, and perforin. Tonsil epitope-specific T cells expressed lymphoid homing marker CCR7 and exhibited lower levels of the activation marker CD25 but higher proliferative potential than PB T cells. Finally, in parallel with the kinetics of mRNA expression, P-977-specific CTLs lysed targets as early as 8 hrs post infection. In contrast, H-892-specific CTLs did not kill unless infected fibroblasts were pretreated with IFN-γ to up regulate HLA class I antigens, and cytotoxicity was delayed until 16–24 hours. These data show that, in contrast to hexon CTLs, central memory type DNA polymerase CTLs dominate the lymphoid compartment and kill fibroblasts earlier after infection without requiring exogenous IFN-γ. Thus, use of CTLs targeted to both early and late Ad proteins may improve the efficacy of immunotherapy for life-threatening Ad disease in SCT recipients