Network analysis of a corpus of undeciphered Indus civilization inscriptions indicates syntactic organization

Archaeological excavations in the sites of the Indus Valley civilization (2500-1900 BCE) in Pakistan and northwestern India have unearthed a large number of artifacts with inscriptions made up of hundreds of distinct signs. To date there is no generally accepted decipherment of these sign sequences and there have been suggestions that the signs could be non-linguistic. Here we apply complex network analysis techniques to a database of available Indus inscriptions, with the aim of detecting patterns indicative of syntactic organization. Our results show the presence of patterns, e.g., recursive structures in the segmentation trees of the sequences, that suggest the existence of a grammar underlying these inscriptions.Comment: 17 pages (includes 4 page appendix containing Indus sign list), 14 figure

La hiperresistència del norovirus

Sent una de les malalties més comunes entre la població, la gastroenteritis aguda (GEA) es relaciona habitualment amb els norovirus. Un grup de virus que pot afectar l'estómac i els intestins, i fàcilment transmissibles en espais tancats o per contacte personal, el que explica que habitualment es donin brots epidèmics durant els creuers. Destaquen per la seva capacitat de resistència a pràctiques higièniques o ambients extrems, per la qual cosa es converteixen en una de les primeres causes de malaltia gastrointestinal. Així doncs, el següent article presenta un estudi comparat de les taxes d'afectació per Salmonella i norovirus a Catalunya durant un període de 12 mesos. Els resultats atribueixen a aquest últim una major incidència d'atac i una clara propensió a l'epidèmia, en comparació amb altres agents infecciosos. Per això, proposen unes mesures higienistes més exhaustives.Siendo una de las enfermedades más comunes entre la población, la gastroenteritis aguda (GEA) se relaciona habitualmente con los norovirus. Un grupo de virus que pueden afectar el estómago y los intestinos, y fácilmente transmisibles en espacios cerrados o por contacto personal, lo que explica que habitualmente se den brotes epidémicos durante los cruceros. Destacan por su capacidad de resistencia a prácticas higiénicas o ambientes extremos, por lo que se convierten en una de las primeras causas de enfermedad gastrointestinal. Así pues, el siguiente artículo presenta un estudio comparado de las tasas de afectación por Salmonella y norovirus en Cataluña durante un periodo de 12 meses. Los resultados atribuyen a éste último una mayor incidencia de ataque y una clara propensión a la epidemia, en comparación con otros agentes infecciosos. Por ello, proponen unas medidas higienistas más exhaustivas y dedicar especial atención a los que siempre son los más débiles: ancianos y niños.Acute gastroenteritis (AGE), often related to noroviruses, is one of the most common diseases suffered by the population. Noroviruses affect the stomach and intestines and are easily transmissible through human contact or in enclosed spaces, which would explain why they appear relatively frequently during cruise trips. This group of viruses stands out for its ability to resist good hygiene habits or extreme environments and is one of the main causes of gastrointestinal diseases. The following article presents a comparative study of the index of Salmonella and norovirus cases in Catalonia over a twelve month period. The results show that there is a higher incidence of norovirus attacks and a clear predisposition to cause epidemics when compared to other infectious agencies. Researchers thus propose establishing more exhaustive hygiene measures and that special attention be given to those who always suffer the most: the elderly and children

Piezoelectric characteristics of CMOS compatible AIN SAW resonators

In this work, we predict the surface acoustic wave characteristics by 2D COMSOL finite element modeling. The dispersion of simulated acoustic mode shapes, acoustic phase velocity and coupling coefficient were performed on a CMOS-compatible 1.4 GHz SAW resonator. C-axis oriented Aluminium Nitride (AIN) was chosen as the piezoelectric material due to its compatibility with CMOS technology and higher phase velocity. The influences of AIN thickness on electromechanical coupling coefficient and phase velocity are discussed. High acoustic velocities (v∼5220 m/s) and coupling factors (k2∼0.19%) can be observed for SAW resonator with khAIN∼ 3.9. The measurement results are found to be consistent with FEM results with deviation less than 6% for resonance frequency and phase velocity

Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: A retrospective cohort study

INTRODUCTION: The impact of in vitro resistance on initially appropriate antibiotic therapy (IAAT) remains unclear. We elucidated the relationship between non-IAAT and mortality, and between IAAT and multi-drug resistance (MDR) in sepsis due to Gram-negative bacteremia (GNS). METHODS: We conducted a single-center retrospective cohort study of adult intensive care unit patients with bacteremia and severe sepsis/septic shock caused by a gram-negative (GN) organism. We identified the following MDR pathogens: MDR P. aeruginosa, extended spectrum beta-lactamase and carbapenemase-producing organisms. IAAT was defined as exposure within 24 hours of infection onset to antibiotics active against identified pathogens based on in vitro susceptibility testing. We derived logistic regression models to examine a) predictors of hospital mortality and b) impact of MDR on non-IAAT. Proportions are presented for categorical variables, and median values with interquartile ranges (IQR) for continuous. RESULTS: Out of 1,064 patients with GNS, 351 (29.2%) did not survive hospitalization. Non-survivors were older (66.5 (55, 73.5) versus 63 (53, 72) years, P = 0.036), sicker (Acute Physiology and Chronic Health Evaluation II (19 (15, 25) versus 16 (12, 19), P <0.001), and more likely to be on pressors (odds ratio (OR) 2.79, 95% confidence interval (CI) 2.12 to 3.68), mechanically ventilated (OR 3.06, 95% CI 2.29 to 4.10) have MDR (10.0% versus 4.0%, P <0.001) and receive non-IAAT (43.4% versus 14.6%, P <0.001). In a logistic regression model, non-IAAT was an independent predictor of hospital mortality (adjusted OR 3.87, 95% CI 2.77 to 5.41). In a separate model, MDR was strongly associated with the receipt of non-IAAT (adjusted OR 13.05, 95% CI 7.00 to 24.31). CONCLUSIONS: MDR, an important determinant of non-IAAT, is associated with a three-fold increase in the risk of hospital mortality. Given the paucity of therapies to cover GN MDRs, prevention and development of new agents are critical

Identifying the favored mutation in a positive selective sweep.

Most approaches that capture signatures of selective sweeps in population genomics data do not identify the specific mutation favored by selection. We present iSAFE (for "integrated selection of allele favored by evolution"), a method that enables researchers to accurately pinpoint the favored mutation in a large region (∼5 Mbp) by using a statistic derived solely from population genetics signals. iSAFE does not require knowledge of demography, the phenotype under selection, or functional annotations of mutations

Positive words carry less information than negative words

We show that the frequency of word use is not only determined by the word length \cite{Zipf1935} and the average information content \cite{Piantadosi2011}, but also by its emotional content. We have analyzed three established lexica of affective word usage in English, German, and Spanish, to verify that these lexica have a neutral, unbiased, emotional content. Taking into account the frequency of word usage, we find that words with a positive emotional content are more frequently used. This lends support to Pollyanna hypothesis \cite{Boucher1969} that there should be a positive bias in human expression. We also find that negative words contain more information than positive words, as the informativeness of a word increases uniformly with its valence decrease. Our findings support earlier conjectures about (i) the relation between word frequency and information content, and (ii) the impact of positive emotions on communication and social links.Comment: 16 pages, 3 figures, 3 table

Phage inducible islands in the gram-positive cocci

The SaPIs are a cohesive subfamily of extremely common phage-inducible chromosomal islands (PICIs) that reside quiescently at specific att sites in the staphylococcal chromosome and are induced by helper phages to excise and replicate. They are usually packaged in small capsids composed of phage virion proteins, giving rise to very high transfer frequencies, which they enhance by interfering with helper phage reproduction. As the SaPIs represent a highly successful biological strategy, with many natural Staphylococcus aureus strains containing two or more, we assumed that similar elements would be widespread in the Gram-positive cocci. On the basis of resemblance to the paradigmatic SaPI genome, we have readily identified large cohesive families of similar elements in the lactococci and pneumococci/streptococci plus a few such elements in Enterococcus faecalis. Based on extensive ortholog analyses, we found that the PICI elements in the four different genera all represent distinct but parallel lineages, suggesting that they represent convergent evolution towards a highly successful lifestyle. We have characterized in depth the enterococcal element, EfCIV583, and have shown that it very closely resembles the SaPIs in functionality as well as in genome organization, setting the stage for expansion of the study of elements of this type. In summary, our findings greatly broaden the PICI family to include elements from at least three genera of cocci

Cytomolecular identification of individual wheat-wheat chromosome arm associations in wheat-rye hybrids

Chromosome pairing in the meiotic metaphase I of wheatrye hybrids has been characterized by sequential genomic and fluorescent in situ hybridization allowing not only the discrimination of wheat and rye chromosomes, but also the identification of the individual wheat and rye chromosome arms involved in the chromosome associations. The majority of associations (93.8%) were observed between the wheat chromosomes. The largest number of wheat-wheat chromosome associations (53%) was detected between the A and D genomes, while the frequency of B-D and A-B associations was significantly lower (32 and 8%, respectively). Among the A-D chromosome associations, pairing between the 3AL and 3DL arms was observed with the highest frequency, while the most frequent of all the chromosome associations (0.113/ cell) was found to be the 3DS-3BS. Differences in the pairing frequency of the individual chromosome arms of wheat-rye hybrids have been discussed in relation to the homoeologous relationships between the constituent genomes of hexaploid wheat

Multidrug resistance, inappropriate empiric treatment and hospital mortality in Acinetobacter baumannii pneumonia and sepsis

Background: The relationship between multidrug resistance (MDR), inappropriate empiric therapy (IET), and mortality among patients with Acinetobacter baumannii (AB) remains unclear. We examined it using a large U.S. database. Methods: We conducted a retrospective cohort study using the Premier Research database (2009–2013) of 175 U.S. hospitals. We included all adult patients admitted with pneumonia or sepsis as their principal diagnosis, or as a secondary diagnosis in the setting of respiratory failure, along with antibiotic administration within 2 days of admission. Only culture-confirmed infections were included. Resistance to at least three classes of antibiotics defined multidrug-resistant AB (MDR-AB). We used logistic regression to compute the adjusted relative risk ratio (RRR) of patients with MDR-AB receiving IET and IET’s impact on mortality. Results: Among 1423 patients with AB infection, 1171 (82.3 %) had MDR-AB. Those with MDR-AB were older (63.7 ± 15.4 vs. 61.0 ± 16.9 years, p = 0.014). Although chronic disease burden did not differ between groups, the MDR-AB group had higher illness severity than those in the non-MDR-AB group (intensive care unit 68.0 % vs. 59. 5 %, p < 0.001; mechanical ventilation 56.2 % vs. 42.1 %, p < 0.001). Patients with MDR-AB were more likely to receive IET than those in the non-MDR-AB group (76.2 % MDR-AB vs. 13.8 % non-MDR-AB, p < 0.001). In a regression model, MDR-AB strongly predicted receipt of IET (adjusted RRR 5.5, 95 % CI 4.0–7.7, p < 0.001). IET exposure was associated with higher hospital mortality (adjusted RRR 1.8, 95 % CI 1.4–2.3, p < 0.001). Conclusions: In this large U.S. database, the prevalence of MDR-AB among patients with AB infection was > 80 %. Harboring MDR-AB increased the risk of receiving IET more than fivefold, and IET nearly doubled hospital mortality