2,258 research outputs found
Antinociceptive activity of Hypericum caprifoliatum and Hypericum polyanthemum (Guttiferae)
A synthetic cyclized antimicrobial peptide with potent effects against drug resistant skin pathogens
Acknowledgments We would like to thank Anna Blasi-Romero for helping with the set-up of the initial scanning electron microscopy experiments. This project was partially supported by the Stiftelsen Olle Engkvist Byggmästare (AB 186 678), Region Stockholm (AB, ALF project 995080), a fellowship grant from the EPSRC (no. EP/S027246/1, W.E.H.), the Bo Rydin Foundation (no. F30/20; NF), the Swedish Research Council (# no. 2011-3403; UG); and Postdoctoral scholarship by Elisabeth and Alfred Ahlqvists Stiftelse, Apotekarsocieteten (TM). The graphical abstract was created with a BioRender standard academic license.Peer reviewedPublisher PD
Incretins in patients with rheumatoid arthritis
Background: The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin effect are disrupted in patients with RA and if they are related to the IR found in these patients. Methods: We conducted a cross-sectional study that encompassed 361 subjects without diabetes, 151 patients with RA, and 210 sex-matched control subjects. Insulin, C-peptide, glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), dipeptidyl peptidase 4 (DPP-4) soluble form, and IR indexes by homeostatic model assessment (HOMA2) were assessed. A multivariable analysis adjusted for IR-related factors was performed. Additionally, ten patients and ten control subjects underwent a 566-kcal meal test so that we could further study the postprandial differences of these molecules between patients and control subjects. Results: Insulin, C-peptide, and HOMA2-IR indexes were higher in patients than in control subjects. This was also the case for GLP-1 (0.49 ± 1.28 vs. 0.71 ± 0.22 ng/ml, p = 0.000) and GIP (0.37 ± 0.40 vs. 1.78 ± 0.51 ng/ml, p = 0.000). These differences remained significant after multivariable adjustment including glucocorticoid intake. Disease Activity Score in 28 joints with erythrocyte sedimentation rate (? coefficient 46, 95% CI 6?87, p = 0.026) and Clinical Disease Activity Index (? coefficient 7.74, 95% CI 1.29?14.20, p = 0.019) were associated with DPP-4 serum levels. GLP-1 positively correlated with ?-cell function (HOMA2 of ?-cell production calculated with C-peptide) in patients but not in control subjects (interaction p = 0.003). The meal test in patients with RA revealed a higher total and late response AUC for glucose response, a later maximal response of C-peptide, and a flatter curve in GIP response. Conclusions: The incretin-insulin axis, both during fasting and postprandial, is impaired in patients with RA.This work was supported by grants from the Spanish Ministry of Health,
Subdirección General de Evaluación y Fomento de la Investigación, Plan
Estatal de Investigación Científica y Técnica y de Innovación 2013–2016
Instituto de Salud Carlos III [ISCIII] PI14/00394) and by the Fondo Europeo de
Desarrollo Regional (FEDER) (to IFA). The research of MAGG was supported
by European Union FEDER funds and by the “Fondo de Investigación
Sanitaria” (grants PI06/0024, PS09/00748, PI12/00060, and PI15/00525) of the
Instituto de Salud Carlos III (ISCIII; Spanish Health Ministry). The research of
MAGG was also partially supported by RETICS Programs RD12/0009 (RIER)
and RD12/0009/0013 from the ISCIII (Spanish Health Ministry)
Chemical and mineralogical characterization of Aguada Portezuelo pottery from Catamarca, north-western Argentina: PIXE, XRD and SEM-EDS studies applied to surface pre- and post-firing paints, slips and pastes
Particle-induced X-ray emission (PIXE), X-ray diffraction (XRD), electron microprobe analysis (EDS) and scanning electron microscopy (SEM) analytical techniques were used to characterize surface paints in pre- and post-fired Aguada Portezuelo decorated pottery. Surface paintings in black, white, red, brown, burgundy and ochre were analysed. Major, minor and trace elements were detected by PIXE, whereas XRD and SEM-EDS gave information on the main mineral phases and the characteristic morphology for each analysed pigment. The results obtained indicate that the main colour groups can be easily discriminated by PIXE, and they are characterized by only one pigment for each colour: hematite (red) and manganese mineral oxides (black), respectively, whereas white pigments are characterized by calcite, ghelenite and gypsum.Fil: de la Fuente, Guillermo Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Escuela de Arqueología; ArgentinaFil: Galván Josa, Víctor Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Castellano, Gustavo Eugenio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Limandri, Silvina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Vera, Sergio David. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Catamarca. Universidad Nacional de Catamarca. Centro de Investigaciones y Transferencia de Catamarca; Argentina. Universidad Nacional de Catamarca. Escuela de Arqueología; ArgentinaFil: Días, Johnny Ferraz. Universidade Federal do Rio Grande do Sul; BrasilFil: Suarez, Sergio Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Bernardi, Guillermo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Bertolino, Silvana Raquel Alina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentin
Transiting exoplanets from the CoRoT space mission IX. CoRoT-6b: a transiting `hot Jupiter' planet in an 8.9d orbit around a low-metallicity star
The CoRoT satellite exoplanetary team announces its sixth transiting planet
in this paper. We describe and discuss the satellite observations as well as
the complementary ground-based observations - photometric and spectroscopic -
carried out to assess the planetary nature of the object and determine its
specific physical parameters. The discovery reported here is a `hot Jupiter'
planet in an 8.9d orbit, 18 stellar radii, or 0.08 AU, away from its primary
star, which is a solar-type star (F9V) with an estimated age of 3.0 Gyr. The
planet mass is close to 3 times that of Jupiter. The star has a metallicity of
0.2 dex lower than the Sun, and a relatively high Li abundance. While
thelightcurveindicatesamuchhigherlevelof activity than, e.g., the Sun, there is
no sign of activity spectroscopically in e.g., the [Ca ] H&K lines
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Measurement of W± boson production in Pb+Pb collisions at √sNN=5.02Te with the ATLAS detector
A measurement of W± boson production in Pb+Pb collisions at sNN=5.02Te is reported using data recorded by the ATLAS experiment at the LHC in 2015, corresponding to a total integrated luminosity of 0.49nb-1. The W± bosons are reconstructed in the electron or muon leptonic decay channels. Production yields of leptonically decaying W± bosons, normalised by the total number of minimum-bias events and the nuclear thickness function, are measured within a fiducial region defined by the detector acceptance and the main kinematic requirements. These normalised yields are measured separately for W+ and W- bosons, and are presented as a function of the absolute value of pseudorapidity of the charged lepton and of the collision centrality. The lepton charge asymmetry is also measured as a function of the absolute value of lepton pseudorapidity. In addition, nuclear modification factors are calculated using the W± boson production cross-sections measured in pp collisions. The results are compared with predictions based on next-to-leading-order calculations with CT14 parton distribution functions as well as with predictions obtained with the EPPS16 and nCTEQ15 nuclear parton distribution functions. No dependence of normalised production yields on centrality and a good agreement with predictions are observed for mid-central and central collisions. For peripheral collisions, the data agree with predictions within 1.7 (0.9) standard deviations for W- (W+) bosons
Penetración y degradación de la terbutilazina en el suelo. Efectos del riego de incorporación
En este experimento se trató de ver el comportamiento
(degradación y lixiviación) de la terbutilazina en el suelo, bajo seis diferentes
manejos de la combinación tratamiento-riego. Se observa en general, como
dicho herbicida se adsorbe en los primeros cm del suelo, así como su elevada
persistencia. Las mayores acumulaciones del producto al inicio del
experimento se manifiestan con la herbigación, mientras que al final del
mismo tiende a ser igual la acumulación de terbutilazina en los seis tipos
diferentes de combinación tratamiento-riego
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