Melanoma maligne : estudi sobre diverses tècniques d'anàlisi

El pronòstic de supervivència dels malalts afectats per un melanoma maligne depèn de la presència o absència de cèl·lules tumorals en els denominats ganglis sentinelles. Científics de l'Hospital Germans Trias i Pujol han dut a terme un estudi sobre l'efectivitat de les tècniques d'anàlisi emprades per detectar-les.El pronóstico de supervivencia de los enfermos afectados por un melanoma maligno depende la presencia o ausencia de células tumorales en los denominados ganglios centinelas. Científicos del Hospital Germans Trias i Pujol han estudiado la efectividad de las técnicas de análisis empleadas para detectarlas

Diseño y parametrización de modelos de ruedas de bicicleta para la transformación digital de la industria dentro del sector

[ES] En el presente Trabajo Final de Grado (TFG), se realiza el proceso de la digitalización del diseño y fabricación de ruedas de bicicletas mediante el diseño parametrizado de todos sus elementos. Durante el transcurso del proyecto se atraviesan diferentes fases del desarrollo de producto, tales como: • Fase de diseño, donde se modelarán y parametrizarán los elementos que componen la rueda. • Fase de ingeniería donde se explicarán y se demostrarán como mediante un diseño parametrizado y tablas de familia, que permitirá obtener diferentes configuraciones de ruedas con un mismo archivo CAD, con el cálculo automatizado de la longitud de los radios en función de las variables geométricas del resto de componentes. • Fase de proceso de fabricación, donde se define el procedimiento del ensamblado dependiendo de las características del modelo de rueda, mediante la elaboración de la documentación técnica digital (listado de materiales, planos acotados y secuencia de operaciones).[CA] En el present Treball Final de Grau (*TFG), es realitza el procés de la digitalització del disseny i fabricació de rodes de bicicletes mitjançant el disseny parametritzat de tots els seus elements. Durant el transcurs del projecte es travessen diferents fases del desenvolupament de producte, com ara: • Fase de disseny, on es modelaran i parametritzaran els elements que componen la roda. • Fase d'enginyeria, on s'explicaran i es demostraran com mitjançant un disseny parametritzat i taules de família, que permetrà obtindre diferents configuracions de rodes amb un mateix arxiu CAD, amb el càlcul automatitzat de la longitud dels radis en funció de les variables geomètriques de la resta de components. • Fase de procés de fabricació, on es defineix el procediment de l'assemblat depenent de les característiques del model de roda, mitjançant l'elaboració de la documentació tècnica digital (llistat de materials, plans delimitats i seqüència d'operacions).[EN] In this Final Degree Project, the process of digitizing the design and manufacture of bicycle wheels is carried out through the parameterized design of all its elements. During the project, different phases of product development are going through, such as: • Design phase, where the elements that build the wheel will be modeled and parameterized. • Engineering phase where they will be explained and demonstrated, by means of a parameterized design and family tables, which will allow obtaining different wheel configurations with the same CAD file, with the automated calculation of the length of the spokes based on the geometric variables of the rest of components. • Manufacturing process phase, where the assembly procedure is defined depending on the characteristics of the wheel model, through the preparation of digital technical documentation (list of materials, dimensioned drawings and sequence of operations).Ferrándiz Romero, C. (2021). Diseño y parametrización de modelos de ruedas de bicicleta para la transformación digital de la industria dentro del sector. Universitat Politècnica de València. http://hdl.handle.net/10251/174739TFG

Sistema de reconocimiento de emociones

Se realizará un estudio de distintas arquitecturas de aprendizaje profundo para determinar cuál de ellas es la mejor para reconocer emociones. Se usarán distintos conjuntos de datos de imágenes

Holothuria tubulosa as a bioindicator to analyse metal pollution on the coast of Alicante (Spain)

Metal pollution is a major concern worldwide. The concentration of several metals in marine sediments from Alicante, Spain (Western Mediterranean): Cabo de la Huerta, Albufereta, San Gabriel and Cabo de Santa Pola has been studied, being areas with contrasted metal stress due to anthropogenic pressures, and their bioaccumulation in different tissues of Holothuria tubulosa (body wall, guts and intestine). The metals with more different levels among samples were Fe, Al, V, Mn, Pb, Ga, As, Cr, Zn and B. The body wall was the tissue that showed a significantly different signature of metal levels compared to the other body parts and the sediment. The guts, followed by the intestines, were the tissues with greatest bioaccumulation. The standard guidelines for safety limits (US EPA) for As, Cr, Pb and Zn are in the range “non-polluted”. In all the areas, the quality guidelines for Effect Level, Probable Effect Level, Effect Range Low and Effect Range Medium for As, Cr, Pb and Zn are much lower than those established, indicating no biologically adverse effects resulting from exposure to these metals. Regarding the potential ecological risk, for all metals it is <40 with low risk in all zones. The metals studied present a negative Igeo (area not contaminated). Arsenic in Albufereta and strontium in all the areas studied are the only ones that present a level 2 (uncontaminated to moderately contaminated). The Enrichment Factor (EF), with Fe as the normalising element, had a level 1–3 (minor enrichment), with the exception of Pb, B, As and Sr. Despite the concentrations in sediments being lower compared with other parts of the world, the Biota-Sediment Assimilation Factor from the body wall was higher at As (9.2) and B (7.3). It is necessary to highlight the high levels of As in the body wall (17 to 23 mg/kg of dry material), this is surprising, and it seems to be a general trend throughout the world.The authors wish to thank the Generalitat Valenciana (Spain) for the financial help of the Project CIAICO/2021. This study was partially financed by the University of Alicante’s Chemical Engineering Department, Marine Sciences & Applied Biology Department and University Institute of Water and Environmental Sciences (IUACA)

La pesca, la sal y el comercio en el Círculo del Estrecho : Estado de la cuestión.

[email protected] travail analyse les sujets qui concernent le rôle de la pêche, ses produits dérivés et industries subordonnées —l’exploitation du sel et la production des amphores pour le transport— dans l’économie de la région du Détroit de Gibraltar, dès l’époque phénicienne et punique jusqu’à la romanisation. Les temples ou les villes et, enfin, l’État romain, ont contrôlé l’exploitation du sel et de la fabrication des récipients destinés au commerce des conserves de poisson, dont les bénéfices devaient être très importants

Nivolumab-Induced Bullous Pemphigoid Managed without Drug Withdrawal

The widespread use of anti-programmed cell death receptor-1 (PD-1) agents has shed light to unusual immune-related adverse effects, especially affecting the skin. We report a case of bullous pemphigoid secondary to nivolumab therapy for metastatic renal carcinoma with a previously unreported complete response to clobetasol ointment alone. The autoimmune blistering disease was successfully treated without oral corticosteroids, and the anti-PD-1 agent could be maintained without recurrence of the skin lesions. Topical therapy remains a good option in selected, mild-to-moderate cases of induced bullous pemphigoid

Therapeutic goals and treatment response evaluation in moderate to severe psoriasis: an experts opinion document

Objective: To critically analyse and define therapeutic objectives, response to treatment evaluation and related decisions in psoriasis. Methods: Expert consensus meetings, a systematic and narrative reviews and a collaborative Delphi procedure were carried out. A steering committee from the Spanish Group of Psoriasis was established who based on the reviews generated a set of related statements. Subsequently, a group of 40 experts tested their agreement with the statements, through 3 Delphi rounds. Results: We found a great variability in clinical guidelines regarding to the definition of treatment goal and the response. In general, treatment failure was considered if a PASI50 is not achieved. The panel of experts agreed on (1) clearly differentiate between ideal and a realistic goals when establishing the therapeutic goal in moderate to severe psoriasis; (2) treatment goals should be in general established regardless of the type of drug for psoriasis; (3) treatment failure if PASI75 response is not reached; (4) an absolute PASI is in general preferred to the rate of PASI improvement from baseline; (5) disease characteristics, patients and physicians opinions/needs and treatment adherence influence treatment goals. Conclusions: A clear treatment decision making framework is vital to improve management of psoriasis.KEY MESSAGES Psoriasis characteristics, patients and physicians opinions/needs and treatment adherence influence treatment goals. Different disease indexes could be used to assess treatment response but absolute PASI is preferred In general psoriasis treatment failure should be considered if PASI75 response is not reachedThis project was promoted and funded by the Spanish Academy of Dermatology and Venereology (AEDV) with unrestricted grant from Leo Pharma

Torque de desinserción y propiedades fisico-químicas de implantes dentales grabados con ácidos fluorhídrico y nítrico: estudio experimental en perros Beagle

Objetivo: Estudiar la composición, características superficiales y respuesta al torque de desinserción de una superficie implantaria tratada inicialmente con ácido fluorhídrico y posterior pasivado con ácidos fluorhídrico y nítrico. Diseño del estudio: En una primera fase, se seleccionaron 12 implantes en los que se estudiaron las características fisico-químicas mediante mediciones de energía dispersa de rayos X (EDS), microscopio electrónico de barrido y análisis de XPS (espectrometría de fotoelectrones). Asimismo, se colocaron 24 implantes 'doce de 8 mm y doce de 10 mm de longitud-, en seis perros beagle, en los que tras un período de reposo, se procedió a la retirada de 12 implantes a las seis semanas y los 12 restantes a las doce semanas, mediante un calibrador de torque Gauge TonichiR modelo BGT150CN-S -con un rango de registro de fuerza de 0 a 150 Ncm. Resultados: El análisis de la composición química superficial mediante EDS sólo mostró la presencia de titanio en las superficies grabadas. En el análisis mediante XPS, al igual que sucede con las superficies de otros implantes dentales, aparecieron trazas de otros elementos presentes en la superficie, fundamentalmente de carbono. La morfología de la superficie tras el doble grabado con ácido, permitió observar la rugosidad creada por el ataque ácido, con una morfología bastante homogénea. Los valores de rugosidad obtenidos fueron superiores al micrómetro. Los valores medios encontrados para el torque de desinserción, a las seis semanas, fueron de 79,7 Ncm para los implantes de 8 mm de longitud y 115 Ncm para los implantes de 10 mm. A las doce semanas, estos valores incrementaron hasta 101,2 Ncm para los implantes de 8 mm y 139,7 Ncm para los implantes de 10 mm de longitud. Conclusiones: El grabado con ácido fluorhídrico y nítrico, posee características superficiales óptimas y comparables al de otras superficies. Los valores de torque de desinserción abren la posibilidad para su aplicación en clínica humana para procedimientos de carga precoz o inmediata.Objective: To study the composition, surface characteristics and response to removal torque of an implant surface subjected to hydrofluoric acid etching and posterior passivating with hydrofluoric and nitric acid. Study design: Twelve implants were initially selected and their physico-chemical characteristics were evaluated by means of energy-dispersive X-rays (EDS), scanning electron microscopy (SEM) and photoelectron spectroscopy (XPS). In addition, 24 implants ' 12 measuring 8 mm and 12 measuring 10 mm in length ' were implanted in 6 Beagle dogs. Twelve implants were removed after a recovery period of 6 weeks, followed by removal of the remaining 12 implants after 12 Medeweeks, using a torque calibrator (Gauge Tonichi® model BGT150CN-S) with a force registry range of 0-150 Ncm. Results: EDS analysis of the surface chemical composition only revealed the presence of titanium in the etched surfaces. In the same way as with the surfaces of other dental implants, XPS analysis revealed traces of other elements present in the surface, fundamentally carbon. Following dual acid etching, the surface showed the roughness resulting from acid action, with a morphology that proved to be quite homogeneous. The roughness values obtained exceeded 1 ìm. The mean removal torque values after 6 weeks were 79.7 Ncm for the 8 mm implants and 115 Ncm for the 10 mm implants. After 12 weeks, these values increased to 101.2 Ncm and 139.7 Ncm, respectively. Conclusions: Hydrofluoric and nitric acid etching affords optimum surface characteristics comparable to those of other surfaces. The recorded removal torque values raise the possibility of human clinical application for early or immediate loading procedures

Use of Ultrasound in the Determination of Isobaric LLV, SLV, and SLLV Equilibrium Data. Application to the Determination of the Water + Na2SO4 or K2SO4 + 2-Methylpropan-2-ol Systems at 101.3 kPa and Boiling Conditions

The importance of good dispersion and homogenization of liquid and solid phases in the determination of isobaric liquid–liquid–vapor (LLV), solid–liquid–vapor (SLV), and solid–liquid–liquid–vapor (SLLV) equilibrium data is shown by analyzing the fluctuations observed during the LLV equilibrium determination of the heterogeneous azeotrope of the water + 1-butanol and water + cyclohexane systems, explaining the causes of these fluctuations, studying how to avoid them, and extending them to systems with solid phases. The LLV, SLV, and SLLV equilibrium data of systems that are easily dispersed (similar phase densities and low interfacial tension) can be determined by using the traditional equipment for determination of LV equilibria. In contrast, mixtures that are difficult to homogenize require more sophisticated equipment because it is difficult to obtain good phase dispersion of the liquid phases by mere agitation. In most cases, this type of system could be dispersed by coupling an ultrasonic homogenizer to the boiling flask of the equipment. This apparatus, with ultrasonic waves and modifications to control the temperature of the recirculated phases, has been applied to the determination of the water + Na2SO4 or K2SO4 + 2-methylpropan-2-ol system at 101.3 kPa and boiling conditions. Comparison of both systems shows the size of the LLV region is larger in the system containing Na2SO4. The determined experimental data of these systems were correctly predicted by the extended UNIQUAC model for electrolytes, in spite of several interaction parameters having been obtained without their experimental data.We thank the DGICYT of Spain for the financial support of project CTQ2014-59496