The Bose–Hubbard model with squeezed dissipation

The stationary properties of the Bose–Hubbard model under squeezed dissipation are investigated. The dissipative model does not possess aU (1) symmetry but conserves parity. We find that 〈a j 〉 = 0 always holds, so no symmetry breaking occurs. Without the onsite repulsion, the linear case is known to be critical. At the critical point the system freezes to an EPR state with infinite two mode entanglement. We show here that the correlations are rapidly destroyed whenever the repulsion is switched on. As we increase the latter, the system approaches a thermal state with an effective temperature defined in terms of the squeezing parameter in the dissipators. We characterize this transition by means of a Gutzwiller ansatz and the Gaussian Hartree–Fock–Bogoliubov approximation

Muons in air showers at the Pierre Auger Observatory: Mean number in highly inclined events

We present the first hybrid measurement of the average muon number in air showers at ultrahigh energies, initiated by cosmic rays with zenith angles between 62° and 80°. The measurement is based on 174 hybrid events recorded simultaneously with the surface detector array and the fluorescence detector of the Pierre Auger Observatory. The muon number for each shower is derived by scaling a simulated reference profile of the lateral muon density distribution at the ground until it fits the data. A 10^19  eV shower with a zenith angle of 67°, which arrives at the surface detector array at an altitude of 1450 m above sea level, contains on average (2.68±0.04±0.48(sys))×10^7 muons with energies larger than 0.3 GeV. The logarithmic gain d ln N_μ/dlnE of muons with increasing energy between 4×1018  eV and 5×1019  eV is measured to be (1.029±0.024±0.030(sys)

How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions

[EN] The present work characterises how selection for reproduction (by comparing two generations - 16th and 36th - of the V line selected for litter size at weaning) or foundation for reproductive longevity (the LP line) can affect the blood lymphocytes populations of reproductive rabbit does under normal [conventional housing, average daily minimum and maximum temperatures of 14 degrees C and 20 degrees C, respectively] and heat stress conditions [climatic chamber, 25 degrees C and 36 degrees C] from the first to the second parturition. Housing under heat stress conditions significantly reduced the B lymphocytes counts in female rabbits (-34 x 10(6)/L; P < 0.05). The highest lymphocytes population value in blood (total, T CD5(+), CD4(+) and CD8(+)) was noted at the first parturition, while the B lymphocytes count was significantly lower at the second parturition (-61 x 10(6)/L; P < 0.05). Selection for litter size at weaning (V females) reduced the average counts of total and B lymphocytes in blood (-502 and -60 x 10(6)/L, respectively; P < 0.01), mainly because these populations in V36 females continuously lowered from the first to the second parturition under normal housing conditions. Thus, more selected females (V36) at the second parturition showed significantly lower counts in blood for total, T CD5(+) and CD25(+) lymphocytes (-1303, -446 and -33 x 10(6)/L, respectively; P < 0.05). The main differences in blood counts between V36 and V16 females disappeared when housed under heat stress conditions, except for T CD5(+) and CD25(+), which significantly increased (T CD5(+): +428 x 10(6)/L; CD25(+): +41 x 10(6)/L; P < 0.01) in the V16 vs. V36 females on day 10 post-partum. Under normal conditions, no differences between LP and V36 females were found for most lymphocyte populations; only higher counts were noted in CD25(+) (+20 x 10(6)/L; P < 0.05) for LP females. However, the lymphocytes counts [especially total (+1327 x 10(6)/L; P < 0.01) and T CD5(+) (+376 x 10(6)/L; P < 0.10)] of LP females increased under heat vs. normal conditions when lymphocytes populations presented the lowest values (second parturition), while V36 females' counts remained invariable. Positive correlations were found between feed intake (r = +0.51; P < 0.001) and females' perirenal fat thickness (r = +0.40; P < 0.001) with B lymphocytes counts in the blood of primiparous rabbit females in the week 2 of lactation. These results indicate that selection for litter size at weaning might diminish their immune system's response and adaptation capacity, while the foundation for reproductive longevity criteria leads to more robust rabbit females as they present greater modulation under heat stress conditions when the immune system is affected. (c) 2012 Elsevier B.V. All rights reserved.This study has been supported by grants from the CEU-Cardenal Herrera University (Banco Santander/CEU-UCH: Copernicus Program), Generalitat Valenciana (ACOMP/2009/207 and ACOMP/2010/062) and the Comision Interministerial de Ciencia y Tecnologia (AGL2008-00273/GAN, AGL2008-03274/GAN and AGL2011-30170-CO2-02). Grants for Selena Ferrian and Irene Guerrero from Generalitat Valenciana (the Santiago Grisolia programme) and from the Universidad CEU-Cardenal Herrera, respectively, are also gratefully acknowledged.Ferrian, S.; Guerrero, I.; Blas Ferrer, E.; García Diego, FJ.; Viana, D.; Pascual Amorós, JJ.; Corpa, JM. (2012). How selection for reproduction or foundation for longevity could have affected blood lymphocyte populations of rabbit does under conventional and heat stress conditions. Veterinary Immunology and Immunopathology. 150(1-2):53-60. doi:10.1016/j.vetimm.2012.08.007S53601501-

Dataset on water–glycerol flow in a horizontal pipeline with and without leaks

The dataset presented in this article was collected in a laboratory flow circuit, which was designed to investigate highviscosity flows. The data set is composed of 1200 s (equivalent to 12,000 samples) of mass flow and pressure measurements taken at five points along the pipeline. The first 300 s were recorded when the flow in the loop was composed only of glycerol. The remaining data were acquired when the flow was composed of a water–glycerol mixture. During the data acquisition, two extractions were produced. The research reported in [1] uses 160 s of the data provided here. This article explains in detail the experimental set-up and the principal instruments used for obtaining the dataset. The dataset is in the form of seven columns: Time, Mass Flow, Pressure 1, Pressure 2, Pressure 3, Pressure 4, Pressure 5, in supplementary Excel and Matlab files

Denervación renal en el tratamiento de la hipertensión arterial. Posicionamiento conjunto de la SEH-LELHA y la ACI-SEC

Hypertension is the most prevalent cardiovascular risk factor. Despite pharmacological treatment, a high percentage of patients do not achieve an adequate blood pressure control. Renal sympathetic denervation is a minimally invasive intervention for the management of hypertension involving the interruption of the renal artery sympathetic nervous system using a catheter-based approach. The early studies showed promising results, but the controversial results coming from the SYMPLICITY HTN-3 trial sent this technique into oblivion. Over the last 3 years, new clinical trials have appeared including new devices used in different populations, which definitively proves the effectiveness of renal sympathetic denervation. This joint position statement from the Spanish Society of Hypertension-Spanish League for Combating High Blood Pressure (SEH-LELHA), and the Interventional Cardiology Association of the Spanish Society of Cardiology (ACI-SEC) reviews the evidence available on the efficacy and safety profile of renal sympathetic denervation for the management of hypertension. Based on the results of clinical trials, recommendations have been established on what patients may be eligible for renal sympathetic denervation and under what circumstances

HF broadband antenna design for shipboard communications: Simulation and measurements

The objective pursued in this work is to highlight the convenience of using electromagnetic simulation software as an alternative to the traditional scale model measurement when dealing with the design of HF antennas on real complex platforms. The experience was developed during the building process of a real vessel. A low and a medium band antennas (fan-wire type) were designed ad-hoc for this project. The HF broadband antennas’ study covered from the preliminary design stages to the final verification measurements completed onboard the ship. The experiment has demonstrated that more accurate results can be obtained when using an adequate electromagnetic simulation code, which, besides, brings important advantages in flexibility and usability. These advantages, inherent to the use of virtual models, hinge on the ability of the simulation tools to properly handle any modification of the vessel’s structure that might arise during the platform construction

Pharmacological Opportunities for Prevention of Preeclampsia

Preeclampsia (PE) is a disorder that occurs during pregnancy, it has an estimated worldwide prevalence of 5–8%, being one of the leading causes of maternal and perinatal morbidity and mortality. Currently, different diagnostic criteria exist, however, due to its complexity; the clinical presentation that makes up this syndrome could make its presence unclear. The pathophysiology of PE has been recently postulated and divided into three processes: inadequate uterine remodeling, placental dysfunction and maternal endothelial dysfunction. Despite the advances in the treatment of PE, the outcome of the medical interventions has failed to decrease the morbidity and mortality of this disease. The main reason might be the multifactorial origin of pathogenic processes that lead to the development of PE. That is why treatment is focused on the prevention of PE in patients that might present the risk before developing it late in pregnancy. The knowledge of the pathophysiological factors that trigger the processes that culminate in the presentation of PE, is key for prevention of this disease. However, the origin of these processes is poorly understood. It may be attributed to the ethical considerations that come with the study of these population of patients compared with the study of non-pregnant women

Tracing the retina to analyze the integrity and phagocytic capacity of the retinal pigment epithelium

We have developed a new technique to study the integrity, morphology and functionality of the retinal neurons and the retinal pigment epithelium (RPE). Young and old control albino (Sprague-Dawley) and pigmented (Piebald Virol Glaxo) rats, and dystrophic albino (P23H-1) and pigmented (Royal College of Surgeons) rats received a single intravitreal injection of 3% Fluorogold (FG) and their retinas were analyzed from 5 minutes to 30 days later. Retinas were imaged in vivo with SD-OCT and ex vivo in flat-mounts and in cross-sections. Fifteen minutes and 24 hours after intravitreal administration of FG retinal neurons and the RPE, but no glial cells, were labeled with FG-filled vesicles. The tracer reached the RPE 15 minutes after FG administration, and this labeling remained up to 30 days. Tracing for 15 minutes or 24 hours did not cause oxidative stress. Intraretinal tracing delineated the pathological retinal remodelling occurring in the dystrophic strains. The RPE of the P23H-1 strain was highly altered in aged animals, while the RPE of the RCS strain, which is unable to phagocytose, did not accumulate the tracer even at young ages when the retinal neural circuit is still preserved. In both dystrophic strains, the RPE cells were pleomorphic and polymegathic.This study was supported by the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III, Fondo Europeo de Desarrollo Regional “Una manera de hacer Europa” (PI16/00031, PI16/00380, PI19/00071, PI19/00203, SAF2015-67643-P, RD16/0008, RD16/0008/0026 and RD16/0008/0016) and by the Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (19881/GERM/15)

Clinical Trials in Pregnant Women with Preeclampsia

Preeclampsia (PE) is the leading cause of preterm birth by medical indication when associated with premature detachment of placenta normoinserta, and Intrauterine growth restriction (IUGR) is associated with high perinatal morbidity and mortality and long-term sequelae. The main problem of PE is threefold: the diagnostic difficulty, the complicated interrelationship of the pathophysiological processes, and the vulnerability of the maternal-fetal binomial to the therapeutic interventions. The approach for management with PE is preventing its late occurrence in pregnancy. The key to preventing PE is knowledge of the factors that trigger the pathophysiological processes that culminate in the presentation of PE. Understanding the developmental characteristics of the placenta in pregnancy at high risk for PE is essential for understanding the pathophysiology and developing strategies for prevention. When deciding that the population of study is a group of pregnant women, the first ethical criteria that need to be reviewed are those aimed at the protection of the fetus. There are no specific guidelines on how to assess fetal well-being during pregnancy routinely in the clinic, and this deficiency is shifted to clinical research with pregnant women

An energy-efficient internet of things (IoT) architecture for preventive conservation of cultural heritage

[EN] Internet of Things (IoT) technologies can facilitate the preventive conservation of cultural heritage (CH) by enabling the management of data collected from electronic sensors. This work presents an IoT architecture for this purpose. Firstly, we discuss the requirements from the artwork standpoint, data acquisition, cloud processing and data visualization to the end user. The results presented in this work focuses on the most critical aspect of the architecture, which are the sensor nodes. We designed a solution based on LoRa and Sigfox technologies to produce the minimum impact in the artwork, achieving a lifespan of more than 10 years. The solution will be capable of scaling the processing and storage resources, deployed either in a public or on-premise cloud, embedding complex predictive models. This combination of technologies can cope with different types of cultural heritage environments.This work was partially funded by the Generalitat Valenciana project AICO/2016/058 and by the Plan Nacional de I+D, Comision Interministerial de Ciencia y TecnologiA (FEDER-CICYT) under the project HAR2013-47895-C2-1-P.Perles Ivars, A.; Pérez Marín, E.; Mercado Romero, R.; Segrelles Quilis, JD.; Blanquer Espert, I.; Zarzo Castelló, M.; García Diego, FJ. (2018). An energy-efficient internet of things (IoT) architecture for preventive conservation of cultural heritage. Future Generation Computer Systems. 81:566-581. https://doi.org/10.1016/j.future.2017.06.030S5665818