Holistic or Traditional Conceptions of Heritage among Early-Childhood and Primary Trainee Teachers

This study examines the conception of heritage—holistic or traditional—among future early-childhood and primary teachers. In order to do this, our objective was to analyze trainee teachers’ perceptions surrounding the conception of heritage. To carry out the analysis, we designed and validated a questionnaire with closed-ended questions (Likert scale 1–5) and one open-ended question about the elements that respondents considered to be part of what we define as heritage. The participants (n = 602) study at the universities of Alicante, Murcia, and Córdoba, and the investigation took place during 2018/19 and 2019/20 academic years. The results show a traditional conception that is still attached to immovable monumental heritage, with lower scores for intangible and natural heritage. However, there were some high scores for traditions and popular festivals, which are a frequent educational resource in early-childhood and primary classrooms. In conclusion, this non-holistic conception of heritage could be changed if an active and varied use of heritage resources were introduced from the early stages of education.This research was funded by the UNIVERSITY OF ALICANTE, grant number GRE18-13A; by the MINISTRY OF SCIENCE, INNOVATION AND UNIVERSITITES grant number PGC2018-094491-B-C33, and by GENERAL DIRECTORATE OF SCIENTIFIC AND TECHNICAL RESEARCH grant number HAR2015-68059-C2-1-R. This work was supported by the I3CE Network Programme of Research in University Teaching of the Vice-Rectorate of Educational Quality and Innovation–Institute of Educational Sciences of the UNIVERSITY OF ALICANTE (convened 2019–20), Grant number 4825

Green and blue materials for the ceramic industry from pink MgCoxNi1-xSiO4 (0 ≤ x ≤ 1) solid solutions

In this study, MgCoxNi1-xSiO4 (0.0 ≤ x ≤ 1.0) solid solutions with an olivine structure were synthetized via the chemical coprecipitation method and materials with a smaller M(II) (M = Co, Ni) amount than Co2SiO4 and Ni2SiO4 compounds were obtained. At 1200 °C, the Co(II) and Ni(II) were randomly distributed in the MgCoxNi1-xSiO4 (0.0 ≤ x ≤ 1.0) solid solutions with the olivine structure, but the occupation of Co(II) and Ni(II) ions in M1 (4a) octahedral sites was obtained at a higher level than in M2 (4c) octahedral sites. The Mg(II) ions prefer the M2 sites. This preference explains the main contribution of the M1 sites in spectra of octahedral Co(II) ions and the M1-O and M2-O distances jointly explain the pink colour of the MgCoxNi1-xSiO4 (0.0 ≤ x ≤ 1.0) solid solutions, while the colour of Co2SiO4 is blue. Spectra can be interpreted as the sum of Ni(II) and Co(II) ions in octahedral sites. When these solid solutions are enamelled, the pink colouring changes to green or blue because of the presence of tetrahedral Co(II).Funding for open access charge: CRUE-Universitat Jaume

EL MALTRATO FÍSICO Y PSICOLÓGICO DE LOS NIÑOS DENTRO DEL AMBIENTE INTRAFAMILIAR EN HOGARES DISFUNCIONALES Y SU INFLUENCIA EN EL COMPORTAMIENTO EN EDAD ESCOLAR

Physical and Psychological Maltreatment within the dysfunctional intrafamilial environment influences the behavior of the school-age children of the Educational Unit, Federico González Suárez of the Rocafuerte Slip site, since we understand that violence is general, but a main consequence for derive all these situations of violence at all levels is given from family circle, where people develop and where they begin to acquire new knowledge and that is forging the character, way of being and acting. It is an important link that occurs from the union of parents and the conception and upbringing of children, which forms the family circle, giving this new being with identical profiles and family traits that will lead from generation to generation. For this reason, this article will be based on an important topic such as the family that is part of it, but when in these ties of love and fraternity, some moment is broken, acts of violence are committed, a family breakdown is generated, and in many cases it ends with the disunion of the whole family, so it is very interesting to analyze these situations that affect schoolchildren in search of the best solutions. The training actions allowed the parents to guide their actions in fields of interest for both families and society; among them the promotion of domestic coresponsibility and the education of children, the development of healthy sports habits, the promotion of reading and study habits, the prevention of school failure, the proper use of free time, among others.El Maltrato Físico y Psicológico dentro del ambiente intrafamiliar disfuncional influye en el comportamiento de los niños en edad escolar de la Unidad Educativa, Federico González Suárez del sitio Resbalón de Rocafuerte toda vez que entendemos que la violencia es general, pero una principal consecuencia para que se deriven todas estas situaciones de violencia a todos los niveles se da desde círculo familiar, donde se desenvuelven las personas y donde se comienza a adquirir nuevos conocimientos y que va forjando el carácter, manera de ser y actuar. Es un eslabón importante que se da desde la unión de los padres y la concepción y crianza de los niños, que se forma el círculo familiar, dando a esto nuevos seres con idénticos perfiles y rasgos familiares que llevarán de generación en generación. Por ello este artículo estará basado en un tema importante como lo es la familia que forma parte, pero cuando en estos lazos de amor y fraternidad, algún momento se rompe, se cometen actos de violencia, se genera una ruptura familiar, y en muchas ocasiones se termina con la desunión de toda la familia por ello es muy interesante analizar estas situaciones que afectan a niños y niñas en edad escolar en búsqueda de las mejores soluciones. Las acciones de capacitación permitieron a los padres de familia orientar sus acciones en campos de interés tanto para las familias como para la sociedad; entre ellas el fomento de la corresponsabilidad doméstica y de la educación de los niños, el desarrollo de hábitos deportivos saludables, el fomento de la lectura y de los hábitos de estudio, la prevención del fracaso escolar, la utilización adecuada del tiempo libre, entre otros

Integrative transcriptome, genome and quantitative trait loci resources identify single nucleotide polymorphisms in candidate genes for growth traits in turbot

Growth traits represent a main goal in aquaculture breeding programs and may be related to adaptive variation in wild fisheries. Integrating quantitative trait loci (QTL) mapping and next generation sequencing can greatly help to identify variation in candidate genes, which can result in marker-assisted selection and better genetic structure information. Turbot is a commercially important flatfish in Europe and China, with available genomic information on QTLs and genome mapping. Muscle and liver RNA-seq from 18 individuals was carried out to obtain gene sequences and markers functionally related to growth, resulting in a total of 20,447 genes and 85,344 single nucleotide polymorphisms (SNPs). Many growth-related genes and SNPs were identified and placed in the turbot genome and genetic map to explore their co-localization with growth-QTL markers. Forty-five SNPs on growth-related genes were selected based on QTL co-localization and relevant function for growth traits. Forty-three SNPs were technically feasible and validated in a wild Atlantic population, where 91% were polymorphic. The integration of functional and structural genomic resources in turbot provides a practical approach for QTL mining in this species. Validated SNPs represent a useful set of growth-related gene markers for future association, functional and population studies in this flatfish species

Integrative Transcriptome, Genome and Quantitative Trait Loci Resources Identify Single Nucleotide Polymorphisms in Candidate Genes for Growth Traits in Turbot

Growth traits represent a main goal in aquaculture breeding programs and may be related to adaptive variation in wild fisheries. Integrating quantitative trait loci (QTL) mapping and next generation sequencing can greatly help to identify variation in candidate genes, which can result in marker-assisted selection and better genetic structure information. Turbot is a commercially important flatfish in Europe and China, with available genomic information on QTLs and genome mapping. Muscle and liver RNA-seq from 18 individuals was carried out to obtain gene sequences and markers functionally related to growth, resulting in a total of 20,447 genes and 85,344 single nucleotide polymorphisms (SNPs). Many growth-related genes and SNPs were identified and placed in the turbot genome and genetic map to explore their co-localization with growth-QTL markers. Forty-five SNPs on growth-related genes were selected based on QTL co-localization and relevant function for growth traits. Forty-three SNPs were technically feasible and validated in a wild Atlantic population, where 91% were polymorphic. The integration of functional and structural genomic resources in turbot provides a practical approach for QTL mining in this species. Validated SNPs represent a useful set of growth-related gene markers for future association, functional and population studies in this flatfish speciesThis work was funded by Spanish Ministry of Economy and Competitiveness and European Regional Development Funds (AGL2012-35904), and Ministry of Science and Innovation (Consolider Ingenio, Aquagenomics, CSD200700002). DR was supported by a FPU fellowship funded by Spanish Ministry of Education, Culture and Sport. Thanks to Lucía Ínsua for technical assistance. We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics for the generation of the sequencing data, and the Spanish National Genotyping Center (CEGEN-ISCIII)-USC node for SNP genotyping support. We acknowledge the support of the Centro de Supercomputación de Galicia (CESGA) in the completion of this workS

Hybrid RSS-RTT Localization Scheme for Indoor Wireless Networks

[EN]Nowadays, a variety of information related to the distance between two wireless devices can be easily obtained. This paper presents a hybrid localization scheme that combines received signal strength (RSS) and round-trip time (RTT) information with the aim of improving the previous localization schemes. The hybrid localization scheme is based on an RSS ranging technique that uses RTT ranging estimates as constraints among other heuristic constraints. Once distances have been well estimated, the position of the mobile station (MS) to be located is estimated using a new robust least-squared multilateration (RLSM) technique that combines the RSS and RTT ranging estimates mitigating the negative effect of outliers. The hybrid localization scheme coupled with simulations and measurements demonstrates that it outperforms the conventional RSS-based and RTT-based localization schemes, without using either a tracking technique or a previous calibration stage of the environment.Dirección General de Telecomunicaciones de la Consejería de Fomento de Castilla y Leó

Transcriptomic differences in MSA clinical variants

Background: Multiple system atrophy (MSA) is a rare oligodendroglial synucleinopathy of unknown etiopathogenesis including two major clinical variants with predominant parkinsonism (MSA-P) or cerebellar dysfunction (MSA-C). Objective: To identify novel disease mechanisms we performed a blood transcriptomic study investigating differential gene expression changes and biological process alterations in MSA and its clinical subtypes. Methods: We compared the transcriptome from rigorously gender and age-balanced groups of 10 probable MSA-P, 10 probable MSA-C cases, 10 controls from the Catalan MSA Registry (CMSAR), and 10 Parkinson Disease (PD) patients. Results: Gene set enrichment analyses showed prominent positive enrichment in processes related to immunity and inflammation in all groups, and a negative enrichment in cell differentiation and development of the nervous system in both MSA-P and PD, in contrast to protein translation and processing in MSA-C. Gene set enrichment analysis using expression patterns in different brain regions as a reference also showed distinct results between the different synucleinopathies. Conclusions: In line with the two major phenotypes described in the clinic, our data suggest that gene expression and biological processes might be differentially affected in MSA-P and MSA-C. Future studies using larger sample sizes are warranted to confirm these results

HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease

We investigated the associations with HLA and microtubule-associated protein tau (MAPT) H1 haplotype in anti-IgLON5 disease, a recently identified disorder characterized by gait instability, brainstem dysfunction, and a prominent sleep disorder in association with IgLON5 antibodies and pathologic findings of a novel neuronal-specific tauopathy. We compared the HLA alleles and MAPT H1/H1 genotype of 35 patients with anti-IgLON5 with healthy controls. The on-line server tool NetMHCIIpan 3.1 was used to predict the IgLON5 peptide binding to HLA Class II molecules. The HLA-DRB1*10:01-DQB1*05:01 haplotype was overrepresented in patients with anti-IgLON5 disease (OR = 54.5; 95% CI: 22.2-133.9, p < 0.0001). In addition, HLA-DQA was genotyped in 27 patients, and 25 (92.6%) of them had DQ molecules composed by DQA1*01 and DQB1*05 chains compared with 148/542 (27.3%) controls (OR = 43.9; 95% CI: 10.4-185.5, p < 0.0001). Patients DRB1*10:01 positive developed more frequently sleep or bulbar symptoms than those carrying other HLA alleles (70.0% vs 26.7%; p = 0.011). Prediction algorithms identified 2 IgLON5 peptides (1 located in the signal sequence) that showed strong binding to HLA-DRB1*10:01 and other HLA-DRB1, but not to HLA-DQA and HLA-DQB molecules. The MAPT H1/H1 homozygous genotype was present in 20/24 (83.3%) anti-IgLON5 Caucasian patients compared with 54/116 (46.5%) healthy controls (p = 0.0007). The robust association of anti-IgLON5 disease with distinct HLA Class II molecules supports a primary autoimmune origin. The significant association of MAPT H1 haplotype also suggests that an underlying neurodegenerative process could be involved in anti-IgLON5 disease